Dr Nigel J Brand

Publications


Journals

  • Roy A; Brand NJ; Yacoub MH. (May 2000). Molecular characterization of interstitial cells isolated from human heart valves. J HEART VALVE DIS. 9:459-464.
  • Sanchez-Feutrie M; Santalucia T; Fandos C; Noe V; Vinals F; Brand NJ; Ciudad CJ; Palacin M; et alZorzano A. (2004). A novel muscle DNA-binding activity in the GLUT1 promoter. Cell Mol Life Sci. 61:709-720.
  • Moreno H; Serrano AL; Santalucia T; Guma A; Canto C; Brand NJ; Palacin M; Schiaffino S; et alZorzano A. (2003). Differential regulation of the muscle-specific GLUT4 enhancer in regenerating and adult skeletal muscle. J Biol Chem. 278:40557-40564.
  • Stagg MA; Coppen SR; Suzuki K; Varela-Carver A; Lee J; Brand NJ; Fukushima S; Yacoub MH; et alTerracciano CM. (Apr 2006). Evaluation of frequency, type, and function of gap junctions between skeletal myoblasts overexpressing connexin43 and cardiomyocytes: relevance to cell transplantation. FASEB J. 20:744-746. DOI.
  • BRAND NJ; FERSHT AR. (1 Jan 1986). MOLECULAR-CLONING OF THE GENE ENCODING THE VALYL-TRANSFER-RNA SYNTHETASE FROM BACILLUS-STEAROTHERMOPHILUS. GENE. 44:139-142. Author weblink DOI.
  • BORGFORD TJ; BRAND NJ; GRAY TE; FERSHT AR. (5 May 1987). THE VALYL-TRANSFER RNA-SYNTHETASE FROM BACILLUS-STEAROTHERMOPHILUS HAS CONSIDERABLE SEQUENCE HOMOLOGY WITH THE ISOLEUCYL-TRANSFER RNA-SYNTHETASE FROM ESCHERICHIA-COLI. BIOCHEMISTRY. 26:2480-2486. DOI.
  • Davies JM; Hawe N; Kabarowski J; Huang QH; Zhu J; Brand NJ; Leprince D; Dhordain P; et alCook M; Morriss-Kay G; Zelent A. (14 Jan 1999). Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. ONCOGENE. 18:365-375. Author weblink DOI.
  • Santalucia T; Boheler KR; Brand NJ; Sahye U; Fandos C; Vinals F; Ferre J; Testar X; et alPalacin M; Zorzano A. (18 Jun 1999). Factors involved in GLUT-1 glucose transporter gene transcription in cardiac muscle. JOURNAL OF BIOLOGICAL CHEMISTRY. 274:17626-17634. Author weblink DOI.
  • Roy A; Brand NJ; Yacoub MH. (1 Mar 2000). Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valve. JOURNAL OF HEART VALVE DISEASE. 9:256-260. Author weblink.
  • Suzuki K; Brand NJ; Smolenski RT; Jayakumar J; Murtuza B; Yacoub MH. (7 Nov 2000). Development of a novel method for cell transplantation through the coronary artery. CIRCULATION. 102:359-364. Author weblink.
  • Suzuki K; Smolenski RT; Jayakumar J; Murtuza B; Brand NJ; Yacoub MH. (7 Nov 2000). Heat shock treatment enhances graft cell survival in skeletal myoblast transplantation to the heart. CIRCULATION. 102:216-221. Author weblink.
  • Brand NJ; Roy A; Hoare G; Chester A; Yacoub MH. (Jan 2006). Cultured interstitial cells from human heart valves express both specific skeletal muscle and non-muscle markers. Int J Biochem Cell Biol. 38:30-42. DOI.
  • JONES MD; BRAND NJ; FERSHT AR. (22 Dec 1986). SINGLE-STRANDED M13 DNA - USE AS A CLONING VECTOR. NUCLEIC ACIDS RESEARCH. 14:10116-10116. Author weblink DOI.
  • Borgford TJ; Gray TE; Brand NJ; Fersht AR. (17 Nov 1987). Site-directed mutagenesis reveals transition-state stabilization as a general catalytic mechanism for aminoacyl-tRNA synthetases. Biochemistry. 26:7246-7250.
  • Vallins WJ; Brand NJ; Dabhade N; Butler-Browne G; Yacoub MH; Barton PJ. (17 Sep 1990). Molecular cloning of human cardiac troponin I using polymerase chain reaction. FEBS Lett. 270:57-61.
  • Brand NJ; Dabhade N; Yacoub M; Barton PJ. (30 Sep 1991). Determination of the 5' exon structure of the human cardiac alpha-myosin heavy chain gene. Biochem Biophys Res Commun. 179:1255-1258.
  • Sasse S; Brand NJ; Kyprianou P; Dhoot GK; Wade R; Arai M; Periasamy M; Yacoub MH; et alBarton PJ. (May 1993). Troponin I gene expression during human cardiac development and in end-stage heart failure. Circ Res. 72:932-938.
  • Bhavsar PK; Brand NJ; Yacoub MH; Barton PJ. (1 Jul 1996). Isolation and characterization of the human cardiac troponin I gene (TNNI3). Genomics. 35:11-23. DOI.
  • Webb BL; Lindsay MA; Seybold J; Brand NJ; Yacoub MH; Haddad EB; Barnes PJ; Adcock IM; et alGiembycz MA. (1 Jul 1997). Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level. Biochem Pharmacol. 54:199-205.
  • el Oakley RM; Brand NJ; Burton PB; McMullen MC; Adams GB; Poznansky MC; Barton PJ; Yacoub MH. (Jan 1998). Efficiency of a high-titer retroviral vector for gene transfer into skeletal myoblasts. J Thorac Cardiovasc Surg. 115:1-8.
  • Christer JF; Yacoub MH; Brand NJ. (1 Feb 1998). A versatile method for unidirectional cloning of oligonucleotide cassettes: application to creating concatamerized transcription factor binding sites. Anal Biochem. 256:142-145. DOI.
  • Barton PJ; Townsend PJ; Brand NJ; Yacoub MH. (Nov 1997). Localization of the fast skeletal muscle troponin I gene (TNNI2) to 11p15.5: genes for troponin I and T are organized in pairs. Ann Hum Genet. 61:519-523. DOI.
  • Brand NJ. (Dec 1997). Myocyte enhancer factor 2 (MEF2). Int J Biochem Cell Biol. 29:1467-1470.
  • Barton PJ; Cullen ME; Townsend PJ; Brand NJ; Mullen AJ; Norman DA; Bhavsar PK; Yacoub MH. (1 Apr 1999). Close physical linkage of human troponin genes: organization, sequence, and expression of the locus encoding cardiac troponin I and slow skeletal troponin T. Genomics. 57:102-109. DOI.
  • Bhavsar PK; Dellow KA; Yacoub MH; Brand NJ; Barton PJ. (Jan 2000). Identification of cis-acting DNA elements required for expression of the human cardiac troponin I gene promoter. J Mol Cell Cardiol. 32:95-108. DOI.
  • Suzuki K; Murtuza B; Beauchamp JR; Brand NJ; Barton PJ; Varela-Carver A; Fukushima S; Coppen SR; et alPartridge TA; Yacoub MH. (14 Sep 2004). Role of interleukin-1beta in acute inflammation and graft death after cell transplantation to the heart. Circulation. 110:II219-II224. DOI.
  • Barton PJ; Felkin LE; Koban MU; Cullen ME; Brand NJ; Dhoot GK. (Aug 2004). The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart. Mol Cell Biochem. 263:91-97.
  • Santalucía T; Sánchez-Feutrie M; Felkin LE; Bhavsar PK; Barton PJ; Zorzano A; Yacoub MH; Brand NJ. (Apr 2005). Phenylephrine requires the TATA box to activate transcription of GLUT1 in neonatal rat cardiac myocytes. J Mol Cell Cardiol. 38:677-684. DOI.
  • Suzuki K; Murtuza B; Brand NJ; Varela-Carver A; Fukushima S; Yacoub MH. (Apr 2004). Enhanced effect of myocardial gene transfection by VP22-mediated intercellular protein transport. J Mol Cell Cardiol. 36:603-606. DOI.
  • Santalucía T; Christmann M; Yacoub MH; Brand NJ. (1 Sep 2003). Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1. Cardiovasc Res. 59:639-648.
  • Taylor PM; Batten P; Brand NJ; Thomas PS; Yacoub MH. (Feb 2003). The cardiac valve interstitial cell. Int J Biochem Cell Biol. 35:113-118.
  • Brand NJ; Barton PJ. (Mar 2002). Myocardial molecular biology: an introduction. Heart. 87:284-293.
  • Santalucía T; Moreno H; Palacín M; Yacoub MH; Brand NJ; Zorzano A. (23 Nov 2001). A novel functional co-operation between MyoD, MEF2 and TRalpha1 is sufficient for the induction of GLUT4 gene transcription. J Mol Biol. 314:195-204. DOI.
  • Suzuki K; Brand NJ; Allen S; Khan MA; Farrell AO; Murtuza B; Oakley RE; Yacoub MH. (Oct 2001). Overexpression of connexin 43 in skeletal myoblasts: Relevance to cell transplantation to the heart. J Thorac Cardiovasc Surg. 122:759-766. DOI.
  • Dellow KA; Bhavsar PK; Brand NJ; Barton PJ. (Apr 2001). Identification of novel, cardiac-restricted transcription factors binding to a CACC-box within the human cardiac troponin I promoter. Cardiovasc Res. 50:24-33.
  • Suzuki K; Smolenski RT; Jayakumar J; Murtuza B; Brand NJ; Yacoub MH. (7 Nov 2000). Heat shock treatment enhances graft cell survival in skeletal myoblast transplantation to the heart. Circulation. 102:III216-III221.
  • Suzuki K; Brand NJ; Smolenski RT; Jayakumar J; Murtuza B; Yacoub MH. (7 Nov 2000). Development of a novel method for cell transplantation through the coronary artery. Circulation. 102:III359-III364.
  • Li Y; McCormack AM; Brand NJ; Yacoub MH. (May 2000). A strategy for inducing immune tolerance to valve endothelial cells through gene transfer. J Heart Valve Dis. 9:439-444.

Chapters in books

  • Barton PJR; Dellow KA; Bhavsar PK; Cullen ME; Mullen AJ; Brand NJ. Regulation and organization of human troponin genes. 129-141. (2001).
  • Barton PJ; Bhavsar PK; Brand NJ; Chan-Thomas PS; Dabhade N; Farza H; Townsend PJ; Yacoub MH. Gene expression during cardiac development. 46:251-264. (1992).

Conferences

  • Brand NJ; Raman M; Felkin LE; Lara-Pezzi E; Risebro C; Riley P; Barton PJR. Differential expression of the human cardiac troponin I gene by nuclear factor 1-A isoforms generated through alternative splicing. Annual Scientific Conference of the British-Cardiovascular-Society. 94:A52-A52. (Jul 2008).
  • Barton PJ; Felkin LE; Lara-Pezzi E; Brand NJ; Breckenridge R; Mohun TJ; Yacoub MH; Birks EJ. HAND1 gene expression is down regulated during myocardial recovery from heart failure and is associated with mitochondrial energy pathways. 80th Annual Scientific Session of the American-Heart-Association. 116:732-732. (16 Oct 2007).
  • Chester AH; Azam R; Felkin L; Brand NJ. Functional consequences for alternative splicing of the endothelin a receptor gene. 76th Annual Scientific Session of the American-Heart-Association. 108:20-20. (28 Oct 2003).
  • Raman M; Yacoub MH; Barton PJR; Brand NJ. Cloning of HCB1 & HCB2, two novel cardiac-enriched transcription factors. Annual Autumn Meeting of the British-Society-for-Cardiovascular-Research. 92:U63-U63. (Feb 2006).
  • Raman M; Yacoub MH; Barton PJR; Brand NJ. Yeast one hybrid cloning of factors which bind a critical CACC/Sp1 element in the human cardiac troponin I gene. 92. B M J PUBLISHING GROUP (1 Sep 2006). Author weblink.
  • Brand NJ; Barton PJR; Felkin LE; Clark LA; Chester AH; Soppa GK; Terracciano CMN; Lara-Pezzi E; et alYacoub MH. Igf-1 transcription in cardiac myocytes and fibroblasts: Relevance to heart failure. Annual Autumn Meeting of the British-Society-for-Cardiovascular-Research, 15 Sep 2005 - 16 Sep 2005. 92. B M J PUBLISHING GROUP (1 Feb 2006). Author weblink.
  • Azam R; Felkin L; Brand NJ; Chester AH. Functional consequences for alternative splicing of the ETA receptor gene. 14th Annual Symposium of the London-Hypertension-Society, 20 May 2003. 56:244-244. BLACKWELL PUBLISHING LTD (1 Aug 2003). Author weblink.
  • Coppen SR; Varela-Carver A; Stagg MA; Lee J; Fukushima S; Brand NJ; Terracciano CM; Suzuki K. An investigation of gap junction formation between skeletal myoblasts and adult cardiac myocytes using myoblasts overexpressing Connexin43. 77th Scientific Meeting of the American-Heart-Association, 7 Nov 2004 - 10 Nov 2004. 110:396-396. LIPPINCOTT WILLIAMS & WILKINS (26 Oct 2004). Author weblink.
  • Stagg MA; Coppen SR; Lee A; Varela-Carver A; Brand NJ; Fukushima S; Suzuki K; Terracciano CM. Connexin43 overexpression increases gap junctional conductance between skeletal myoblasts and adult rat ventricular myocytes in coculture. 77th Scientific Meeting of the American-Heart-Association, 7 Nov 2004 - 10 Nov 2004. 110:280-280. LIPPINCOTT WILLIAMS & WILKINS (26 Oct 2004). Author weblink.
  • Barton PJ; Townsend PJ; Brand NJ; Bhavsar PK. Genes encoding the striated muscle thin filament proteins troponin I and troponin T are organised in paralogous pairs at three chromosomal sites. 96:1315-1315. AMER HEART ASSOC (21 Oct 1997). Author weblink.
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