Dr Nicholas S Hopkinson

Publications


Journals

  • Wieboldt J; Atallah L; Kelly JL; Shrikrishna D; Gyi KM; Lo B; Yang GZ; Bilton D; et alPolkey MI; Hopkinson NS. (4 Jan 2012). Effect of acute exacerbations on skeletal muscle strength and physical activity in cystic fibrosis. J Cyst Fibros. DOI.
  • Dyer F; Flude L; Bazari F; Jolley C; Englebretsen C; Lai D; Polkey MI; Hopkinson NS. (2011). Non-invasive ventilation (NIV) as an aid to rehabilitation in acute respiratory disease. BMC Pulm Med. 11:58. DOI.
  • Lee JY; Hopkinson NS; Kemp PR. (2 Dec 2011). Myostatin induces autophagy in skeletal muscle in vitro. Biochem Biophys Res Commun. 415:632-636. DOI.
  • Smith SM; Bell D; Hopkinson NS; Valentine J; Shaw EL; Partridge MR; Elkin SL. (Oct 2011). A review of discharge planning for people with chronic obstructive pulmonary disease at high risk for readmission. CLIN MED. 11:510-511.
  • Lewis A; Riddoch-Contreras J; Natanek SA; Donaldson A; Man WD; Moxham J; Hopkinson NS; Polkey MI; et alKemp PR. (Jan 2012). Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD. Thorax. 67:26-34. DOI.
  • Hopkinson NS; Englebretsen C; Cooley N; Kennie K; Lim M; Woodcock T; Laverty AA; Wilson S; et alElkin SL; Caneja C; Falzon C; Burgess H; Bell D; Lai D. (Jan 2012). Designing and implementing a COPD discharge care bundle. Thorax. 67:90-92. DOI.
  • Murphy PB; Kumar A; Reilly C; Jolley C; Walterspacher S; Fedele F; Hopkinson NS; Man WD; et alPolkey MI; Moxham J; Hart N. (Jul 2011). Neural respiratory drive as a physiological biomarker to monitor change during acute exacerbations of COPD. Thorax. 66:602-608. DOI.
  • Natanek SA; Riddoch-Contreras J; Marsh GS; Hopkinson NS; Man WD; Moxham J; Polkey MI; Kemp PR. (Jun 2011). Yin Yang 1 expression and localisation in quadriceps muscle in COPD. Arch Bronconeumol. 47:296-302. DOI.
  • Sharshar T; Porcher R; Siami S; Rohaut B; Bailly-Salin J; Hopkinson NS; Clair B; Guidoux C; et alIacobone E; Sonneville R; Polito A; Aboab J; Gaudry S; Morla O; Amouyal G; Azuar J; Allary J; Vieillard-Baron A; Wolff M; Cariou A; Annane D; Paris-Ouest Study Group on Neurological Effect of Sedation (POSGNES). (Aug 2011). Brainstem responses can predict death and delirium in sedated patients in intensive care unit. Crit Care Med. 39:1960-1967. DOI.
  • Dodd JW; Hogg L; Nolan J; Jefford H; Grant A; Lord VM; Falzon C; Garrod R; et alLee C; Polkey MI; Jones PW; Man WD; Hopkinson NS. (May 2011). The COPD assessment test (CAT): response to pulmonary rehabilitation. A multicentre, prospective study. Thorax. 66:425-429. DOI.
  • Hopkinson NS; Shah PL; Polkey MI. (27 Jan 2011). Endobronchial valves for emphysema. N Engl J Med. 364:381-382. DOI.
  • Freilich S; Usmani OS; Polkey MI; Hopkinson NS. (2010). Emphysema due to smoke from a herbal asthma remedy. JRSM Short Rep. 1:8. DOI.
  • Skipworth JR; Puthucheary Z; Raptis DA; Rawal J; Shrikrishna D; Windsor J; Cramer D; Polkey MI; et alMontgomery HE; Hopkinson NS. (Aug 2011). Effect of acute hypoxia on QTc interval in respiratory patients undergoing fitness to fly tests. Thorax. 66:726-727. DOI.
  • Hopkinson NS; Kemp SV; Toma TP; Hansell DM; Geddes DM; Shah PL; Polkey MI. (Jun 2011). Atelectasis and survival after bronchoscopic lung volume reduction for COPD. Eur Respir J. 37:1346-1351. DOI.
  • Falzon C; Elkin SL; Kelly JL; Lynch F; Blake ID; Hopkinson NS. (Jul 2011). Can financial incentives for improvements in healthcare quality enhance identification of COPD in primary care?. Thorax. 66:630. DOI.
  • Lord VM; Cave P; Hume VJ; Flude EJ; Evans A; Kelly JL; Polkey MI; Hopkinson NS. (2010). Singing teaching as a therapy for chronic respiratory disease--a randomised controlled trial and qualitative evaluation. BMC Pulm Med. 10:41. DOI.
  • Ghanei M; Naderi M; Kosar AM; Harandi AA; Hopkinson NS; Poursaleh Z. (Aug 2010). Long-term pulmonary complications of chemical warfare agent exposure in Iraqi Kurdish civilians. Inhal Toxicol. 22:719-724. DOI.
  • Nacul L; Soljak M; Samarasundera E; Hopkinson NS; Lacerda E; Indulkar T; Flowers J; Walford H; et alMajeed A. (Mar 2011). COPD in England: a comparison of expected, model-based prevalence and observed prevalence from general practice data. J Public Health (Oxf). 33:108-116. DOI.
  • Moore AJ; Soler RS; Cetti EJ; Amanda Sathyapala S; Hopkinson NS; Roughton M; Moxham J; Polkey MI. (Sep 2010). Sniff nasal inspiratory pressure versus IC/TLC ratio as predictors of mortality in COPD. Respir Med. 104:1319-1325. DOI.
  • Hopkinson NS; Dayer MJ; Moxham J; Polkey MI. (2010). Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease. Respir Res. 11:15. DOI.
  • Hopkinson NS; Polkey MI. (May 2010). Does physical inactivity cause chronic obstructive pulmonary disease?. Clin Sci (Lond). 118:565-572. DOI.
  • Hopkinson NS; Polkey MI. (12 Dec 2009). Chronic obstructive pulmonary disease in non-smokers. LANCET. 374:1964-1964.
  • Hopkinson NS; Polkey MI. (12 Dec 2009). Chronic obstructive pulmonary disease in non-smokers. Lancet. 374:1964. DOI.
  • Swallow EB; Barreiro E; Gosker H; Sathyapala SA; Sanchez F; Hopkinson NS; Moxham J; Schols A; et alGea J; Polkey MI; ENIGMA in COPD project. (Dec 2009). Quadriceps muscle strength in scoliosis. Eur Respir J. 34:1429-1435. DOI.
  • Seymour JM; Spruit MA; Hopkinson NS; Natanek SA; Man WD; Jackson A; Gosker HR; Schols AM; et alMoxham J; Polkey MI; Wouters EF. (Jul 2010). The prevalence of quadriceps weakness in COPD and the relationship with disease severity. Eur Respir J. 36:81-88. DOI.
  • von Haehling S; Hopkinson NS; Polkey MI; Niethammer M; Anker SD; Genth-Zotz S. (Jun 2009). Elevated TNF alpha production in whole blood in patients with severe COPD: the potential link to disease severity. WIEN KLIN WOCHENSCHR. 121:303-308. DOI.
  • Hopkinson NS; Li KW; Kehoe A; Humphries SE; Roughton M; Moxham J; Montgomery H; Polkey MI. (Feb 2008). Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease. AM J CLIN NUTR. 87:385-390.
  • Hosseini-Khalili AR; Thompson J; Kehoe A; Hopkinson NS; Khoshbaten A; Soroush MR; Humphries SE; Montgomery H; et alGhanei M. (2008). Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure. BMC Pulm Med. 8:15. DOI.
  • Nickol AH; Hart N; Hopkinson NS; Hamnegård CH; Moxham J; Simonds A; Polkey MI. (2008). Mechanisms of improvement of respiratory failure in patients with COPD treated with NIV. Int J Chron Obstruct Pulmon Dis. 3:453-462.
  • Swallow EB; Gosker HR; Ward KA; Moore AJ; Dayer MJ; Hopkinson NS; Schols AM; Moxham J; et alPolkey MI. (Sep 2007). A novel technique for nonvolitional assessment of quadriceps muscle endurance in humans. J Appl Physiol. 103:739-746. DOI.
  • Dayer MJ; Jonville S; Chatwin M; Swallow EB; Porcher R; Sharshar T; Ross ET; Hopkinson NS; et alMoxham J; Polkey MI. (15 Mar 2007). Exercise-induced depression of the diaphragm motor evoked potential is not affected by non-invasive ventilation. Respir Physiol Neurobiol. 155:243-254. DOI.
  • Hopkinson NS; Tennant RC; Dayer MJ; Swallow EB; Hansel TT; Moxham J; Polkey MI. (13 Mar 2007). A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease. RESP RES. 8. DOI.
  • Hopkinson NS. (Mar 2007). Bronchoscopic lung volume reduction: indications, effects and prospects. Curr Opin Pulm Med. 13:125-130. DOI.
  • Swallow EB; Reyes D; Hopkinson NS; Man WD; Porcher R; Cetti EJ; Moore AJ; Moxham J; et alPolkey MI. (Feb 2007). Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease. Thorax. 62:115-120. DOI.
  • Nickol AH; Hart N; Hopkinson NS; Moxham J; Simonds A; Polkey MI. (Jun 2006). Improvement of respiratory failure with NIV - Authors' reply. THORAX. 61:545-545.
  • Gibson GJ. (Jun 2006). Improvement of respiratory failure with NIV. Thorax. 61:545.
  • Hopkinson NS; Eleftheriou KI; Payne J; Nickol AH; Hawe E; Moxham J; Montgomery H; Polkey MI. (Apr 2006). +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease. Am J Clin Nutr. 83:912-917.
  • Hopkinson NS; Polkey MI. (15 Jan 2006). One-way valves in emphysema treatment: What should bronchial stenting be called and how does it really work?. AM J RESP CRIT CARE. 173:248-249.
  • Dayer MJ; Hopkinson NS; Ross ET; Jonville S; Sharshar T; Kearney M; Moxham J; Polkey MI. (Jan 2006). Does symptom-limited cycle exercise cause low frequency diaphragm fatigue in patients with heart failure?. Eur J Heart Fail. 8:68-73. DOI.
  • Man WD; Hopkinson NS; Harraf F; Nikoletou D; Polkey MI; Moxham J. (Sep 2005). Abdominal muscle and quadriceps strength in chronic obstructive pulmonary disease. Thorax. 60:718-722. DOI.
  • Nickol AH; Hart N; Hopkinson NS; Moxham J; Simonds A; Polkey MI. (Sep 2005). Mechanisms of improvement of respiratory failure in patients with restrictive thoracic disease treated with non-invasive ventilation. Thorax. 60:754-760. DOI.
  • Hopkinson NS; Toma TP; Hansell DM; Goldstraw P; Moxham J; Geddes DM; Polkey MI. (1 Mar 2005). Effect of bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysema. Am J Respir Crit Care Med. 171:453-460. DOI.
  • Sharshar T; Hopkinson NS; Ross ET; Jonville S; Dayer MJ; Nickol AH; Lofaso F; Moxham J; et alPolkey MI. (Mar 2005). Motor control of the costal and crural diaphragm--insights from transcranial magnetic stimulation in man. Respir Physiol Neurobiol. 146:5-19. DOI.
  • Sharshar T; Hopkinson NS; Orlikowski D; Annane D. (Feb 2005). Science review: The brain in sepsis--culprit and victim. Crit Care. 9:37-44. DOI.
  • Sharshar T; Hopkinson NS; Jonville S; Prigent H; Carlier R; Dayer MJ; Swallow EB; Lofaso F; et alMoxham J; Polkey MI. (1 Nov 2004). Demonstration of a second rapidly conducting cortico-diaphragmatic pathway in humans. J Physiol. 560:897-908. DOI.
  • Hopkinson NS; Nickol AH; Payne J; Hawe E; Man WDC; Moxham J; Montgomery H; Polkey MI. (1 Sep 2004). ACE gene polymorphism in COPD - Reply. AM J RESP CRIT CARE. 170:572-573.
  • Hopkinson NS; Nickol AH; Payne J; Hawe E; Man WD; Moxham J; Montgomery H; Polkey MI. (15 Aug 2004). Angiotensin converting enzyme genotype and strength in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 170:395-399. DOI.
  • Toma TP; Hopkinson NS; Polkey MI; Geddes DM. (Aug 2004). Endobronchial volume reduction: a myth or a marvel?. Semin Respir Crit Care Med. 25:399-404. DOI.
  • Hopkinson NS; Sharshar T; Ross ET; Nickol AH; Dayer MJ; Porcher R; Jonville S; Moxham J; et alPolkey MI. (12 Jul 2004). Corticospinal control of respiratory muscles in chronic obstructive pulmonary disease. Respir Physiol Neurobiol. 141:1-12. DOI.
  • Hopkinson NS; Man WD; Dayer MJ; Ross ET; Nickol AH; Hart N; Moxham J; Polkey MI. (Jul 2004). Acute effect of oral steroids on muscle function in chronic obstructive pulmonary disease. Eur Respir J. 24:137-142.
  • Sharshar T; Ross ET; Hopkinson NS; Porcher R; Nickol AH; Jonville S; Dayer MJ; Hart N; et alMoxham J; Lofaso F; Polkey MI. (Jul 2004). Depression of diaphragm motor cortex excitability during mechanical ventilation. J Appl Physiol. 97:3-10. DOI.
  • De Jonghe B; Sharshar T; Hopkinson N; Outin H. (Feb 2004). Paresis following mechanical ventilation. Curr Opin Crit Care. 10:47-52.
  • Verin E; Ross E; Demoule A; Hopkinson N; Nickol A; Fauroux B; Moxham J; Similowski T; et alPolkey MI. (Jan 2004). Effects of exhaustive incremental treadmill exercise on diaphragm and quadriceps motor potentials evoked by transcranial magnetic stimulation. J Appl Physiol. 96:253-259. DOI.
  • Sharshar T; Annane D; de la Grandmaison GL; Brouland JP; Hopkinson NS; Françoise G. (Jan 2004). The neuropathology of septic shock. Brain Pathol. 14:21-33.
  • Sharshar T; Gray F; Lorin de la Grandmaison G; Hopkinson NS; Ross E; Dorandeu A; Orlikowski D; Raphael JC; et alGajdos P; Annane D. (29 Nov 2003). Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet. 362:1799-1805.
  • Sharshar T; Ross E; Hopkinson NS; Dayer M; Nickol A; Lofaso F; Moxham J; Similowski T; et alPolkey MI. (Jul 2003). Effect of voluntary facilitation on the diaphragmatic response to transcranial magnetic stimulation. J Appl Physiol. 95:26-34. DOI.
  • Toma TP; Hopkinson NS; Hillier J; Hansell DM; Morgan C; Goldstraw PG; Polkey MI; Geddes DM. (15 Mar 2003). Bronchoscopic volume reduction with valve implants in patients with severe emphysema. Lancet. 361:931-933. DOI.
  • Greig JR; Khan MA; Hopkinson NS; Marshall BG; Wilson PO; Rahman SU. (Jul 2001). Pulmonary infection with Scedosporium prolificans in an immunocompetent individual. J Infect. 43:15-17. DOI.
  • Silber E; Lane RJ; Hopkinson NS. (Jul 1998). Demyelinating polyneuropathy in a patient with chronic myeloid leukemia. Muscle Nerve. 21:974-975.

Conferences

  • Dyer F; Bazari F; Jolley C; Flude L; Lord V; Polkey MI; Hopkinson NS. FEASIBILITY AND ACCEPTABILITY OF NON-INVASIVE VENTILATION (NIV) AS AN AID TO EXERCISE IN PATIENTS ADMITTED WITH ACUTE EXACERBATION OF CHRONIC RESPIRATORY DISEASE. 66:A177-A178. (Dec 2011). DOI.
  • Kon SSC; Patel MS; Clark AL; Ingram KA; Fowler RP; Marns P; Canavan JL; Hopkinson NS; et alPolkey MI; Man WDC. MUSCLE MASS IN COPD PATIENTS RECEIVING ANGIOTENSIN II RECEPTOR BLOCKERS AND ACE-INHIBITORS. 66:A82-A83. (Dec 2011). DOI.
  • Hopkinson NS; Englebretsen C; Cooley N; Kennie K; Lim M; Woodcock T; Laverty A; Wilson S; et alElkin SL; Caneja C; Falzon C; Burgess H; Bell D; Lai D. DESIGNING AND IMPLEMENTING A COPD DISCHARGE CARE BUNDLE. 66:A108-A108. (Dec 2011). DOI.
  • Boutou AK; Shrikrishna D; Tanner RJ; Smith C; Kelly JL; Coissi G; Polkey MI; Hopkinson NS. TRANSFER FACTOR AND ARTERIAL OXYGEN PARTIAL PRESSURE ARE PREDICTORS OF SURVIVAL IN HOSPITAL OUTPATIENTS WITH COPD. 66:A157-A157. (Dec 2011). DOI.
  • Elia D; Kelly JL; Martolini D; Renzoni E; Boutou AK; Chetta A; Polkey MI; Hopkinson NS. RESPIRATORY MUSCLE FATIGUE FOLLOWING EXERCISE IN PATIENTS WITH INTERSTITIAL LUNG DISEASE. 66:A54-A54. (Dec 2011). DOI.
  • Shrikrishna D; Tanner R; Seymour JM; Patel M; Connolly BA; Puthucheary ZA; Walsh SLF; Bloch SA; et alSidhu PS; Hart N; Moxham J; Polkey MI; Hopkinson NS. ULTRASOUND MEASUREMENT OF QUADRICEPS WASTING IN EARLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS RELATIONSHIP WITH DAILY PHYSICAL ACTIVITY. 66:A44-A45. (Dec 2011). DOI.
  • Rohaut B; Porcher R; Siami S; Bailly-Salin J; Hopkinson NS; Guidoux C; Iacobone E; Sonneville R; et alPolito A; Aboab J; Gaudry S; Morla O; Amouyal G; Azuar J; Vieillard-Baron A; Annane D; Sharshar T. Brainstem responses can predict death and delirium in sedated patients in intensive care units. 17:572-572. (Sep 2010).
  • Dodd JW; Hogg L; Nolan J; Jefford H; Lord VM; Garrod R; Polkey MI; Jones PW; et alMan WDC; Hopkinson NS. THE COPD ASSESSMENT TEST SCORE (CAT): A MULTICENTRE, PROSPECTIVE STUDY OF RESPONSE TO PULMONARY REHABILITATION. 65:A36-A36. (Dec 2010). DOI.
  • Natanek SA; Langen RCJ; Gosker HR; Marsh GS; Slot I; Hopkinson NS; Man WDC; Kemp PR; et alMoxham J; Schols AMWJ; Polkey MI. NF-KAPPA B (NF-kappa B) AND ACTIVATOR PROTEIN-1 (AP-1) DNA BINDING IN THE QUADRICEPS OF COPD PATIENTS. 65:A138-A139. (Dec 2010). DOI.
  • Natanek SA; Gosker HR; Slot I; Marsh GS; Langen RCJ; Hopkinson NS; Man WDC; Moxham J; et alKemp PR; Schols AMWJ; Polkey MI. MUSCLE FIBRE ATROPHY AND AEROBIC TO ANAEROBIC FIBRE TYPE SHIFT IN THE QUADRICEPS IN COPD. 65:A139-A139. (Dec 2010). DOI.
  • Hopkinson NS; Kemp SV; Toma TP; Hansell DM; Geddes DM; Shah PL; Polkey MI. ATELECTASIS FOLLOWING BRONCHOSCOPIC LUNG VOLUME REDUCTION (BLVR) IS ASSOCIATED WITH IMPROVED SURVIVAL IN COPD. 65:A137-A137. (Dec 2010). DOI.
  • Dodd JW; Van den Broek M; Shrikrishna D; Hopkinson NS; Jones PW. COGNITIVE LOSS IN STABLE NON-HYPDXAEMIC PATIENTS WITH MODERATE CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD). 65:A140-A140. (Dec 2010). DOI.
  • Darby AC; Barraclough R; Burge PS; Hopkinson NS; Hoyle JL; Lawson RA; Niven RM; Stenton SC; et alWarburton CJ; Barber CM; Blanc PD; Curran AD; Fishwick D. COPD CAUSATION; AN ASSESSMENT OF AGREEMENT BETWEEN EXPERT CLINICAL RATERS. 65:A77-A78. (Dec 2010). DOI.
  • Shrikrishna D; Kelly JL; Mendoza L; Jackson AS; Kemp SV; Lord V; Polkey MI; Hopkinson NS. MULTIPLE-FREQUENCY BIOELECTRICAL IMPEDANCE ANALYSIS AND QUADRICEPS STRENGTH IN PATIENTS WITH COPD. 64:A134-A134. (Dec 2009). DOI.
  • Mendoza L; Gogali A; Shrikrishna D; Kemp SV; Jackson AS; Shaikh ZF; Polkey MI; Wells AU; et alHopkinson NS. QUADRICEPS ENDURANCE IS REDUCED IN FIBROTIC IDIOPATHIC INTERSTITIAL PNEUMONIA. 64:A44-A45. (Dec 2009). DOI.
  • Kelly JL; Mehta P; Shrikrishna D; Cramer D; Polkey MI; Hopkinson NS. EFFECT OF GOLD STAGE ON RATE OF DECLINE IN GAS TRANSFER AND SPIROMETRY IN COPD. 64:A159-A159. (Dec 2009). DOI.
  • Lewis A; Sathyapala SA; Riddoch-Contreras J; Man WDC; Marsh GS; Polkey MI; Hopkinson NS; Kemp PR. REDUCED EXPRESSION AND ACTIVITY OF MYOCARDIN-RELATED TRANSCRIPTION FACTORS CONTRIBUTES TO FIBRE TYPE CHANGES IN THE QUADRICEPS OF PATIENTS WITH COPD. 64:A134-A134. (Dec 2009). DOI.
  • Skipworth JRA; Raptis DA; Puthucheary Z; Rawal J; Shrikrishna D; Windsor J; Cramer D; Polkey MI; et alMontgomery HE; Hopkinson NS. THE EFFECT OF ACUTE HYPOXIA ON QT INTERVAL IN RESPIRATORY PATIENTS UNDERGOING FITNESS TO FLY TESTS. 64:A45-A46. (Dec 2009). DOI.
  • Man WDC; Steier J; Hopkinson NS; Luo YM; Jolley CJ; Mustfa N; Harraf F; Nikoletou D; et alRafferty GF; Polkey MI; Moxham J. SNIFF AND TWITCH TRANSDIAPHRAGMATIC PRESSURES IN HEALTH AND DISEASE. 63:A31-A32. (Dec 2008).
  • Atallah L; Elsaify A; Lo B; Hopkinson NS; Yang GZ. Gaussian Process Prediction for Cross Channel Consensus in Body Sensor Networks. 105-108. (2008).
  • Toma TP; Hopkinson NS; Shen N; Hillier J; Goldstraw P; Morgan C; Hansell DM; Polkey MI; et alGeddes DM. Bronchoscopic lung volume reduction (BLVR) with endobronchial valve implants. 57. (Dec 2002).
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