Dr Mark Perry

Mark Perry is currently a research associate in Experimental Studies, within the Section of Airway Disease at the NHLI. He obtained his BSc in Biomedical Science from The North East Surrey College of Technology and subsequently a PhD in Molecular Biology from Imperial College. This was followed by a post-doctoral position in Biopharmaceutics at the NHLI.

For the past six years, Dr Perry has worked in the field of respiratory cell biology with a particular interest in the effect of miRNAs upon cellular inflammation in lung diseases such as asthma and COPD. His work has focussed upon how miRNAs are altered in the disease state and the investigation of altering these to act as novel therapeutic targets. He has published his work in high impact medical journals and has presented both nationally and internationally as well as acting as a reviewer for current respiratory medical journals.

Recent Publications

Perry, M. M., Hui, C. K., Whiteman, M., Wood, M. E., Adcock, I., Kirkham, P., Michaeloudes, C., and Chung, K. F. (2011). Hydrogen Sulfide Inhibits Proliferation and Release of IL-8 from Human Airway Smooth Muscle Cells. Am J Respir.Cell Mol Biol

Larner-Svensson,H.M, Williams A.E, Tsitsoiu,E., Perry M.M., Xiaoying Jiang, Fan Chung K, and Lindsay M.A. (2010). Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle. Respiratory Research 2010, 11:68doi:10.1186/1465-9921-11-68.

 Perry M.M., Williams,A.E., Tsitsoiu,E., Larner-Svensson,H.M., and Lindsay,M.A. (2009). Divergent intracellular pathways regulate interleukin-1β-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells. FEBS Lett. 583 3349-3355

 Williams A.E, Larner-Svensson H.M, Perry M.M., Campbell G.A, Herrick S.E, Adcock I.M, Erjefalt J.S, Chung K.F, Lindsay M.A. (2009). MicroRNA Expression Profiling in Mild Asthmatic Human Airways and Effect of Corticosteroid Therapy. PLoS ONE 4(6): e5889. doi:10.1371/journal.pone.0005889

 Williams,A.E., Perry M.M., Moschos S.A, Larner-Svensson H.M and Lindsay M.A. (2008). Role of microRNA-146a in the regulation of the innate immune response and cancer. Biochemical Society Transactions 36:1211-1215.

 Perry M.M., Moschos S.A, Williams A.E, Shepherd M.J, Larner-Svensson H.M and Lindsay M.A. (2008). Rapid changes in microRNA-146a expression negatively regulate the IL-1b-induced inflammatory response in human lung alveolar epithelial cells. Journal of Immunology 180: 5689-5698.