Professor Matthew C Pickering

Publications


Journals

  • Vernon KA; Goicoechea de Jorge E; Hall AE; Fremeaux-Bacchi V; Aitman TJ; Cook HT; Hangartner R; Koziell A; et alPickering MC. (12 Apr 2012). Acute Presentation and Persistent Glomerulonephritis Following Streptococcal Infection in a Patient With Heterozygous Complement Factor H-Related Protein 5 Deficiency. Am J Kidney Dis. DOI.
  • Sargsyan SA; Serkova NJ; Renner B; Hasebroock KM; Larsen B; Stoldt C; McFann K; Pickering MC; et alThurman JM. (1 Jan 2012). Detection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritis. KIDNEY INTERNATIONAL. 81:152-159. DOI.
  • Menikou S; Patel MP; Rose KL; Botto M; Warner JO; Pickering MC; Boyle RJ. (2012). Relationship between complotype and severity of reported systemic allergic reactions to peanut. Journal of Allergy and Clinical Immunology.
  • Gale DP; Pickering MC. (1 Nov 2011). Regulating complement in the kidney: insights from CFHR5 nephropathy. DISEASE MODELS & MECHANISMS. 4:721-726. Author weblink DOI.
  • Smith RJH; Harris CL; Pickering MC. (1 Aug 2011). Dense deposit disease. MOLECULAR IMMUNOLOGY. 48:1604-1610. Author weblink DOI.
  • Renner B; Ferreira VP; Cortes C; Goldberg R; Ljubanovic D; Pangburn MK; Pickering MC; Tomlinson S; et alHolland-Neidermyer A; Strassheim D; Holers VM; Thurman JM. (1 Jul 2011). Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. KIDNEY INTERNATIONAL. 80:166-174. DOI.
  • Mehta P; Patel L; Roncaroli F; Pickering MC; Brand A. (Mar 2012). Painful myositis in the anti-synthetase syndrome with anti-PL12 antibodies. Rheumatol Int. 32:825-827. DOI.
  • Vernon KA; Pickering MC; Cook T. (2011). Experimental models of membranoproliferative glomerulonephritis, including dense deposit disease. Contrib Nephrol. 169:198-210. DOI.
  • de Jorge EG; Macor P; Paixão-Cavalcante D; Rose KL; Tedesco F; Cook HT; Botto M; Pickering MC. (Jan 2011). The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol. 22:137-145. DOI.
  • Vernon KA; Gale DP; de Jorge EG; McLean AG; Galliford J; Pierides A; Maxwell PH; Taube D; et alPickering MC; Cook HT. (Jan 2011). Recurrence of complement factor H-related protein 5 nephropathy in a renal transplant. Am J Transplant. 11:152-155. DOI.
  • Goicoechea de Jorge E; Pickering MC. (Oct 2010). Atypical hemolytic uremic syndrome: telling the difference between H and Y. Kidney Int. 78:721-723. DOI.
  • Gale DP; de Jorge EG; Cook HT; Martinez-Barricarte R; Hadjisavvas A; McLean AG; Pusey CD; Pierides A; et alKyriacou K; Athanasiou Y; Voskarides K; Deltas C; Palmer A; Fremeaux-Bacchi V; Rodriguez de Cordoba S; Maxwell PH; Pickering MC. (4 Sep 2010). Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. LANCET. 376:794-801. DOI.
  • Fakhouri F; Fremeaux-Bacchi V; Noel L-H; Cook HT; Pickering MC. (1 Aug 2010). C3 glomerulopathy: a new classification. NATURE REVIEWS NEPHROLOGY. 6:494-499. DOI.
  • Pickering MC; Botto M. (Aug 2010). Are anti-C1q antibodies different from other SLE autoantibodies?. Nat Rev Rheumatol. 6:490-493. DOI.
  • Fakhouri F; de Jorge EG; Brune F; Azam P; Cook HT; Pickering MC. (Aug 2010). Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice. Kidney Int. 78:279-286. DOI.
  • Waters AM; Pappworth I; Marchbank K; Bockenhauer D; Tullus K; Pickering MC; Strain L; Sebire N; et alShroff R; Marks SD; Goodship THJ; Rees L. (1 Jan 2010). Successful Renal Transplantation in Factor H Autoantibody Associated HUS with CFHR1 and 3 Deficiency and CFH Variant G2850T. AMERICAN JOURNAL OF TRANSPLANTATION. 10:168-172. Author weblink DOI.
  • Mehta P; Norsworthy PJ; Hall AE; Kelly SJ; Walport MJ; Botto M; Pickering MC. (Apr 2010). SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience. Rheumatology (Oxford). 49:823-824. DOI.
  • Leung VWY; Yun S; Botto M; Mason JC; Malik TH; Song W; Paixao-Cavalcante D; Pickering MC; et alBoyle JJ; Haskard DO. (1 Oct 2009). Decay-Accelerating Factor Suppresses Complement C3 Activation and Retards Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. AMERICAN JOURNAL OF PATHOLOGY. 175:1757-1767. Author weblink DOI.
  • Mehta P; Fernando MMA; Pickering MC; Wilson Y; Molloy S; Colaco CB. (1 Sep 2009). Lateral medullary syndrome with anti-neuronal antibodies (anti-Ta/Ma2) in primary Sjogren's syndrome. RHEUMATOLOGY. 48:1174-1176. Author weblink DOI.
  • Botto M; Kirschfink M; Macor P; Pickering MC; Würzner R; Tedesco F. (Sep 2009). Complement in human diseases: Lessons from complement deficiencies. Mol Immunol. 46:2774-2783. DOI.
  • Paixão-Cavalcante D; Hanson S; Botto M; Cook HT; Pickering MC. (Jun 2009). Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase. Mol Immunol. 46:1942-1950. DOI.
  • Taylor SR; Turner CM; Elliott JI; McDaid J; Hewitt R; Smith J; Pickering MC; Whitehouse DL; et alCook HT; Burnstock G; Pusey CD; Unwin RJ; Tam FW. (Jun 2009). P2X7 deficiency attenuates renal injury in experimental glomerulonephritis. J Am Soc Nephrol. 20:1275-1281. DOI.
  • Ruseva MM; Hughes TR; Donev RM; Sivasankar B; Pickering MC; Wu X; Harris CL; Morgan BP. (1 Feb 2009). Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury. MOLECULAR IMMUNOLOGY. 46:803-811. Author weblink DOI.
  • Paixao-Cavalcante D; Botto M; Cook HT; Pickering MC. (1 Feb 2009). Shiga toxin-2 results in renal tubular injury but not thrombotic microangiopathy in heterozygous factor H-deficient mice. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 155:339-347. Author weblink DOI.
  • Pickering MC; Macor P; Fish J; Durigutto P; Bossi F; Petry F; Botto M; Tedesco F. (1 Oct 2008). Complement C1q and C8 beta deficiency in an individual with recurrent bacterial meningitis and adult-onset systemic lupus erythematosus-like illness. RHEUMATOLOGY. 47:1588-1589. Author weblink DOI.
  • Rose KL; Paixao-Cavalcante D; Fish J; Manderson AP; Malik TH; Bygrave AE; Lin T; Sacks SH; et alWalport MJ; Cook HT; Botto M; Pickering MC. (1 Feb 2008). Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice. JOURNAL OF CLINICAL INVESTIGATION. 118:608-618. Author weblink DOI.
  • Pickering MC; Cook HT. (Feb 2008). Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals. Clin Exp Immunol. 151:210-230. DOI.
  • Coffey PJ; Gias C; McDermott CJ; Lundh P; Pickering MC; Sethi C; Bird A; Fitzke FW; et alMaass A; Chen LL; Holder GE; Luthert PJ; Salt TE; Moss SE; Greenwood J. (16 Oct 2007). Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction. Proc Natl Acad Sci U S A. 104:16651-16656. DOI.
  • Smith RJ; Alexander J; Barlow PN; Botto M; Cassavant TL; Cook HT; de Córdoba SR; Hageman GS; et alJokiranta TS; Kimberling WJ; Lambris JD; Lanning LD; Levidiotis V; Licht C; Lutz HU; Meri S; Pickering MC; Quigg RJ; Rops AL; Salant DJ; Sethi S; Thurman JM; Tully HF; Tully SP; van der Vlag J; Walker PD; Würzner R; Zipfel PF; Dense Deposit Disease Focus Group. (Sep 2007). New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 18:2447-2456. DOI.
  • Abrera-Abeleda MA; Xu Y; Pickering MC; Smith RJH; Sethi S. (1 Jun 2007). Mesangial immune complex glomerulonephritis due to complement factor D deficiency. KIDNEY INTERNATIONAL. 71:1142-1147. Author weblink DOI.
  • Pickering MC; de Jorge EG; Martinez-Barricarte R; Recalde S; Garcia-Layana A; Rose KL; Moss J; Walport MJ; et alCook HT; de Córdoba SR; Botto M. (11 Jun 2007). Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. J Exp Med. 204:1249-1256. DOI.
  • Pickering MC; Warren J; Rose KL; Carlucci F; Wang Y; Walport MJ; Cook HT; Botto M. (20 Jun 2006). Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. Proc Natl Acad Sci U S A. 103:9649-9654. DOI.
  • Braun MC; Li L; Ke BZ; Dubinsky WP; Pickering MC; Chang JY. (1 Jan 2006). Proteomic profiling of urinary protein excretion in the factor H-deficient mouse. AMERICAN JOURNAL OF NEPHROLOGY. 26:127-135. Author weblink DOI.
  • Alexander JJ; Pickering MC; Haas M; Osawe I; Quigg RJ. (1 Jan 2005). Complement factor H limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 16:52-57. Author weblink DOI.
  • Patel SM; Cohen P; Pickering MC; Gazzard BG; Andreyev J. (Sep 2003). Successful treatment of acute haemorrhagic cytomegalovirus colitis with ganciclovir in an individual without overt immunocompromise. Eur J Gastroenterol Hepatol. 15:1055-1060. DOI.
  • Pickering MC; Cook HT; Warren J; Bygrave AE; Moss J; Walport MJ; Botto M. (Aug 2002). Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet. 31:424-428. DOI.
  • Taylor PR; Pickering MC; Kosco-Vilbois MH; Walport MJ; Botto M; Gordon S; Martinez-Pomares L. (1 Jul 2002). The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues. EUROPEAN JOURNAL OF IMMUNOLOGY. 32:1888-1896. Author weblink.
  • Mitchell DA; Pickering MC; Warren J; Fossati-Jimack L; Cortes-Hernandez J; Cook HT; Botto M; Walport MJ. (1 Mar 2002). C1q deficiency and autoimmunity: the effects of genetic background on disease expression. J Immunol. 168:2538-2543.
  • Manderson AP; Pickering MC; Botto M; Walport MJ; Parish CR. (17 Sep 2001). Continual low-level activation of the classical complement pathway. JOURNAL OF EXPERIMENTAL MEDICINE. 194:747-756. Author weblink DOI.
  • Pickering MC; Warren J; Bygrave AE; Moss J; Sim RB; Cook HT; Walport MJ; Botto M. (1 Aug 2001). Membranoproliferative glomerulonephritis in factor H-deficient mice. MOLECULAR IMMUNOLOGY. 38:116-117. Author weblink.
  • Pickering MC; Fischer S; Lewis MR; Walport MJ; Botto M; Cook HT. (Jul 2001). Ultraviolet-radiation-induced keratinocyte apoptosis in C1q-deficient mice. J Invest Dermatol. 117:52-58. DOI.
  • Pickering MC; Haskard DO. (1 Dec 2000). False-positive results obtained using the Mantoux test in Behcet's syndrome: comment on the article by Garcia-Porrua et al. ARTHRITIS AND RHEUMATISM. 43:2855-2855. Author weblink DOI.
  • Pickering MC; Haskard DO. (Mar 2000). Behçet's syndrome. J R Coll Physicians Lond. 34:169-177.
  • Pickering MC; Barkham T; Mason JC; Shaunak S; Davies KA. (1 Feb 2000). Bilateral gluteal abscesses as a unique manifestation of Fusobacterium septicaemia. RHEUMATOLOGY. 39:224-225. Author weblink DOI.
  • Pickering MC; Walport MJ. (Feb 2000). Links between complement abnormalities and systemic lupus erythematosus. Rheumatology (Oxford). 39:133-141.
  • Pickering MC; Botto M; Taylor PR; Lachmann PJ; Walport MJ. (2000). Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv Immunol. 76:227-324.
  • Pickering MC; Walport MJ. (Nov 1998). Eosinophilic myopathic syndromes. Curr Opin Rheumatol. 10:504-510.

Conferences

  • Menikou S; Warner JO; Botto M; Pickering MC; Boyle RJ. The role of the complotype in determining the severity of systemic allergic reactions to peanuts. Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI), 11 Jul 2011 - 13 Jul 2011. 41:1860-1861. WILEY-BLACKWELL (1 Dec 2011). Author weblink.
  • Vernon KA; de Jorge EG; Rose KL; Hall AE; Rigby E; Hangartner R; Cook HT; Koziell A; et alPickering MC. Complement Factor H-related protein 5 deficiency is a risk factor for chronic renal disease following acute post-streptococcal glomerulonephritis. 13th European Meeting on Complement in Human Disease, 21 Aug 2011 - 24 Aug 2011. 48:1728-1728. PERGAMON-ELSEVIER SCIENCE LTD (1 Aug 2011). Author weblink DOI.
  • Smith RJH; Zhang Y; Nester CM; Corchado JC; Marsh H; de Jorge EG; Fakhouri F; Paixao-Cavalcante D; et alHarris CL; Pickering MC. Dense deposit disease-A 2011 update. 13th European Meeting on Complement in Human Disease, 21 Aug 2011 - 24 Aug 2011. 48:1679-1679. PERGAMON-ELSEVIER SCIENCE LTD (1 Aug 2011). Author weblink DOI.
  • Vernon KA; Malik T; Botto M; Pickering MC. A new model of atypical haemolytic uraemic syndrome. 13th European Meeting on Complement in Human Disease, 21 Aug 2011 - 24 Aug 2011. 48:1678-1678. PERGAMON-ELSEVIER SCIENCE LTD (1 Aug 2011). Author weblink DOI.
  • de Jorge EG; Harris CL; Patel MP; Pickering MC. Differential binding of CFHR5 and factor H to C3 metabolites suggests that these two proteins regulate complement activation at different stages. 13th European Meeting on Complement in Human Disease, 21 Aug 2011 - 24 Aug 2011. 48:1675-1675. PERGAMON-ELSEVIER SCIENCE LTD (1 Aug 2011). Author weblink DOI.
  • Vernon KA; Gale DP; de Jorge EG; McLean AG; Maxwell PH; Pickering MC; Cook HT. Recurrence of complement factor H-related protein 5 nephropathy in a renal transplant. 23rd International National Complement Workshop, 1 Aug 2010 - 5 Aug 2010. 47:2202-2202. PERGAMON-ELSEVIER SCIENCE LTD (1 Aug 2010). DOI.
  • Fakhouri F; de Jorge EG; Brune F; Azam P; Cook HT; Pickering MC. Human CFH rapidly reverses renal complement deposition in factor H-deficient mice. 23rd International National Complement Workshop, 1 Aug 2010 - 5 Aug 2010. 47:2201-2201. PERGAMON-ELSEVIER SCIENCE LTD (1 Aug 2010). DOI.
  • de Jorge EG; Cook HT; Botto M; Pickering MC. Insights into the role of complement dysregulation in atypical haemolytic uremic syndrome. 12th European Meeting on Complement in Human Disease, 5 Sep 2009 - 8 Sep 2009. 46:2851-2851. PERGAMON-ELSEVIER SCIENCE LTD (1 Sep 2009). DOI.
  • de Jorge EG; Gale DP; Cook HT; Martinez-Barricarte R; Hadjisavvas A; Pusey CD; Palmer A; Fremeaux-Bacchi V; et alRodriguez de Cordoba S; Maxwell PH; Pickering MC. A mutant complement factor H-related 5 protein is associated with familial C3 glomerulonephritis. 12th European Meeting on Complement in Human Disease, 5 Sep 2009 - 8 Sep 2009. 46:2822-2822. PERGAMON-ELSEVIER SCIENCE LTD (1 Sep 2009). Author weblink DOI.
  • Botto M; Kirschfink M; Macor P; Pickering MC; Wuerzner R; Tedesco F. Complement in human diseases: Lessons from complement deficiencies. 12th European Meeting on Complement in Human Disease, 5 Sep 2009 - 8 Sep 2009. 46:2774-2783. PERGAMON-ELSEVIER SCIENCE LTD (1 Sep 2009). Author weblink DOI.
  • Mehta P; Norsworthy PJ; Walport MJ; Botto M; Pickering MC. SLE WITH C1Q DEFICIENCY TREATED WITH FRESH FROZEN PLASMA (FFP): A TEN-YEAR EXPERIENCE. Annual Meeting of the British-Society-of-Rheumatology, 28 Apr 2009 - 1 May 2009. 48:I21-I22. OXFORD UNIV PRESS (1 Apr 2009). Author weblink.
  • Paixao-Cavalcante D; Hanson S; Cook HT; Botto M; Pickering MC. Administration of purified mouse factor H into factor H-deficient mice removes glomerular basement membrane C3. 22nd International Complement Workshop, 28 Sep 2008 - 2 Oct 2008. 45:4127-4127. PERGAMON-ELSEVIER SCIENCE LTD (1 Oct 2008). Author weblink DOI.
  • de Jorge EG; Paixao-Cavalcante D; Rose KL; Cook HT; Botto M; Pickering MC. C5 activation is required for the development of atypical haemolytic uraemic syndrome in Cfh-/-FH Delta 16-20 mice. 22nd International Complement Workshop, 28 Sep 2008 - 2 Oct 2008. 45:4100-4101. PERGAMON-ELSEVIER SCIENCE LTD (1 Oct 2008). Author weblink DOI.
  • Pickering MC; Rose K; Botto M; Sontheimer RD. Clq is not required for the induction and elicitation of murine allergic contact dermatitis. 66th Annual Meeting of the Society-for-Investigative-Dermatology. 124:A117-A117. (Apr 2005).
  • Pickering MC; Turnberg DA; Warren J; Carlucci F; Cook HT; Botto M. The role of the alternative pathway in accelerated serum nephrotoxic nephritis in C57BL/6 mice. 10th Meeting on Complement in Human Disease. 43:170-170. (Jan 2006).
  • Pickering MC; Rose KL; Carlucci F; Howard J; Cook HT; Botto M. Increased susceptibility of heterozygous factor H deficient mice to accelerated serum nephrotoxic nephritis. 21st International Complement Workshop. 44:228-228. (Jan 2007).
  • Pickering MC; de Jorge EG; Rose KL; Moss J; Cook HT; de Cordoba SR; Botto M. Spontaneous haemolytic uraemic syndrome (HUS) in factor H-deficient mice transgenic for murine factor H protein lacking the five C-terminal domains (FH Delta 16-20). 21st International Complement Workshop, 22 Oct 2006 - 26 Oct 2006. 44:227-228. PERGAMON-ELSEVIER SCIENCE LTD (1 Jan 2007). Author weblink DOI.
  • Pickering MC; Warren J; Rose K; Carlucci F; Moss J; Wang Y; Walport MJ; Cook HT; et alBotto M. Prevention of C5 activation ameliorates membranoproliferative glomerulonephritis associated with factor H deficiency. 10th Meeting on Complement in Human Disease, 9 Sep 2005 - 13 Sep 2005. 43:140-141. PERGAMON-ELSEVIER SCIENCE LTD (1 Jan 2006). Author weblink.
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