Dr Marco Purbhoo

Publications


Journals

  • Liu H; Purbhoo MA; Davis DM; Rudd CE. (1 Jun 2010). SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering. Proc Natl Acad Sci U S A. 107:10166-10171. DOI.
  • Purbhoo MA; Liu H; Oddos S; Owen DM; Neil MA; Pageon SV; French PM; Rudd CE; et alDavis DM. (2010). Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse. Sci Signal. 3:ra36. DOI.
  • Fadda L; Borhis G; Ahmed P; Cheent K; Pageon SV; Cazaly A; Stathopoulos S; Middleton D; et alMulder A; Claas FH; Elliott T; Davis DM; Purbhoo MA; Khakoo SI. (1 Jun 2010). Peptide antagonism as a mechanism for NK cell activation. Proc Natl Acad Sci U S A. 107:10160-10165. DOI.
  • Varela-Rohena A; Molloy PE; Dunn SM; Li Y; Suhoski MM; Carroll RG; Milicic A; Mahon T; et alSutton DH; Laugel B; Moysey R; Cameron BJ; Vuidepot A; Purbhoo MA; Cole DK; Phillips RE; June CH; Jakobsen BK; Sewell AK; Riley JL. (Dec 2008). Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nat Med. 14:1390-1395. DOI.
  • Oddos S; Dunsby C; Purbhoo MA; Chauveau A; Owen DM; Neil MA; Davis DM; French PM. (15 Nov 2008). High-speed high-resolution imaging of intercellular immune synapses using optical tweezers. Biophys J. 95:L66-L68. DOI.
  • Sowinski S; Jolly C; Berninghausen O; Purbhoo MA; Chauveau A; Koehler K; Oddos S; Eissmann P; et alBrodsky FM; Hopkins C; Oenfelt B; Sattentau Q; Davis DM. (1 Feb 2008). Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. NATURE CELL BIOLOGY. 10:211-219. Author weblink DOI.
  • Seggewiss R; Price DA; Purbhoo MA. (2008). Immunomodulatory effects of imatinib and second-generation tyrosine kinase inhibitors on T cells and dendritic cells: an update. Cytotherapy. 10:633-641. DOI.
  • Purbhoo MA; Li Y; Sutton DH; Brewer JE; Gostick E; Bossi G; Laugel B; Moysey R; et alBaston E; Liddy N; Cameron B; Bennett AD; Ashfield R; Milicic A; Price DA; Classon BJ; Sewell AK; Jakobsen BK. (Jul 2007). The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor. Mol Cancer Ther. 6:2081-2091. DOI.
  • Onfelt B; Nedvetzki S; Benninger RK; Purbhoo MA; Sowinski S; Hume AN; Seabra MC; Neil MA; et alFrench PM; Davis DM. (15 Dec 2006). Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol. 177:8476-8483.
  • Treanor B; Lanigan PM; Kumar S; Dunsby C; Munro I; Auksorius E; Culley FJ; Purbhoo MA; et alPhillips D; Neil MA; Burshtyn DN; French PM; Davis DM. (3 Jul 2006). Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses. J Cell Biol. 174:153-161. DOI.
  • Purbhoo MA; Sutton DH; Brewer JE; Mullings RE; Hill ME; Mahon TM; Karbach J; Jäger E; et alCameron BJ; Lissin N; Vyas P; Chen JL; Cerundolo V; Jakobsen BK. (15 Jun 2006). Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors. J Immunol. 176:7308-7316.
  • Onfelt B; Purbhoo MA; Nedvetzki S; Sowinski S; Davis DM. (6 Dec 2005). Long-distance calls between cells connected by tunneling nanotubules. Sci STKE. 2005:pe55. DOI.
  • Scriba TJ; Purbhoo M; Day CL; Robinson N; Fidler S; Fox J; Weber JN; Klenerman P; et alSewell AK; Phillips RE. (15 Nov 2005). Ultrasensitive detection and phenotyping of CD4(+) T cells with optimized HLA class II tetramer staining. JOURNAL OF IMMUNOLOGY. 175:6334-6343. Author weblink.
  • Purbhoo MA; Irvine DJ; Huppa JB; Davis MM. (1 Jun 2004). T cell killing does not require the formation of a stable mature immunological synapse (vol 5, pg 524, 2004). NATURE IMMUNOLOGY. 5:658-658. DOI.
  • Purbhoo MA; Irvine DJ; Huppa JB; Davis MM. (May 2004). T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol. 5:524-530. DOI.
  • Krogsgaard M; Huppa JB; Purbhoo MA; Davis MM. (Dec 2003). Linking molecular and cellular events in T-cell activation and synapse formation. Semin Immunol. 15:307-315. DOI.
  • Davis MM; Krogsgaard M; Huppa JB; Sumen C; Purbhoo MA; Irvine DJ; Wu LC; Ehrlich L. (2003). Dynamics of cell surface molecules during T cell recognition. Annu Rev Biochem. 72:717-742. DOI.
  • Irvine DJ; Purbhoo MA; Krogsgaard M; Davis MM. (24 Oct 2002). Direct observation of ligand recognition by T cells. Nature. 419:845-849. DOI.
  • Smith K; Seddon B; Purbhoo MA; Zamoyska R; Fisher AG; Merkenschlager M. (5 Nov 2001). Sensory adaptation in naive peripheral CD4 T cells. J Exp Med. 194:1253-1261.
  • Purbhoo MA; Boulter JM; Price DA; Vuidepot AL; Hourigan CS; Dunbar PR; Olson K; Dawson SJ; et alPhillips RE; Jakobsen BK; Bell JI; Sewell AK. (31 Aug 2001). The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain. J Biol Chem. 276:32786-32792. DOI.
  • Xu XN; Purbhoo MA; Chen N; Mongkolsapaya J; Cox JH; Meier UC; Tafuro S; Dunbar PR; et alSewell AK; Hourigan CS; Appay V; Cerundolo V; Burrows SR; McMichael AJ; Screaton GR. (1 May 2001). A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha 3 domain mutants of MHC class I/peptide complex. IMMUNITY. 14:591-602. Author weblink DOI.
  • Whelan JA; Dunbar PR; Price DA; Purbhoo MA; Lechner F; Ogg GS; Griffiths G; Phillips RE; et alCerundolo V; Sewell AK. (15 Oct 1999). Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent. J Immunol. 163:4342-4348.
  • Sewell AK; Gerth UC; Price DA; Purbhoo MA; Boulter JM; Gao GF; Bell JI; Phillips RE; et alJakobsen BK. (Apr 1999). Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nat Med. 5:399-404. DOI.
  • Price DA; Meier UC; Klenerman P; Purbhoo MA; Phillips RE; Sewell AK. (Sep 1998). The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection. J Mol Med (Berl). 76:699-708.
  • Purbhoo MA; Sewell AK; Klenerman P; Goulder PJ; Hilyard KL; Bell JI; Jakobsen BK; Phillips RE. (14 Apr 1998). Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade. Proc Natl Acad Sci U S A. 95:4527-4532.

Conferences

  • Sabaratnam K; Dyball S; Seyedmohammad S; Purbhoo MA. Viral ligands reposition activating and inhibitory receptors at the T-cell immune synapse to enhance inhibitory signalling: a novel mechanism for immune escape. Annual Congress of the British-Society-for-Immunology, 5 Dec 2011 - 8 Dec 2011. 135:48-48. WILEY-BLACKWELL (1 Dec 2011). Author weblink.
  • Purbhoo MA; Liu H; Oddos S; Owen DM; Neil MAA; Pageon SV; French PMW; Rudd CE; et alDavis DM. Dynamics of sub-synaptic vesicles and surface microclusters at the T cell immunological synapse. Annual Congress of the British-Society-for-Immunology, 6 Dec 2010 - 10 Dec 2010. 131:175-175. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2010). Author weblink.
  • Borhis G; Purbhoo M; Ahmed PS; Fadda L; Davis DM; Khakoo SI. Effects of MHC class I peptides on KIR2DL3 clustering and signalling. Annual Congress of the British-Society-for-Immunology, 6 Dec 2010 - 10 Dec 2010. 131:134-134. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2010). Author weblink.
  • Ashfield R; Sutton D; Bossi G; Brewer J; Purbhoo M; Dennis R; Karbach J; Mahon T; et alCameron B; Jakobsen B. High affinity T cell receptors as therapeutic agents. 7th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, 7 Jun 2007 - 11 Jun 2007. 123:S7-S7. ACADEMIC PRESS INC ELSEVIER SCIENCE (1 Jan 2007). DOI.
  • Brewer JE; Sutton DH; Purbhoo MA; Lissin N; Johnson A; Molloy P; Dunn SM; Moysey R; et alDepta J; Mullings RE; Pumphrey N; Li Y; Jakobsen BK. Cancer immunotherapy with soluble T cell receptors; Intracellular tumour proteins become valid targets for treatment. 4th International Symposium on Targeted Anticancer Therapies, 16 Mar 2006 - 18 Mar 2006. 17:48-48. OXFORD UNIV PRESS (1 Jan 2006).
  • Purbhoo M. Quantification and visualization of peptide/major histocompatability complex antigens on live cells using high-affinity soluble T cell receptors. 19th Annual Scientific Meeting of the International-Society-for-Biological-Therapy-of-Cancer, 4 Nov 2004 - 7 Nov 2004. 27:S36-S37. LIPPINCOTT WILLIAMS & WILKINS (1 Nov 2004). DOI.
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