Publications

Journals

• Anveden A; Sjoholm K; Jacobson P; Palsdottir V; Walley AJ; Froguel P; Al-Daghri N; McTernan PG; et alMejhert N; Arner P; Sjostrom L; Carlsson LMS; Svensson P-A. (1 Apr 2012). ITIH-5 Expression in Human Adipose Tissue Is Increased in Obesity. OBESITY. 20:708-714. Author weblink DOI.
• Louis-Dit-Picard H; Barc J; Trujillano D; Miserey-Lenkei S; Bouatia-Naji N; Pylypenko O; Beaurain G; Bonnefond A; et alSand O; Simian C; Vidal-Petiot E; Soukaseum C; Mandet C; Broux F; Chabre O; Delahousse M; Esnault V; Fiquet B; Houillier P; Bagnis CI; Koenig J; Konrad M; Landais P; Mourani C; Niaudet P; Probst V; Thauvin C; Unwin RJ; Soroka SD; Ehret G; Ossowski S; Caulfield M; Bruneval P; Estivill X; Froguel P; Hadchouel J; Schott J-J; Jeunemaitre X. (1 Apr 2012). KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. NATURE GENETICS. 44:456-U143. Author weblink DOI.
• Vaxillaire M; Bonnefond A; Froguel P. (Apr 2012). The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis. Best Pract Res Clin Endocrinol Metab. 26:171-187. DOI.
• Limou S; Delaneau O; van Manen D; An P; Sezgin E; Le Clerc S; Coulonges C; Troyer JL; et alVeldink JH; van den Berg LH; Spadoni J-L; Taing L; Labib T; Montes M; Delfraissy J-F; Schachter F; O'Brien SJ; Buchbinder S; van Natta ML; Jabs DA; Froguel P; Schuitemaker H; Winkler CA; Zagury J-F. (1 Apr 2012). Multicohort Genomewide Association Study Reveals a New Signal of Protection Against HIV-1 Acquisition. JOURNAL OF INFECTIOUS DISEASES. 205:1155-1162. DOI.
• Cauchi S; Ezzidi I; El Achhab Y; Mtiraoui N; Chaieb L; Salah D; Nejjari C; Labrune Y; et alYengo L; Beury D; Vaxillaire M; Mahjoub T; Chikri M; Froguel P. (29 Mar 2012). European genetic variants associated with type 2 diabetes in North African Arabs. Diabetes Metab. DOI.
• Saeed S; Butt TA; Anwer M; Arslan M; Froguel P. (May 2012). High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. Mol Genet Metab. 106:121-126. DOI.
• Ichimura A; Hirasawa A; Poulain-Godefroy O; Bonnefond A; Hara T; Yengo L; Kimura I; Leloire A; et alLiu N; Iida K; Choquet H; Besnard P; Lecoeur C; Vivequin S; Ayukawa K; Takeuchi M; Ozawa K; Tauber M; Maffeis C; Morandi A; Buzzetti R; Elliott P; Pouta A; Jarvelin M-R; Koerner A; Kiess W; Pigeyre M; Caiazzo R; Van Hul W; Van Gaal L; Horber F; Balkau B; Levy-Marchal C; Rouskas K; Kouvatsi A; Hebebrand J; Hinney A; Scherag A; Pattou F; Meyre D; Koshimizu T-A; Wolowczuk I; Tsujimoto G; Froguel P. (15 Mar 2012). Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. NATURE. 483:350-U149. DOI.
• Postel-Vinay S; Veron AS; Tirode F; Pierron G; Reynaud S; Kovar H; Oberlin O; Lapouble E; et alBallet S; Lucchesi C; Kontny U; Gonzalez-Neira A; Picci P; Alonso J; Patino-Garcia A; de Paillerets BB; Laud K; Dina C; Froguel P; Clavel-Chapelon F; Doz F; Michon J; Chanock SJ; Thomas G; Cox DG; Delattre O. (1 Mar 2012). Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. NATURE GENETICS. 44:323-U133. DOI.
• Rouskas K; Meyre D; Stutzmann F; Paletas K; Papazoglou D; Vatin V; Marchand M; Kouvatsi A; et alFroguel P. (26 Mar 2012). Loss-of-Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population. Obesity (Silver Spring). DOI.
• Lamri A; Khalil CA; Jaziri R; Velho G; Lantieri O; Vol S; Froguel P; Balkau B; et alMarre M; Fumeron F. (1 Feb 2012). Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study. INTERNATIONAL JOURNAL OF OBESITY. 36:218-224. Author weblink DOI.
• Froguel P; Ndiaye NC; Bonnefond A; Bouatia-Naji N; Dechaume A; Siest G; Herbeth B; Falchi M; et alBottolo L; Guéant-Rodriguez RM; Lecoeur C; Langlois MR; Labrune Y; Ruokonen A; El Shamieh S; Stathopoulou MG; Morandi A; Maffeis C; Meyre D; Delanghe JR; Jacobson P; Sjöström L; Carlsson LM; Walley A; Elliott P; Jarvelin MR; Dedoussis GV; Visvikis-Siest S. (2012). A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. PLoS One. 7:e32327. DOI.
• Riveline J-P; Rousseau E; Reznik Y; Fetita S; Philippe J; Dechaume A; Hartemann A; Polak M; et alPetit C; Charpentier G; Gautier J-F; Froguel P; Vaxillaire M. (1 Feb 2012). Clinical and Metabolic Features of Adult-Onset Diabetes Caused by ABCC8 Mutations. DIABETES CARE. 35:248-251. Author weblink DOI.
• Beulens JW; van der Schouw YT; Bergmann MM; Rohrmann S; Schulze MB; Buijsse B; Grobbee DE; Arriola L; et alCauchi S; Tormo MJ; Allen NE; van der A DL; Balkau B; Boeing H; Clavel-Chapelon F; de Lauzon-Guillan B; Franks P; Froguel P; Gonzales C; Halkjaer J; Huerta JM; Kaaks R; Key TJ; Khaw KT; Krogh V; Molina-Montes E; Nilsson P; Overvad K; Palli D; Panico S; Ramón Quirós J; Ronaldsson O; Romieu I; Romaguera D; Sacerdote C; Sánchez MJ; Spijkerman AM; Teucher B; Tjonneland A; Tumino R; Sharp S; Forouhi NG; Langenberg C; Feskens EJ; Riboli E; Wareham NJ; The InterAct Consortium. (21 Feb 2012). Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body sizeThe EPIC-InterAct study. J Intern Med. DOI.
• Creemers JWM; Choquet H; Stijnen P; Vatin V; Pigeyre M; Beckers S; Meulemans S; Than ME; et alYengo L; Tauber M; Balkan B; Elliott P; Jarvelin M-R; Van Hul W; Van Gaal L; Horber F; Pattou F; Froguel P; Meyre D. (1 Feb 2012). Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity. DIABETES. 61:383-390. Author weblink DOI.
• Kilpelaeinen TO; Qi L; Brage S; Sharp SJ; Sonestedt E; Demerath E; Ahmad T; Mora S; et alKaakinen M; Sandholt CH; Holzapfel C; Autenrieth CS; Hyppoenen E; Cauchi S; He M; Kutalik Z; Kumari M; Stancakova A; Meidtner K; Balkau B; Tan JT; Mangino M; Timpson NJ; Song Y; Zillikens MC; Jablonski KA; Garcia ME; Johansson S; Bragg-Gresham JL; Wu Y; van Vliet-Ostaptchouk JV; Onland-Moret NC; Zimmermann E; Rivera NV; Tanaka T; Stringham HM; Silbernagel G; Kanoni S; Feitosa MF; Snitker S; Ruiz JR; Metter J; Martinez Larrad MT; Atalay M; Hakanen M; Amin N; Cavalcanti-Proenca C; Grontved A; Hallmans G; Jansson J-O; Kuusisto J; Kahonen M; Lutsey PL; Nolan JJ; Palla L; Pedersen O; Perusse L; Renstrom F; Scott RA; Shungin D; Sovio U; Tammelin TH; Ronnemaa T; Lakka TA; Uusitupa M; Serrano Rios M; Ferrucci L; Bouchard C; Meirhaeghe A; Fu M; Walker M; Borecki IB; Dedoussis GV; Fritsche A; Ohlsson C; Boehnke M; Bandinelli S; van Duijn CM; Ebrahim S; Lawlor DA; Gudnason V; Harris TB; Sorensen TIA; Mohlke KL; Hofman A; Uitterlinden AG; Tuomilehto J; Lehtimaki T; Raitakari O; Isomaa B; Njolstad PR; Florez JC; Liu S; Ness A; Spector TD; Tai ES; Froguel P; Boeing H; Laakso M; Marmot M; Bergmann S; Power C; Khaw K-T; Chasman D; Ridker P; Hansen T; Monda KL; Illig T; Jarvelin M-R; Wareham NJ; Hu FB; Groop LC; Orho-Melander M; Ekelund U; Franks PW; Loos RJF. (1 Nov 2011). Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children. PLOS MEDICINE. 8. DOI.
• Bonnefond A; Clément N; Fawcett K; Yengo L; Vaillant E; Guillaume JL; Dechaume A; Payne F; et alRoussel R; Czernichow S; Hercberg S; Hadjadj S; Balkau B; Marre M; Lantieri O; Langenberg C; Bouatia-Naji N; Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC); Charpentier G; Vaxillaire M; Rocheleau G; Wareham NJ; Sladek R; McCarthy MI; Dina C; Barroso I; Jockers R; Froguel P. (Mar 2012). Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat Genet. 44:297-301. DOI.
• Marquez M; Huyvaert M; Perry JR; Pearson RD; Falchi M; Morris AP; Vivequin S; Lobbens S; et alYengo L; Gaget S; Pattou F; Poulain-Godefroy O; Charpentier G; Carlsson LM; Jacobson P; Sjöström L; Lantieri O; Heude B; Walley A; Balkau B; Marre M; Froguel P; Cauchi S; DIAGRAM Consortium. (Feb 2012). Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes. 61:524-530. DOI.
• Gieger C; Radhakrishnan A; Cvejic A; Tang W; Porcu E; Pistis G; Serbanovic-Canic J; Elling U; et alGoodall AH; Labrune Y; Lopez LM; Mägi R; Meacham S; Okada Y; Pirastu N; Sorice R; Teumer A; Voss K; Zhang W; Ramirez-Solis R; Bis JC; Ellinghaus D; Gögele M; Hottenga JJ; Langenberg C; Kovacs P; O'Reilly PF; Shin SY; Esko T; Hartiala J; Kanoni S; Murgia F; Parsa A; Stephens J; van der Harst P; Ellen van der Schoot C; Allayee H; Attwood A; Balkau B; Bastardot F; Basu S; Baumeister SE; Biino G; Bomba L; Bonnefond A; Cambien F; Chambers JC; Cucca F; D'Adamo P; Davies G; de Boer RA; de Geus EJ; Döring A; Elliott P; Erdmann J; Evans DM; Falchi M; Feng W; Folsom AR; Frazer IH; Gibson QD; Glazer NL; Hammond C; Hartikainen AL; Heckbert SR; Hengstenberg C; Hersch M; Illig T; Loos RJ; Jolley J; Tee Khaw K; Kühnel B; Kyrtsonis MC; Lagou V; Lloyd-Jones H; Lumley T; Mangino M; Maschio A; Mateo Leach I; McKnight B; Memari Y; Mitchell BD; Montgomery GW; Nakamura Y; Nauck M; Navis G; Nöthlings U; Nolte IM; Porteous DJ; Pouta A; Pramstaller PP; Pullat J; Ring SM; Rotter JI; Ruggiero D; Ruokonen A; Sala C; Samani NJ; Sambrook J; Schlessinger D; Schreiber S; Schunkert H; Scott J; Smith NL; Snieder H; Starr JM; Stumvoll M; Takahashi A; Tang WH; Taylor K; Tenesa A; Lay Thein S; Tönjes A; Uda M; Ulivi S; van Veldhuisen DJ; Visscher PM; Völker U; Wichmann HE; Wiggins KL; Willemsen G; Yang TP; Hua Zhao J; Zitting P; Bradley JR; Dedoussis GV; Gasparini P; Hazen SL; Metspalu A; Pirastu M; Shuldiner AR; Joost van Pelt L; Zwaginga JJ; Boomsma DI; Deary IJ; Franke A; Froguel P; Ganesh SK; Jarvelin MR; Martin NG; Meisinger C; Psaty BM; Spector TD; Wareham NJ; Akkerman JW; Ciullo M; Deloukas P; Greinacher A; Jupe S; Kamatani N; Khadake J; Kooner JS; Penninger J; Prokopenko I; Stemple D; Toniolo D; Wernisch L; Sanna S; Hicks AA; Rendon A; Ferreira MA; Ouwehand WH; Soranzo N. (8 Dec 2011). New gene functions in megakaryopoiesis and platelet formation. Nature. 480:201-208. DOI.
• Gautier A; Roussel R; Lange C; Piguel X; Cauchi S; Vol S; Froguel P; Balkau B; et alBonnet F. (1 Oct 2011). Effects of Genetic Susceptibility for Type 2 Diabetes on the Evolution of Glucose Homeostasis Traits Before and After Diabetes Diagnosis Data From the DESIR Study. DIABETES. 60:2654-2663. Author weblink DOI.
• Strawbridge RJ; Dupuis J; Prokopenko I; Barker A; Ahlqvist E; Rybin D; Petrie JR; Travers ME; et alBouatia-Naji N; Dimas AS; Nica A; Wheeler E; Chen H; Voight BF; Taneera J; Kanoni S; Peden JF; Turrini F; Gustafsson S; Zabena C; Almgren P; Barker DJP; Barnes D; Dennison EM; Eriksson JG; Eriksson P; Eury E; Folkersen L; Fox CS; Frayling TM; Goel A; Gu HF; Horikoshi M; Isomaa B; Jackson AU; Jameson KA; Kajantie E; Kerr-Conte J; Kuulasmaa T; Kuusisto J; Loos RJF; Luan J; Makrilakis K; Manning AK; Teresa Martinez-Larrad M; Narisu N; Mannila MN; Ohrvik J; Osmond C; Pascoe L; Payne F; Sayer AA; Sennblad B; Silveira A; Stancakova A; Stirrups K; Swift AJ; Syvanen A-C; Tuomi T; van 't Hooft FM; Walker M; Weedon MN; Xie W; Zethelius B; Ongen H; Malarstig A; Hopewell JC; Saleheen D; Chambers J; Parish S; Danesh J; Kooner J; Ostenson C-G; Lind L; Cooper CC; Serrano-Rios M; Ferrannini E; Forsen TJ; Clarke R; Franzosi MG; Seedorf U; Watkins H; Froguel P; Johnson P; Deloukas P; Collins FS; Laakso M; Dermitzakis ET; Boehnke M; McCarthy MI; Wareham NJ; Groop L; Pattou F; Gloyn AL; Dedoussis GV; Lyssenko V; Meigs JB; Barroso I; Watanabe RM; Ingelsson E; Langenberg C; Hamsten A; Florez JC. (1 Oct 2011). Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes. DIABETES. 60:2624-2634. Author weblink DOI.
• Semplici F; Vaxillaire M; Fogarty S; Semache M; Bonnefond A; Fontés G; Philippe J; Meur G; et alDiraison F; Sessions RB; Rutter J; Poitout V; Froguel P; Rutter GA. (23 Dec 2011). Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion. J Biol Chem. 286:44005-44014. DOI.
• Chambers JC; Zhang W; Sehmi J; Li X; Wass MN; Van der Harst P; Holm H; Sanna S; et alKavousi M; Baumeister SE; Coin LJ; Deng G; Gieger C; Heard-Costa NL; Hottenga JJ; Kühnel B; Kumar V; Lagou V; Liang L; Luan J; Vidal PM; Mateo Leach I; O'Reilly PF; Peden JF; Rahmioglu N; Soininen P; Speliotes EK; Yuan X; Thorleifsson G; Alizadeh BZ; Atwood LD; Borecki IB; Brown MJ; Charoen P; Cucca F; Das D; de Geus EJ; Dixon AL; Döring A; Ehret G; Eyjolfsson GI; Farrall M; Forouhi NG; Friedrich N; Goessling W; Gudbjartsson DF; Harris TB; Hartikainen AL; Heath S; Hirschfield GM; Hofman A; Homuth G; Hyppönen E; Janssen HL; Johnson T; Kangas AJ; Kema IP; Kühn JP; Lai S; Lathrop M; Lerch MM; Li Y; Liang TJ; Lin JP; Loos RJ; Martin NG; Moffatt MF; Montgomery GW; Munroe PB; Musunuru K; Nakamura Y; O'Donnell CJ; Olafsson I; Penninx BW; Pouta A; Prins BP; Prokopenko I; Puls R; Ruokonen A; Savolainen MJ; Schlessinger D; Schouten JN; Seedorf U; Sen-Chowdhry S; Siminovitch KA; Smit JH; Spector TD; Tan W; Teslovich TM; Tukiainen T; Uitterlinden AG; Van der Klauw MM; Vasan RS; Wallace C; Wallaschofski H; Wichmann HE; Willemsen G; Würtz P; Xu C; Yerges-Armstrong LM; Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC); Abecasis GR; Ahmadi KR; Boomsma DI; Caulfield M; Cookson WO; van Duijn CM; Froguel P; Matsuda K; McCarthy MI; Meisinger C; Mooser V; Pietiläinen KH; Schumann G; Snieder H; Sternberg MJ; Stolk RP; Thomas HC; Thorsteinsdottir U; Uda M; Waeber G; Wareham NJ; Waterworth DM; Watkins H; Whitfield JB; Witteman JC; Wolffenbuttel BH; Fox CS; Ala-Korpela M; Stefansson K; Vollenweider P; Völzke H; Schadt EE; Scott J; Järvelin MR; Elliott P; Kooner JS. (Nov 2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 43:1131-1138. DOI.
• Soichot M; Hennart B; Al Saabi A; Leloire A; Froguel P; Levy-Marchal C; Poulain-Godefroy O; Allorge D. (2011). Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene. PLoS One. 6:e25470. DOI.
• Thanabalasingham G; Shah N; Vaxillaire M; Hansen T; Tuomi T; Gasperikova D; Szopa M; Tjora E; et alJames TJ; Kokko P; Loiseleur F; Andersson E; Gaget S; Isomaa B; Nowak N; Raeder H; Stanik J; Njolstad PR; Malecki MT; Klimes I; Groop L; Pedersen O; Froguel P; McCarthy MI; Gloyn AL; Owen KR. (1 Nov 2011). A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes. DIABETOLOGIA. 54:2801-2810. Author weblink DOI.
• Jacquemont S; Reymond A; Zufferey F; Harewood L; Walters RG; Kutalik Z; Martinet D; Shen Y; et alValsesia A; Beckmann ND; Thorleifsson G; Belfiore M; Bouquillon S; Campion D; de Leeuw N; de Vries BB; Esko T; Fernandez BA; Fernández-Aranda F; Fernández-Real JM; Gratacòs M; Guilmatre A; Hoyer J; Jarvelin MR; Kooy RF; Kurg A; Le Caignec C; Männik K; Platt OS; Sanlaville D; Van Haelst MM; Villatoro Gomez S; Walha F; Wu BL; Yu Y; Aboura A; Addor MC; Alembik Y; Antonarakis SE; Arveiler B; Barth M; Bednarek N; Béna F; Bergmann S; Beri M; Bernardini L; Blaumeiser B; Bonneau D; Bottani A; Boute O; Brunner HG; Cailley D; Callier P; Chiesa J; Chrast J; Coin L; Coutton C; Cuisset JM; Cuvellier JC; David A; de Freminville B; Delobel B; Delrue MA; Demeer B; Descamps D; Didelot G; Dieterich K; Disciglio V; Doco-Fenzy M; Drunat S; Duban-Bedu B; Dubourg C; El-Sayed Moustafa JS; Elliott P; Faas BH; Faivre L; Faudet A; Fellmann F; Ferrarini A; Fisher R; Flori E; Forer L; Gaillard D; Gerard M; Gieger C; Gimelli S; Gimelli G; Grabe HJ; Guichet A; Guillin O; Hartikainen AL; Heron D; Hippolyte L; Holder M; Homuth G; Isidor B; Jaillard S; Jaros Z; Jiménez-Murcia S; Helas GJ; Jonveaux P; Kaksonen S; Keren B; Kloss-Brandstätter A; Knoers NV; Koolen DA; Kroisel PM; Kronenberg F; Labalme A; Landais E; Lapi E; Layet V; Legallic S; Leheup B; Leube B; Lewis S; Lucas J; MacDermot KD; Magnusson P; Marshall C; Mathieu-Dramard M; McCarthy MI; Meitinger T; Mencarelli MA; Merla G; Moerman A; Mooser V; Morice-Picard F; Mucciolo M; Nauck M; Ndiaye NC; Nordgren A; Pasquier L; Petit F; Pfundt R; Plessis G; Rajcan-Separovic E; Ramelli GP; Rauch A; Ravazzolo R; Reis A; Renieri A; Richart C; Ried JS; Rieubland C; Roberts W; Roetzer KM; Rooryck C; Rossi M; Saemundsen E; Satre V; Schurmann C; Sigurdsson E; Stavropoulos DJ; Stefansson H; Tengström C; Thorsteinsdóttir U; Tinahones FJ; Touraine R; Vallée L; van Binsbergen E; Van der Aa N; Vincent-Delorme C; Visvikis-Siest S; Vollenweider P; Völzke H; Vulto-van Silfhout AT; Waeber G; Wallgren-Pettersson C; Witwicki RM; Zwolinksi S; Andrieux J; Estivill X; Gusella JF; Gustafsson O; Metspalu A; Scherer SW; Stefansson K; Blakemore AI; Beckmann JS; Froguel P. (6 Oct 2011). Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature. 478:97-102. DOI.
• Pound LD; Sarkar SA; Cauchi S; Wang Y; Oeser JK; Lee CE; Froguel P; Hutton JC; et alO'Brien RM. (Dec 2011). Characterization of the human SLC30A8 promoter and intronic enhancer. J Mol Endocrinol. 47:251-259. DOI.
• Gjesing AP; Nielsen AA; Brandslund I; Christensen C; Sandbaek A; Jorgensen T; Witte D; Bonnefond A; et alFroguel P; Hansen T; Pedersen O. (25 Jul 2011). Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes. BMC MEDICAL GENETICS. 12. Author weblink DOI.
• Kooner JS; Saleheen D; Sim X; Sehmi J; Zhang W; Frossard P; Been LF; Chia KS; et alDimas AS; Hassanali N; Jafar T; Jowett JB; Li X; Radha V; Rees SD; Takeuchi F; Young R; Aung T; Basit A; Chidambaram M; Das D; Grundberg E; Hedman AK; Hydrie ZI; Islam M; Khor CC; Kowlessur S; Kristensen MM; Liju S; Lim WY; Matthews DR; Liu J; Morris AP; Nica AC; Pinidiyapathirage JM; Prokopenko I; Rasheed A; Samuel M; Shah N; Shera AS; Small KS; Suo C; Wickremasinghe AR; Wong TY; Yang M; Zhang F; DIAGRAM; MuTHER; Abecasis GR; Barnett AH; Caulfield M; Deloukas P; Frayling TM; Froguel P; Kato N; Katulanda P; Kelly MA; Liang J; Mohan V; Sanghera DK; Scott J; Seielstad M; Zimmet PZ; Elliott P; Teo YY; McCarthy MI; Danesh J; Tai ES; Chambers JC. (Oct 2011). Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 43:984-989. DOI.
• Langenberg C; Sharp S; Forouhi NG; Franks PW; Schulze MB; Kerrison N; Ekelund U; Barroso I; et alPanico S; Tormo MJ; Spranger J; Griffin S; van der Schouw YT; Amiano P; Ardanaz E; Arriola L; Balkau B; Barricarte A; Beulens JWJ; Boeing H; Bueno-de-Mesquita HB; Buijsse B; Chirlaque Lopez MD; Clavel-Chapelon F; Crowe FL; de Lauzon-Guillan B; Deloukas P; Dorronsoro M; Drogan D; Froguel P; Gonzalez C; Grioni S; Groop L; Groves C; Hainaut P; Halkjaer J; Hallmans G; Hansen T; Huerta Castano JM; Kaaks R; Key TJ; Khaw KT; Koulman A; Mattiello A; Navarro C; Nilsson P; Norat T; Overvad K; Palla L; Palli D; Pedersen O; Peeters PH; Quiros JR; Ramachandran A; Rodriguez-Suarez L; Rolandsson O; Romaguera D; Romieu I; Sacerdote C; Sanchez MJ; Sandbaek A; Slimani N; Sluijs I; Spijkerman AMW; Teucher B; Tjonneland A; Tumino R; van der A DL; Verschuren WMM; Tuomilehto J; Feskens E; McCarthy M; Riboli E; Wareham NJ. (1 Sep 2011). Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. DIABETOLOGIA. 54:2272-2282. DOI.
• Bonnefond A; Lomberk G; Buttar N; Busiah K; Vaillant E; Lobbens S; Yengo L; Dechaume A; et alMignot B; Simon A; Scharfmann R; Neve B; Tanyolac S; Hodoglugil U; Pattou F; Cave H; Iovanna J; Stein R; Polak M; Vaxillaire M; Froguel P; Urrutia R. (12 Aug 2011). Disruption of a Novel Kruppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Mellitus. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:28414-28424. DOI.
• Clark SJ; Falchi M; Olsson B; Jacobson P; Cauchi S; Balkau B; Marre M; Lantieri O; et alAndersson JC; Jernås M; Aitman TJ; Richardson S; Sjöström L; Wong HY; Carlsson LM; Froguel P; Walley AJ. (Jan 2012). Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity. Obesity (Silver Spring). 20:178-185. DOI.
• Rouskas K; Kouvatsi A; Paletas K; Papazoglou D; Tsapas A; Lobbens S; Vatin V; Durand E; et alLabrune Y; Delplanque J; Meyre D; Froguel P. (Feb 2012). Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population. Obesity (Silver Spring). 20:389-395. DOI.
• Barker A; Sharp SJ; Timpson NJ; Bouatia-Naji N; Warrington NM; Kanoni S; Beilin LJ; Brage S; et alDeloukas P; Evans DM; Grontved A; Hassanali N; Lawlor DA; Lecoeur C; Loos RJF; Lye SJ; McCarthy MI; Mori TA; Ndiaye NC; Newnham JP; Ntalla I; Pennell CE; St Pourcain B; Prokopenko I; Ring SM; Sattar N; Visvikis-Siest S; Dedoussis GV; Pahner LJ; Froguel P; Smith GD; Ekelund U; Wareham NJ; Langenberg C. (1 Jun 2011). Association of Genetic Loci With Glucose Levels in Childhood and Adolescence A Meta-Analysis of Over 6,000 Children. DIABETES. 60:1805-1812. DOI.
• Trewick AL; Moustafa JS; de Smith AJ; Froguel P; Greve G; Njølstad PR; Coin LJ; Blakemore AI. (Aug 2011). Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry. Clin Chem. 57:1188-1195. DOI.
• Veron A; Dina C; Froguel P; Thomas G; Cox D. (1 Mar 2011). On the importance of population structure in GWAS using convenience control datasets. BULLETIN DU CANCER. 98:S82-S82. Author weblink.
• Séron K; Couturier C; Belouzard S; Bacart J; Monté D; Corset L; Bocquet O; Dam J; et alVauthier V; Lecœur C; Bailleul B; Hoflack B; Froguel P; Jockers R; Rouillé Y. (20 May 2011). Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. J Biol Chem. 286:17968-17981. DOI.
• Bonnefond A; Lomberk G; Buttar N; Busiah K; Vaillant E; Lobbens S; Yengo L; Dechaume A; et alMignot B; Simon A; Scharfmann R; Neve B; Tanyolaç S; Hodoglugil U; Pattou F; Cavé H; Iovanna J; Stein R; Polak M; Vaxillaire M; Froguel P; Urrutia R. (12 Aug 2011). Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. J Biol Chem. 286:28414-28424. DOI.
• Eleftherohorinou H; Andersson-Assarsson JC; Walters RG; El-Sayed Moustafa JS; Coin L; Jacobson P; Carlsson LM; Blakemore AI; et alFroguel P; Walley AJ; Falchi M. (1 Jul 2011). famCNV: copy number variant association for quantitative traits in families. Bioinformatics. 27:1873-1875. DOI.
• Le Bacquer O; Shu L; Marchand M; Neve B; Paroni F; Conte JK; Pattou F; Froguel P; et alMaedler K. (15 May 2011). TCF7L2 splice variants have distinct effects on beta-cell turnover and function. HUMAN MOLECULAR GENETICS. 20:1906-1915. Author weblink DOI.
• Dorajoo R; Blakemore AI; Sim X; Ong RT; Ng DP; Seielstad M; Wong TY; Saw SM; et alFroguel P; Liu J; Tai ES. (Jan 2012). Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. Int J Obes (Lond). 36:159-163. DOI.
• Coronary Artery Disease (C4D) Genetics Consortium. (Apr 2011). A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet. 43:339-344. DOI.
• Marquez M; Huyyaert M; Vivequin S; Lobbens S; Charpentier G; Balkau B; Froguel P; Cauchi S. (1 Mar 2011). Rarely frequent variants of the HMGA1 gene could be linked to type 2 diabetes. DIABETES & METABOLISM. 37:A66-A66. Author weblink.
• Amara A; Ghezail H; Brahem R; Gribaa M; Philippe J; Dechaume A; Saad A; Chadli-Chaieb M; et alChaieb L; Froguel P; Vaxillaire M. (1 Mar 2011). Lack of mutations of HNF1A genes, HNF4A and INS in ten Tunisian patients with MODY type diabetes. DIABETES & METABOLISM. 37:A64-A65. Author weblink.
• Lamri A; Khalil CA; Jaziri R; Velho G; Lantieri O; Vol S; Froguel P; Balkau B; et alMarre M; Fumeron F. (1 Mar 2011). Lipid consumption and polymorphism of the PPARG locus modulate body mass index and the risk of type 2 diabetes in the DESIR prospective study. DIABETES & METABOLISM. 37:A22-A22. Author weblink.
• Gautier A; Roussel R; Lange C; Piguel X; Vol S; Cauchi S; Froguel P; Balkau B; et alBonnet F. (1 Mar 2011). Accelerated decline of the beta function based on the TCF7L2 genotype after the diagnosis of diabetes in the DESIR group. DIABETES & METABOLISM. 37:A21-A22. Author weblink.
• Le Bacquer O; Shu L; Marchand M; Neve B; Kerr-Conte J; Pattou F; Maedler K; Froguel P. (1 Mar 2011). Alternative splicing of TC7L2 and beta-pancreatic function. DIABETES & METABOLISM. 37:A1-A2. Author weblink.
• Bonnefond A; Lomberk G; Busiah K; Vaillant E; Pattou F; Iovanna J; Stein R; Polak M; et alVaxillaire M; Urrutia R; Froguel P. (1 Mar 2011). The extinction of the biosynthesis of insulin via the alteration of a binding site of transcription factor KLF11 results in a congenital form of neonatal diabetes. DIABETES & METABOLISM. 37:A1-A1. Author weblink.
• de Smith AJ; van Haelst MM; Ellis RJ; Holder SE; Payne SJ; Hashim SK; Froguel P; Blakemore AI. (May 2011). Chromosome 19p13.3 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems. Am J Med Genet A. 155A:1192-1195. DOI.
• Fernando MM; de Smith AJ; Coin L; Morris DL; Froguel P; Mangion J; Blakemore AI; Graham RR; et alBehrens TW; Vyse TJ. (May 2011). Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants. Ann Hum Genet. 75:383-397. DOI.
• Walley AJ; Jacobson P; Falchi M; Bottolo L; Andersson JC; Petretto E; Bonnefond A; Vaillant E; et alLecoeur C; Vatin V; Jernas M; Balding D; Petteni M; Park YS; Aitman T; Richardson S; Sjostrom L; Carlsson LM; Froguel P. (Jan 2012). Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue. Int J Obes (Lond). 36:137-147. DOI.
• Yadav S; Schanz R; Maheshwari A; Khan MS; Slark J; de Silva R; Bentley P; Froguel P; et alKooner J; Shrivastav P; Prasad K; Sharma P. (2011). Bio-Repository of DNA in stroke (BRAINS): a study protocol. BMC Med Genet. 12:34. DOI.
• Buxton JL; Walters RG; Visvikis-Siest S; Meyre D; Froguel P; Blakemore AI. (May 2011). Childhood obesity is associated with shorter leukocyte telomere length. J Clin Endocrinol Metab. 96:1500-1505. DOI.
• Bouhaha R; Choquet H; Meyre D; Kamoun HA; Ennafaa H; Baroudi T; Sassi R; Vaxillaire M; et alElgaaied A; Froguel P; Cauchi S. (1 Dec 2010). TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia. PATHOLOGIE BIOLOGIE. 58:426-429. DOI.
• Olsson M; Olsson B; Jacobson P; Thelle DS; Bjorkegren J; Walley A; Froguel P; Carlsson LMS; et alSjoholm K. (1 Jan 2011). Expression of the selenoprotein S (SELS) gene m subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors. METABOLISM-CLINICAL AND EXPERIMENTAL. 60:114-120. Author weblink DOI.
• Gonsorcikova L; Vaxillaire M; Pruhova S; Dechaume A; Dusatkova P; Cinek O; Pedersen O; Froguel P; et alHansen T; Lebl J. (May 2011). Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations. Pediatr Diabetes. 12:266-269. DOI.
• Blakemore AI; Froguel P. (Dec 2010). Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine. Ann N Y Acad Sci. 1214:180-189. DOI.
• Ma L; Hanson RL; Traurig MT; Muller YL; Kaur BP; Perez JM; Meyre D; Fu M; et alKoerner A; Franks PW; Kiess W; Kobes S; Knowler WC; Kovacs P; Froguel P; Shuldiner AR; Bogardus C; Baler LJ. (1 Nov 2010). Evaluation of A2BP1 as an Obesity Gene. DIABETES. 59:2837-2845. DOI.
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• Rung J; Cauchi S; Albrechtsen A; Shen L; Rocheleau G; Cavalcanti-Proenca C; Bacot F; Balkau B; et alBelisle A; Borch-Johnsen K; Charpentier G; Dina C; Durand E; Elliott P; Hadjadj S; Jaervelin M-R; Laitinen J; Lauritzen T; Marre M; Mazur A; Meyre D; Montpetit A; Pisinger C; Posner B; Poulsen P; Pouta A; Prentki M; Ribel-Madsen R; Ruokonen A; Sandbaek A; Serre D; Tichet J; Vaxillaire M; Wojtaszewski JFP; Vaag A; Hansen T; Polychronakos C; Pedersen O; Froguel P; Sladek R. (1 Oct 2009). Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. NATURE GENETICS. 41:1110-U89. Author weblink DOI.
• Nicolson TJ; Bellomo EA; Wijesekara N; Loder MK; Baldwin JM; Gyulkhandanyan AV; Koshkin V; Tarasov AI; et alCarzaniga R; Kronenberger K; Taneja TK; Xavier GDS; Libert S; Froguel P; Scharfmann R; Stetsyuk V; Ravassard P; Parker H; Gribble FM; Reimann F; Sladek R; Hughes SJ; Johnson PRV; Masseboeuf M; Burcelin R; Baldwin SA; Liu M; Lara-Lemus R; Arvan P; Schuit FC; Wheeler MB; Chimienti F; Rutter GA. (1 Sep 2009). Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants. DIABETES. 58:2070-2083. Author weblink DOI.
• Le Clerc S; Limou S; Coulonges C; Carpentier W; Dina C; Taing L; Delaneau O; Labib T; et alSladek R; ANRS Genomic Group; Deveau C; Guillemain H; Ratsimandresy R; Montes M; Spadoni JL; Therwath A; Schächter F; Matsuda F; Gut I; Lelièvre JD; Lévy Y; Froguel P; Delfraissy JF; Hercberg S; Zagury JF. (15 Oct 2009). Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). J Infect Dis. 200:1194-1201. DOI.
• Blakemore AIF; Meyre D; Delplanque J; Vatin V; Lecoeur C; Marre M; Tichet J; Balkau B; et alFroguel P; Walley AJ. (1 Aug 2009). A Rare Variant in the Visfatin Gene (NAMPT/PBEF1) Is Associated With Protection From Obesity. OBESITY. 17:1549-1553. Author weblink DOI.
• Boissel S; Reish O; Proulx K; Kawagoe-Takaki H; Sedgwick B; Yeo GSH; Meyre D; Golzio C; et alMolinari F; Kadhom N; Etchevers HC; Saudek V; Farooqi IS; Froguel P; Lindahl T; O'Rahilly S; Munnich A; Colleaux L. (10 Jul 2009). Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations. AMERICAN JOURNAL OF HUMAN GENETICS. 85:106-111. Author weblink DOI.
• Prokopenko I; Zeggini E; Hanson RL; Mitchell BD; Rayner NW; Akan P; Baier L; Das SK; et alElliott KS; Fu M; Frayling TM; Groves CJ; Gwilliam R; Scott LJ; Voight BF; Hattersley AT; Hu C; Morris AD; Ng M; Palmer CNA; Tello-Ruiz M; Vaxillaire M; Wang C-R; Stein L; Chan J; Jia W; Froguel P; Elbein SC; Deloukas P; Bogardus C; Shuldiner AR; McCarthy MI. (1 Jul 2009). Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q. DIABETES. 58:1704-1709. Author weblink DOI.
• Traurig M; Mack J; Hanson RL; Ghoussaini M; Meyre D; Knowler WC; Kobes S; Froguel P; et alBogardus C; Baier LJ. (1 Jul 2009). Common Variation in SIM1 Is Reproducibly Associated With BMI in Pima Indians. DIABETES. 58:1682-1689. Author weblink DOI.
• Elliott P; Chambers JC; Zhang W; Clarke R; Hopewell JC; Peden JF; Erdmann J; Braund P; et alEngert JC; Bennett D; Coin L; Ashby D; Tzoulaki I; Brown IJ; Mt-Isa S; McCarthy MI; Peltonen L; Freimer NB; Farrall M; Ruokonen A; Hamsten A; Lim N; Froguel P; Waterworth DM; Vollenweider P; Waeber G; Jarvelin M-R; Mooser V; Scott J; Hall AS; Schunkert H; Anand SS; Collins R; Samani NJ; Watkins H; Kooner JS. (1 Jul 2009). Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 302:37-48. Author weblink.
• Saiki A; Olsson M; Jernås M; Gummesson A; McTernan PG; Andersson J; Jacobson P; Sjöholm K; et alOlsson B; Yamamura S; Walley A; Froguel P; Carlsson B; Sjöström L; Svensson PA; Carlsson LM. (Oct 2009). Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. J Clin Endocrinol Metab. 94:3987-3994. DOI.
• Goossens GH; Petersen L; Blaak EE; Hul G; Arner P; Astrup A; Froguel P; Patel K; et alPedersen O; Polak J; Oppert J-M; Martinez JA; Sorensen TIA; Saris WHM. (1 Jun 2009). Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study. INTERNATIONAL JOURNAL OF OBESITY. 33:669-679. Author weblink DOI.
• Walley AJ; Asher JE; Froguel P. (1 Jul 2009). The genetic contribution to non-syndromic human obesity. NATURE REVIEWS GENETICS. 10:431-442. Author weblink DOI.
• Sparso T; Bonnefond A; Andersson E; Bouatia-Naji N; Holmkvist J; Wegner L; Grarup N; Gjesing AP; et alBanasik K; Cavalcanti-Proenca C; Marchand M; Vaxillaire M; Charpentier G; Jarvelin M-R; Tichet J; Balkau B; Marre M; Levy-Marchal C; Faerch K; Borch-Johnsen K; Jorgensen T; Madsbad S; Poulsen P; Vaag A; Dina C; Hansen T; Pedersen O; Froguel P. (1 Jun 2009). G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release Studies Involving 19,605 Europeans. DIABETES. 58:1450-1456. Author weblink DOI.
• de Smith AJ; Purmann C; Walters RG; Ellis RJ; Holder SE; Van Haelst MM; Brady AF; Fairbrother UL; et alDattani M; Keogh JM; Henning E; Yeo GS; O'Rahilly S; Froguel P; Farooqi IS; Blakemore AI. (1 Sep 2009). A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. Hum Mol Genet. 18:3257-3265. DOI.
• Jernas M; Olsson B; Arner P; Jacobson P; Sjostrom L; Walley A; Froguel P; McTernan PG; et alHoffstedt J; Carlsson LMS. (22 May 2009). Regulation of carboxylesterase 1 (CES1) in human adipose tissue. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 383:63-67. Author weblink DOI.
• Ezzidi I; Mtiraoui N; Cauchi S; Vaillant E; Dechaume A; Chaieb M; Kacem M; Almawi WY; et alFroguel P; Mahjoub T; Vaxillaire M. (15 Apr 2009). Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study. BMC MEDICAL GENETICS. 10. Author weblink DOI.
• Garcia EA; King P; Sidhu K; Ohgusu H; Walley A; Lecoeur C; Gueorguiev M; Khalaf S; et alDavies D; Grossman AB; Kojima M; Petersenn S; Froguel P; Korbonits M. (Aug 2009). The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes. Eur J Endocrinol. 161:307-315. DOI.
• Cauchi S; Stutzmann F; Cavalcanti-Proenca C; Durand E; Pouta A; Hartikainen A-L; Marre M; Vol S; et alTammelin T; Laitinen J; Gonzalez-Izquierdo A; Blakemore AIF; Elliott P; Meyre D; Balkau B; Jaervelin M-R; Froguel P. (1 May 2009). Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. JOURNAL OF MOLECULAR MEDICINE-JMM. 87:537-546. Author weblink DOI.
• Carlsson LMS; Jacobson P; Walley A; Froguel P; Sjostrom L; Svensson P-A; Sjoholm K. (1 May 2009). ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 382:309-314. Author weblink DOI.
• Vaxillaire M; D P; Bonnefond A; Froguel P. (Mar 2009). Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes. Pediatr Endocrinol Rev. 6:405-417.
• Dahlman I; Nilsson M; Gu HF; Lecoeur C; Efendic S; Ostenson CG; Brismar K; Gustafsson J-A; et alFroguel P; Vaxillaire M; Dahlman-Wright K; Steffensen KR. (17 Mar 2009). Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles - a cohort study. BMC MEDICAL GENETICS. 10. Author weblink DOI.
• de Smith AJ; Walters RG; Froguel P; Blakemore AI. (1 Jan 2008). Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease. CYTOGENETIC AND GENOME RESEARCH. 123:17-26. Author weblink DOI.
• Bonnefond A; Bouatia-Naji N; Simon A; Saint-Martin C; Dechaume A; de Lonlay P; Polak M; Bellanne-Chantelot C; et alFroguel P; Vaxillaire M. (1 May 2009). Mutations in G6PC2 do not contribute to monogenic forms of early infancy diabetes and beta cell dysfunction. DIABETOLOGIA. 52:982-985. Author weblink DOI.
• Durand E; Lecoeur C; Delplanque J; Benzinou M; Degraeve F; Boutin P; Marre M; Balkau B; et alCharpentier G; Froguel P; Meyre D. (1 Dec 2008). Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population. OBESITY FACTS. 1:305-309. Author weblink DOI.
• Choquet H; Cavalcanti-Proença C; Lecoeur C; Dina C; Cauchi S; Vaxillaire M; Hadjadj S; Horber F; et alPotoczna N; Charpentier G; Ruiz J; Hercberg S; Maimaitiming S; Roussel R; Boenhnke M; Jackson AU; Patsch W; Krempler F; Voight BF; Altshuler D; Groop L; Thorleifsson G; Steinthorsdottir V; Stefansson K; Balkau B; Froguel P; Meyre D. (1 Jul 2009). The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects. Hum Mol Genet. 18:2495-2501. DOI.
• Bonnofond A; Bouatia-Naji N; Cavalcanti-Proonca C; Marchand M; Oeser J; Levy-Marchal C; Balkau B; Marre M; et alPattou F; Jarvelin MR; O'Brien R; Froguel P. (1 Mar 2009). Variants of the gene promoter G6PC2 could explain the contribution of this locus in the genetic control of blood glucose. DIABETES & METABOLISM. 35:A25-A26. Author weblink.
• Bouatia-Naji N; Bonnefond A; Cavalcanti-Proenca C; Jarvelin MR; Charpentier G; Hadjadj S; Levy-Marchal C; Balkau B; et alMarre M; Visvikis-Siest S; Pedersen O; Froguel P. (1 Mar 2009). Variants of the gene MTNR1B receiver 2 to melatonin increased the glucose and the risk of T2DM: a link between circadian rhythm and diabetes?. DIABETES & METABOLISM. 35:A25-A25. Author weblink.
• Stutzmann F; Ghoussaini M; Couturier C; Vatin V; Corset L; Lecoeur C; Balkau B; Horber F; et alWeill J; Michaud J; Meyre D; Froguel P. (1 Mar 2009). Mutations of the hypothalamic transcription factor SIM1 are responsible for severe monogenic obesity of children. DIABETES & METABOLISM. 35:A6-A6. Author weblink.
• Vaxillaire M; Simon A; Bonnefond A; Vitally M; Dechaumel A; Busiah K; Cave H; Scharfmann R; et alRutter G; Gautier JF; Froguel P; Polak M. (1 Mar 2009). Gene mutations of preproinsulin altering the maturation of insulin and leading to non-autoimmune daibetes in children and type Mody. DIABETES & METABOLISM. 35:A2-A2. Author weblink.
• Gueorguiev M; Lecoeur C; Meyre D; Benzinou M; Mein CA; Hinney A; Vatin V; Weill J; et alHeude B; Hebebrand J; Grossman AB; Korbonits M; Froguel P. (1 Apr 2009). Association Studies on Ghrelin and Ghrelin Receptor Gene Polymorphisms With Obesity. OBESITY. 17:745-754. Author weblink DOI.
• Bosse Y; Bacot F; Montpetit A; Rung J; Qu H-Q; Engert JC; Polychronakos C; Hudson TJ; et alFroguel P; Sladek R; Desrosiers M. (1 Apr 2009). Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans. HUMAN GENETICS. 125:305-318. Author weblink DOI.
• Stutzmann F; Cauchi S; Durand E; Calvacanti-Proenca C; Pigeyre M; Hartikainen A-L; Sovio U; Tichet J; et alMarre M; Weill J; Balkau B; Potoczna N; Laitinen J; Elliott P; Jarvelin M-R; Horber F; Meyre D; Froguel P. (1 Mar 2009). Common genetic variation near MC4R is associated with eating behaviour patterns in European populations. INTERNATIONAL JOURNAL OF OBESITY. 33:373-378. Author weblink DOI.
• Duesing K; Charpentier G; Marre M; Tichet J; Hercberg S; Balkau B; Froguel P; Gibson F. (13 Feb 2009). Evaluating the association of common APOA2 variants with type 2 diabetes. BMC MEDICAL GENETICS. 10. Author weblink DOI.
• El Achhab Y; Meyre D; Boltatia-Naji N; Berraho M; Deweirder M; Vatin V; Delplanque J; Serhier Z; et alLyoussi B; Nejjari C; Froguel P; Chikri M. (1 Feb 2009). Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population. DIABETES & METABOLISM. 35:37-42. Author weblink DOI.
• Meyre D; Delplanque J; Chevre J-C; Lecoeur C; Lobbens S; Gallina S; Durand E; Vatin V; et alDegraeve F; Proenca C; Gaget S; Koerner A; Kovacs P; Kiess W; Tichet J; Marre M; Hartikainen A-L; Horber F; Potoczna N; Hercberg S; Levy-Marchal C; Pattou F; Heude B; Tauber M; McCarthy MI; Blakemore AIF; Montpetit A; Polychronakos C; Weill J; Coin LJM; Asher J; Elliott P; Jarvelin M-R; Visvikis-Siest S; Balkau B; Sladek R; Balding D; Walley A; Dina C; Froguel P. (1 Feb 2009). Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. NATURE GENETICS. 41:157-159. Author weblink DOI.
• Gueorguiev M; Lecoeur C; Benzinou M; Mein CA; Meyre D; Vatin V; Weill J; Heude B; et alGrossman AB; Froguel P; Korbonits M. (1 Jan 2009). A Genetic Study of the Ghrelin and Growth Hormone Secretagogue Receptor (GHSR) Genes and Stature. ANNALS OF HUMAN GENETICS. 73:1-9. Author weblink DOI.
• Limou S; Le Clerc S; Coulonges C; Carpentier W; Dina C; Delaneau O; Labib T; Taing L; et alSladek R; Deveau C; Ratsimandresy R; Montes M; Spadoni J-L; Lelievre J-D; Levy Y; Therwath A; Schaechter F; Matsuda F; Gut I; Froguel P; Delfraissy J-F; Hercberg S; Zagury J-F. (1 Feb 2009). Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02). JOURNAL OF INFECTIOUS DISEASES. 199:419-426. Author weblink DOI.
• Morandi A; Pinelli L; Petrone A; Vatin V; Buzzetti R; Froguel P; Meyre D. (1 Jan 2009). The Q121 Variant of ENPP1 May Protect From Childhood Overweight/obesity in the Italian Population. OBESITY. 17:202-206. Author weblink DOI.
• Weill J; Meyre D; Lecoeur C; Froguel P. (1 Jan 2008). Characterization and heritability of predisposition to insulin resistance: Comparison of an obese with a normal child population. HORMONE RESEARCH. 70:133-133. Author weblink.
• Cauchi S; Froguel P. (1 Apr 2008). TCF7L2 Genetic Defect and Type 2 Diabetes. CURRENT DIABETES REPORTS. 8:149-155. Author weblink DOI.
• Bouatia-Naji N; Bonnefond A; Cavalcanti-Proença C; Sparsø T; Holmkvist J; Marchand M; Delplanque J; Lobbens S; et alRocheleau G; Durand E; De Graeve F; Chèvre JC; Borch-Johnsen K; Hartikainen AL; Ruokonen A; Tichet J; Marre M; Weill J; Heude B; Tauber M; Lemaire K; Schuit F; Elliott P; Jørgensen T; Charpentier G; Hadjadj S; Cauchi S; Vaxillaire M; Sladek R; Visvikis-Siest S; Balkau B; Lévy-Marchal C; Pattou F; Meyre D; Blakemore AI; Jarvelin MR; Walley AJ; Hansen T; Dina C; Pedersen O; Froguel P. (Jan 2009). A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet. 41:89-94. DOI.
• Blakemore AIF; Froguel P. (1 Nov 2008). Is Obesity Our Genetic Legacy?. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 93:S51-S56. Author weblink DOI.
• Dahlman I; Vaxillaire M; Nilsson M; Lecoeur C; Gu HF; Cavalcanti-Proenca C; Efendic S; Ostenson CG; et alBrismar K; Charpentler G; Gustafsson J-A; Froguel P; Dahlman-Wright K; Steffensen KR. (1 Nov 2008). Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose. PHARMACOGENETICS AND GENOMICS. 18:967-975. Author weblink DOI.
• Balkau B; Lange C; Fezeu L; Tichet J; De Lauzon-Guillain B; Cernichow S; Fumeron F; Froguel P; et alVaxillaire M; Cauchi S; Ducimetiere P; Eschwege E. (1 Oct 2008). Predicting Diabetes: Clinical, Biological, and Genetic Approaches Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR). DIABETES CARE. 31:2056-2061. Author weblink DOI.
• Villalobos-Comparan M; Flores-Dorantes T; Villarreal-Molina T; Rodriguez-Cruz M; Garcia-Ulloa AC; Robles L; Huertas-Vazquez A; Saucedo-Villarreal N; et alLopez-Alarcon M; Sanchez-Munoz F; Dominguez-Lopez A; Gutierrez-Aguilar R; Menjivar M; Coral-Vazquez R; Hernandez-Stengele G; Vital-Reyes VS; Acuna-Alonzo V; Romero-Hidalgo S; Ruiz-Gomez DG; Riano-Barros D; Herrera MF; Gomez-Perez FJ; Froguel P; Garcia-Garcia E; Tusie-Luna MT; Aguilar-Salinas CA; Canizales-Quinteros S. (1 Oct 2008). The FTO gene is associated with adulthood obesity in the Mexican population. OBESITY. 16:2296-2301. Author weblink DOI.
• Poulain-Godefroy O; Froguel P. (1 Oct 2008). Response to the letter to the editor: "HIF-1 alpha protein rather than mRNA as a marker of hypoxia in adipose tissue in obesity," by Trayhurn et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 295:R1098-R1098. Author weblink DOI.
• Bouhaha R; Meyre D; Kamoun HA; Ennafaa H; Vaillant E; Sassi R; Baroudi T; Vatin V; et alFroguel P; Elgaaied A; Vaxillaire M. (1 Sep 2008). Effect of ENPP1/PC-1-K121Q and PPAR gamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population. DIABETES RESEARCH AND CLINICAL PRACTICE. 81:278-283. Author weblink DOI.
• Wermter A-K; Scherag A; Meyre D; Reichwald K; Durand E; Nguyen TT; Koberwitz K; Lichtner P; et alMeitinger T; Schaefer H; Hinney A; Froguel P; Hebebrand J; Broenner G. (1 Sep 2008). Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans. EUROPEAN JOURNAL OF HUMAN GENETICS. 16:1126-1134. Author weblink DOI.
• Bouatia-Naji N; Rocheleau G; Van Lommel L; Lemaire K; Schuit E; Marre M; Balkau B; Jarvelin M-R; et alSladek R; Froguel P. (1 Sep 2008). Glucose 6 phosphatase beta cell specific subtype/IGRP gene variation controls fasting plasma glucose levels in humans. DIABETOLOGIA. 51:S127-S127. Author weblink.
• Froguel P; Blakemore AIF. (28 Aug 2008). Focus on research: The power of the extreme in elucidating obesity. NEW ENGLAND JOURNAL OF MEDICINE. 359:891-893. Author weblink DOI.
• Froguel P; Blakemore AI. (28 Aug 2008). The power of the extreme in elucidating obesity. N Engl J Med. 359:891-893. DOI.
• de Smith AJ; Walters RG; Coin LJ; Steinfeld I; Yakhini Z; Sladek R; Froguel P; Blakemore AI. (2008). Small deletion variants have stable breakpoints commonly associated with alu elements. PLoS One. 3:e3104. DOI.
• Vaxillaire M; Cavalcanti-Proenca C; Dechaume A; Tichet J; Marre M; Balkau B; Froguel P. (1 Aug 2008). The common P446L polymorphism in GCAR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. DIABETES. 57:2253-2257. Author weblink DOI.
• Benzinou M; Creemers JWM; Choquet H; Lobbens S; Dina C; Durand E; Guerardel A; Boutin P; et alJouret B; Heude B; Balkau B; Tichet J; Marre M; Potoczna N; Horber F; Le Stunff C; Czernichow S; Sandbaek A; Lauritzen T; Borch-Johnsen K; Andersen G; Kiess W; Koerner A; Kovacs P; Jacobson P; Carlsson LMS; Walley AJ; Jorgensen T; Hansen T; Pedersen O; Meyre D; Froguel P. (1 Aug 2008). Common nonsynonymous variants in PCSK1 confer risk of obesity. NATURE GENETICS. 40:943-945. Author weblink DOI.
• Poulain-Godefroy O; Lecoeur C; Pattou F; Fruhbeck G; Froguel P. (1 Jul 2008). Inflammation is associated with a decrease of lipogenic factors in omental fat in women. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 295:R1-R7. Author weblink DOI.
• Duesing K; Fatemifar G; Charpentier G; Marre M; Tichet J; Hercberg S; Balkau B; Froguel P; et alGibson F. (1 Jul 2008). Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians. DIABETES. 57:1992-1996. Author weblink DOI.
• Martin D; Bellanne-Chantelot C; Deschamps I; Froguel P; Robert J-J; Velho G. (1 Jul 2008). Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2). DIABETES CARE. 31:1321-1323. Author weblink DOI.
• Benzinou M; Chevre J-C; Ward KJ; Lecoeur C; Dina C; Lobbens S; Durand E; Delplanque J; et alHorber FF; Heude B; Balkau B; Borch-Johnsen K; Jorgensen T; Hansen T; Pedersen O; Meyre D; Froguel P. (1 Jul 2008). Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations. HUMAN MOLECULAR GENETICS. 17:1916-1921. Author weblink DOI.
• Bouatia-Naji N; De Graeve F; Broenner G; Lecoeur C; Vatin V; Durand E; Lichtner P; Nguyen TT; et alHeude B; Weill J; Levy-Marchal C; Hebebrand J; Froguel P; Meyre D. (1 Jun 2008). INS VNTR is not associated with childhood obesity in 1,023 families: A family-based study. OBESITY. 16:1471-1475. Author weblink DOI.
• Liu Y-J; Liu X-G; Wang L; Dina C; Yan H; Liu J-F; Levy S; Papasian CJ; et alDrees BM; Hamilton JJ; Meyre D; Delplanque J; Pei Y-F; Zhang L; Recker RR; Froguel P; Deng H-W. (15 Jun 2008). Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. HUMAN MOLECULAR GENETICS. 17:1803-1813. Author weblink DOI.
• Meyre D; Farge M; Lecoeur C; Proenca C; Durand E; Allegaert F; Tichet J; Marre M; et alBalkau B; Weill J; Delplanque J; Froguel P. (15 Jun 2008). R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population. HUMAN MOLECULAR GENETICS. 17:1798-1802. Author weblink DOI.
• Loos RJF; Lindgren CM; Li S; Wheeler E; Zhao JH; Prokopenko I; Inouye M; Freathy RM; et alAttwood AP; Beckmann JS; Berndt SI; Bergmann S; Bennett AJ; Bingham SA; Bochud M; Brown M; Cauchi S; Connell JM; Cooper C; Smith GD; Day I; Dina C; De S; Dermitzakis ET; Doney ASF; Elliott KS; Elliott P; Evans DM; Farooqi IS; Froguel P; Ghori J; Groves CJ; Gwilliam R; Hadley D; Hall AS; Hattersley AT; Hebebrand J; Heid IM; Herrera B; Hinney A; Hunt SE; Jarvelin M-R; Johnson T; Jolley JDM; Karpe F; Keniry A; Khaw K-T; Luben RN; Mangino M; Marchini J; McArdle WL; McGinnis R; Meyre D; Munroe PB; Morris AD; Ness AR; Neville MJ; Nica AC; Ong KK; O'Rahilly S; Owen KR; Palmer CNA; Papadakis K; Potter S; Pouta A; Qi L; Randall JC; Rayner NW; Ring SM; Sandhu MS; Scherag A; Sims MA; Song K; Soranzo N; Speliotes EK; Syddall HE; Teichmann SA; Timpson NJ; Tobias JH; Uda M; Vogel CIG; Wallace C; Waterworth DM; Weedon MN; Willer CJ; Wraight VL; Yuan X; Zeggini E; Hirschhorn JN; Strachan DP; Ouwehand WH; Caulfield MJ; Samani NJ; Frayling TM; Vollenweider P; Waeber G; Mooser V; Deloukas P; McCarthy MI; Wareham NJ; Barroso I. (1 Jun 2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. NATURE GENETICS. 40:768-775. Author weblink DOI.
• Stutzmann F; Tan K; Vatin V; Dina C; Jouret B; Tichet J; Balkau B; Potoczna N; et alHorber F; O'Rahilly S; Farooqi IS; Froguel P; Meyre D. (Sep 2008). Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees. Diabetes. 57:2511-2518. DOI.
• Cauchi S; Nead K; Choquet H; Horber F; Potoczna N; Balkau B; Marre M; Charpentier G; et alFroguel P; Meyre D. (1 Mar 2008). Genetic architecture of type 2 diabetes is modulated by the status of obesity. DIABETES & METABOLISM. 34:A38-A38. Author weblink.
• Vaxillaire M; Proenca C; Dechaume A; Tichet J; Marre M; Balkau B; Froguel P. (1 Mar 2008). The frequent nonsynonymous mutation of P446L GCK-RP module inversion glycemia and triglycerides, and reduces the risk of type 2 diabetes in the general French DESIR population. DIABETES & METABOLISM. 34:A38-A38. Author weblink.
• Cauchi S; Meyre D; Hadjadj S; Charpentier G; Balkau B; Czernichow S; Patsch W; Chikri M; et alGlaser B; Sladek R; Froguel P. (1 Mar 2008). New genes associated with type 2 diabetes : impact of non-european populations and measure of their combined effects. DIABETES & METABOLISM. 34:A16-A16. Author weblink.
• Cauchi S; Nead KT; Choquet H; Horber F; Potoczna N; Balkau B; Marre M; Charpentier G; et alFroguel P; Meyre D. (2008). The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC Med Genet. 9:45. DOI.
• Bouatia-Naji N; Rocheleau G; Van Lommel L; Lemaire K; Schuit F; Cavalcanti-Proenca C; Marchand M; Hartikainen A-L; et alSovio U; De Graeve F; Rung J; Vaxillaire M; Tichet J; Marre M; Balkau B; Weill J; Elliott P; Jarvelin M-R; Meyre D; Polychronakos C; Dina C; Sladek R; Froguel P. (23 May 2008). A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. SCIENCE. 320:1085-1088. Author weblink DOI.
• Gutiérrez-Aguilar R; Froguel P; Hamid YH; Benmezroua Y; Jørgensen T; Borch-Johnsen K; Hansen T; Pedersen O; et alNeve B. (Aug 2008). Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C. J Clin Endocrinol Metab. 93:3128-3135. DOI.
• Chambers JC; Elliott P; Zabaneh D; Zhang W; Li Y; Froguel P; Balding D; Scott J; et alKooner JS. (Jun 2008). Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet. 40:716-718. DOI.
• Duesing K; Charpentier G; Marre M; Tichet J; Hercberg S; Balkau B; Froguel P; Gibson F. (29 Feb 2008). Evaluating the association of common PBX1 variants with type 2 diabetes. BMC MEDICAL GENETICS. 9. Author weblink DOI.
• Vaxillaire M; Froguel P. (May 2008). Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes. Endocr Rev. 29:254-264. DOI.
• Polak M; Dechaume A; Cave H; Nimri R; Crosnier H; Sulmont V; de Kerdanet M; Scharfmann R; et alLebenthal Y; Froguel P; Vaxillaire M. (1 Apr 2008). Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: A report from the French ND (Neonatal Diabetes) Study Group. DIABETES. 57:1115-1119. DOI.
• Duesing K; Fatemifar G; Charpentier G; Marre M; Tichet J; Hercberg S; Balkau B; Froguel P; et alGibson F. (May 2008). Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids. Diabetologia. 51:821-826. DOI.
• Flechtner I; Vaxillaire M; Cave H; Scharfmann R; Froguel P; Polak M. (1 Feb 2008). Neonatal hyperglycaemia and abnormal development of the pancreas. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 22:17-40. Author weblink DOI.
• Tarasov AI; Nicolson TJ; Riveline JP; Taneja TK; Baldwin SA; Baldwin JM; Charpentier G; Gautier JF; et alFroguel P; Vaxillaire M; Rutter GA. (Jun 2008). A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults. Diabetes. 57:1595-1604. DOI.
• Badii R; Bener A; Zirie M; Al-Rikabi A; Simsek M; Al-Hamaq AOAA; Ghoussaini M; Froguel P; et alWareham NJ. (1 Mar 2008). Lack of association between the Pro(12)Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population. ACTA DIABETOLOGICA. 45:15-21. Author weblink DOI.
• Le Stunff C; Dechartres A; Mariot V; Lotton C; Trainor C; Del Giudice EM; Meyre D; Bieche I; et alLaurendeau I; Froguel P; Zelenika D; Fallin D; Lathrop M; Romeo P-H; Bougneres P. (1 Feb 2008). Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children. DIABETES. 57:494-502. Author weblink DOI.
• Franks PW; Rolandsson O; Debenham SL; Fawcett KA; Payne F; Dina C; Froguel P; Mohlke KL; et alWiller C; Olsson T; Wareham NJ; Hallmans G; Barroso I; Sandhu MS. (1 Mar 2008). Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. DIABETOLOGIA. 51:458-463. Author weblink DOI.
• Cauchi S; Choquet H; Gutierrez-Aguilar R; Capel F; Grau K; Proenca C; Dina C; Duval A; et alBalkau B; Marre M; Potoczna N; Langin D; Horber F; Sorensen TIA; Charpentier G; Meyre D; Froguel P. (1 Feb 2008). Effects of TCF7L2 polymorphisms on obesity in European populations. OBESITY. 16:476-482. Author weblink DOI.
• Le Stunff C; Dechartres A; Del Giudice EM; Froguel P; Bougneres P. (1 Jan 2008). A single-nucleotide polymorphism in the p110 beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 93:212-215. Author weblink DOI.
• Gutierrez-Aguilar R; Benmezroua Y; Balkau B; Marre M; Helbecque N; Charpentier G; Polychronakos C; Sladek R; et alFroguel P; Neve B. (1 Nov 2007). Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes. DIABETES & METABOLISM. 33:372-378. Author weblink DOI.
• Cauchi S; Proença C; Choquet H; Gaget S; De Graeve F; Marre M; Balkau B; Tichet J; et alMeyre D; Vaxillaire M; Froguel P; D.E.S.I.R. Study Group. (Mar 2008). Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. J Mol Med (Berl). 86:341-348. DOI.
• Couturier C; Sarkis C; Seron K; Belouzard S; Chen P; Lenain A; Corset L; Dam J; et alVauthier V; Dubartt A; Mallet J; Froguel P; Rouille Y; Jockers R. (4 Dec 2007). Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 104:19476-19481. Author weblink DOI.
• Flechtner I; Vaxillaire M; Cave H; Froguel P; Polak M. (1 Nov 2007). Neonatal diabetes: a disease linked to multiple mechanisms. ARCHIVES DE PEDIATRIE. 14:1356-1365. Author weblink DOI.
• Horikoshi M; Hara K; Ito C; Shojima N; Nagai R; Ueki K; Froguel P; Kadowaki T. (1 Dec 2007). Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. DIABETOLOGIA. 50:2461-2466. Author weblink DOI.
• Duesing K; Charpentier G; Marre M; Tichet J; Hercberg S; Froguel P; Gibson F. (Jan 2008). Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids. Diabetologia. 51:76-81. DOI.
• Gutierrez-Aguilar R; Benmezroua Y; Vaillant E; Balkau B; Marre M; Charpentier G; Sladek R; Froguel P; et alNeve B. (9 Aug 2007). Analysis of KLF transcription factor family gene variants in type 2 diabetes. BMC MEDICAL GENETICS. 8. Author weblink DOI.
• Saunders CL; Chiodini BD; Sham P; Lewis CM; Abkevich V; Adeyemo AA; de Andrade M; Arya R; et alBerenson GS; Blangero J; Boehnke M; Borecki IB; Chagnon YC; Chen W; Comuzzie AG; Deng H-W; Duggirala R; Feitosa MF; Froguel P; Hanson RL; Hebebrand J; Huezo-Dias P; Kissebah AH; Li W; Luke A; Martin LJ; Nash M; Ohman M; Palmer LJ; Peltonen L; Perola M; Price RA; Redline S; Srinivasan SR; Stern MP; Stone S; Stringham H; Turner S; Wijmenga C; Collier DA. (1 Sep 2007). Meta-analysis of genome-wide linkage studies in BMI and obesity. OBESITY. 15:2263-2275. Author weblink DOI.
• Vaxillaire M; Veslot J; Dina C; Proença C; Cauchi S; Charpentier G; Tichet J; Fumeron F; et alMarre M; Meyre D; Balkau B; Froguel P; DESIR Study Group. (Jan 2008). Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study. Diabetes. 57:244-254. DOI.
• Stutzmann F; Vatin V; Cauchi S; Morandi A; Jouret B; Landt O; Tounian P; Levy-Marchal C; et alBuzzetti R; Pinelli L; Balkau B; Horber F; Bougneres P; Froguel P; Meyre D. (1 Aug 2007). Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. HUMAN MOLECULAR GENETICS. 16:1837-1844. Author weblink DOI.
• Neve B; Gutierrez-Aguilar R; Benmezroua Y; Balkau B; Marre M; Helbecque N; Charpentier G; Sladek R; et alFroguel P. (1 Sep 2007). Minor contribution of Smad7 and KLF10 variants to genetic susceptibility of type 2 diabetes. DIABETOLOGIA. 50:S135-S135. Author weblink.
• Meyre D; Bouatia-Naji N; Vatin V; Veslot J; Samson C; Tichet J; Marre M; Balkau B; et alFroguel P. (1 Oct 2007). ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study. DIABETOLOGIA. 50:2090-2096. Author weblink DOI.
• Salonen JT; Uimari P; Aalto J-M; Pirskanen M; Kaikkonen J; Todorova B; Hypponen J; Korhonen V-P; et alAsikainen J; Devine C; Tuomainen T-P; Luedemann J; Nauck M; Kerner W; Stephens RH; New JP; Ollier WE; Gibson JM; Payton A; Horan MA; Pendleton N; Mahoney W; Meyre D; Delplanque J; Froguel P; Luzzatto O; Yakir B; Darvasi A. (1 Aug 2007). Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium. AMERICAN JOURNAL OF HUMAN GENETICS. 81:338-345. Author weblink DOI.
• Bouatia-Naji N; Vatin V; Lecoeur C; Heude B; Proenca C; Veslot J; Jouret B; Tichet J; et alCharpentier G; Marre M; Balkau B; Froguel P; Meyre D. (7 Jul 2007). Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity. BMC MEDICAL GENETICS. 8. Author weblink DOI.
• Cauchi S; Meyre D; Choquet H; Deghmoun S; Durand E; Gaget S; Lecoeur C; Froguel P; et alLevy-Marchal C. (25 Jun 2007). TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population. BMC MEDICAL GENETICS. 8. Author weblink DOI.
• Ghoussaini M; Vatin V; Lecoeur C; Abkevich V; Younus A; Samson C; Wachter C; Heude B; et alTauber M; Tounian P; Hercberg S; Weill J; Levy-Marchal C; Le Stunff C; Bougnères P; Froguel P; Meyre D. (Nov 2007). Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity. J Clin Endocrinol Metab. 92:4403-4409. DOI.
• Valayannopoulos V; Vaxillaire M; Aigrain Y; Jaubert F; Bellanne-Chantelot C; Ribeiro M-J; Brunelle F; Froguel P; et alRobert J-J; Polak M; Nihoul-Fekete C; de Lonlay P. (1 Jun 2007). Coexistence in the same family of both focal and diffuse forms of hyperinsulinism. DIABETES CARE. 30:1590-1592. Author weblink DOI.
• Gueorguiev M; Wiltshire S; Garcia EA; Mein C; Lecoeur C; Kristen B; Allotey R; Hattersley AT; et alWalker M; O'Rahilly S; Froguel P; Grossman AB; McCarthy MI; Hitman GA; Korbonits M. (1 Jun 2007). Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 92:2201-2204. Author weblink DOI.
• de Smith AJ; Tsalenko A; Sampas N; Scheffer A; Yamada NA; Tsang P; Ben-Dor A; Yakhini Z; et alEllis RJ; Bruhn L; Laderman S; Froguel P; Blakemore AI. (1 Dec 2007). Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. Hum Mol Genet. 16:2783-2794. DOI.
• Cauchi S; El Achhab Y; Choquet H; Dina C; Krempler F; Weitgasser R; Nejjari C; Patsch W; et alChikri M; Meyre D; Froguel P. (Jul 2007). TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med (Berl). 85:777-782. DOI.
• Fanciulli M; Norsworthy PJ; Petretto E; Dong R; Harper L; Kamesh L; Heward JM; Gough SC; et alde Smith A; Blakemore AI; Froguel P; Owen CJ; Pearce SH; Teixeira L; Guillevin L; Graham DS; Pusey CD; Cook HT; Vyse TJ; Aitman TJ. (Jun 2007). FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet. 39:721-723. DOI.
• Vaxillaire M; Dechaume A; Busiah K; Cavé H; Pereira S; Scharfmann R; de Nanclares GP; Castano L; et alFroguel P; Polak M; SUR1-Neonatal Diabetes Study Group. (Jun 2007). New ABCC8 mutations in relapsing neonatal diabetes and clinical features. Diabetes. 56:1737-1741. DOI.
• Dina C; Meyre D; Gallina S; Durand E; Koerner A; Jacobson P; Carlsson LMS; Kiess W; et alVatin V; Lecoeur C; Delplanque J; Vaillant E; Pattou F; Ruiz J; Weill J; Levy-Marchal C; Horber F; Potoczna N; Hercberg S; Le Stunff C; Bougneres P; Kovacs P; Marre M; Balkau B; Cauchi S; Chevre J-C; Froguel P. (1 Jun 2007). Variation in FTO contributes to childhood obesity and severe adult obesity. NATURE GENETICS. 39:724-726. Author weblink DOI.
• Poulain-Godefroy O; Froguel P. (11 May 2007). Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochem Biophys Res Commun. 356:662-667. DOI.
• Butler D; Chambon P; Brezin E; Corrignan M; Trautmann A; Choulika A; Froguel P; Rutherford W. (19 Apr 2007). Let science speak for itself. NATURE. 446:850-U1. Author weblink DOI.
• Horikoshi M; Hara K; Ito C; Nagai R; Froguel P; Kadowaki T. (1 Apr 2007). A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population. DIABETOLOGIA. 50:747-751. Author weblink DOI.
• Fairbrother UL; Tankó LB; Walley AJ; Christiansen C; Froguel P; Blakemore AI. (Apr 2007). Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women. J Bone Miner Res. 22:544-550. DOI.
• Chu WS; Das SK; Wang H; Chan JC; Deloukas P; Froguel P; Baier LJ; Jia W; et alMcCarthy MI; Ng MCY; Damcott C; Shuldiner AR; Zeggini E; Elbein SC. (1 Mar 2007). Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. DIABETES. 56:856-862. Author weblink DOI.
• Owen KR; Groves CJ; Hanson RL; Knowler WC; Shuldiner AR; Elbein SC; Mitchell BD; Froguel P; et alNg MCY; Chan JC; Jia W; Deloukas P; Hitman GA; Walker M; Frayling TM; Hattersley AT; Zeggini E; McCarthy MI. (1 Mar 2007). Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects. DIABETES. 56:879-883. Author weblink DOI.
• Meyre D; Sladek R; Boutin P; Hadjadj S; Marre M; Balkau B; Charpentier G; Polychronakos C; et alDina C; Froguel P. (1 Mar 2007). Identification of new genes with susceptibility to type 2 diabetes by a study of complete genome association by DNA chips in the French population. DIABETES & METABOLISM. 33:S29-S30. Author weblink.
• Meyre D; Bouatia-Naji N; Vatin V; Leccour C; Veslot J; Samson C; Tichet J; Marre M; et alBalkaul B; Froguel P. (1 Mar 2007). K121Q Polymorphism of ENPP1 is associated with severe obesity and type 2 diabetes, and increases impact of hyperglycemia in DESIR prospective study. DIABETES & METABOLISM. 33:S127-S127. Author weblink.
• Vaxillaire M; Dechaume A; Busiah K; Cave H; Castano L; Charpentier G; Rivellne JP; Polak M; et alFroguel P. (1 Mar 2007). New activator mutations of ABDD8/SUR1 gene in neonatal transitional diabetes and in adults. DIABETES & METABOLISM. 33:S127-S127. Author weblink.
• Bell CG; Meyre D; Petretto E; Levy-Marchal C; Hercberg S; Charles MA; Boyle C; Weill J; et alTauber M; Mein CA; Aitman TJ; Froguel P; Walley AJ. (Mar 2007). No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases. Eur J Hum Genet. 15:320-327. DOI.
• Vaxillaire M; Dina C; Veslot J; Jaziri R; Fumeron F; Balkau B; Marre M; Froguel P. (1 Mar 2007). Predictive risk of genetic variants associated with type 2 diabetes in the DESIR French prospective cohort. DIABETES & METABOLISM. 33:S29-S29. Author weblink.
• Siddiq A; Gueorguiev M; Samson C; Hercberg S; Heude B; Levy-Marchal C; Jouret B; Weill J; et alMeyre D; Walley A; Froguel P. (Mar 2007). Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. Diabetologia. 50:574-584. DOI.
• Yamauchi T; Nio Y; Maki T; Kobayashi M; Takazawa T; Iwabu M; Okada-Iwabu M; Kawamoto S; et alKubota N; Kubota T; Ito Y; Kamon J; Tsuchida A; Kumagai K; Kozono H; Hada Y; Ogata H; Tokuyama K; Tsunoda M; Ide T; Murakami K; Awazawa M; Takamoto I; Froguel P; Hara K; Tobe K; Nagai R; Ueki K; Kadowaki T. (1 Mar 2007). Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. NATURE MEDICINE. 13:332-339. Author weblink DOI.
• Sladek R; Rocheleau G; Rung J; Dina C; Shen L; Serre D; Boutin P; Vincent D; et alBelisle A; Hadjadj S; Balkau B; Heude B; Charpentier G; Hudson TJ; Montpetit A; Pshezhetsky AV; Prentki M; Posner BI; Balding DJ; Meyre D; Polychronakos C; Froguel P. (22 Feb 2007). A genome-wide association study identifies novel risk loci for type 2 diabetes. NATURE. 445:881-885. Author weblink DOI.
• Vasseur F; Guérardel A; Barat-Houari M; Cottel D; Amouyel P; Froguel P; Helbecque N. (Feb 2007). Impact of a CART promoter genetic variation on plasma lipid profile in a general population. Mol Genet Metab. 90:199-204. DOI.
• Dina C; Meyre D; Samson C; Tichet J; Marre M; Jouret B; Charles MA; Balkau B; et alFroguel P. (12 Jan 2007). Comment on "A common genetic variant is associated with adult and childhood obesity". Science. 315:187. DOI.
• Cauchi S; Vaxillaire M; Choquet H; Durand E; Duval A; Polak M; Froguel P. (Jan 2007). No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects. Diabetologia. 50:214-216. DOI.
• Hummel M; Vasseur F; Mathieu C; Bellanne-Chantelot C; Froguel P; Standl E; Fuechtenbusch M. (1 Jan 2007). Two Caucasian families with the hepatocyte nuclear factor-1 alpha mutation Tyr218Cys. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES. 115:62-64. Author weblink DOI.
• Santos JL; Boutin P; Verdich C; Holst C; Larsen LH; Toubro S; Dina C; Saris WHM; et alBlaak EE; Hoffstedt J; Taylor MA; Polak J; Clement K; Langin D; Astrup A; Froguel P; Pedersen O; Sorensen TIA; Alfredo Martinez J. (1 Dec 2006). Genotype-by-nutrient interactions assessed in European obese women - A case-only study. EUROPEAN JOURNAL OF NUTRITION. 45:454-462. Author weblink DOI.
• Wiltshire S; Bell JT; Groves CJ; Dina C; Hattersley AT; Frayling TM; Walker M; Hitman GA; et alVaxillaire M; Farrall M; Froguel P; McCarthy MI. (1 Nov 2006). Epistasis between type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans. ANNALS OF HUMAN GENETICS. 70:726-737. Author weblink DOI.
• Cauchi S; Meyre D; Choquet H; Dina C; Born C; Marre M; Balkau B; Froguel P; et alDESIR Study Group. (Nov 2006). TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Diabetes. 55:3189-3192. DOI.
• Walley AJ; Blakemore AI; Froguel P. (15 Oct 2006). Genetics of obesity and the prediction of risk for health. Hum Mol Genet. 15 Spec No 2:R124-R130. DOI.
• Séron K; Corset L; Vasseur F; Boutin P; Gómez-Ambrosi J; Salvador J; Frühbeck G; Froguel P. (6 Oct 2006). Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Biochem Biophys Res Commun. 348:1232-1238. DOI.
• Benzinou M; Walley A; Lobbens S; Charles MA; Jouret B; Fumeron F; Balkau B; Meyre D; et alFroguel P. (Oct 2006). Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians. Diabetes. 55:2876-2882. DOI.
• Cauchi S; Meyre D; Dina C; Choquet H; Samson C; Gallina S; Balkau B; Charpentier G; et alPattou F; Stetsyuk V; Scharfmann R; Staels B; Frühbeck G; Froguel P. (Oct 2006). Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes. 55:2903-2908. DOI.
• Tsuchiya T; Schwarz PEH; del Bosque-Plata L; Hayes MG; Dina C; Froguel P; Towers GW; Fischer S; et alTemelkova-Kurktschiev T; Rietzsch H; Graessler J; Vcelak J; Palyzova D; Selisko T; Bendlova B; Schulze J; Julius U; Hanefeld M; Weedon MN; Evans JC; Frayling TM; Hattersley AT; Orho-Melander M; Groop L; Malecki MT; Hansen T; Pedersen O; Fingerlin TE; Boehnke M; Hanis CL; Cox NJ; Bell GI. (1 Sep 2006). Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses. MOLECULAR GENETICS AND METABOLISM. 89:174-184. Author weblink DOI.
• Das SK; Chu WS; Hale TC; Wang X; Craig RI; Wang H; Shuldiner AR; Froguel P; et alDeloukas P; McCarthy MI; Zeggini E; Hasstedt SJ; Elbein SC. (1 Sep 2006). Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. DIABETES. 55:2631-2639. Author weblink DOI.
• Zeggini E; Damcott CM; Hanson RL; Karim MA; Rayner NW; Groves CJ; Baier LJ; Hale TC; et alHattersley AT; Hitman GA; Hunt SE; Knowler WC; Mitchell BD; Ng MCY; O'Connell JR; Pollin TI; Vaxillaire M; Walker M; Wang X; Whittaker P; Kunsun X; Jia W; Chan JCN; Froguel P; Deloukas P; Shuldiner AR; Elbein SC; McCarthy MI. (1 Sep 2006). Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. DIABETES. 55:2541-2548. Author weblink DOI.
• Babenko AP; Polak M; Cave H; Busiah K; Czernichow P; Scharfmann R; Bryan J; Aguilar-Bryan L; et alVaxillaire M; Froguel P. (3 Aug 2006). Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. NEW ENGLAND JOURNAL OF MEDICINE. 355:456-466. Author weblink DOI.
• Sorensen TIA; Boutin P; Taylor MA; Larsen LH; Verdich C; Petersen L; Holst C; Echwald SM; et alDina C; Toubro S; Petersen M; Polak J; Clement K; Martinez JA; Langin D; Oppert J-M; Stich V; Macdonald I; Arner P; Saris WHM; Pedersen O; Astrup A; Froguel P. (30 Jun 2006). Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets. PLOS CLINICAL TRIALS. 1. Author weblink DOI.
• Vaxillaire M; Froguel P. (Jun 2006). Genetic basis of maturity-onset diabetes of the young. Endocrinol Metab Clin North Am. 35:371-x. DOI.
• Vu-Hong TA; Durand E; Deghmoun S; Boutin P; Meyre D; Chevenne D; Czernichow P; Froguel P; et alLevy-Marchal C. (Jun 2006). The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults. J Clin Endocrinol Metab. 91:2437-2440. DOI.
• Hara K; Horikoshi M; Kitazato H; Lto C; Noda M; Ohashi J; Froguel P; Tokunaga K; et alTobe K; Nagai R; Kadowaki T. (1 May 2006). Hepatocyte nuclear factor-4 alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population. DIABETES. 55:1260-1264. Author weblink DOI.
• Cheyssac C; Dina C; Leprêtre F; Vasseur-Delannoy V; Dechaume A; Lobbens S; Balkau B; Ruiz J; et alCharpentier G; Pattou F; Joly E; Prentki M; Hansen T; Pedersen O; Vaxillaire M; Froguel P. (Apr 2006). EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families. Diabetes. 55:1171-1176.
• Jaziri R; Lobbens S; Aubert R; Pean F; Lahmidi S; Vaxillaire M; Porchay I; Bellili N; et alTichet J; Balkau B; Froguel P; Marre M; Fumeron F. (1 Apr 2006). The PPARG pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism - The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. DIABETES. 55:1157-1162. Author weblink DOI.
• Meyre D; Froguel P. (Mar 2006). [ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes]. Med Sci (Paris). 22:308-312. DOI.
• Vaxillaire M; Dechaume A; Busiah K; Cave H; Aguilar-Bryan L; Polak M; Froguel P. (1 Mar 2006). Activator mutations of the sulfamids receptor SUR1/ABCC8 in neonatal permanent diabetes and transitional with the frequent inherited congregation of diabetes. DIABETES & METABOLISM. 32:S29-S30. Author weblink.
• Bacart J; Seron K; Choquet H; Charles MA; Balkau B; Fumeron F; Meyre D; Boutin P; et alFroguel P. (1 Mar 2006). Analytical analysis of the variants of the LEPROTL1 gene, the new gene candidate of the infantile obesity. DIABETES & METABOLISM. 32:S44-S44. Author weblink.
• Ghoussaini M; Meyre D; Couturier C; Vatin V; Lecoeur C; Samson C; Froguel P. (1 Mar 2006). Contribution of the variants of the gene SIM1 in severe forms of obesity in French population. DIABETES & METABOLISM. 32:S11-S11. Author weblink.
• Cheyssac C; Lecoeur C; Dechaume A; Charpentier G; Balkau B; Marre M; Froguel P; Vaxillaire M. (1 Mar 2006). Effect of variable C gene PTPN1, coding tyrosine phosphatase 1B protein (PTP1B), on the risk of diabetes of the type 2 (DT2) and obesity in French population. DIABETES & METABOLISM. 32:S45-S45. Author weblink.
• Vaxillaire M; Dechaume A; Vasseur-Delannoy V; Lahmidi S; Vatin V; Leprêtre F; Boutin P; Hercberg S; et alCharpentier G; Dina C; Froguel P. (Mar 2006). Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. Diabetes. 55:856-861.
• Bouatia-Naji N; Meyre D; Lobbens S; Seron K; Fumeron F; Balkau B; Heude B; Jouret B; et alScherer PE; Dina C; Weill J; Froguel P. (1 Mar 2006). Genetic variants of the adiponectin gene (ACDC) are associated with the infantile obesity and morbid obesity in adults. DIABETES & METABOLISM. 32:S9-S9. Author weblink.
• Seron K; Belousard S; Corset L; Rouille Y; Froguel P. (1 Mar 2006). Role of proteins from the OB-RGRP family in the expression of the receptor in leptin on the surface of cells. DIABETES & METABOLISM. 32:S104-S105. Author weblink.
• Gutierrez-Aguilar R; Vaillant E; Benmezroua Y; Froguel P; Neve B. (1 Mar 2006). Variant AS-1659 G > C of KLF11, associated to the diabetes of type 2, modifies transcription of KLF11. DIABETES & METABOLISM. 32:S44-S44. Author weblink.
• Meyre D; Degraeve F; Heude B; Vatin V; Ghoussaini M; Durand E; Boutin P; Dina C; et alCharles MA; Froguel P. (1 Mar 2006). VNTR of the insulin: molecular determiner of thrifty genotype?. DIABETES & METABOLISM. 32:S45-S46. Author weblink.
• Lee YS; Challis BG; Thompson DA; Yeo GSH; Keogh JM; Madonna ME; Wraight V; Sims M; et alVatin V; Meyre D; Shield J; Burren C; Ibrahim Z; Cheetham T; Swift P; Blackwood A; Hung CCC; Wareham NJ; Froguel P; Millhauser GL; O'Rahilly S; Farooqi IS. (1 Feb 2006). A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. CELL METABOLISM. 3:135-140. Author weblink DOI.
• Bouatia-Naji N; Meyre D; Lobbens S; Séron K; Fumeron F; Balkau B; Heude B; Jouret B; et alScherer PE; Dina C; Weill J; Froguel P. (Feb 2006). ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes. 55:545-550.
• Vasseur F; Meyre D; Froguel P. (2006). Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies. Expert Rev Mol Med. 8:1-12. DOI.
• Cheyssac C; Lecoeur C; Dechaume A; Bibi A; Charpentier G; Balkau B; Marre M; Froguel P; et alGibson F; Vaxillaire M. (2006). Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population. BMC Med Genet. 7:44. DOI.
• Guérardel A; Tankó LB; Boutin P; Christiansen C; Froguel P. (Jan 2006). Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women. Osteoporos Int. 17:156-157. DOI.
• Tanko LB; Siddiq A; Lecoeur C; Larsen PJ; Christiansen C; Walley A; Froguel P. (1 Dec 2005). ACDC/adiponectin and PPAR-gamma gene polymorphisms: Implications for features of obesity. OBESITY RESEARCH. 13:2113-2121. Author weblink DOI.
• Lacquemant C; Vasseur F; Lepretre F; Froguel P. (1 Dec 2005). Adipocytokins, obesity and development of type 2 diabetes. M S-MEDECINE SCIENCES. 21:10-18. Author weblink.
• Grasberger H; Vaxillaire M; Pannain S; Beck JC; Mimouni-Bloch A; Vatin V; Vassart G; Froguel P; et alRefetoff S. (1 Dec 2005). Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1. HUMAN GENETICS. 118:348-355. Author weblink DOI.
• Bell CG; Meyre D; Samson C; Boyle C; Lecoeur C; Tauber M; Jouret B; Jaquet D; et alLevy-Marchal C; Charles MA; Weill J; Gibson F; Mein CA; Froguel P; Walley AJ. (Oct 2005). Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity. Diabetes. 54:3049-3055.
• Gibson F; Hercberg S; Froguel P. (Oct 2005). Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians. Diabetes. 54:3040-3042.
• Siddiq A; Lepretre F; Hercberg S; Froguel P; Gibson F. (Aug 2005). A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians. Diabetes. 54:2477-2481.
• Meyre D; Bouatia-Naji N; Tounian A; Samson C; Lecoeur C; Vatin V; Ghoussaini M; Wachter C; et alHercberg S; Charpentier G; Patsch W; Pattou F; Charles MA; Tounian P; Clement K; Jouret B; Weill J; Maddux BA; Goldfine ID; Walley A; Boutin P; Dina C; Froguel P. (1 Aug 2005). Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. NATURE GENETICS. 37:863-867. Author weblink DOI.
• Meyre D; Bouatia-Naji N; Tounian A; Samson C; Lecoeur C; Vatin V; Ghoussaini M; Wachter C; et alHercberg S; Charpentier G; Patsch W; Pattou F; Charles MA; Tounian P; Clément K; Jouret B; Weill J; Maddux BA; Goldfine ID; Walley A; Boutin P; Dina C; Froguel P. (Aug 2005). Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet. 37:863-867. DOI.
• Hara K; Horikoshi M; Kitazato H; Yamauchi T; Ito C; Noda M; Ohashi J; Froguel P; et alTokunaga K; Nagai R; Kadowaki T. (1 Jul 2005). Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. DIABETOLOGIA. 48:1307-1314. Author weblink DOI.
• Boutin P; Froguel P. (1 Jul 2005). GAD2: A polygenic contribution to genetic susceptibility for common obesity?. PATHOLOGIE BIOLOGIE. 53:305-307. Author weblink DOI.
• Vasseur F; Helbecque N; Lobbens S; Vasseur-Delannoy V; Dina C; Clément K; Boutin P; Kadowaki T; et alScherer PE; Froguel P. (May 2005). Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia. 48:892-899. DOI.
• Guerardel A; Barat-Houari M; Vasseur F; Dina C; Vatin V; Clement K; Eberle D; Vasseur-Delannoy V; et alBell CG; Galan P; Hercberg S; Helbecque N; Potoczna N; Horber FF; Boutin P; Froguel P. (11 Apr 2005). Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population. BMC GENETICS. 6. Author weblink DOI.
• Meyre D; Boutin P; Tounian A; Deweirder M; Aout M; Jouret B; Heude B; Weill J; et alTauber M; Tounian P; Froguel P. (Apr 2005). Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children?. J Clin Endocrinol Metab. 90:2384-2390. DOI.
• Neve B; Fernandez-Zapico ME; Ashkenazi-Katalan V; Dina C; Hamid YH; Joly E; Vaillant E; Benmezroua Y; et alDurand E; Bakaher N; Delannoy V; Vaxillaire M; Cook T; Dallinga-Thie GM; Jansen H; Charles MA; Clément K; Galan P; Hercberg S; Helbecque N; Charpentier G; Prentki M; Hansen T; Pedersen O; Urrutia R; Melloul D; Froguel P. (29 Mar 2005). Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proc Natl Acad Sci U S A. 102:4807-4812. DOI.
• Ghoussaini M; Meyre D; Lobbens S; Charpentier G; Clement K; Charles MA; Tauber M; Weill J; et alFroguel P. (22 Mar 2005). Implication of the Pro 12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population. BMC MEDICAL GENETICS. 6. Author weblink DOI.
• Vaxillaire M; Dina C; Lobbens S; Dechaume A; Vasseur-Delannoy V; Helbecque N; Charpentier G; Froguel P. (Mar 2005). Effect of common polymorphisms in the HNF4alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population. Diabetologia. 48:440-444. DOI.
• Bell CG; Walley AJ; Froguel P. (Mar 2005). The genetics of human obesity. Nat Rev Genet. 6:221-234. DOI.
• de Courten BV; Hanson RL; Funahashi T; Lindsay RS; Matsuzawa Y; Tanaka S; Thameem F; Gruber JD; et alFroguel P; Wolford JK. (1 Jan 2005). Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians. DIABETES. 54:284-289. Author weblink.
• Leprêtre F; Linton KJ; Lacquemant C; Vatin V; Samson C; Dina C; Chikri M; Ali S; et alScherer P; Séron K; Vasseur F; Aitman T; Froguel P. (Nov 2004). Genetic study of the CD36 gene in a French diabetic population. Diabetes Metab. 30:459-463.
• Gibson F; Froguel P. (Nov 2004). Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians. Diabetes. 53:2977-2983.
• Vaxillaire M; Populaire C; Busiah K; Cavé H; Gloyn AL; Hattersley AT; Czernichow P; Froguel P; et alPolak M. (Oct 2004). Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients. Diabetes. 53:2719-2722.
• Durand E; Boutin P; Meyre D; Charles MA; Clement K; Dina C; Froguel P. (Sep 2004). Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. Diabetes. 53:2483-2486.
• Eberle D; Clement K; Meyre D; Sahbatou M; Vaxillaire M; Le Gall A; Ferre P; Basdevant A; et alFroguel P; Foufelle F. (1 Aug 2004). SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. DIABETES. 53:2153-2157. Author weblink DOI.
• Tsuchida A; Yamauchi T; Ito Y; Hada Y; Maki T; Takekawa S; Kamon J; Kobayashi M; et alSuzuki R; Hara K; Kubota N; Terauchi Y; Froguel P; Nakae J; Kasuga M; Accili D; Tobe K; Ueki K; Nagai R; Kadowaki T. (16 Jul 2004). Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. JOURNAL OF BIOLOGICAL CHEMISTRY. 279:30817-30822. Author weblink DOI.
• Leprêtre F; Vasseur F; Vaxillaire M; Scherer PE; Ali S; Linton K; Aitman T; Froguel P. (Jul 2004). A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. Hum Mutat. 24:104. DOI.
• Bell CG; Benzinou M; Siddiq A; Lecoeur C; Dina C; Lemainque A; Clément K; Basdevant A; et alGuy-Grand B; Mein CA; Meyre D; Froguel P. (Jul 2004). Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q. Diabetes. 53:1857-1865.
• Kipfer-Coudreau S; Eberle D; Sahbatou M; Bonhomme A; Guy-Grand B; Froguel P; Galan P; Basdevant A; et alClement K. (1 Jul 2004). Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects. DIABETOLOGIA. 47:1278-1284. Author weblink DOI.
• Lacquemant C; Froguel P; Lobbens S; Izzo P; Dina C; Ruiz J. (Jul 2004). The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus. Diabet Med. 21:776-781. DOI.
• Weill J; Vanderbecken S; Froguel P. (Jun 2004). Understanding the rising incidence of type 2 diabetes in adolescence. Arch Dis Child. 89:502-504.
• Lepretre F; Cheyssac C; Amouyel P; Froguel P; Helbecque N. (1 Apr 2004). A promoter polymorphism in CD36 is associated with an atherogenic lipid profile in a French general population. ATHEROSCLEROSIS. 173:375-377. Author weblink DOI.
• Fumeron F; Aubert R; Siddiq A; Betoulle D; Pean F; Hadjadj S; Tichet J; Wilpart E; et alChesnier MC; Balkau B; Froguel P; Marre M. (1 Apr 2004). Adiponectin gene polymorphisms and adiponectin levels are indedendently associated with the development of hyperglycemia during a 3-year period - The Epidemiologic Data on the Insulin Resistance Syndrome prospective study. DIABETES. 53:1150-1157. Author weblink DOI.
• Meyre D; Lecoeur C; Delplanque J; Francke S; Vatin V; Durand E; Weill J; Dina C; et alFroguel P. (Mar 2004). A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. Diabetes. 53:803-811.
• Heude B; Dubois S; Charles MA; Deweirder M; Dina C; Borys JM; Ducimetiere P; Froguel P. (1 Mar 2004). VNTR polymorphism of the insulin gene and childhood overweight in a general population. OBESITY RESEARCH. 12:499-504. Author weblink DOI.
• Boutin P; Dina C; Vasseur F; Dubois S; Corset L; Séron K; Bekris L; Cabellon J; et alNeve B; Vasseur-Delannoy V; Chikri M; Charles MA; Clement K; Lernmark A; Froguel P. (Dec 2003). GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLoS Biol. 1:E68. DOI.
• Waki H; Yamauchi T; Kamon J; Ito Y; Uchida S; Kita S; Hara K; Hada Y; et alVasseur F; Froguel P; Kimura S; Nagai R; Kadowaki T. (10 Oct 2003). Impaired multimerization of human adiponectin mutants associated with diabetes - Molecular structure and multimer formation of adiponectin. JOURNAL OF BIOLOGICAL CHEMISTRY. 278:40352-40363. DOI.
• Coudreau SK; Tounian P; Bonhomme G; Froguel P; Girardet JP; Guy-Grand B; Basdevant A; Clement K. (1 Oct 2003). Role of the DGAT gene C79T single-nucleotide polymorphism in french obese subjects. OBESITY RESEARCH. 11:1163-1167. Author weblink DOI.
• Lopes C; Dina C; Durand E; Froguel P. (Sep 2003). PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population. Diabetologia. 46:1284-1290. DOI.
• Lacquemant C; Vasseur F; Leprêtre F; Froguel P. (Aug 2003). [Adipocytokins, obesity and development of type 2 diabetes]. Med Sci (Paris). 19:809-817. DOI.
• Demenais F; Kanninen T; Lindgren CM; Wiltshire S; Gaget S; Dandrieux C; Almgren P; Sjogren M; et alHattersley A; Dina C; Tuomi T; McCarthy MI; Froguel P; Groop LC. (1 Aug 2003). A meta-analysis of four European genome screens (GIFT consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes. HUMAN MOLECULAR GENETICS. 12:1865-1873. Author weblink DOI.
• Yamauchi T; Kamon J; Ito Y; Tsuchida A; Yokomizo T; Kita S; Sugiyama T; Miyagishi M; et alHara K; Tsunoda M; Murakami K; Ohteki T; Uchida S; Takekawa S; Waki H; Tsuno NH; Shibata Y; Terauchi Y; Froguel P; Tobe K; Koyasu S; Taira K; Kitamura T; Shimizu T; Nagai R; Kadowaki T. (12 Jun 2003). Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. NATURE. 423:762-769. Author weblink DOI.
• Froguel P. (Jun 2003). [Maturity-onset diabetes of the young (MODY): the history of its dismemberment]. Ann Endocrinol (Paris). 64:S12-S16.
• Beales PL; Badano JL; Ross AJ; Ansley SJ; Hoskins BE; Kirsten B; Mein CA; Froguel P; et alScambler PJ; Lewis RA; Lupski JR; Katsanis N. (1 May 2003). Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome. AMERICAN JOURNAL OF HUMAN GENETICS. 72:1187-1199. Author weblink DOI.
• Veiga-da-Cunha M; Delplanque J; Gillain A; Bonthron DT; Boutin P; Van Schaftingen E; Froguel P. (1 May 2003). Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians. DIABETOLOGIA. 46:704-711. DOI.
• Helbecque N; Abderrahamani A; Meylan L; Riederer B; Mooser V; Miklossy J; Delplanque J; Boutin P; et alNicod P; Haefliger JA; Cottel D; Amouyel P; Froguel P; Waeber G. (Apr 2003). Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease. Mol Psychiatry. 8:413-363. DOI.
• Vasseur F; Leprêtre F; Lacquemant C; Froguel P. (Apr 2003). The genetics of adiponectin. Curr Diab Rep. 3:151-158.
• Frayling TM; Lindgren CM; Chevre JC; Menzel S; Wishart M; Benmezroua Y; Brown A; Evans JC; et alRao PS; Dina C; Lecoeur C; Kanninen T; Almgren P; Bulman MP; Wang YX; Mills J; Wright-Pascoe R; Mahtani MM; Prisco F; Costa A; Cognet I; Hansen T; Pedersen O; Ellard S; Tuomi T; Groop LC; Froguel P; Hattersley AT; Vaxillaire M. (1 Mar 2003). A genome-wide scan in families with maturity-onset diabetes of the young - Evidence for further genetic heterogeneity. DIABETES. 52:872-881. Author weblink DOI.
• Populaire C; Mori Y; Dina C; Vasseur F; Vaxillaire M; Kadowaki T; Froguel P. (1 Mar 2003). Does the-11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families?. DIABETOLOGIA. 46:443-445. Author weblink DOI.
• Yamauchi T; Kamon J; Waki H; Imai Y; Shimozawa N; Hioki K; Uchida S; Ito Y; et alTakakuwa K; Matsui J; Takata M; Eto K; Terauchi Y; Komeda K; Tsunoda M; Murakami K; Ohnishi Y; Naitoh T; Yamamura K; Ueyama Y; Froguel P; Kimura S; Nagai R; Kadowaki T. (24 Jan 2003). Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. JOURNAL OF BIOLOGICAL CHEMISTRY. 278:2461-2468. Author weblink DOI.
• Lubrano-Berthelier C; Durand E; Dubern B; Shapiro A; Dazin P; Weill J; Ferron C; Froguel P; et alVaisse C. (15 Jan 2003). Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. HUMAN MOLECULAR GENETICS. 12:145-153. Author weblink DOI.
• Leprêtre F; Delannoy V; Froguel P; Vasseur F; Montpellier C. (2003). Dissection of an inverted X(p21.3q27.1) chromosome associated with mental retardation. Cytogenet Genome Res. 101:124-129. DOI.
• Martin LJ; Comuzzie AG; Dupont S; Vionnet N; Dina C; Gallina S; Houari M; Blangero J; et alFroguel P. (1 Dec 2002). A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family. DIABETES. 51:3568-3572. Author weblink DOI.
• Yamauchi T; Kamon J; Minokoshi Y; Ito Y; Waki H; Uchida S; Yamashita S; Noda M; et alKita S; Ueki K; Eto K; Akanuma Y; Froguel P; Foufelle F; Ferre P; Carling D; Kimura S; Nagai R; Kahn BB; Kadowaki T. (1 Nov 2002). Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. NATURE MEDICINE. 8:1288-1295. Author weblink DOI.
• Vasseur F; Helbecque N; Dina C; Lobbens S; Delannoy V; Gaget S; Boutin P; Vaxillaire M; et alLeprêtre F; Dupont S; Hara K; Clément K; Bihain B; Kadowaki T; Froguel P. (1 Oct 2002). Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet. 11:2607-2614.
• Mitchell SMS; Vaxillaire M; Thomas H; Parrizas M; Benmezroua Y; Costa A; Hansen T; Owen KR; et alTuomi T; Pirie F; Ryffel GU; Ferrer J; Froguel P; Hattersley AT; Frayling TM. (1 Sep 2002). Rare variants identified in the HNF-4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes. DIABETOLOGIA. 45:1344-1348. Author weblink DOI.
• Challis BG; Pritchard LE; Creemers JWM; Delplanque J; Keogh JM; Luan J; Wareham NJ; Yeo GSH; et alBhattacharyya S; Froguel P; White A; Farooqi IS; O'Rahilly S. (15 Aug 2002). A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. HUMAN MOLECULAR GENETICS. 11:1997-2004. Author weblink DOI.
• Korbonits M; Gueorguiev M; O'Grady E; Lecoeur C; Swan DC; Mein CA; Weill J; Grossman AB; et alFroguel P. (1 Aug 2002). A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 87:4005-4008. Author weblink DOI.
• McCarthy MI; Froguel P. (Aug 2002). Genetic approaches to the molecular understanding of type 2 diabetes. Am J Physiol Endocrinol Metab. 283:E217-E225. DOI.
• Kubota N; Terauchi Y; Yamauchi T; Kubota T; Moroi M; Matsui J; Eto K; Yamashita T; et alKamon J; Satoh H; Yano W; Froguel P; Nagai R; Kimura S; Kadowaki T; Noda T. (19 Jul 2002). Disruption of adiponectin causes insulin resistance and neointimal formation. JOURNAL OF BIOLOGICAL CHEMISTRY. 277:25863-25866. Author weblink DOI.
• Reis AF; Hani EH; Beressi N; Robert JJ; Bresson JL; Froguel P; Velho G. (1 Jun 2002). Allelic variation in exon 18 of the sulfonylurea receptor 1 (SUR1) gene, insulin secretion and insulin sensitivity in nondiabetic relatives of type 2 diabetic subjects. DIABETES & METABOLISM. 28:209-215. Author weblink.
• Barat-Houari M; Clément K; Vatin V; Dina C; Bonhomme G; Vasseur F; Guy-Grand B; Froguel P. (May 2002). Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes. Diabetes. 51:1640-1643.
• Neve B; Froguel P; Corset L; Vaillant E; Vatin V; Boutin P. (May 2002). Rapid SNP allele frequency determination in genomic DNA pools by pyrosequencing. Biotechniques. 32:1138-1142.
• Mori Y; Otabe S; Dina C; Yasuda K; Populaire C; Lecoeur C; Vatin V; Durand E; et alHara K; Okada T; Tobe K; Boutin P; Kadowaki T; Froguel P. (1 Apr 2002). Genome-wide search for type 2 diabetes in Japanese affected sib-pails confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p. DIABETES. 51:1247-1255. Author weblink DOI.
• Vaxillaire M; Samson C; Cave H; Metz C; Froguel P; Polak M. (1 Mar 2002). Glucokinase gene mutations are not a common cause of permanent neonatal diabetes in France. DIABETOLOGIA. 45:454-455. Author weblink.
• Stride A; Vaxillaire M; Tuomi T; Barbetti F; Njolstad PR; Hansen T; Costa A; Conget I; et alPedersen O; Sovik O; Lorini R; Groop L; Froguel P; Hattersley AT. (1 Mar 2002). The genetic abnormality in the beta cell determines the response to an oral glucose load. DIABETOLOGIA. 45:427-435. Author weblink DOI.
• Hara K; Boutin P; Mori Y; Tobe K; Dina C; Yasuda K; Yamauchi T; Otabe S; et alOkada T; Eto K; Kadowaki H; Hagura R; Akanuma Y; Yazaki Y; Nagai R; Taniyama M; Matsubara K; Yoda M; Nakano Y; Kimura S; Tomita M; Kimura S; Ito C; Froguel P; Kadowaki T. (1 Feb 2002). Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. DIABETES. 51:536-540. Author weblink.
• Delplanque J; Vasseur F; Durand E; Abderrahmani A; Dina C; Waeber G; Guy-Grand B; Clement K; et alWeill J; Boutin P; Froguel P. (Feb 2002). Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians. J Clin Endocrinol Metab. 87:867-869.
• Collet C; Ducorps M; Mayaudon H; Dupuy O; Ceppa F; Boutin P; Froguel P; Bauduceau B. (1 Feb 2002). Prevalence of the missense mutation Gly574Ser in the hepatocyte nuclear factor-1 alpha in Africans with diabetes. DIABETES & METABOLISM. 28:39-44. Author weblink.
• Marchal-Victorion S; Vionnet N; Escrieut C; Dematos F; Dina C; Dufresne M; Vaysse N; Pradayrol L; et alFroguel P; Fourmy D. (1 Jan 2002). Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients. PHARMACOGENETICS. 12:23-30. Author weblink DOI.
• Clement K; Boutin P; Froguel P. (2002). Genetics of obesity. Am J Pharmacogenomics. 2:177-187.
• Froguel P; Boutin P. (Dec 2001). Genetics of pathways regulating body weight in the development of obesity in humans. Exp Biol Med (Maywood). 226:991-996.
• Francke S; Manraj M; Lacquemant C; Lecoeur C; Leprêtre F; Passa P; Hebe A; Corset L; et alYan SL; Lahmidi S; Jankee S; Gunness TK; Ramjuttun US; Balgobin V; Dina C; Froguel P. (15 Nov 2001). A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Hum Mol Genet. 10:2751-2765.
• Froguel P; Mori Y; Otabe S; Dina C; Yasuda K; Lecoeur C; Hara K; Tobe K; et alBoutin P; Kadowaki T. (1 Oct 2001). Genome-wide search for type2 diabetes susceptibility genes in Japanese affected sibpairs. AMERICAN JOURNAL OF HUMAN GENETICS. 69:537-537. Author weblink.
• Boutin P; Froguel P. (Sep 2001). Genetics of human obesity. Best Pract Res Clin Endocrinol Metab. 15:391-404. DOI.
• Frayling TM; Menzel S; Wishart M; Vaxillaire M; Lindgren C; Tuomi T; Wang Y; Brown A; et alBulman MP; Ellard S; Evans JC; Rao PVS; Mills J; Tack C; Dina C; Froguel P; Groop L; Mahtani M; Hattersley AT. (1 Aug 2001). A genome scan reveals heterogeneity among European families with maturity onset diabetes of the young. DIABETOLOGIA. 44:A64-A64.
• Vasseur F; Lacquemant C; Boutin P; Dina C; Dupont S; Guy-Grand B; Froguel P. (1 Aug 2001). Association of APM1 (adiponectin) gene SNPs with type 2 diabetes and CHD in French populations. DIABETOLOGIA. 44:A38-A38. Author weblink.
• Mori Y; Otabe S; Dina C; Yasuda K; Lecoeur C; Hara K; Tobe K; Boutin P; et alKadowaki T; Froguel P. (1 Aug 2001). Genome-wide search for type2 diabetes susceptibility genes in Japanese affected sibpairs. DIABETOLOGIA. 44:A37-A37. Author weblink.
• Manraj M; Francke S; Hebe A; LeeKwaiYan S; Semfa N; Ramjutun US; Froguel P. (1 Aug 2001). Linkage disequilibrium between APOC3 -455 T > C and premature coronary heart disease in Indo-Mauritians. DIABETOLOGIA. 44:A311-A311. Author weblink.
• Dubern B; Clement K; Pelloux V; Froguel P; Girardet JP; Guy-Grand B; Tounian P. (1 Aug 2001). Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children. JOURNAL OF PEDIATRICS. 139:204-209. Author weblink DOI.
• Moore T; Hecquet S; McLellann A; Ville D; Grid D; Picard F; Moulard B; Asherson P; et alMakoff AJ; McCormick D; Nasef L; Froguel P; Arzimanoglou A; LeGuern E; Bailleul B. (1 Aug 2001). Polymorphism analysis of JRK/JH8, the human homologue of mouse jerky, and description of a rare mutation in a case of CAE evolving to JME. EPILEPSY RESEARCH. 46:157-167. Author weblink DOI.
• Yamauchi T; Kamon J; Waki H; Terauchi Y; Kubota N; Hara K; Mori Y; Ide T; et alMurakami K; Tsuboyama-Kasaoka N; Ezaki O; Akanuma Y; Gavrilova O; Vinson C; Reitman ML; Kagechika H; Shudo K; Yoda M; Nakano Y; Tobe K; Nagai R; Kimura S; Tomita M; Froguel P; Kadowaki T. (1 Aug 2001). The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. NATURE MEDICINE. 7:941-946. Author weblink DOI.
• Martin CC; Bischof LJ; Bergman B; Hornbuckle LA; Hilliker C; Frigeri C; Wahl D; Svitek CA; et alWong R; Goldman JK; Oeser JK; Lepretre F; Froguel P; O'Brien RM; Hutton JC. (6 Jul 2001). Cloning and characterization of the human and rat islet-specific glucose-8-phosphatase catalytic subunit-related protein (IGRP) genes. JOURNAL OF BIOLOGICAL CHEMISTRY. 276:25197-25207. Author weblink DOI.
• Hani EH; Dupont S; Durand E; Dina C; Gallina S; Gantz I; Froguel P. (Jun 2001). Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians. J Clin Endocrinol Metab. 86:2895-2898.
• Vaxillaire M; Benmezroua Y; Durand E; Vasseur F; Froguel P. (1 Jun 2001). No evidence for diabetes-associated mutations of PEK/EIF2AK3 gene in French patients with early-onset Type II diabetes. DIABETOLOGIA. 44:786-786. Author weblink.
• Boutin P; Vasseur F; Samson C; Wahl C; Froguel P. (Jun 2001). Routine mutation screening of HNF-1alpha and GCK genes in MODY diagnosis: how effective are the techniques of DHPLC and direct sequencing used in combination?. Diabetologia. 44:775-778.
• Dupont S; Hani EH; Cras-Méneur C; De Matos F; Lobbens S; Lecoeur C; Vaxillaire M; Scharfmann R; et alFroguel P. (May 2001). No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes. 50:1219-1221.
• Manraj M; Francke S; Hebe A; Ramjuttun US; Froguel P. (1 Jan 2001). Genetic and environmental nature of the insulin resistance syndrome in Indo-Mauritian subjects with premature coronary heart disease: contribution or beta 3-adrenoreceptor gene polymorphism and beta blockers on triglyceride and HDL concentrations. DIABETOLOGIA. 44:115-122. Author weblink DOI.
• Froguel P; Velho G. (2001). Genetic determinants of type 2 diabetes. Recent Prog Horm Res. 56:91-105.
• Leprêtre F; Montpellier C; Delannoy V; Froguel P; Vasseur F. (2001). Molecular and cytogenetic characterisation of a small interstitial de novo 20p13-->p12.3 deletion in a patient with severe growth deficit. Cytogenet Cell Genet. 94:142-146.
• Froguel P. (Dec 2000). [Genetics of type II diabetes]. Arch Mal Coeur Vaiss. 93 Spec No 4:7-12.
• Froguel P. (Dec 2000). [Recent advances in the genetics of obesity]. Ann Endocrinol (Paris). 61 Suppl 6:3.
• Vionnet N; Hani EH; Dupont S; Gallina S; Francke S; Dotte S; De Matos F; Durand E; et alLeprêtre F; Lecoeur C; Gallina P; Zekiri L; Dina C; Froguel P. (Dec 2000). Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet. 67:1470-1480. DOI.
• Froguel P. (1 Dec 2000). Genomic approach to obesity: understanding a complex syndrome. ANNALES D ENDOCRINOLOGIE. 61:50-55. Author weblink.
• Delplanque J; Barat-Houari M; Dina C; Gallina P; Clément K; Guy-Grand B; Vasseur F; Boutin P; et alFroguel P. (Dec 2000). Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families. Diabetologia. 43:1554-1557. DOI.
• Froguel P. (1 Dec 2000). Recent advances in the genetics of obesity ... Foreword. ANNALES D ENDOCRINOLOGIE. 61:3-3. Author weblink.
• Meirhaeghe A; Amouyel P; Helbecque N; Cottel D; Otabe S; Froguel P; Vasseur F. (Nov 2000). An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort. Diabetologia. 43:1424-1428. DOI.
• Lacquemant C; Lepretre F; Pineda Torra I; Manraj M; Charpentier G; Ruiz J; Staels B; Froguel P. (Nov 2000). Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease. Diabetes Metab. 26:393-401.
• Pontoglio M; Prie D; Cheret C; Doyen A; Leroy C; Froguel P; Velho G; Yaniv M; et alFriedlander G. (1 Oct 2000). HNF1 alpha controls renal glucose reabsorption in mouse and man. EMBO REPORTS. 1:359-365. Author weblink DOI.
• Duhern B; Tounian P; Vaisse C; Varille V; Pelloux-Gervais V; Froguel P; Girardet JP; Guy-Grand B; et alClement K. (1 Oct 2000). Identification of two new mutations of MC4R in a population of French obese children. OBESITY RESEARCH. 8:20S-20S. Author weblink.
• Dina C; Dubois S; Vaillant E; Froguel P. (1 Aug 2000). Affected sib-pairs analysis of morbid obesity confirmed a major obesity locus on chromosome 10p. DIABETOLOGIA. 43:A32-A32. Author weblink.
• Collet C; Mayaudon H; Ducorps M; Dupuy O; Ceppa F; Boutin P; Froguel P; Bauduceau B. (1 Aug 2000). High prevalence of the missense mutation Gly574Ser of the hepatic transcription factor HNF 1 alpha in a population of African diabetic subjects. DIABETOLOGIA. 43:A81-A81. Author weblink.
• Velho G; Hattersley AT; Froguel P. (1 Aug 2000). Maternal diabetes alters birth weight in glucokinase-deficient (MODY2) kindred but has no influence on adult weight, height, insulin secretion or insulin sensitivity. DIABETOLOGIA. 43:1060-1063. Author weblink DOI.
• Velho G; Hattersley AT; Froguel P. (1 Aug 2000). Maternal diabetes, birth weight and adult weight, insulin secretion and sensitivity in MODY2 kindreds. DIABETOLOGIA. 43:A81-A81. Author weblink.
• James RW; Leviev I; Ruiz J; Passa P; Froguel P; Garin MCB. (1 Aug 2000). Promoter polymorphism T(-107)C of the paraoxonase PON1 gene is a risk factor for coronary heart disease in type 2 diabetic patients. DIABETES. 49:1390-1393. Author weblink DOI.
• Vaxillaire M; Chevre JC; Benmezroua Y; Lecoeur C; Dina C; Costa A; Conget I; Hansen T; et alFrayling T; Hattersley AT; Froguel P. (1 Aug 2000). Search for new genetic determinants of early-onset type 2 diabetes: Genetic and clinical dissection of MODY-like inherited diabetes. DIABETOLOGIA. 43:A81-A81. Author weblink.
• Lahlou N; Clement K; Carel JC; Vaisse C; Lotton C; Le Bihan Y; Basdevant A; Lebouc Y; et alFroguel P; Roger M; Guy-Grand B. (1 Aug 2000). Soluble leptin receptor in serum of subjects with complete resistance to leptin - Relation to fat mass. DIABETES. 49:1347-1352. Author weblink DOI.
• Mercer JG; Moar KM; Hoggard N; Strosberg AD; Froguel P; Bailleul B. (1 Jul 2000). B219/OB-R 5 '-UTR and leptin receptor gene-related protein gene expression in mouse brain and placenta: Tissue-specific leptin receptor promoter activity. JOURNAL OF NEUROENDOCRINOLOGY. 12:649-655. Author weblink.
• Vaisse C; Clement K; Durand E; Hercberg S; Guy-Grand B; Froguel P. (Jul 2000). Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest. 106:253-262. DOI.
• Lacquemant C; Gaucher C; Delorme C; Chatellier G; Gallois Y; Rodier M; Passa P; Balkau B; et alMazurier C; Marre M; Froguel P. (Apr 2000). Association between high von willebrand factor levels and the Thr789Ala vWF gene polymorphism but not with nephropathy in type I diabetes. The GENEDIAB Study Group and the DESIR Study Group. Kidney Int. 57:1437-1443. DOI.
• Costa A; Bescos M; Velho G; Chevre JC; Vidal J; Sesmilo G; Bellanne-Chantelot C; Froguel P; et alCasamitjana R; Rivera-Fillat F; Gomis R; Conget I. (1 Apr 2000). Genetic and clinical characterisation of maturity-onset diabetes of the young in Spanish families. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 142:380-386. Author weblink DOI.
• Froguel P; Guy-Grand B; Clément K. (18 Mar 2000). Genetics of obesity: towards the understanding of a complex syndrome. Presse Med. 29:564-571.
• Waeber G; Delplanque J; Bonny C; Mooser V; Steinmann M; Widmann C; Maillard A; Miklossy J; et alDina C; Hani EH; Vionnet N; Nicod P; Boutin P; Froguel P. (1 Mar 2000). The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. NATURE GENETICS. 24:291-295. Author weblink DOI.
• Clement K; Hereberg S; Passinge B; Galan P; Varroud-Vial M; Shuldiner AR; Beamer BA; Charpentier G; et alGuy-Grand B; Froguel P; Vaisse C. (1 Mar 2000). The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes. INTERNATIONAL JOURNAL OF OBESITY. 24:391-393. Author weblink DOI.
• Otabe S; Clement K; Dina C; Pelloux V; Guy-Grand B; Froguel P; Vasseur F. (Feb 2000). A genetic variation in the 5' flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity. Diabetologia. 43:245-249. DOI.
• Abderrahmani A; Chèvre JC; Otabe S; Chikri M; Hani EH; Vaxillaire M; Hinokio Y; Horikawa Y; et alBell GI; Froguel P. (Feb 2000). Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians. Diabetes. 49:306-308.
• Boutin P; Wahl C; Samson C; Vasseur F; Laget F; Froguel P. (1 Jan 2000). Big Dye (TM) Terminator Cycle Sequencing Chemistry: Accuracy of the dilution process and application for screening mutations in the TCF1 and GCK genes. HUMAN MUTATION. 15:201-203. Author weblink DOI.
• Godart F; Bellanné-Chantelot C; Clauin S; Gragnoli C; Abderrahmani A; Blanché H; Boutin P; Chèvre JC; et alFroguel P; Bailleul B. (2000). Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients. Hum Mutat. 15:173-180. DOI.
• Vaxillaire M; Abderrahman A; Boutin P; Bailleul B; Froguel P; Yaniv M; Pontoglio M. (10 Dec 1999). Anatomy of a homeoprotein revealed by the analysis of human MODY3 mutations. JOURNAL OF BIOLOGICAL CHEMISTRY. 274:35639-35646. Author weblink DOI.
• Dupont S; Dina C; Hani EH; Froguel P. (Dec 1999). Absence of replication in the French population of the association between beta 2/NEUROD-A45T polymorphism and type 1 diabetes. Diabetes Metab. 25:516-517.
• Vaxillaire M; Pueyo ME; Clément K; Fiet J; Timsit J; Philippe J; Robert JJ; Tappy L; et alFroguel P; Velho G. (Dec 1999). Insulin secretion and insulin sensitivity in diabetic and non-diabetic subjects with hepatic nuclear factor-1alpha (maturity-onset diabetes of the young-3) mutations. Eur J Endocrinol. 141:609-618.
• Hani EH; Stoffers DA; Chèvre JC; Durand E; Stanojevic V; Dina C; Habener JF; Froguel P. (Nov 1999). Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest. 104:R41-R48. DOI.
• van der Merwe MT; Panz VR; Crowther NJ; Schlaphoff GP; Gray IP; Froguel P; Joffe BI; Lonnroth PN. (1 Sep 1999). Free fatty acids and insulin levels - relationship to leptin levels and body composition in various patient groups from South Africa. INTERNATIONAL JOURNAL OF OBESITY. 23:909-917. Author weblink DOI.
• Massin P; Virally-Monod M; Vialettes B; Paques M; Gin H; Porokhov B; Caillat-Zucman S; Froguel P; et alPaquis-Fluckinger V; Gaudric A; Guillausseau PJ. (1 Sep 1999). Prevalence of macular pattern dystrophy in maternally inherited diabetes and deafness. OPHTHALMOLOGY. 106:1821-1827. Author weblink DOI.
• Froguel P. (1 Sep 1999). The role of transcription factors in the pathogenesis of type 2 diabetes. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE. 2-5. Author weblink.
• Boullu-Sanchis S; Lepretre F; Hedelin G; Donnet JP; Schaffer P; Froguel P; Pinget M. (1 Jun 1999). Type 2 diabetes mellitus: Association study of five candidate genes in an Indian population of Guadeloupe, genetic contribution of FABP2 polymorphism. DIABETES & METABOLISM. 25:150-156. Author weblink.
• Froguel P; Velho G. (May 1999). Molecular Genetics of Maturity-onset Diabetes of the Young. Trends Endocrinol Metab. 10:142-146.
• Dupont S; Vionnet N; Chèvre JC; Gallina S; Dina C; Seino Y; Yamada Y; Froguel P. (Apr 1999). No evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type II diabetes in France. Diabetologia. 42:480-484. DOI.
• Boutin P; Gresh L; Cisse A; Hara M; Bell G; Babu S; Eisenbarth G; Froguel P. (1 Mar 1999). Missense mutation Gly574Ser in the transcription factor HNF-1 alpha, is a marker of atypical diabetes mellitus in African-American children. DIABETOLOGIA. 42:380-381. Author weblink.
• Clement K; Dina C; Basdevant A; Chastang N; Pelloux V; Lahlou N; Berlan M; Langin D; et alGuy-Grand B; Froguel P. (1 Feb 1999). A sib-pair analysis study of 15 candidate genes in French families with morbid obesity - Indication for linkage with islet 1 locus on chromosome 5q. DIABETES. 48:398-402. Author weblink DOI.
• Otabe S; Clement K; Dubois S; Lepretre F; Pelloux V; Leibel R; Chung W; Boutin P; et alGuy-Grand B; Froguel P; Vasseur F. (Jan 1999). Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients. Diabetes. 48:206-208.
• Froguel P. (1 Jan 1999). What did we learn from genetics of type 2 diabetes and its 59 complications?. NEPHROLOGIE. 20:59-63. Author weblink.
• Froguel P. (5 Dec 1998). Nuclear factors and type 2 diabetes. Schweiz Med Wochenschr. 128:1936-1939.
• Hani EH; Boutin P; Durand E; Inoue H; Permutt MA; Velho G; Froguel P. (Dec 1998). Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians. Diabetologia. 41:1511-1515. DOI.
• Hager J; Dina C; Francke S; Dubois S; Houari M; Vatin V; Vaillant E; Lorentz N; et alBasdevant A; Clement K; Guy-Grand B; Froguel P. (Nov 1998). A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nat Genet. 20:304-308. DOI.
• Froguel P. (Nov 1998). The genetics of complex traits: from diabetes mellitus to obesity. Pathol Biol (Paris). 46:713-714.
• Francke S; Hager J; Froguel P; Lennarz M; Ludwig MM; Stumpe KO. (27 Oct 1998). Quantitative association study with five candidate genes for essential hypertension and salt-sensitivity in normotensive subjects. CIRCULATION. 98:392-392. Author weblink.
• Vaisse C; Clement K; Guy-Grand B; Froguel P. (1 Oct 1998). A frameshift mutation in human MC4R is associated with a dominant form of obesity. NATURE GENETICS. 20:113-114. Author weblink DOI.
• Dupont S; Dubois D; Vionnet N; Boitard C; Caillat-Zucman S; Timsit J; Froguel P. (Oct 1998). No association between the Friedreich's ataxia gene and NIDDM in the French population. Diabetes. 47:1654-1656.
• Surmely JF; Guenat E; Philippe J; Dussoix P; Schneiter P; Temler E; Vaxillaire M; Froguel P; et alJequier E; Tappy L. (1 Sep 1998). Glucose utilization and production in patients with maturity-onset diabetes of the young caused by a mutation of the hepatocyte nuclear factor-1 alpha gene. DIABETES. 47:1459-1463. Author weblink DOI.
• Chèvre JC; Hani EH; Boutin P; Vaxillaire M; Blanché H; Vionnet N; Pardini VC; Timsit J; et alLarger E; Charpentier G; Beckers D; Maes M; Bellanné-Chantelot C; Velho G; Froguel P. (Sep 1998). Mutation screening in 18 Caucasian families suggest the existence of other MODY genes. Diabetologia. 41:1017-1023. DOI.
• Pirie FJ; York DF; Motala AA; Amod A; Omar MAK; Chevre JC; Froguel P. (1 Aug 1998). Candidate genes in South African Indians with type 2 diabetes. DIABETOLOGIA. 41:A113-A113. Author weblink.
• Costa A; Boutin P; Vidal J; Chevre JC; Dell'Anna C; Casamitjana R; Ferrer J; Froguel P; et alVelho G; Gomis R; Conget I. (1 Aug 1998). Genetic and metabolic characterisation of MODY in Spain. DIABETOLOGIA. 41:A107-A107. Author weblink.
• Vaxillaire M; Abderrahmani A; Boutin P; Bailleul B; Yaniv M; Froguel P; Pontoglio M. (1 Aug 1998). MODY3 mutations affect transcriptional activity of hepatocyte nuclear factor 1 alpha (HNF1 alpha). DIABETOLOGIA. 41:A185-A185. Author weblink.
• Godart F; Bellanne-Chantelot C; Boutin P; Chevre JC; Clauin S; Abderrahmani A; Froguel P; Bailleul B. (1 Aug 1998). Mutations in the HNF1 alpha promoter in MODY3 affect HNF1 alpha expression at transcriptional level. DIABETOLOGIA. 41:A107-A107. Author weblink.
• Ruiz J; Castillo E; Temler E; James RW; Blatter-Garin MC; Passa P; Froguel P; Gaillard RC. (1 Aug 1998). Paraoxonase-2 gene G148 variant is associated with elevated paraoxonase levels but not with coronary heart disease in type 2 diabetes. DIABETOLOGIA. 41:A31-A31. Author weblink.
• Velho G; Benque-Blanchet F; Vaxillaire M; Pontoglio M; Froguel P; Friedlander G; Prie D. (1 Aug 1998). Renal proximal tubular defects associated to the MODY3 phenotype. DIABETOLOGIA. 41:A108-A108. Author weblink.
• Chevre JC; Boutin P; Hani EH; Vaxillaire M; Velho G; Vionnet N; Froguel P. (1 Aug 1998). Search for a sixth maturity-onset diabetes of the young causing-gene: Studies with twelve candidate genes in nine MODY families. DIABETOLOGIA. 41:A112-A112. Author weblink.
• Leprêtre F; Vionnet N; Budhan S; Dina C; Powell KL; Génin E; Das AK; Nallam V; et alPassa P; Froguel P. (Jun 1998). Genetic studies of polymorphisms in ten non-insulin-dependent diabetes mellitus candidate genes in Tamil Indians from Pondichery. Diabetes Metab. 24:244-250.
• Pontoglio M; Sreenan S; Roe M; Pugh W; Ostrega D; Doyen A; Pick AJ; Baldwin A; et alVelho G; Froguel P; Levisetti M; Bonner-Weir S; Bell GI; Yaniv M; Polonsky KS. (15 May 1998). Defective insulin secretion in hepatocyte nuclear factor 1 alpha-deficient mice. JOURNAL OF CLINICAL INVESTIGATION. 101:2215-2222. Author weblink DOI.
• Chèvre JC; Hani EH; Stoffers DA; Habener JF; Froguel P. (May 1998). Insulin promoter factor 1 gene is not a major cause of maturity-onset diabetes of the young in French Caucasians. Diabetes. 47:843-844.
• Otabe S; Clement K; Rich N; Warden C; Pecqueur C; Neverova M; Raimbault S; Guy-Grand B; et alBasdevant A; Ricquier D; Froguel P; Vasseur F. (May 1998). Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians. Diabetes. 47:840-842.
• Clement K; Vaisse C; Lahlou N; Cabrol S; Pelloux V; Cassuto D; Gourmelen M; Dina C; et alChambaz J; Lacorte JM; Basdevant A; Bougneres P; Lebouc Y; Froguel P; Guy-Grand B. (26 Mar 1998). A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. NATURE. 392:398-401. Author weblink.
• Hani EH; Suaud L; Boutin P; Chèvre JC; Durand E; Philippi A; Demenais F; Vionnet N; et alFuruta H; Velho G; Bell GI; Laine B; Froguel P. (1 Feb 1998). A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus. J Clin Invest. 101:521-526. DOI.
• Boutin P; Chèvre JC; Hani EH; Gomis R; Pardini VC; Guillausseau PJ; Vaxillaire M; Velho G; et alFroguel P. (Dec 1997). An automated fluorescent single-strand conformation polymorphism technique for screening mutations in the hepatocyte nuclear factor-1alpha gene (maturity-onset diabetes of the young). Diabetes. 46:2108-2109.
• Julier C; Delepine M; Keavney B; Terwilliger J; Davis S; Weeks DE; Bui T; Jeunemaitre X; et alVelho G; Froguel P; Ratcliffe P; Corvol P; Soubrier F; Lathrop GM. (1 Nov 1997). Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. HUMAN MOLECULAR GENETICS. 6:2077-2086. Author weblink DOI.
• Zouali H; Hani EH; Philippi A; Vionnet N; Beckmann JS; Demenais F; Froguel P. (1 Sep 1997). A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. HUMAN MOLECULAR GENETICS. 6:1401-1408. Author weblink DOI.
• Hani EH; Hager J; Philippi A; Demenais F; Froguel P; Vionnet N. (Jul 1997). Mapping NIDDM susceptibility loci in French families: studies with markers in the region of NIDDM1 on chromosome 2q. Diabetes. 46:1225-1226.
• Roche C; Boutin P; Dina C; Gyapay G; Basdevant A; Hager J; Guy-Grand B; Clément K; et alFroguel P. (Jun 1997). Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity. Diabetologia. 40:671-675. DOI.
• Vionnet N; Hani EH; Lesage S; Philippi A; Hager J; Varret M; Stoffel M; Tanizawa Y; et alChiu KC; Glaser B; Permutt MA; Passa P; Demenais F; Froguel P. (Jun 1997). Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs. Diabetes. 46:1062-1068.
• Chevre JC; Hani E; Boutin P; Vionnet N; Vaxillaire M; Yamagata K; Froguel P. (1 Jun 1997). Mutation screening of the hepatocyte nuclear factor -1 alpha and -4 alpha genes in MODY families: Suggestion of the existence of at least a fourth MODY gene. DIABETOLOGIA. 40:612-612. Author weblink.
• Vaxillaire M; Chevre JC; Philippe J; Timsit J; Charpentier G; Velho G; Froguel P. (1 Jun 1997). Mutations in hepatocyte nuclear factor 1 alpha gene associated with NIDDM in French MODY3 families. DIABETOLOGIA. 40:624-624. Author weblink.
• Dussoix P; Vaxillaire M; Iynedjian PB; Tiercy JM; Ruiz J; Spinas GA; Berger W; Zahnd G; et alFroguel P; Philippe J. (1 Apr 1997). Diagnostic heterogeneity of diabetes in lean young adults - Classification based on immunological and genetic parameters. DIABETES. 46:622-631. Author weblink DOI.
• Hani EH; Clément K; Velho G; Vionnet N; Hager J; Philippi A; Dina C; Inoue H; et alPermutt MA; Basdevant A; North M; Demenais F; Guy-Grand B; Froguel P. (Apr 1997). Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians. Diabetes. 46:688-694.
• Vaxillaire M; Rouard M; Yamagata K; Oda N; Kaisaki PJ; Boriraj VV; Chevre JC; Boccio V; et alCox RD; Lathrop GM; Dussoix P; Philippe J; Timsit J; Charpentier G; Velho G; Bell GI; Froguel P. (Apr 1997). Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3). Hum Mol Genet. 6:583-586.
• Velho G; Blanche H; Vaxillaire M; BellanneChantelot C; Pardini VC; Timsit J; Passa P; Deschamps I; et alRobert JJ; Weber IT; Marotta D; Pilkis SJ; Lipkind GM; Bell GI; Froguel P. (1 Feb 1997). Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families. DIABETOLOGIA. 40:217-224. Author weblink DOI.
• Delepine M; Pociot F; Habita C; Hashimoto L; Froguel P; Rotter J; CambonThomsen A; Deschamps I; et alDjoulah S; Weissenbach J; Nerup J; Lathrop M; Julier C. (1 Jan 1997). Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6. AMERICAN JOURNAL OF HUMAN GENETICS. 60:174-187. Author weblink.
• Garin MCB; James RW; Dussoix P; Blanche H; Passa P; Froguel P; Ruiz J. (1 Jan 1997). Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme - A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes. JOURNAL OF CLINICAL INVESTIGATION. 99:62-66. Author weblink DOI.
• Brulhart MC; Dussoix P; Ruiz J; Passa P; Froguel P; James RW. (1 Jan 1997). The (Ala-Val) mutation of methylenetetrahydrofolate reductase as a genetic risk factor for vascular disease in non-insulin-dependent diabetic patients. AMERICAN JOURNAL OF HUMAN GENETICS. 60:228-229. Author weblink.
• Strosberg AD; Froguel P. (7 Dec 1996). beta 3-adrenoceptor gene variant in obesity and insulin resistance. LANCET. 348:1585-1585. Author weblink DOI.
• Yamagata K; Oda N; Kaisaki PJ; Menzel S; Furuta H; Vaxillaire M; Southam L; Cox RD; et alLathrop GM; Boriraj VV; Chen XN; Cox NJ; Oda Y; Yano H; LeBeau MM; Yamada S; Nishigori H; Takeda J; Fajans SS; Hattersley AT; Iwasaki N; Hansen T; Pedersen O; Polonsky KS; Turner RC; Velho G; Chevre JC; Froguel P; Bell GI. (5 Dec 1996). Mutations in the hepatocyte nuclear factor-1 alpha gene in maturity-onset diabetes of the young (MODY3). NATURE. 384:455-458. Author weblink DOI.
• Byrne MM; Sturis J; Menzel S; Yamagata K; Fajans SS; Dronsfield MJ; Bain SC; Hattersley AT; et alVelho G; Froguel P; Bell GI; Polonsky KS. (1 Nov 1996). Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12. DIABETES. 45:1503-1510. Author weblink DOI.
• Velho G; Petersen KF; Perseghin G; Hwang JH; Rothman DL; Pueyo ME; Cline GW; Froguel P; et alShulman GI. (15 Oct 1996). Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. JOURNAL OF CLINICAL INVESTIGATION. 98:1755-1761. Author weblink DOI.
• Velho G; Vaxillaire M; Boccio V; Charpentier G; Froguel P. (1 Sep 1996). Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q. DIABETES CARE. 19:915-919. Author weblink DOI.
• Clement K; Ruiz J; CassardDoulcier AM; Bouillaud F; Ricquier D; Basdevant A; GuyGrand B; Froguel P. (1 Aug 1996). Additive effect of A->G (-3826) variant of the uncoupling protein gene and the TRP64ARG mutation of the beta 3 - Adrenergic receptor gene on weight gain in morbid obesity. DIABETOLOGIA. 39:14-14. Author weblink.
• Velho G; Pueyo ME; Vaxillaire M; Clement K; Froguel P; Robert JJ. (1 Aug 1996). Insulin secretion and sensitivity in diabetic and non-diabetic carriers of MODY-3 susceptibility haplotypes. DIABETOLOGIA. 39:271-271. Author weblink.
• Hani E; Vionnet N; Clement K; Velho G; Hager J; Permutt MA; Froguel P. (1 Aug 1996). Sib-pair linkage and association studies of the sulfonylurea receptor gene locus in NIDDM and morbid obesity in French Caucasians. DIABETOLOGIA. 39:267-267. Author weblink.
• Hansen LH; Abrahamsen N; Hager J; Jelinek L; Kindsvogel W; Froguel P; Nishimura E. (1 Jun 1996). The Gly40Ser mutation in the human glucagon receptor gene associated with NIDDM results in a receptor with reduced sensitivity to glucagon. DIABETES. 45:725-730. Author weblink DOI.
• Clement K; Garner C; Hager J; Philippi A; LeDuc C; Carey A; Harris TJR; Jury C; et alCardon LR; Basdevant A; Demenais F; GuyGrand B; North M; Froguel P. (1 May 1996). Indication for linkage of the human OB gene region with extreme obesity. DIABETES. 45:687-690. Author weblink DOI.
• Velho G; Byrne MM; Clement K; Sturis J; Pueyo ME; Blanche H; Vionnet N; Fiet J; et alPassa P; Robert JJ; Polonsky KS; Froguel P. (1 Apr 1996). Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNA(Leu(UUR)) gene mutation. DIABETES. 45:478-487. Author weblink DOI.
• Clément K; Pueyo ME; Vaxillaire M; Rakotoambinina B; Thuillier F; Passa P; Froguel P; Robert JJ; et alVelho G. (Jan 1996). Assessment of insulin sensitivity in glucokinase-deficient subjects. Diabetologia. 39:82-90.
• Gauguier D; Froguel P; Parent V; Bernard C; Bihoreau MT; Portha B; James MR; Penicaud L; et alLathrop M; Ktorza A. (1 Jan 1996). Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. NATURE GENETICS. 12:38-43. Author weblink DOI.
• RUIZ J; BLANCHE H; JAMES RW; GARIN MCB; VAISSE C; CHARPENTIER G; COHEN N; MORABIA A; et alPASSA P; FROGUEL P. (30 Sep 1995). GLN-ARG192 POLYMORPHISM OF PARAOXONASE AND CORONARY HEART-DISEASE IN TYPE-2 DIABETES. LANCET. 346:869-872. Author weblink DOI.
• Clément K; Vaisse C; Manning BS; Basdevant A; Guy-Grand B; Ruiz J; Silver KD; Shuldiner AR; et alFroguel P; Strosberg AD. (10 Aug 1995). Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med. 333:352-354. DOI.
• BLANCHE H; RUIZ J; BONNARDEAUX A; COHEN N; SOUBRIER F; PASSA P; FROGUEL P. (1 Aug 1995). ASSOCIATION OF ANGIOTENSIN-II CONVERTING-ENZYME AND ANGIOTENSIN-II TYPE-1 RECEPTOR GENES WITH CORONARY HEART-DISEASE IN NIDDM. DIABETOLOGIA. 38:A228-A228. Author weblink.
• VELHO G; CLEMENT K; PUEYO ME; VAXILLAIRE M; PASSA P; ROBERT JJ; FROGUEL P. (1 Aug 1995). CLINICAL AND METABOLIC PROFILES OF MODY FAMILIES LINKED TO MARKERS ON CHROMOSOME-12Q. DIABETOLOGIA. 38:A34-A34. Author weblink.
• GAUGUIER D; PARENT V; BERNARD C; BIHOREAU MT; JAMES MR; PENICAUD L; FROGUEL P; LATHROP M; et alKTORZA A. (1 Aug 1995). GENETIC DISSECTION ON NON-INSULIN-DEPENDENT DIABETES IN THE GOTO-KAKIZAKI (GK) RAT. DIABETOLOGIA. 38:A79-A79. Author weblink.
• Vaxillaire M; Boccio V; Philippi A; Vigouroux C; Terwilliger J; Passa P; Beckmann JS; Velho G; et alLathrop GM; Froguel P. (Apr 1995). A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nat Genet. 9:418-423. DOI.
• Froguel P. (1995). [1995 Bouchardat Apollinaire Award. Genetic approach to sugar diabetes]. Journ Annu Diabetol Hotel Dieu. 53-66.
• JULIER C; LUCASSEN A; VILLEDIEU P; DELEPINE M; LEVYMARCHAL C; DANZE PM; BIANCHI F; BOITARD C; et alFROGUEL P; BELL J; LATHROP GM. (1 Dec 1994). MULTIPLE DNA VARIANT ASSOCIATION ANALYSIS - APPLICATION TO THE INSULIN GENE REGION IN TYPE-I DIABETES. AMERICAN JOURNAL OF HUMAN GENETICS. 55:1247-1254. Author weblink.

Conferences

• Froguel P. Where next for genetics of type-2 diabetes?. British Human Genetics Conference, 6 Sep 2010 - 8 Sep 2010. 47:S36-S36. B M J PUBLISHING GROUP (1 Sep 2010). Author weblink.
• Froguel P. Harnessing our knowledge of human genetics in the prevention and treatment of childhood obesity. 19th Workshop of the European-Childhood-Obesity-Group, 17 Sep 2009 - 19 Sep 2009. 5:42-42. TAYLOR & FRANCIS INC (1 Jan 2010).
• Elliot P; Chambers J; Sehmi J; Clarke R; Erdmann J; Braund P; Engert J; Ashby D; et alTzoulaki I; Peltonen L; Farrall M; Hamsten A; Froguel P; Waterworth D; Vollenweider P; Waeber G; Jarvelin M-R; Scott J; Hall A; Schunkert H; Anand S; Collins R; Samani N; Watkins H; Kooner J. Does CRP Play a Causal Role in the Development of Coronary Heart Disease: Results of a Mendelian Randomisation Experiment Involving 128,935 People. 82nd Scientific Session of the American-Heart-Association, 14 Nov 2009 - 18 Nov 2009. 120:S467-S468. LIPPINCOTT WILLIAMS & WILKINS (3 Nov 2009). Author weblink.
• Dupuis J; Langenberg C; Prokopenko I; Saxena R; Soranzo N; Jackson AU; Wheeler E; Glazer NL; et alBouatia-Naji N; McCullogh L; Gloyn A; Sladek R; Froguel P; Watanabe RM; Meigs JB; Groop L; Boehnke M; McCarthy MI; Florez JC; Barroso I. Novel Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Related Metabolic Traits. 18th Annual Meeting of the International-Genetic-Epidemiology-Society, 10 Oct 2009 - 20 Oct 2009. 33:788-788. WILEY-LISS (1 Dec 2009). Author weblink.
• Buxton J; Coin LJM; Walters RG; Andersson J; de Smith AJ; Moustafa JSE-S; Sladek R; Froguel P; et alBlakemore AIF. Identification and validation of novel genomic CNVs associated with Type 2 diabetes. British Human Genetics Conference, 31 Aug 2009 - 2 Sep 2009. 46:S93-S93. B M J PUBLISHING GROUP (1 Sep 2009). Author weblink.
• Trewick AL; Froguel P; Coin LJM; Blakemore AIF. Assignment of trisomic genotypes using the Sequenom iPLEX MALDI TOF assay reveals transmission disequilibrium of two SNP loci in the Type VI Collagen gene cluster associated with CHD in Down's Syndrome. British Human Genetics Conference, 31 Aug 2009 - 2 Sep 2009. 46:S92-S92. B M J PUBLISHING GROUP (1 Sep 2009). Author weblink.
• Moustafa JSE-S; Coin LJM; de Smith AJ; Walters RG; Buxton JL; Asher JE; Meyre D; Dina C; et alFroguel P; Blakemore AIF. CNVs in Obesity: Uncovering a New Level of Genomic Variation. British Human Genetics Conference, 31 Aug 2009 - 2 Sep 2009. 46:S91-S91. B M J PUBLISHING GROUP (1 Sep 2009). Author weblink.
• Asher J; Walley AJ; Froguel P; Blakemore AIF. Genes in the ACAD family show preliminary evidence of association with polygenic obesity. British Human Genetics Conference, 31 Aug 2009 - 2 Sep 2009. 46:S89-S89. B M J PUBLISHING GROUP (1 Sep 2009). Author weblink.
• de Smith AJ; Purmann C; Walters RG; Ellis RJ; Holder SE; van Haelst MM; Brady AF; Fairbrother UL; et alDattani M; Keogh JM; Henning E; Yeo GSH; O'Rahilly S; Froguel P; Farooqi IS; Blakemore AIF. Elucidating the aetiology of Prader-Willi syndrome: deletion of the HBII-85 class of snoRNA is associated with hyperphagia, obesity and hypogonadism. British Human Genetics Conference, 31 Aug 2009 - 2 Sep 2009. 46:S83-S83. B M J PUBLISHING GROUP (1 Sep 2009). Author weblink.
• Clark S; Falchi M; Olsson B; Meyre D; Andersson J; Balkau B; Marre M; Tichet J; et alWong HY; Carlsson L; Froguel P; Walley AJ. Association of variants in the Sirtuin 1 (SIRT1) gene with severe obesity. British Human Genetics Conference, 31 Aug 2009 - 2 Sep 2009. 46:S65-S65. B M J PUBLISHING GROUP (1 Sep 2009). Author weblink.
• Cauchi S; Del Guerra S; Choquet H; D'Aleo V; Groves C; Lupi R; McCarthy M; Froguel P; et alMarchetti P. Functional effects of the common SLC30A8 Arg325Trp polymorphism on isolated human pancreatic islets. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 30 Sep 2009 - 2 Oct 2009. 52:S169-S170. SPRINGER (1 Sep 2009).
• Bonnefond A; Vaxillaire M; Bouatia-Naji N; Balkau B; Marre M; Tichet J; Jarvelin M-R; Levy-Marchal C; et alHorber F; Hadjadj S; Riveline J-P; Charpentier G; Sladek R; Meyre D; Froguel P. The genetic association between HK1 and increased HbA(1c) but not other glycaemic control related traits reveals the link between anaemia and HbA(1c). 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 29 Sep 2009 - 2 Oct 2009. 52:S146-S146. SPRINGER (1 Sep 2009). Author weblink.
• Stutzmann F; Ghoussaini M; Couturier C; Marchand M; Vatin V; Corset L; Lecoeur C; Balkau B; et alHorber F; Driscoll DJ; Goldstone AP; Weill J; Michaud JL; Meyre D; Froguel P. Loss-of-function mutations in SIM1 cause a specific form of Prader-Willi-like syndrome. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 30 Sep 2009 - 2 Oct 2009. 52:S104-S104. SPRINGER (1 Sep 2009). Author weblink.
• Meur G; Rutter GA; Simon A; Harun N; Dechaume A; Bonnefond A; Virally M; Tarasov A; et alBoesgaard TW; Hansen T; Pedersen O; Gautier J-F; Froguel P; Polak M; Vaxillaire M. Mutations in the insulin gene resulting in a MODY phenotype: marked differences in clinical presentation, metabolic status and pathogenic effect through ER retention. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 30 Sep 2009 - 2 Oct 2009. 52:S103-S103. SPRINGER (1 Sep 2009). Author weblink.
• de Smith A; Walters RG; Coin LJM; Steinfeld I; Yakhini Z; Sladek R; Froguel P; Blakemore AIF. Alu elements implicated in the generation of 9/20 CNV deletions investigated by breakpoint sequencing. British Human Genetics Conference, 15 Sep 2008 - 17 Sep 2008. 45:S90-S90. B M J PUBLISHING GROUP (1 Sep 2008). Author weblink.
• Froguel P. Familial hyperglycemia due to glucokinase gene mutations. 15th International-Diabetes-Federation Congress, 6 Nov 1994 - 11 Nov 1994. 1100:155-157. ELSEVIER SCIENCE PUBL B V (1 Jan 1995). Author weblink.
• Froguel P. Results of 10-years genetic studies in French families with type 2 diabetes. 7th European Symposium on Metabolism - Insulin Resistance, Metabolic Diseases and Diabetic Complications, 30 Sep 1998 - 3 Oct 1998. 1177:33-36. ELSEVIER SCIENCE BV (1 Jan 1999). Author weblink.
• Froguel P; Velho G. Medical genetics of MODYs. Symposium on Molecular Pathogenesis of MODYs, 6 Nov 1998 - 8 Nov 1998. 15:35-43. KARGER (1 Jan 2000). Author weblink.
• Boutini P; Froguel P. Genomic approach to common human obesity. Conference on Brain Somatic Cross-Talk and the Central Control of Metabolism, 28 Jan 2002. 155-163. SPRINGER-VERLAG BERLIN (1 Jan 2003). Author weblink.
• Froguel P. Do our genes make us fat?. National Symposium on Obesity, May 2001. 25-38. TAYLOR & FRANCIS LTD (1 Jan 2003). Author weblink DOI.
• Bouatia-Naji N; Rocheleau G; Van Lommel L; Lemaire K; Schuit E; Marre M; Balkau B; Jarvelin MR; et alSladek R; Froguel P. Glucose 6 phosphatase beta cell specific subtype/IGRP gene variation controls fasting plasma glucose levels in humans. 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 51:S127-S127. (Sep 2008).
• Poulain-Godefroy O; Lecoeur C; Pattou F; Fruhbeck G; Froguel P. Inflammation impairs adipocyte differentiation and is associated with a decrease of lipogenic factors in omental fat. 16th European Congress on Obesity. 32:S15-S15. (May 2008).
• Froguel P. Will the human genome give us the answer to obesity? A debate - the case for. 16th European Congress on Obesity. 32:S1-S1. (May 2008).
• Stutzmann F; Tan K; Balkau B; Potoczna N; Horber F; O'Rahilly S; Farooqi IS; Meyre D; et alFroguel P. Prevalence, inheritance and clinical characteristics of MC4R deficiency in a study of 5,675 European children and adults. 16th European Congress on Obesity, 14 May 2008 - 17 May 2008. 32:S37-S37. NATURE PUBLISHING GROUP (1 May 2008). Author weblink.
• Goossens GH; Petersen L; Blaak EE; Hul G; Arner P; Astrup A; Froguel P; Patel K; et alPedersen O; Polak J; Oppert J-M; Martinez A; Sorensen TIA; Saris WHM. Several gene polymorphisms but not FTO variants modulate resting energy expenditure and fat-induced thermogenesis in obese subjects: The NUGENOB Study. 16th European Congress on Obesity, 14 May 2008 - 17 May 2008. 32:S26-S26. NATURE PUBLISHING GROUP (1 May 2008). Author weblink.
• Riveline JP; Vaxillaire M; Fetita LS; Tarasov A; Nicolson T; Charpentier G; Franc S; Froguel P; et alRutter GA; Gautier JF. Metabolic consequences of a new ABCC8/SUR1 gene mutation found in adult type 2 diabetic patients and their lineage. 34:A78-A78. MASSON EDITEUR (1 Mar 2008). Author weblink.
• Blakemore A; de Smith AJ; Tsalenko A; Sampas N; Scheffer A; Yamada A; Tsang P; Ben-Dor A; et alYakhini Z; Ellis R; Bruhn L; Laderman S; Froguel P. Interpretation of array CGH data: adding to the growing list of copy number variants in healthy subjects. British Human Genetics Conference. 44:S31-S31. (Sep 2007).
• Neve B; Gutierrez-Aguilar R; Benmezroua Y; Balkau B; Marre M; Helbecque N; Charpentier G; Sladek R; et alFroguel P. Minor contribution of Smad7 and KLF10 variants to genetic susceptibility of type 2 diabetes. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 50:S135-S135. (Sep 2007).
• Salonen JT; Uimari P; Aalto JM; Pirskanen M; Todorova B; Tuomainen TP; Luedemann J; Gibson M; et alPendleton N; Mahoney W; Meyre D; Delplanque J; Froguel P; Yakir B; Darvasi A. Type 2 diabetes whole genome association study in four populations: the DiaGen consortium. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 50:S40-S40. (Sep 2007).
• Corpeleijn E; Petersen L; Sorensen T; Saris WHM; Pedersen O; Froguel P; Blaak EE. Genetic polymorphisms explain variation in the ability to regulate fat oxidation. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 18 Sep 2007 - 21 Sep 2007. 50:S136-S136. SPRINGER (1 Sep 2007). Author weblink.
• Prokopenko I; Zeggini E; Rayner NW; Groves CJ; Hanson RL; Mitchell BD; Vaxillaire M; Hunt SE; et alCardon LR; Froguel P; Elbein SC; Shuldiner AR; Deloukas P; McCarthy MI. High-density association mapping and comprehensive tagging of the type 2 diabetes linkage region on chromosome 1q in 4 European populations. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 18 Sep 2007 - 21 Sep 2007. 50:S75-S75. SPRINGER (1 Sep 2007). Author weblink.
• Neve B; Gutierrez-Aguilar R; Benmezroua Y; Vaillant E; Dina C; Balkau B; Marre M; Charpentier G; et alFroguel P. A KLF9 promoter variant that is predicted to affect TCF7L2 binding is associated with type 2 diabetes. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). 49:17-17. (Sep 2006).
• Gutierrez-Aguilar R; Hamid YH; Vaillant E; Benmezroua Y; Jorgensen T; Borch-Johnsen K; Hansen T; Froguel P; et alPedersen O; Neve B. Association of KLF11 with insulin resistance is mediated via STAT3 binding to KLF11 variant -1659 G > C. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), 14 Sep 2006 - 17 Sep 2006. 49:162-163. SPRINGER (1 Sep 2006). Author weblink.
• Ward KJ; Boutin P; Chevre JC; Lobbens S; Lecoeur C; Wachter C; Dina C; Larsen PJ; et alTanko LB; Horber FF; Charpentier G; Balkau B; Meyre D; Froguel P. Cannabinoid receptor 1 gene variation increases risk for obesity and type 2 diabetes and modulates phenotypes related to endocannabinoid-mediated physiological pathways. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). 49:215-216. (Sep 2006).
• Meyre D; Samson C; Vatin V; Tichet J; Marre M; Balkau B; Froguel P. ENPP1 K121Q associates with severe obesity and T2D, and predicts overweight/class III obesity and familial glucose intolerance/T2D incidence in the prospective DESIR Study. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). 49:217-218. (Sep 2006).
• Tanko LB; Boutin P; Larsen P; Froguel P; Christiansen C. Single-nucleotide polymorphism of the cannabinoid receptor 1 gene: A genetic link between osteoporosis and cardiovascular disease?. 28th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research. 21:S148-S148. (Sep 2006).
• Cauchi S; Meyrel D; Choquet H; Samson C; Polychronakos C; Balkau B; Scharfmann R; Fruhbeck G; et alCharpentier G; Sladek R; Froguel P. TCF7L2 gene strongly associates with type 2 diabetes, with lower age of onset and BMI in the French population, and its adipose expression is impaired in diabetes. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). 49:14-15. (Sep 2006).
• Roussel R; Bellili N; Fumeron F; Meyre D; Fysekidis M; Velho G; Hadjadj S; Tichet J; et alVaxillaire M; Alhenc-Gelas F; Balkau B; Froguel P; Marrel M. The TT genotype of the subtype 2 bradykinin receptor (BDKRB2) is associated with a high risk for type 2 diabetes (T2D) in the general population: the DESIR study. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). 49:36-37. (Sep 2006).
• Froguel P. New insight into the genetics of childhood obesity. 16th Workshop of the European-Childhood-Obesity-Group. 30:S19-S19. (Jun 2006).
• Froguel P. The genetics of human obesity. 14th Meeting of the International-Society-of-Atherosclerosis. 7:310-311. (Jun 2006).
• Fairbrother U; Walley AJ; Boyle C; Tauber M; Jouret B; Jaquet D; Levy-Marchal C; Charles MA; et alWeill J; Froguel P; Blakemore AIF. Coding SNPs in the human leptin receptor gene contribute to severe obesity in French Caucasian adults. British Human Genetics Conference, 12 Sep 2005 - 14 Sep 2005. 42:S116-S116. B M J PUBLISHING GROUP (1 Sep 2005). Author weblink.
• Froguel P. From genome scans to genes predisposing to familial metabolic syndrome and diabesity. 75th Congress of the European-Atherosclerosis-Society, 23 Apr 2005 - 26 Apr 2005. 6:56-56. ELSEVIER IRELAND LTD (1 Apr 2005). Author weblink DOI.
• Zeggini E; Rayner W; Groves CJ; Hanson RL; Mitchell BD; O'Connell J; Vaxillaire M; Froguel P; et alHunt S; Cardon L; Elbein SC; Shuldiner A; Deloukas P; McCarthy MI. Linkage disequilibrium mapping of the type 2 diabetes susceptibility variants on chromosome Iq in European populations. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 10 Sep 2005 - 15 Sep 2005. 48:A128-A128. SPRINGER (1 Jan 2005). Author weblink.
• Rayner W; Zeggini E; Groves CJ; Wiltshire S; Hunt S; Whittaker P; Delgado M; Morrison J; et alVaxillaire M; Cardon L; Deloukas P; Froguel P; McCarthy MI. Positional candidate gene selection on chromosome 1q using bioinformatics and large scale association analysis. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 48:A108-A108. (Jan 2005).
• Lombardo E; Jaziri R; Bellili N; Porchay I; Pean F; Aubert R; Tichet J; Balkau B; et alFroguel P; Fumeron F; Marre M. Relationship between non alcoholic steatohepatitis (NASH) and insulin resistance and role of PPAR gamma 2 and adiponectin polymorphisms in these metabolic disorders. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 10 Sep 2005 - 15 Sep 2005. 48:A60-A60. SPRINGER (1 Jan 2005). Author weblink.
• Dina C; Boutin P; Froguel P. Genetic association analyses of GAD2 (GABA pathway) with food behaviour scores and latent obesity. 12th World Congress of Psychiatric Genetics, 9 Oct 2004 - 13 Oct 2004. 130B:119-119. WILEY-LISS (15 Sep 2004). Author weblink.
• Neve B; Fernandez-Zapico ME; Ashkenazi-Katalan V; Dina C; Vaxillaire M; Urrutia R; Melloul D; Froguel P. Altered functional variants of TGF beta-inducible transcription factor KLF11 are associated with diabetes. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A81-A81. (Aug 2004).
• Vaxillaire M; Cheyssac C; Dina C; Vasseur-Delannoy V; Lepretre F; Siddiq A; Froguel P. EIF4 alpha 2 on chromosome 3q27 is a positional candidate gene for Type 2 diabetes. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 47:A81-A81. (Aug 2004).
• Yamauchi T; Kamon J; Terauchi Y; Froguel P; Tobe K; Nagai R; Kadowaki T. Cloning of receptors for adiponectin that mediates anti-diabetic and anti-atherogenic effeccts. 76th Annual Scientific Session of the American-Heart-Association. 108:113-113. (28 Oct 2003).
• Clement L; Cruciani C; Gaasenbeek M; Quesneville H; McCarthy M; Froguel P; Ktorza A; Magnan C. Differential hypothalamic gene expression profile after, intracerebroventricular infusion of lipids for 48h in Wistar rats. 18th Congress of the International-Diabetes-Federation. 46:A230-A231. (Aug 2003).
• Meyre D; Dupuy L; Lecoeur C; Gaget S; Guemas I; Weill J; Froguel P. Phenotypic analysis of childhood obesity linked to 16q22.1-q23 chromosomal region. 18th Congress of the International-Diabetes-Federation. 46:A139-A139. (Aug 2003).
• Lubrano-Berthelier C; Cavazos M; Dubern B; Shapiro A; Le Stunff C; Zhang SM; Picart F; Govaerts C; et alFroguel P; Bougneres P; Clement K; Vaisse C. Molecular genetics of human obesity-associated MC4R mutations. 5th International Melanocortin Meeting, 25 Aug 2002 - 28 Aug 2002. 994:49-57. NEW YORK ACAD SCIENCES (1 Jan 2003). Author weblink.
• Patel S; Unwin NC; Vasseur F; Froguel P; Walker M. Investigation of the role of the T to G SNP in the adiponectin (AMP1) gene in abdominal obesity using parent-offspring trios. 38th EASD Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 1 Sep 2002 - 5 Sep 2002. 45:A124-A124. SPRINGER-VERLAG (1 Aug 2002). Author weblink.
• Groves CJ; Wiltshire S; Menzel S; Bennett A; Hattersley AT; Frayling TM; Walker M; Levy JC; et alO'Rahilly S; Hitman GA; Cardon LR; Dina C; Froguel P. Linkage studies of the Type 2 diabetes susceptibility locus on chromosome 1q: Combined analysis of 1200 UK and French affected sibpairs. 38th EASD Annual Meeting of the European-Association-for-the-Study-of-Diabetes, 1 Sep 2002 - 5 Sep 2002. 45:A55-A56. SPRINGER-VERLAG (1 Aug 2002). Author weblink.
• Fredriksson JEM; Orho-Melander M; Vasseur F; Lobbens S; Froguel P; Groop L. Putative role for variations in the adiponectin gene in Type 2 diabetes and cardiovascular disease in Finns. 38th EASD Annual Meeting of the European-Association-for-the-Study-of-Diabetes. 45:A136-A136. (Aug 2002).
• Neve B; Froguel P; Corset L; Vaillant E; Vatin V; Boutin P. Rapid SNP allele frequency determination to accelerate LD mapping strategies. European-Society-of-Human-Genetics European Human Genetics Conference in Conjuction With European Meeting on Psychosocial Aspects of Genetics. 10:214-214. (May 2002).
• Pearson ER; Velho G; Clark P; Stride A; Shepherd M; Frayling TM; Bulman MP; Ellard S; et alFroguel P; Hattersley AT. beta-cell genes and diabetes: Quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1 alpha and glucokinase mutations. 1st Servier-IGIS Symposium, 23 Mar 2000 - 25 Mar 2000. 50:S101-S107. AMER DIABETES ASSOC (1 Feb 2001). Author weblink DOI.
• Froguel P. Genetics in type 2 diabetes. Meeting on Diabetes and the Heart: From Physiopathology to Practice. 93:7-12. (Dec 2000).
• Lacquemant C; Gaucher C; Delorme C; Chatellier G; Gallois Y; Rodier M; Passa P; Balkau B; et alMazurier C; Marre M; Froguel P; GENEDIAB Study Grp; DESIR Study Grp. Association between high von Willebrand factor levels and the Thr789Ala VWF gene polymorphism but not with nephropathy in type 1 diabetes. Conference on Forefronts in Nephrology - News in Aldosterone Action. 57:1437-1443. (Apr 2000).