Dr Michael R Edwards

Publications


Journals

  • Vareille M; Kieninger E; Alves MP; Kopf BS; Moller A; Geiser T; Johnston, S.L.; Edwards, M.R.; et alRegamey, N.R.. (4 Jan 2012). Impaired type I and type III interferon induction and rhinovirus control in human cystic fibrosis airway epithelial cells. Thorax.
  • Ouda R; Onomoto K; Takahasi K; Edwards MR; Kato H; Yoneyama M; Fujita T. (22 Jul 2011). Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections by Minor Group Rhinoviruses through Down-regulation of the Very Low Density Lipoprotein Receptor. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:26210-U901. DOI.
  • Zdrenghea MT; Telcian AG; Laza-Stanca V; Bellettato CM; Edwards MR; Nikonova A; Khaitov MR; Azimi N; et alGroh V; Mallia P; Johnston SL; Stanciu LA. (Mar 2012). RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells. Eur Respir J. 39:712-720. DOI.
  • Vareille M; Kieninger E; Edwards MR; Regamey N. (1 Jul 2011). The Airway Epithelium: Soldier in the Fight against Respiratory Viruses (vol 24, pg 210, 2011). CLINICAL MICROBIOLOGY REVIEWS. 24:631-631. DOI.
  • Stokes CA; Ismail S; Dick EP; Bennett JA; Johnston SL; Edwards MR; Sabroe I; Parker LC. (1 Aug 2011). Role of Interleukin-1 and MyD88-Dependent Signaling in Rhinovirus Infection. JOURNAL OF VIROLOGY. 85:7912-7921. DOI.
  • Laza-Stanca V; Message SD; Edwards MR; Parker HL; Zdrenghea MT; Kebadze T; Kon OM; Mallia P; et alStanciu LA; Johnston SL. (Jul 2011). The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. PLoS Pathog. 7:e1002114. DOI.
  • Edwards MR; Johnston SL. (Jun 2011). Interferon-lambda as a new approach for treatment of allergic asthma?. EMBO Mol Med. 3:306-308. DOI.
  • Vareille M; Kieninger E; Edwards MR; Regamey N. (1 Jan 2011). The Airway Epithelium: Soldier in the Fight against Respiratory Viruses. CLINICAL MICROBIOLOGY REVIEWS. 24:210-+. DOI.
  • Telcian AG; Laza-Stanca V; Edwards MR; Harker JA; Wang H; Bartlett NW; Mallia P; Zdrenghea MT; et alKebadze T; Coyle AJ; Openshaw PJ; Stanciu LA; Johnston SL. (1 Jan 2011). RSV-induced bronchial epithelial cell PD-L1 expression inhibits CD8+ T cell nonspecific antiviral activity. J Infect Dis. 203:85-94. DOI.
  • Slater L; Bartlett NW; Haas JJ; Zhu J; Message SD; Walton RP; Sykes A; Dahdaleh S; et alClarke DL; Belvisi MG; Kon OM; Fujita T; Jeffery PK; Johnston SL; Edwards MR. (2010). Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. PLoS Pathog. 6:e1001178. DOI.
  • Mallia P; Message SD; Gielen V; Contoli M; Gray K; Kebadze T; Aniscenko J; Laza-Stanca V; et alEdwards MR; Slater L; Papi A; Stanciu LA; Kon OM; Johnson M; Johnston SL. (15 Mar 2011). Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation. Am J Respir Crit Care Med. 183:734-742. DOI.
  • Hewson CA; Haas JJ; Bartlett NW; Message SD; Laza-Stanca V; Kebadze T; Caramori G; Zhu J; et alEdbrooke MR; Stanciu LA; Kon OM; Papi A; Jeffery PK; Edwards MR; Johnston SL. (Dec 2010). Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways. Eur Respir J. 36:1425-1435. DOI.
  • Gielen V; Johnston SL; Edwards MR. (Sep 2010). Azithromycin induces anti-viral responses in bronchial epithelial cells. Eur Respir J. 36:646-654. DOI.
  • Johnston SL; Edwards MR. (1 Sep 2009). Mechanisms of adverse effects of beta-agonists in asthma. THORAX. 64:739-741. Author weblink DOI.
  • Khaitov MR; Laza-Stanca V; Edwards MR; Walton RP; Rohde G; Contoli M; Papi A; Stanciu LA; et alKotenko SV; Johnston SL. (Mar 2009). Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells. Allergy. 64:375-386. DOI.
  • Papi A; Contoli M; Gasparini P; Bristot L; Edwards MR; Chicca M; Leis M; Ciaccia A; et alCaramori G; Johnston SL; Pinamonti S. (17 Oct 2008). Role of xanthine oxidase activation and reduced glutathione depletion in rhinovirus induction of inflammation in respiratory epithelial cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:28595-28606. Author weblink DOI.
  • Edwards MR; Bartlett NW; Clarke D; Birrell M; Belvisi M; Johnston SL. (Jan 2009). Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease. Pharmacol Ther. 121:1-13. DOI.
  • Edwards MR; Johnston SL. (Sep 2008). Deficient interferon in virus-induced asthma exacerbations. Clin Exp Allergy. 38:1416-1418. DOI.
  • Bartlett NW; Walton RP; Edwards MR; Aniscenko J; Caramori G; Zhu J; Glanville N; Choy KJ; et alJourdan P; Burnet J; Tuthill TJ; Pedrick MS; Hurle MJ; Plumpton C; Sharp NA; Bussell JN; Swallow DM; Schwarze J; Guy B; Almond JW; Jeffery PK; Lloyd CM; Papi A; Killington RA; Rowlands DJ; Blair ED; Clarke NJ; Johnston SL. (Feb 2008). Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat Med. 14:199-204. DOI.
  • Edwards MR; Slater L; Johnston SL. (1 Sep 2007). Signalling pathways mediating type I interferon gene expression. MICROBES AND INFECTION. 9:1245-1251. Author weblink DOI.
  • Edwards MR; Brouwer, W; Choi, CH; Ruhno, J; Ward, RL; Collins, AM. (Jun 2015). Analysis of IgE antibodies from a patient with atopic dermatitis: biased V gene usage and evidence for polyreactive IgE heavy chain complementarity-determining region 3. Jounal of Immunology. 168:6305-6313. Publisher weblink.
  • Edwards MR; Haas J; Panettieri RA; Johnson M; Johnston SL. (25 May 2007). Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements. J Biol Chem. 282:15366-15375. DOI.
  • Edwards MR; Hewson CA; Laza-Stanca V; Lau HT; Mukaida N; Hershenson MB; Johnston SL. (Mar 2007). Protein kinase R, IkappaB kinase-beta and NF-kappaB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells. Mol Immunol. 44:1587-1597. DOI.
  • Contoli M; Message SD; Laza-Stanca V; Edwards MR; Wark PA; Bartlett NW; Kebadze T; Mallia P; et alStanciu LA; Parker HL; Slater L; Lewis-Antes A; Kon OM; Holgate ST; Davies DE; Kotenko SV; Papi A; Johnston SL. (Sep 2006). Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med. 12:1023-1026. DOI.
  • Laza-Stanca V; Stanciu LA; Message SD; Edwards MR; Gern JE; Johnston SL. (Aug 2006). Rhinovirus replication in human macrophages induces NF-kappaB-dependent tumor necrosis factor alpha production. J Virol. 80:8248-8258. DOI.
  • Edwards MR; Johnson MW; Johnston SL. (May 2006). Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells. Am J Respir Cell Mol Biol. 34:616-624. DOI.
  • Edwards MR; Kebadze T; Johnson MW; Johnston SL. (2006). New treatment regimes for virus-induced exacerbations of asthma. Pulm Pharmacol Ther. 19:320-334. DOI.
  • Hewson CA; Jardine A; Edwards MR; Laza-Stanca V; Johnston SL. (Oct 2005). Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cells. J Virol. 79:12273-12279. DOI.
  • Edwards MR; Mukaida N; Johnson M; Johnston SL. (2005). IL-1beta induces IL-8 in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids. Pulm Pharmacol Ther. 18:337-345. DOI.
  • Collins AM; Sewell WA; Edwards MR. (1 Nov 2003). Immunoglobulin gene rearrangement, repertoire diversity, and the allergic response. PHARMACOLOGY & THERAPEUTICS. 100:157-170. Author weblink DOI.
  • Yip, YL; Novotny, J; Edwards M; Ward RL. (Apr 2003). Structural analysis of the ErbB-2 receptor using monoclonal antibodies: Implications for receptor signalling. International Journal of Cancer. 104:303-309.
  • Mitchell, AJ; Edwards, MR; Collins, AM. (Oct 2001). Valency or wahlency: is the epitope diversity of the B-cell response regulated or chemically determined?. Immunology & Cell Biology. 79:507-511.
  • Edwards, MR; Collins, AM; Ward, RL. (Sep 2001). The application of phage display in allergy research: characterization of IgE, identification of allergens and development of novel therapeutics. Current Pharmaceutocal Biotechnology. 2:225-240.
  • Philips, JR; Brouwer, W; Edwards, M; Mahler, S; Ruhno, J; Collins, AM. (Apr 1999). The effectiveness of different rat IgG subclasses as IgE-blocking antibodies in the rat basophil leukaemia cell model. Immunology & Cell Biology. 77:121-126.

Conferences

  • Stokes CA; Dick EP; Bennett JA; Ismail S; Edwards MR; Sabroe L; Parker LC. THE ROLE OF MYD88 IN RHINOVIRUS 1B INFECTION. British-Thoracic-Society-Winter-Meeting 2010, 1 Dec 2010 - 3 Dec 2010. 65:A37-A38. B M J PUBLISHING GROUP (1 Dec 2010). DOI.
  • Khaitov MR; Laza-Stanca V; Edwards MR; Walton RP; Johnston SL; DuBuske LM. Type I and type III interferon expression during rhinovirus infection. 64th Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology, 14 Mar 2008 - 18 Mar 2008. 121:S119-S119. MOSBY-ELSEVIER (1 Feb 2008). Author weblink DOI.
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