Dr Nicole Horwood

Publications


Journals

  • Horwood NJ; Urbaniak AM; Danks L. (Apr 2012). Tec family kinases in inflammation and disease. Int Rev Immunol. 31:87-103. DOI.
  • Vattakuzhi Y; Abraham SM; Freidin A; Clark AR; Horwood NJ. (24 Jan 2012). Dual Specificity Phosphatase 1 null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis. Arthritis Rheum. DOI.
  • Smolinska MJ; Page TH; Urbaniak AM; Mutch BE; Horwood NJ. (1 Dec 2011). Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1. J Immunol. 187:6043-6051. DOI.
  • Poellinger B; Junt T; Metzler B; Walker UA; Tyndall A; Allard C; Bay S; Keller R; et alRaulf F; Di Padova F; O'Reilly T; Horwood NJ; Patel DD; Littlewood-Evans A. (15 Feb 2011). Th17 Cells, Not IL-17(+) gamma delta T Cells, Drive Arthritic Bone Destruction in Mice and Humans. JOURNAL OF IMMUNOLOGY. 186:2602-2612. Author weblink DOI.
  • Hu M; Bassett JH; Danks L; Howell PG; Xu K; Spanoudakis E; Kotsianidis I; Boyde A; et alWilliams GR; Horwood N; Roberts IA; Karadimitris A. (1 Mar 2011). Activated invariant NKT cells regulate osteoclast development and function. J Immunol. 186:2910-2917. DOI.
  • Glass GE; Chan JK; Freidin A; Feldmann M; Horwood NJ; Nanchahal J. (25 Jan 2011). TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells. Proc Natl Acad Sci U S A. 108:1585-1590. DOI.
  • Lymperi S; Ersek A; Ferraro F; Dazzi F; Horwood NJ. (3 Feb 2011). Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo. Blood. 117:1540-1549. DOI.
  • Smallie T; Ricchetti G; Horwood NJ; Feldmann M; Clark AR; Williams LM. (27 Sep 2010). IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages. J Exp Med. 207:2081-2088. DOI.
  • Danks L; Workman S; Webster D; Horwood NJ. (Jan 2011). Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts. J Bone Miner Res. 26:182-192. DOI.
  • Gingery A; Bradley EW; Pederson L; Ruan M; Horwood NJ; Oursler MJ. (10 Sep 2008). TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival. EXPERIMENTAL CELL RESEARCH. 314:2725-2738. Author weblink DOI.
  • Matthews BG; Bava U; Horwood NJ; Callon KE; Reid IR; Cornish J; Nao D. (1 Jul 2008). Keratin 18 is upregulated in cells from pagetic lesions and affects gene expression in human osteoblasts. CALCIFIED TISSUE INTERNATIONAL. 83:25-25. Author weblink.
  • Danks LL; Workman S; Webster DA; Foxwell BM; Horwood NJ. (1 Jan 2008). Reduced bone density in XLA patients, an effect of b-cell deficiency on osteoclast differentiation and osteolytic activity. CALCIFIED TISSUE INTERNATIONAL. 82:S128-S129. Author weblink.
  • Matthews BG; Bava U; Horwood NJ; Callon KE; Reid IR; Cornish J; Naot D. (1 Jan 2008). Keratin 18 is upregulated in cells from pagetic lesions and affects gene expression in human osteoblasts. CALCIFIED TISSUE INTERNATIONAL. 82:S111-S111. Author weblink.
  • Palmer CD; Mutch BE; Page TH; Horwood NJ; Foxwell BM. (13 Jun 2008). Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts. Biochem Biophys Res Commun. 370:599-602. DOI.
  • Palmer CD; Mutch BE; Workman S; McDaid JP; Horwood NJ; Foxwell BM. (15 Feb 2008). Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity. Blood. 111:1781-1788. DOI.
  • Smolinska MJ; Horwood NJ; Page TH; Smallie T; Foxwell BM. (Feb 2008). Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages. Mol Immunol. 45:990-1000. DOI.
  • Lymperi S; Horwood N; Marley S; Gordon MY; Cope AP; Dazzi F. (1 Feb 2008). Strontium can increase some osteoblasts without increasing hematopoietic stem cells. BLOOD. 111:1173-1181. Author weblink DOI.
  • Horwood N. (1 Jan 2008). Lymphocyte-derived cytokines in inflammatory arthritis. AUTOIMMUNITY. 41:230-238. Author weblink DOI.
  • Dazzi F; Horwood NJ. (Nov 2007). Potential of mesenchymal stem cell therapy. Curr Opin Oncol. 19:650-655. DOI.
  • Jones S; Horwood N; Cope A; Dazzi F. (1 Sep 2007). The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells. J Immunol. 179:2824-2831.
  • Horwood NJ; Page TH; McDaid JP; Palmer CD; Campbell J; Mahon T; Brennan FM; Webster D; et alFoxwell BM. (15 Mar 2006). Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production. J Immunol. 176:3635-3641.
  • Campbell J; Ciesielski CJ; Hunt AE; Horwood NJ; Beech JT; Hayes LA; Denys A; Feldmann M; et alBrennan FM; Foxwell BM. (1 Dec 2004). A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis. J Immunol. 173:6928-6937.
  • Häusler KD; Horwood NJ; Chuman Y; Fisher JL; Ellis J; Martin TJ; Rubin JS; Gillespie MT. (Nov 2004). Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. J Bone Miner Res. 19:1873-1881. DOI.
  • Horwood NJ; Mahon T; McDaid JP; Campbell J; Mano H; Brennan FM; Webster D; Foxwell BM. (16 Jun 2003). Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production. J Exp Med. 197:1603-1611. DOI.
  • Mirosavljevic D; Quinn JM; Elliott J; Horwood NJ; Martin TJ; Gillespie MT. (Jun 2003). T-cells mediate an inhibitory effect of interleukin-4 on osteoclastogenesis. J Bone Miner Res. 18:984-993. DOI.
  • Cornish J; Gillespie MT; Callon KE; Horwood NJ; Moseley JM; Reid IR. (Apr 2003). Interleukin-18 is a novel mitogen of osteogenic and chondrogenic cells. Endocrinology. 144:1194-1201.
  • Feldmann M; Andreakos E; Smith C; Bondeson J; Yoshimura S; Kiriakidis S; Monaco C; Gasparini C; et alSacre S; Lundberg A; Paleolog E; Horwood NJ; Brennan FM; Foxwell BM. (Nov 2002). Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?. Ann Rheum Dis. 61 Suppl 2:ii13-ii18.
  • Horwood NJ; Smith C; Andreakos E; Quattrocchi E; Brennan FM; Feldmann M; Foxwell BM. (2002). High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets. Arthritis Res. 4 Suppl 3:S215-S225.
  • Horwood NJ; Elliott J; Martin TJ; Gillespie MT. (15 Apr 2001). IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro. J Immunol. 166:4915-4921.
  • Quinn JM; Horwood NJ; Elliott J; Gillespie MT; Martin TJ. (Aug 2000). Fibroblastic stromal cells express receptor activator of NF-kappa B ligand and support osteoclast differentiation. J Bone Miner Res. 15:1459-1466. DOI.

Conferences

  • Ersek A; Lymperi S; Dazzi F; Horwood N. Osteoclast activity regulates the size of the haematopoietic stem cell pool. 3rd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society, 7 May 2011 - 11 May 2011. 48:S124-S124. ELSEVIER SCIENCE INC (7 May 2011). Author weblink DOI.
  • Xu K; Antonopoulos A; Spanoudakis E; Parry S; Chaidos A; Hu M; Butters T; Dell A; et alRahemtulla A; Horwood N; Karadimitris A. Glucose Ceramide Synthase Inhibitors Inhibit Osteoclast Activation Induced by Myeloma-Derived and De Novo Synthesized Glycosphingolipids. 51st Annual Meeting of the American-Society-of-Hematology, 5 Dec 2009 - 8 Dec 2009. 114:176-176. AMER SOC HEMATOLOGY (20 Nov 2009).
  • Danks L; Workman S; Nicolaidou V; Webster DA; Foxwell BM; Horwood NJ. Osteoclast defects in XLA patients are negated by lack of mature B cells and elevated inflammatory cytokine production. 36th European Symposium on Calcified Tissues, 23 May 2009 - 27 May 2009. 44:S216-S216. ELSEVIER SCIENCE INC (1 Jun 2009). Author weblink DOI.
  • Lymperi S; Horwood N; Dazzi F. Osteoclast Function Is Essential in the Hematopoietic Stem Cell Niche. 50th Annual Meeting of the American-Society-of-Hematology, 6 Dec 2008 - 9 Dec 2008. 112:205-205. AMER SOC HEMATOLOGY (16 Nov 2008). Author weblink.
  • Hu M; Basssett JHD; Danks L; Spanoudakis E; Xu K; Howell PGT; Boyde A; Horwood N; et alWilliams G; Roberts IAG; Karadimitris A. Invariant NKT Cells Regulate Osteoclast Development and Function Under Homeostatic and during Conditions of Immune Activation. 50th Annual Meeting of the American-Society-of-Hematology, 6 Dec 2008 - 9 Dec 2008. 112:46-46. AMER SOC HEMATOLOGY (16 Nov 2008). Author weblink.
  • Gwyer EL; Danks L; Vekaria S; Horwood NJ; Hussell T. T cell control of osteoclastogenesis through the late co-stimulator OX40L. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:37-37. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2008). Author weblink.
  • Danks L; Workman S; Webster DA; Foxwell BM; Horwood NJ. Reduced bone density in XLA patients, an effect of B cell deficiency on osteoclast differentiation and osteolytic activity. Annual Meeting of the British-Society-Rheumatology/Spring Meeting of British Health Professional in Rheumatology, 22 Apr 2008 - 25 Apr 2008. 47:II176-II176. OXFORD UNIV PRESS (1 Apr 2008). Author weblink.
  • Danks L; Workman S; Welaster AD; Foxwell BM; Feldman M; Horwood NJ. Lack of Bruton's tyrosine kinase results in osteoporosis, despite defects in osteoclast function. 29th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, 16 Sep 2007 - 19 Sep 2007. 22:S255-S255. AMER SOC BONE & MINERAL RES (1 Sep 2007). Author weblink.
  • Jones F; Horwood N; Cope A; Dazzi F. Mesenchymal stem cell mediated immunosuppression is not confined to progenitor status. 12th Congress of the European-Hematology-Association, 7 Jun 2007 - 10 Jun 2007. 92:316-316. FERRATA STORTI FOUNDATION (1 Jun 2007). Author weblink.
  • Lymperi S; Horwood N; Cope A; Dazzi F. The anabolic effects of strontium increase the number of progenitor but not primitive haemopoietic stem cells. 12th Congress of the European-Hematology-Association. 92:122-122. (Jun 2007).
  • Gingery A; Pederson L; Ruan M; Horwood NJ; Oursler MJ. TGF-beta activates a novel smad-independent pathway to promote osteoclast survival. 28th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, 15 Sep 2006 - 19 Sep 2006. 21:S66-S66. AMER SOC BONE & MINERAL RES (1 Sep 2006). Author weblink.
  • Danks L; Foxwell BM; Horwood NJ. The Tec kinases: Bmx and Btk play distinct regulatory roles in osteoclast differentiation. 27th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, 23 Sep 2005 - 27 Sep 2005. 20:S148-S148. AMER SOC BONE & MINERAL RES (1 Sep 2005). Author weblink.
  • Danks L; Horwood NJ. Expression of Bruton's tyrosine kinase in osteoclasts. Annual Meeting of the Bone-and-Tooth-Society, 4 Jul 2005 - 5 Jul 2005. 20:1309-1309. AMER SOC BONE & MINERAL RES (1 Jul 2005). Author weblink.
  • Danks L; Owen S; Feldmann M; Brennan F; Horwood NJ. NK cells support osteoclast formation in vitro. Joint Meeting of the British-Society-for-Rheumatology/Deutsche-Gesellschaft-fur-Rheumatologie and Spring Meeting of the British-Health-Professionals-in-Rheumatology, 19 Apr 2005 - 22 Apr 2005. 44:I30-I30. OXFORD UNIV PRESS (1 Mar 2005). Author weblink.
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