Professor Peter J Barnes

Publications


Journals

  • Rossios C; To Y; Osoata G; Ito M; Barnes PJ; Ito K. (17 Jan 2012). Corticosteroid insensitivity is reversed by formoterol via phosphoinositide 3 kinase inhibition. Br J Pharmacol. DOI.
  • Barnes PJ; Breckenridge A. (16 Jan 2012). David Jack (1924-2011) who revolutionised the treatment of asthma. Thorax. DOI.
  • Kobayashi Y; Mercado N; Barnes PJ; Ito K. (2011). Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma. PLoS One. 6:e27627. DOI.
  • Barnes PJ. (Jan 2012). Severe asthma: advances in current management and future therapy. J Allergy Clin Immunol. 129:48-59. DOI.
  • To M; Yamamura S; Akashi K; Charron C; Haruki K; Barnes PJ; Ito K. (15 Dec 2011). Defect of adaptation to hypoxia in COPD patients due to reduction of histone deacetylase 7. Chest. DOI.
  • Malhotra D; Thimmulappa RK; Mercado N; Ito K; Kombairaju P; Kumar S; Ma J; Feller-Kopman D; et alBarnes P; Biswal S. (2011). Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. J Clin Invest. 121:4289-4302.
  • Barnes PJ; Adcock IM. (15 Oct 2011). Chronic Obstructive Pulmonary Disease and Lung Cancer: A Lethal Association. AM J RESP CRIT CARE. 184:866-867. DOI.
  • Paschalaki K; Starke RD; Mercado N; Haskard DO; Barnes PJ; Randi AM. (Oct 2011). ENDOTHELIAL COLONY FORMING CELLS (ECFC) ARE SENESCENT AND DYSFUNCTIONAL IN COPD DUE TO REDUCED SIRTUIN-1 LEVELS. HEART. 97:20-20. DOI.
  • Adcock IM; Barnes PJ. (15 Sep 2011). Con: Genome-Wide Association Studies Have Not Been Useful in Understanding Asthma. AM J RESP CRIT CARE. 184:633-636. DOI.
  • Barnes PJ. (Oct 2011). Interview with Peter Barnes. Future Med Chem. 3:1575-1579. DOI.
  • Kirkham PA; Caramori G; Casolari P; Papi AA; Edwards M; Shamji B; Triantaphyllopoulos K; Hussain F; et alPinart M; Khan Y; Heinemann L; Stevens L; Yeadon M; Barnes PJ; Chung KF; Adcock IM. (1 Oct 2011). Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 184:796-802. DOI.
  • Mercado N; To Y; Kobayashi Y; Adcock IM; Barnes PJ; Ito K. (Dec 2011). p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma. Mol Pharmacol. 80:1128-1135. DOI.
  • Rossios C; To Y; To M; Ito M; Barnes PJ; Adcock IM; Johnson M; Ito K. (16 Nov 2011). Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells. Eur J Pharmacol. 670:244-251. DOI.
  • Essilfie-Quaye S; Ito K; Ito M; Kharitonov SA; Barnes PJ. (Dec 2011). Comparison of Symbicort® versus Pulmicort® on steroid pharmacodynamic markers in asthma patients. Respir Med. 105:1784-1789. DOI.
  • Donnelly LE; Barnes PJ. (Jun 2011). CHEMOKINE RECEPTOR CXCR2 ANTAGONISM TO PREVENT AIRWAYS INFLAMMATION. DRUG FUTURE. 36:465-472. DOI.
  • Antczak A; Piotrowski W; Marczak J; Ciebiada M; Gorski P; Barnes PJ. (2011). Correlation between eicosanoids in bronchoalveolar lavage fluid and in exhaled breath condensate. DIS MARKERS. 30:213-220. DOI.
  • Koarai A; Traves SL; Fenwick PS; Brown SM; Chana KK; Russell RE; Nicholson AG; Barnes PJ; et alDonnelly LE. (1 Sep 2011). Expression of Muscarinic Receptors by Human Macrophages. Eur Respir J. DOI.
  • Caramori G; Lasagna L; Casalini AG; Adcock IM; Casolari P; Contoli M; Tafuro F; Padovani A; et alChung KF; Barnes PJ; Papi A; Rindi G; Bertorelli G. (28 Jul 2011). Immune Response to Mycobacterium tuberculosis Infection in the Parietal Pleura of Patients with Tuberculous Pleurisy. PLOS ONE. 6. DOI.
  • Barnes PJ. (23 Sep 2011). Biochemical basis of asthma therapy. J Biol Chem. 286:32899-32905. DOI.
  • Teng Y; Sun PL; Zhang JY; Yu RB; Bai JL; Yao X; Huang M; Adcock IM; et alBarnes PJ. (Jul 2011). Hydrogen Peroxide in Exhaled Breath Condensate in Patients with Asthma A Promising Biomarker?. CHEST. 140:108-116. DOI.
  • Lavorini F; Corrigan CJ; Barnes PJ; Dekhuijzen PRN; Levy ML; Pedersen S; Roche N; Vincken W; et alCrompton GK; Aerosol Drug Management Improvemen. (Jul 2011). Retail sales of inhalation devices in European countries: So much for a global policy. RESP MED. 105:1099-1103. DOI.
  • Nicholson GC; Kariyawasam HH; Tan AJ; Hohlfeld JM; Quinn D; Walker C; Rodman D; Westwick J; et alJurcevic S; Kon OM; Barnes PJ; Krug N; Hansel TT. (Oct 2011). The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge. J Allergy Clin Immunol. 128:800-807.e9. DOI.
  • Gajdocsi R; Bikov A; Antus B; Horvath I; Barnes PJ; Kharitonov SA. (Dec 2011). Assessment of reproducibility of exhaled hydrogen peroxide concentration and the effect of breathing pattern in healthy subjects. J Aerosol Med Pulm Drug Deliv. 24:271-275. DOI.
  • Barnes PJ. (Jul 2011). Pathophysiology of allergic inflammation. Immunol Rev. 242:31-50. DOI.
  • Usmani OS; Barnes PJ. (17 Jun 2011). Assessing and treating small airways disease in asthma and chronic obstructive pulmonary disease. Ann Med. DOI.
  • Barnes PJ. (Jun 2011). Triple inhalers for obstructive airways disease: will they be useful?. Expert Rev Respir Med. 5:297-300. DOI.
  • Kirkham PA; Caramori G; Casolari P; Papi A; Edwards M; Shamji B; Triantaphyllopoulos K; Hussain F; et alPinart M; Khan Y; Heinemann L; Stevens L; Yeadon M; Barnes PJ; Chung KF; Adcock IM. (16 Jun 2011). Oxidative Stress-induced Antibodies to Carbonyl-modified Protein Correlate with Severity of COPD. Am J Respir Crit Care Med. DOI.
  • Caramori G; Adcock IM; Casolari P; Ito K; Jazrawi E; Tsaprouni L; Villetti G; Civelli M; et alCarnini C; Chung KF; Barnes PJ; Papi A. (Jun 2011). Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. THORAX. 66:521-527. DOI.
  • Dooms C; Barnes PJ. (2011). Epithelial Cell and Lung Cancer: Introduction. RESPIRATION. 81:2-3. DOI.
  • Adcock IM; Caramori G; Barnes PJ. (2011). Chronic obstructive pulmonary disease and lung cancer: new molecular insights. Respiration. 81:265-284. DOI.
  • Pridgeon C; Bugeon L; Donnelly L; Straschil U; Tudhope SJ; Fenwick P; Lamb JR; Barnes PJ; et alDallman MJ. (Jun 2011). Regulation of IL-17 in chronic inflammation in the human lung. Clin Sci (Lond). 120:515-524. DOI.
  • Mercado N; Thimmulappa R; Thomas CM; Fenwick PS; Chana KK; Donnelly LE; Biswal S; Ito K; et alBarnes PJ. (11 Mar 2011). Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun. 406:292-298. DOI.
  • Paredi P; Kharitonov SA; Barnes PJ. (2001). Measurement of exhaled hydrocarbons. Methods Mol Med. 56:109-118. DOI.
  • Mercado N; To Y; Ito K; Barnes PJ. (May 2011). Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ. J Pharmacol Exp Ther. 337:465-470. DOI.
  • Barnes PJ. (May 2011). Glucocorticosteroids: current and future directions. Br J Pharmacol. 163:29-43. DOI.
  • To M; Ito K; Ausin PM; Kharitonov SA; Barnes PJ. (Jul 2011). Osteoprotegerin in sputum is a potential biomarker in COPD. Chest. 140:76-83. DOI.
  • Paredi P; Usmani OS; Kharitonov SA; Siafakas NM; Pride NB; Barnes PJ. (Nov 2010). In memoriam Michael Goldman (1936-2010). EUR RESPIR J. 36:977-978. DOI.
  • Maneechotesuwan K; Ekjiratrakul W; Kasetsinsombat K; Wongkajornsilp A; Barnes PJ. (Oct 2010). Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase. J ALLERGY CLIN IMMUN. 126:754-U121. DOI.
  • Barnes PJ. (1 Oct 2010). Medicine. Neutrophils find smoke attractive. Science. 330:40-41. DOI.
  • Barnes PJ; Dweik RA; Gelb AF; Gibson PG; George SC; Grasemann H; Pavord ID; Ratjen F; et alSilkoff PE; Taylor DR; Zamel N. (Sep 2010). Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest. 138:682-692. DOI.
  • Barnes PJ. (Dec 2004). New drugs for asthma. Discov Med. 4:421-426.
  • Agusti A; Barnes PJ. (1 Jul 2010). What the Journal Would Like to Publish on Chronic Obstructive Pulmonary Disease. AM J RESP CRIT CARE. 182:1-2. DOI.
  • Salvi S; Barnes PJ. (10 Jul 2010). Is Exposure to Biomass Smoke the Biggest Risk Factor for COPD Globally?. CHEST. 138:3-6. DOI.
  • Barnes PJ. (2010). New therapies for chronic obstructive pulmonary disease. Med Princ Pract. 19:330-338. DOI.
  • Zhang JY; Yao X; Yu RB; Bai JL; Sun Y; Huang M; Adcock IM; Barnes PJ. (30 Apr 2010). Exhaled carbon monoxide in asthmatics: a meta-analysis. RESP RES. 11. DOI.
  • Joos GF; Barnes PJ. (Jun 2010). Inflammatory Airways Diseases and Clinical Allergy Assembly contribution to the celebration of 20 years of the ERS. EUR RESPIR J. 35:1197-1199. DOI.
  • Barnes PJ. (Jul 2010). New therapies for asthma: is there any progress?. Trends Pharmacol Sci. 31:335-343. DOI.
  • Barnes PJ. (2010). Inhaled corticosteroids in COPD: a controversy. Respiration. 80:89-95. DOI.
  • Barnes PJ. (Aug 2007). Introducing expert review of respiratory medicine. Expert Rev Respir Med. 1:1-2. DOI.
  • Montuschi P; Santonico M; Mondino C; Pennazza G; Mantini G; Martinelli E; Capuano R; Ciabattoni G; et alPaolesse R; Di Natale C; Barnes PJ; D'Amico A. (Apr 2010). Diagnostic Performance of an Electronic Nose, Fractional Exhaled Nitric Oxide, and Lung Function Testing in Asthma. CHEST. 137:790-796. DOI.
  • To Y; Ito K; Kizawa Y; Failla M; Ito M; Kusama T; Elliott WM; Hogg JC; et alAdcock IM; Barnes PJ. (1 Oct 2010). Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 182:897-904. DOI.
  • Barnes PJ. (Mar 2010). Chronic obstructive pulmonary disease: effects beyond the lungs. PLoS Med. 7:e1000220. DOI.
  • Paredi P; Goldman M; Alamen A; Ausin P; Usmani OS; Pride NB; Barnes PJ. (Mar 2010). Comparison of inspiratory and expiratory resistance and reactance in patients with asthma and chronic obstructive pulmonary disease. Thorax. 65:263-267. DOI.
  • Ford PA; Durham AL; Russell RE; Gordon F; Adcock IM; Barnes PJ. (Jun 2010). Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD. Chest. 137:1338-1344. DOI.
  • Barnes PJ. (31 May 2010). Mechanisms and resistance in glucocorticoid control of inflammation. J Steroid Biochem Mol Biol. 120:76-85. DOI.
  • Papi A; Caramori G; Adock IM; Barnes PJ. (Jan 2010). Rescue Treatment in Asthma Response. CHEST. 137:240-241. DOI.
  • Barnes PJ; Pocock SJ; Magnussen H; Iqbal A; Kramer B; Higgins M; Lawrence D. (Jun 2010). Integrating indacaterol dose selection in a clinical study in COPD using an adaptive seamless design. Pulm Pharmacol Ther. 23:165-171. DOI.
  • Charron CE; Chou PC; Coutts DJC; Kumar V; To M; Akashi K; Pinhu L; Griffiths M; et alAdcock IM; Barnes PJ; Ito K. (25 Dec 2009). Hypoxia-inducible Factor 1 alpha Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription. J BIOL CHEM. 284:36047-36054. DOI.
  • Barnes PJ; Celli BR. (Dec 2009). Comorbidities in COPD. EUR RESPIR J. 34:1498-1498. DOI.
  • Salvi SS; Barnes PJ. (12 Dec 2009). Chronic obstructive pulmonary disease in non-smokers Reply. LANCET. 374:1965-1966.
  • Varani K; Caramori G; Vincenzi F; Tosi A; Barczyk A; Contoli M; Casolari P; Triggiani M; et alHansel T; Leung E; Maclennan S; Barnes PJ; Chung KF; Adcock I; Papi A; Borea PA. (Apr 2010). Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease. FASEB J. 24:1192-1204. DOI.
  • Barnes PJ. (Dec 2009). Targeting the epigenome in the treatment of asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 6:693-696. DOI.
  • Barnes PJ. (Dec 2009). The Cytokine Network in Chronic Obstructive Pulmonary Disease. AM J RESP CELL MOL. 41:631-638. DOI.
  • Bateman ED; Rennard S; Barnes PJ; Dicpinigaitis PV; Gosens R; Gross NJ; Nadel JA; Pfeifer M; et alRacke K; Rabe KF; Rubin BK; Welte T; Wessler I. (Dec 2009). Alternative mechanisms for tiotropium. PULM PHARMACOL THER. 22:533-542. DOI.
  • Donnelly LE; Tudhope SJ; Fenwick PS; Barnes PJ. (Jul 2010). Effects of formoterol and salmeterol on cytokine release from monocyte-derived macrophages. Eur Respir J. 36:178-186. DOI.
  • Di Stefano A; Caramori G; Gnemmi I; Contoli M; Bristot L; Capelli A; Ricciardolo FLM; Magno F; et alD'Anna SE; Zanini A; Carbone M; Sabatini F; Usai C; Brun P; Chung KF; Barnes PJ; Papi A; Adcock IM; Balbi B. (Nov 2009). Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD. THORAX. 64:968-975. DOI.
  • Taylor AE; Finney-Hayward TK; Quint JK; Thomas CM; Tudhope SJ; Wedzicha JA; Barnes PJ; Donnelly LE. (May 2010). Defective macrophage phagocytosis of bacteria in COPD. Eur Respir J. 35:1039-1047. DOI.
  • Finney-Hayward TK; Popa MO; Bahra P; Li S; Poll CT; Gosling M; Nicholson AG; Russell RE; et alKon OM; Jarai G; Westwick J; Barnes PJ; Donnelly LE. (Sep 2010). Expression of transient receptor potential c6 channels in human lung macrophages. Am J Respir Cell Mol Biol. 43:296-304. DOI.
  • Brindicci C; Kharitonov SA; Ito M; Elliott MW; Hogg JC; Barnes PJ; Ito K. (1 Jan 2010). Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 181:21-30. DOI.
  • Barnes PJ. (Oct 2009). Histone deacetylase-2 and airway disease. Ther Adv Respir Dis. 3:235-243. DOI.
  • Cooper PR; Poll CT; Barnes PJ; Sturton RG. (Aug 2010). Involvement of IL-13 in tobacco smoke-induced changes in the structure and function of rat intrapulmonary airways. Am J Respir Cell Mol Biol. 43:220-226. DOI.
  • Caramori G; Casolari P; Di Gregorio C; Saetta M; Baraldo S; Boschetto P; Ito K; Fabbri LM; et alBarnes PJ; Adcock IM; Cavallesco G; Chung KF; Papi A. (Sep 2009). MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. HISTOPATHOLOGY. 55:321-331. DOI.
  • Hansel TT; Barnes PJ. (Aug 2009). New drugs for exacerbations of chronic obstructive pulmonary disease. LANCET. 374:744-755.
  • Salvi SS; Barnes PJ. (Aug 2009). Chronic obstructive pulmonary disease in non-smokers. LANCET. 374:733-743.
  • Ford PA; Russell RE; Barnes PJ. (2009). ICS and COPD: time to clear the air. Int J Chron Obstruct Pulmon Dis. 4:289-290.
  • Barnes PJ. (Aug 2009). Intrinsic asthma: not so different from allergic asthma but driven by superantigens?. CLIN EXP ALLERGY. 39:1145-1151. DOI.
  • Di Stefano A; Caramori G; Gnemmi I; Contoli M; Vicari C; Capelli A; Magno F; D'Anna SE; et alZanini A; Brun P; Casolari P; Chung KF; Barnes PJ; Papi A; Adcock I; Balbi B. (Aug 2009). T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. CLIN EXP IMMUNOL. 157:316-324. DOI.
  • Suissa S; Barnes PJ. (Jul 2009). Inhaled corticosteroids in COPD: the case against. EUR RESPIR J. 34:13-16. DOI.
  • Spears M; Donnelly I; Jolly L; Brannigan M; Ito K; McSharry C; Lafferty J; Chaudhuri R; et alBraganza G; Bareille P; Sweeney L; Adcock IM; Barnes PJ; Wood S; Thomson NC. (Jul 2009). Bronchodilatory Effect of the PPAR-gamma Agonist Rosiglitazone in Smokers With Asthma. CLIN PHARMACOL THER. 86:49-53. DOI.
  • Papi A; Caramori G; Adcock IM; Barnes PJ. (Jun 2009). Rescue Treatment in Asthma More Than As-Needed Bronchodilation. CHEST. 135:1628-1633. DOI.
  • Barnes PJ; Adcock IM. (30 May 2009). Glucocorticoid resistance in inflammatory diseases. Lancet. 373:1905-1917. DOI.
  • Spears M; Donnelly I; Jolly L; Brannigan M; Ito K; McSharry C; Lafferty J; Chaudhuri R; et alBraganza G; Adcock IM; Barnes PJ; Wood S; Thomson NC. (May 2009). Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. EUR RESPIR J. 33:1010-1017. DOI.
  • Cosio BG; Iglesias A; Rios A; Noguera A; Sala E; Ito K; Barnes PJ; Agusti A. (May 2009). Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD. THORAX. 64:424-429. DOI.
  • Maneechotesuwan K; Yao X; Ito K; Jazrawi E; Usmani OS; Adcock IM; Barnes PJ. (12 May 2009). Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease. PLoS Med. 6:e1000076. DOI.
  • Barnes PJ; Celli BR. (May 2009). Systemic manifestations and comorbidities of COPD. Eur Respir J. 33:1165-1185. DOI.
  • Osoata GO; Yamamura S; Ito M; Vuppusetty C; Adcock IM; Barnes PJ; Ito K. (3 Jul 2009). Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. Biochem Biophys Res Commun. 384:366-371. DOI.
  • Paredi P; Barnes PJ. (May 2009). The airway vasculature: recent advances and clinical implications. Thorax. 64:444-450. DOI.
  • Nakamaru Y; Vuppusetty C; Wada H; Milne JC; Ito M; Rossios C; Elliot M; Hogg J; et alKharitonov S; Goto H; Bemis JE; Elliott P; Barnes PJ; Ito K. (Sep 2009). A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J. 23:2810-2819. DOI.
  • Perttunen H; Moilanen E; Zhang XZ; Barnes PJ; Kankaanranta H. (Jun 2008). beta(2)-Agonists Potentiate Corticosteroid-Induced Neutrophil Survival. COPD. 5:163-169. DOI.
  • Wenzel SE; Barnes PJ; Bleecker ER; Bousquet J; Busse W; Dahlen SE; Holgate ST; Meyers DA; et alRabe KF; Antczak A; Baker J; Horvath I; Mark Z; Bernstein D; Kerwin E; Schlenker-Herceg R; Lo KH; Watt R; Barnathan ES; Chanez P; T03 Asthma Investigators. (1 Apr 2009). A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-alpha Blockade in Severe Persistent Asthma. AM J RESP CRIT CARE. 179:549-558. DOI.
  • Caramori G; Oates T; Nicholson AG; Casolari P; Ito K; Barnes PJ; Papi A; Adcock IM; et alChung KF. (Mar 2009). Activation of NF-kappa B transcription factor in asthma death. HISTOPATHOLOGY. 54:507-509. DOI.
  • Pedersen L; Lund TK; Molgaard E; Kharitonov SA; Barnes PJ; Backer V. (Feb 2009). The acute effect of swimming on airway inflammation in adolescent elite swimmers. J ALLERGY CLIN IMMUN. 123:502-504. DOI.
  • Adcock IM; Barnes PJ. (Feb 2009). Molecular Mechanisms of Corticosteroid Resistance Response. CHEST. 135:586-586. DOI.
  • Maneachotesuwan K; Wamanuttajinda V; Kasetsinsombat K; Huabprasert S; Yaikwawong M; Barnes PJ; Wongkajornsilp A. (Jan 2009). Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. J ALLERGY CLIN IMMUN. 123:239-248. DOI.
  • Osoata GO; Hanazawa T; Brindicci C; Ito M; Barnes PJ; Kharitonov S; Ito K. (Jun 2009). Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine. Chest. 135:1513-1520. DOI.
  • Finney-Hayward TK; Bahra P; Li S; Poll CT; Nicholson AG; Russell RE; Ford PA; Westwick J; et alFenwick PS; Barnes PJ; Donnelly LE. (May 2009). Leukotriene B4 release by human lung macrophages via receptor- not voltage-operated Ca2+ channels. Eur Respir J. 33:1105-1112. DOI.
  • Marwick JA; Caramori G; Stevenson CS; Casolari P; Jazrawi E; Barnes PJ; Ito K; Adcock IM; et alKirkham PA; Papi A. (1 Apr 2009). Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med. 179:542-548. DOI.
  • Ito K; Barnes PJ. (Jan 2009). COPD as a disease of accelerated lung aging. Chest. 135:173-180. DOI.
  • O'Byrne PM; Naya IP; Kallen A; Postma DS; Barnes PJ. (Dec 2008). Increasing Doses of Inhaled Corticosteroids Compared to Adding Long-Acting Inhaled beta(2)-Agonists in Achieving Asthma Control. CHEST. 134:1192-1199. DOI.
  • Barnes PJ. (Dec 2008). Emerging pharmacotherapies for COPD. Chest. 134:1278-1286. DOI.
  • Ito K; Herbert C; Siegle JS; Vuppusetty C; Hansbro N; Thomas PS; Foster PS; Barnes PJ; et alKumar RK. (Nov 2008). Steroid-Resistant Neutrophilic Inflammation in a Mouse Model of an Acute Exacerbation of Asthma. AM J RESP CELL MOL. 39:543-550. DOI.
  • Barnes PJ. (1 Dec 2008). Future treatments for chronic obstructive pulmonary disease and its comorbidities. Proc Am Thorac Soc. 5:857-864. DOI.
  • Barnes PJ. (Nov 2008). The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest. 118:3546-3556. DOI.
  • Marwick JA; Wallis G; Meja K; Kuster B; Bouwmeester T; Chakravarty P; Fletcher D; Whittaker PA; et alBarnes PJ; Ito K; Adcock IM; Kirkham PA. (19 Dec 2008). Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 377:797-802. DOI.
  • Barnes PJ. (Aug 2008). Role of GATA-3 in allergic diseases. CURR MOL MED. 8:330-334.
  • Lucidi V; Ciabattoni G; Bella S; Barnes PJ; Montuschi P. (15 Sep 2008). Exhaled 8-isoprostane and prostaglandin E-2 in patients with stable and unstable cystic fibrosis. FREE RADICAL BIO MED. 45:913-919. DOI.
  • Barnes PJ. (15 Sep 2008). Defective antioxidant gene regulation in COPD: A case for broccoli. AM J RESP CRIT CARE. 178:552-554. DOI.
  • Barnes PJ. (2009). Role of HDAC2 in the pathophysiology of COPD. Annu Rev Physiol. 71:451-464. DOI.
  • Kaur M; Holden NS; Wilson SM; Sukkar MB; Chung KF; Barnes PJ; Newton R; Giembycz MA. (Sep 2008). Effect of beta(2)-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A. AM J PHYSIOL-LUNG C. 295:L505-L514. DOI.
  • Bhavsar P; Hew M; Khorasani N; Torrego A; Barnes PJ; Adcock I; Chung KF. (Sep 2008). Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. THORAX. 63:784-790. DOI.
  • Adcock IM; Barnes PJ. (Aug 2008). Molecular mechanisms of corticosteroid resistance. CHEST. 134:394-401. DOI.
  • Brindicci C; Ito K; Torre O; Barnes PJ; Kharitonov SA. (Feb 2009). Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients. Chest. 135:353-367. DOI.
  • Sturton G; Persson C; Barnes PJ. (Jul 2008). Small airways: an important but neglected target in the treatment of obstructive airway diseases. TRENDS PHARMACOL SCI. 29:340-345. DOI.
  • Torre O; Olivieri D; Barnes PJ; Kharitonov SA. (Oct 2008). Feasibility and interpretation of FE(NO) measurements in asthma patients in general practice. Respir Med. 102:1417-1424. DOI.
  • Pedersen L; Lund TK; Barnes PJ; Kharitonov SA; Backer V. (Aug 2008). Airway responsiveness and inflammation in adolescent elite swimmers. J Allergy Clin Immunol. 122:322-327.e1. DOI.
  • Ahmad T; Barnes PJ; Adcock IM. (May 2008). Overcoming steroid insensitivity in smoking asthmatics. CURR OPIN INVEST DR. 9:470-477.
  • Barnes PJ. (Jun 2008). Frontrunners in novel pharmacotherapy of COPD. Curr Opin Pharmacol. 8:300-307. DOI.
  • Barnes PJ. (29 Apr 2008). A blood test for lung fibrosis. PLoS Med. 5:e98. DOI.
  • Erin EM; Zacharasiewicz AS; Nicholson GC; Tan AJ; Neighbour H; Engelstätter R; Hellwig M; Kon OM; et alBarnes PJ; Hansel TT. (Oct 2008). Rapid effect of inhaled ciclesonide in asthma: a randomized, placebo-controlled study. Chest. 134:740-745. DOI.
  • Cazzola M; MacNee W; Martinez FJ; Rabe KF; Franciosi LG; Barnes PJ; Brusasco V; Burge PS; et alCalverley PMA; Celli BR; Jones PW; Mahler DA; Make B; Miravitlles M; Page CP; Palange P; Parr D; Pistolesi M; Rennard SI; Molken MPRV; Stockley R; Sullivan SD; Wedzicha JA; Wouters EF. (Feb 2008). Outcomes for COPD pharmacological trials: from lung function to biomarkers. EUR RESPIR J. 31:416-468. DOI.
  • Virchow JC; Crompton GK; Dal Negro R; Pedersen S; Magnan A; Seidenbergf J; Barnes PJ. (Jan 2008). Importance of inhaler devices in the management of airway disease. RESP MED. 102:10-19. DOI.
  • Barnes PJ. (Mar 2008). Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 8:183-192. DOI.
  • Erin EM; Jenkins GR; Kong OM; Zacharasiewicz AS; Nicholson GC; Neighbour H; Tennant RC; Tan AJ; et alLeaker BR; Bush A; Jose PJ; Barnes PJ; Hansel TT. (15 Jan 2008). Optimized dialysis and protease inhibition of sputum dithiothreitol supernatants (Retracted article. See vol. 183, pg. 418, 2011). AM J RESP CRIT CARE. 177:132-141. DOI.
  • Costa C; Rufino R; Traves SL; Lapa e Silva JR; Barnes PJ; Donnelly LE. (Jan 2008). CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. CHEST. 133:26-33. DOI.
  • Maneechotesuwan K; Supawita S; Kasetsinsombat K; Wongkajornsilp A; Barnes PJ. (Jan 2008). Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids. J ALLERGY CLIN IMMUN. 121:43-50. DOI.
  • Barbaro MPF; Carpagnano GE; Spanevello A; Cagnazzo MG; Barnes PJ. (Oct 2007). Inflammation, oxidative stress and systemic effects in mild chronic obstructive pulmonary disease. INT J IMMUNOPATH PH. 20:753-763.
  • Montuschi P; Mondino C; Koch P; Ciabattoni G; Barnes PJ; Baviera G. (Dec 2007). Effects of Montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma. CHEST. 132:1876-1881.
  • Tudhope SJ; Catley MC; Fenwick PS; Russell RE; Rumsey WL; Newton R; Barnes PJ; Donnelly LE. (1 Nov 2007). The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells. J Immunol. 179:6237-6245.
  • Sturton RG; Trifilieff A; Nicholson AG; Barnes PJ. (Jan 2008). Pharmacological characterization of indacaterol, a novel once daily inhaled 2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices. J Pharmacol Exp Ther. 324:270-275. DOI.
  • Tudhope SJ; Finney-Hayward TK; Nicholson AG; Mayer RJ; Barnette MS; Barnes PJ; Donnelly LE. (Jan 2008). Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage. J Pharmacol Exp Ther. 324:306-312. DOI.
  • Barnes PJ. (8 Sep 2007). Using a combination inhaler (budesonide plus formoterol) as rescue therapy improves asthma control. BRIT MED J. 335:513-513. DOI.
  • Brindicci C; Ito K; Barnes PJ; Viaritonov SA. (Aug 2007). Effect of an inducible nitric oxide synthase inhibitor on differential Flow-exhaled nitric oxide in asthmatic patients and healthy volunteers. CHEST. 132:581-588. DOI.
  • Moschos SA; Jones SW; Perry MM; Williams AE; Erjefalt JS; Turner JJ; Barnes PJ; Sproat BS; et alGait MJ; Lindsay MA. (Sep 2007). Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity. Bioconjug Chem. 18:1450-1459. DOI.
  • Barnes PJ. (May 2007). Chronic obstructive pulmonary disease: A growing but neglected global epidemic. PLOS MED. 4:779-780. DOI.
  • Barnes PJ. (2002). Glucocorticoids and asthma. E SCHERING RES FDN W. 40:1-23.
  • Barnes PJ. (Oct 2004). The size of the problem of managing asthma. RESP MED. 98:S4-S8.
  • Baraldi E; de Jongste JD; Gaston B; Alving K; Barnes PJ; Bisgaard H; Bush A; Gaultier C; et alGrasemann H; Hunt JF; Kissoon N; Piacentini GL; Ratjen F; Silkoff P; Stick S. (2002). Measurement of exhaled nitric oxide in children, 2001 ERS/ATS Statement. Eur Respir J. 20:223-237.
  • Barnes PJ. (2001). Modern management of COPD in the elderly. Ann Longterm Care. 9:51-56.
  • Barnes PJ. (2002). Are mast cells still important in asthma?. Rev Fr Allergol Immunol Clin. 42:20-27.
  • Barnes PJ. (2001). Cytokine modulators for allergic diseases. Curr Opin Allergy Clin Immunol. 1:555-560.
  • Erin EM; Williams TJ; Barnes PJ; Hansel TT. (2002). Eotaxin receptor (CCR3) antagonism in asthma and allergic disease. Curr Drug Targets - Inflammation & Allergy. 1:201-214.
  • Hansel TT; Barnes PJ. (2001). Letter of reply: Eosinophils and airway hyperresponsiveness. Lancet. 357:1446.
  • Hansel TT; Barnes PJ. (2001). Novel drugs for treating asthma. Curr Allergy Asthma Rep. 1:164-173.
  • Kharitonov SA; Barnes PJ. (2001). Exhaled markers of inflammation. Curr Opin Allergy Clin Immunol. 1:217-224.
  • Maneechotesuwan K; Essilfie-Quaye S; Kharitonov SA; Adcock IM; Barnes PJ. (Jul 2007). Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils. Chest. 132:98-105. DOI.
  • Barnes PJ. (1 May 2007). Unexpected failure of anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease. AM J RESP CRIT CARE. 175:866-867. DOI.
  • Celli BR; Barnes PJ. (Jun 2007). Exacerbations of chronic obstructive pulmonary disease. Eur Respir J. 29:1224-1238. DOI.
  • Newton R; Holden NS; Catley MC; Oyelusi W; Leigh R; Proud D; Barnes PJ. (May 2007). Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule I kappa B kinase inhibitors. J PHARMACOL EXP THER. 321:734-742. DOI.
  • Barnes PJ. (24 May 2007). Prevention of death in COPD. N Engl J Med. 356:2211. DOI.
  • Brindicci C; Ito K; Barnes PJ; Kharitonov SA. (May 2007). Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity. Chest. 131:1353-1362. DOI.
  • Paredi P; Ward S; Cramer D; Barnes PJ; Kharitonov SA. (Apr 2007). Normal bronchial blood flow in COPD is unaffected by inhaled corticosteroids and correlates with exhaled nitric oxide. Chest. 131:1075-1081. DOI.
  • Barnes PJ. (May 2007). New molecular targets for the treatment of neutrophilic diseases. J Allergy Clin Immunol. 119:1055-1062. DOI.
  • Barnes PJ. (Mar 2007). Scientific rationale for using a single inhaler for asthma control. Eur Respir J. 29:587-595. DOI.
  • Erin EM; Kon OM; Barnes PJ; Hansel TT. (1 Feb 2007). Anti-tumor necrosis factor-alpha in asthma. AM J RESP CRIT CARE. 175:288-289.
  • Barnes PJ. (Dec 2005). Emerging targets for COPD therapy. Curr Drug Targets Inflamm Allergy. 4:675-683.
  • Erin EM; Kon OM; Barnes PJ; Hansel TT. (15 Jan 2007). Study of infliximab treatment in asthma - From the authors. AM J RESP CRIT CARE. 175:196-197.
  • Maneechotesuwan K; Xin Y; Ito K; Jazrawi E; Lee KY; Usmani OS; Barnes PJ; Adcock IM. (15 Feb 2007). Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3. J Immunol. 178:2491-2498.
  • Ford PA; Barnes PJ; Usmani OS. (27 Jan 2007). Chronic cough and Holmes-Adie syndrome. Lancet. 369:342. DOI.
  • Barnes PJ. (2002). Advances in chronic obstructive pulmonary disease. Trans Med Soc Lond. 119:41-51.
  • Barnes PJ. (2007). The problem of cough and development of novel antitussives. Pulm Pharmacol Ther. 20:416-422. DOI.
  • Williams AE; Moschos SA; Perry MM; Barnes PJ; Lindsay MA. (Feb 2007). Maternally imprinted microRNAs are differentially expressed during mouse and human lung development. Dev Dyn. 236:572-580. DOI.
  • Adcock IM; Ito K; Barnes PJ. (Dec 2005). Histone deacetylation: an important mechanism in inflammatory lung diseases. COPD. 2:445-455.
  • Kraft M; Barnes PJ. (1 Nov 2006). Beyond the Dutch hypothesis. AM J RESP CRIT CARE. 174:1057-1057.
  • Barnes PJ. (1 Nov 2006). Rebuttal by Dr. Barnes. AM J RESP CRIT CARE. 174:974-974. DOI.
  • Barnes PJ. (1 Nov 2006). Treatment with (R)-albuterol has no advantage over racemic albuterol. AM J RESP CRIT CARE. 174:969-972. DOI.
  • Kharitonov SA; Barnes PJ. (Nov 2006). Exhaled biomarkers. Chest. 130:1541-1546. DOI.
  • Vasavda N; Eichholtz T; Takahashi A; Affleck K; Matthews JG; Barnes PJ; Adcock IM. (Nov 2006). Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma. J Allergy Clin Immunol. 118:1090-1096. DOI.
  • Moreno L; Perez-Vizcaino F; Harrington L; Faro R; Sturton G; Barnes PJ; Mitchell JA. (2006). Pharmacology of airways and vessels in lung slices in situ: role of endogenous dilator hormones. Respir Res. 7:111. DOI.
  • Biddiscombe MF; Barnes PJ; Usmani OS. (2006). Generating monodisperse pharmacological aerosols using the spinning-top aerosol generator. J Aerosol Med. 19:245-253. DOI.
  • Barnes PJ. (Nov 2006). New therapies for asthma. Trends Mol Med. 12:515-520. DOI.
  • Barnes PJ. (2006). Beclometasone dipropionate/formoterol in an HFA-propelled pressurised metered-dose inhaler. DRUGS. 66:1484-1484.
  • Barnes PJ. (Apr 2004). Alveolar macrophages as orchestrators of COPD. COPD. 1:59-70. DOI.
  • Montuschi P; Mondino C; Koch P; Barnes PJ; Ciabattoni G. (Aug 2006). Effects of a leukotriene receptor antagonist on exhaled leukotriene E-4 and prostanoids in children with asthma. J ALLERGY CLIN IMMUN. 118:347-353. DOI.
  • Crompton GK; Barnes PJ; Broeders M; Corrigan C; Corbetta L; Dekhuijzen R; Dubus JC; Magnan A; et alMassone F; Sanchis J; Viejo JL; Voshaar T. (Sep 2006). The need to improve inhalation technique in Europe: A report from the Aerosol Drug Management Improvement Team. RESP MED. 100:1479-1494. DOI.
  • Barnes PJ. (Sep 2006). Theophylline for COPD. Thorax. 61:742-744. DOI.
  • Smith SJ; Fenwick PS; Nicholson AG; Kirschenbaum F; Finney-Hayward TK; Higgins LS; Giembycz MA; Barnes PJ; et alDonnelly LE. (Oct 2006). Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages. Br J Pharmacol. 149:393-404. DOI.
  • Barnes PJ. (1 Aug 2006). Against the Dutch hypothesis: Asthma and chronic obstructive pulmonary disease are distinct diseases. AM J RESP CRIT CARE. 174:240-243. DOI.
  • Barnes PJ. (2006). Beclometasone Dipropionate/Formoterol in an HFA-Propelled Pressurised Metered-Dose Inhaler: A Viewpoint by Peter J. Barnes. Drugs. 66:1484-1485. Publisher weblink.
  • Donnelly LE; Barnes PJ. (Oct 2006). Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease. Trends Pharmacol Sci. 27:546-553. DOI.
  • Barnes PJ. (3 Aug 2006). Allergy: The history of a modern malady. NATURE. 442:513-513. DOI.
  • Barnes PJ. (29 Jul 2006). ABC of chronic obstructive pulmonary disease. Future treatments. BMJ. 333:246-248. DOI.
  • Erin EM; Leaker BR; Nicholson GC; Tan AJ; Green LM; Neighbour H; Zacharasiewicz AS; Turner J; et alBarnathan ES; Kon OM; Barnes PJ; Hansel TT. (1 Oct 2006). The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma. Am J Respir Crit Care Med. 174:753-762. DOI.
  • Hansel TT; Benezet O; Kafé H; Ponitz HH; Cheung D; Engelstätter R; Barnes PJ. (Jun 2006). A multinational, 12-week, randomized study comparing the efficacy and tolerability of ciclesonide and budesonide in patients with asthma. Clin Ther. 28:906-920. DOI.
  • Barnes PJ. (Sep 2006). Transcription factors in airway diseases. Lab Invest. 86:867-872. DOI.
  • Invernizzi G; Boffi R; Ruprecht AA; Barnes PJ; Kharitonov SA; Paredi P. (May 2006). Real-time measurement of particulate matter deposition in the lung. BIOMARKERS. 11:221-232. DOI.
  • Barczyk A; Pierzchała W; Kon OM; Cosio B; Adcock IM; Barnes PJ. (Jun 2006). Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease. J Allergy Clin Immunol. 117:1484-1492. DOI.
  • Lex C; Zacharasiewicz A; Payne DNR; Wilson NM; Nicholson AG; Kharitonov SA; Barnes PJ; Bush A. (7 Apr 2006). Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: A pilot study. RESP RES. 7. DOI.
  • Barnes PJ. (22 Feb 1996). Is immunotherapy for asthma worthwhile?. NEW ENGL J MED. 334:531-532.
  • Hallsworth MP; Giembycz MA; Barnes PJ; Lee TH. (Jan 1996). Cyclic AMP-elevating agents prolong or inhibit eosinophil survival depending on prior exposure to GM-CSF. BRIT J PHARMACOL. 117:79-86.
  • Fuller RW; Maxwell DL; Conradson TB; Dixon CM; Barnes PJ. (Sep 1987). Circulatory and respiratory effects of infused adenosine in conscious man. Br J Clin Pharmacol. 24:309-317.
  • Barnes PJ. (1988). Nocturnal asthma. Postgrad Med J. 64 Suppl 4:68-73.
  • Mak JC; Barnes PJ. (Sep 1988). Autoradiographic localization of calcitonin gene-related peptide (CGRP) binding sites in human and guinea pig lung. Peptides. 9:957-963.
  • McCormack DG; Salonen RO; Barnes PJ. (1989). Effect of sensory neuropeptides on canine bronchial and pulmonary vessels in vitro. Life Sci. 45:2405-2412.
  • Barnes PJ. (1989). Effects of nedocromil sodium on airway microvascular leakage and neural reflexes. Drugs. 37 Suppl 1:94-100.
  • Chung KF; Dent G; Barnes PJ. (Feb 1989). Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man. Thorax. 44:102-107.
  • Chung KF; Barnes PJ. (Feb 1989). Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects. Thorax. 44:108-115.
  • Barnes PJ. (Mar 1989). Muscarinic receptor subtypes: implications for lung disease. Thorax. 44:161-167.
  • Ichinose M; Barnes PJ. (25 Apr 1989). Inhibitory histamine H3-receptors on cholinergic nerves in human airways. Eur J Pharmacol. 163:383-386.
  • Rogers DF; Barnes PJ. (29 Apr 1989). Opioid inhibition of neurally mediated mucus secretion in human bronchi. Lancet. 1:930-932.
  • Ichinose M; Stretton CD; Schwartz JC; Barnes PJ. (May 1989). Histamine H3-receptors inhibit cholinergic neurotransmission in guinea-pig airways. Br J Pharmacol. 97:13-15.
  • Kroegel C; Yukawa T; Dent G; Venge P; Chung KF; Barnes PJ. (15 May 1989). Stimulation of degranulation from human eosinophils by platelet-activating factor. J Immunol. 142:3518-3526.
  • Ukena D; Krogel C; Dent G; Yukawa T; Sybrecht G; Barnes PJ. (15 May 1989). PAF-receptors on eosinophils: identification with a novel ligand, [3H]WEB 2086. Biochem Pharmacol. 38:1702-1705.
  • McCusker MT; Chung KF; Roberts NM; Barnes PJ. (Jun 1989). Effect of topical capsaicin on the cutaneous responses to inflammatory mediators and to antigen in man. J Allergy Clin Immunol. 83:1118-1124.
  • Kioumis I; Ukena D; Barnes PJ. (Jun 1989). Effect of nedocromil sodium on down-regulation of pulmonary beta-adrenoceptors. Clin Sci (Lond). 76:599-602.
  • Stretton CD; Barnes PJ. (Jul 1989). Cholecystokinin-octapeptide constricts guinea-pig and human airways. Br J Pharmacol. 97:675-682.
  • Belvisi MG; Ichinose M; Barnes PJ. (Aug 1989). Modulation of non-adrenergic, non-cholinergic neural bronchoconstriction in guinea-pig airways via GABAB-receptors. Br J Pharmacol. 97:1225-1231.
  • Lammers JW; Minette P; McCusker MT; Chung KF; Barnes PJ. (Aug 1989). Capsaicin-induced bronchodilation in mild asthmatic subjects: possible role of nonadrenergic inhibitory system. J Appl Physiol. 67:856-861.
  • Barnes PJ. (Aug 1989). Airway receptors. Postgrad Med J. 65:532-542.
  • McCormack DG; Mak JC; Coupe MO; Barnes PJ. (Sep 1989). Calcitonin gene-related peptide vasodilation of human pulmonary vessels. J Appl Physiol. 67:1265-1270.
  • Chung KF; Cuss FM; Barnes PJ. (Sep 1989). Platelet activating factor: effects on bronchomotor tone and bronchial responsiveness in human beings. Allergy Proc. 10:333-337.
  • Barnes PJ; Chung KF. (16 Sep 1989). Difficult asthma. BMJ. 299:695-698.
  • McCormack DG; Barnes PJ; Evans TW. (Oct 1989). Purinoceptors in the pulmonary circulation of the rat and their role in hypoxic vasoconstriction. Br J Pharmacol. 98:367-372.
  • Dent G; Ukena D; Sybrecht GW; Barnes PJ. (10 Oct 1989). [3H]WEB 2086 labels platelet activating factor receptors in guinea pig and human lung. Eur J Pharmacol. 169:313-316.
  • Liu SF; McCormack DG; Evans TW; Barnes PJ. (Nov 1989). Evidence for two P2-purinoceptor subtypes in human small pulmonary arteries. Br J Pharmacol. 98:1014-1020.
  • Rhoden KJ; Barnes PJ. (21 Nov 1989). Epithelial modulation of non-adrenergic, non-cholinergic and vasoactive intestinal peptide-induced responses: role of neutral endopeptidase. Eur J Pharmacol. 171:247-250.
  • Nichol GM; Nix A; Chung KF; Barnes PJ. (Dec 1989). Characterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma. Thorax. 44:1009-1014.
  • Stretton CD; Belvisi MG; Barnes PJ. (Dec 1989). The effect of sensory nerve depletion on cholinergic neurotransmission in guinea-pig airways. Br J Pharmacol. 98 Suppl:782P.
  • Stretton CD; Belvisi MG; Barnes PJ. (Dec 1989). Neuropeptide Y modulates non-adrenergic, non-cholinergic neural bronchoconstriction in vivo and in vitro. Br J Pharmacol. 98 Suppl:781P.
  • Liu SF; McCormack DG; Evans TW; Barnes PJ. (Dec 1989). Characterization and distribution of P2-purinoceptor subtypes in rat pulmonary vessels. J Pharmacol Exp Ther. 251:1204-1210.
  • Minette PA; Lammers JW; Dixon CM; McCusker MT; Barnes PJ. (Dec 1989). A muscarinic agonist inhibits reflex bronchoconstriction in normal but not in asthmatic subjects. J Appl Physiol. 67:2461-2465.
  • Stretton CD; Belvisi MG; Barnes PJ. (Dec 1989). Sensory nerve depletion potentiates non-adrenergic, non-cholinergic inhibitory nerves in guinea-pig trachea. Br J Pharmacol. 98 Suppl:780P.
  • Ichinose M; Barnes PJ. (12 Dec 1989). Histamine H3-receptors modulate nonadrenergic noncholinergic neural bronchoconstriction in guinea-pig in vivo. Eur J Pharmacol. 174:49-55.
  • Rogers DF; Aursudkij B; Barnes PJ. (19 Dec 1989). Effects of tachykinins on mucus secretion in human bronchi in vitro. Eur J Pharmacol. 174:283-286.
  • Barnes PJ. (1990). The role of neurotransmitters in bronchial asthma. Lung. 168 Suppl:57-65.
  • Barnes PJ. (1990). Neuropeptides as modulators of airway function. Agents Actions Suppl. 31:175-196.
  • Rhoden KJ; Barnes PJ. (Jan 1990). Potentiation of nonadrenergic neural relaxation in guinea pig airways by a cyclic cAMP phosphodiesterase inhibitor. J Pharmacol Exp Ther. 252:396-402.
  • Ichinose M; Belvisi MG; Barnes PJ. (Jan 1990). Histamine H3-receptors inhibit neurogenic microvascular leakage in airways. J Appl Physiol. 68:21-25.
  • Barnes PJ. (Jan 1990). Neurogenic inflammation in airways and its modulation. Arch Int Pharmacodyn Ther. 303:67-82.
  • Barnes PJ. (1990). Neural control of airway function: new perspectives. Mol Aspects Med. 11:351-423.
  • Barnes PJ. (1990). Reactive oxygen species and airway inflammation. Free Radic Biol Med. 9:235-243.
  • Mak JC; Barnes PJ. (Feb 1990). Peripheral type benzodiazepine receptors in human and guinea pig lung: characterization and autoradiographic mapping. J Pharmacol Exp Ther. 252:880-885.
  • Barnes PJ. (Feb 1990). Effect of corticosteroids on airway hyperresponsiveness. Am Rev Respir Dis. 141:S70-S76.
  • Nix A; Nichol GM; Robson A; Barnes PJ; Chung KF. (Mar 1990). Effect of formoterol, a long-lasting beta 2-adrenoceptor agonist, against methacholine-induced bronchoconstriction. Br J Clin Pharmacol. 29:321-324.
  • Ichinose M; Barnes PJ. (Mar 1990). A potassium channel activator modulates both excitatory noncholinergic and cholinergic neurotransmission in guinea pig airways. J Pharmacol Exp Ther. 252:1207-1212.
  • Minette PA; Barnes PJ. (Mar 1990). Muscarinic receptor subtypes in lung. Clinical implications. Am Rev Respir Dis. 141:S162-S165.
  • Evans TW; Rogers DF; Belvisi MG; Rohde JA; Chung KF; Barnes PJ. (Mar 1990). Endotoxin-induced plasma exudation in guinea-pig airways in vivo and the effect of neutrophil depletion. Eur Respir J. 3:299-303.
  • Chung KF; Rogers DF; Barnes PJ; Evans TW. (Mar 1990). The role of increased airway microvascular permeability and plasma exudation in asthma. Eur Respir J. 3:329-337.
  • Yukawa T; Read RC; Kroegel C; Rutman A; Chung KF; Wilson R; Cole PJ; Barnes PJ. (Apr 1990). The effects of activated eosinophils and neutrophils on guinea pig airway epithelium in vitro. Am J Respir Cell Mol Biol. 2:341-353.
  • Belvisi MG; Stretton CD; Barnes PJ. (May 1990). Modulation of cholinergic neurotransmission in guinea-pig airways by opioids. Br J Pharmacol. 100:131-137.
  • Lötvall JO; Skoogh BE; Barnes PJ; Chung KF. (May 1990). Effects of aerosolised substance P on lung resistance in guinea-pigs: a comparison between inhibition of neutral endopeptidase and angiotensin-converting enzyme. Br J Pharmacol. 100:69-72.
  • Barnes PJ. (May 1990). Muscarinic receptors in airways: recent developments. J Appl Physiol. 68:1777-1785.
  • Giembycz MA; Kroegel C; Barnes PJ. (1 May 1990). Platelet activating factor stimulates cyclo-oxygenase activity in guinea pig eosinophils. Concerted biosynthesis of thromboxane A2 and E-series prostaglandins. J Immunol. 144:3489-3497.
  • Barnes PJ; Belvisi MG; Rogers DF. (May 1990). Modulation of neurogenic inflammation: novel approaches to inflammatory disease. Trends Pharmacol Sci. 11:185-189.
  • McCormack DG; Barnes PJ; Evans TW. (May 1990). Effects of dopexamine hydrochloride on hypoxic pulmonary vasoconstriction in isolated rat lung. Crit Care Med. 18:520-523.
  • Yukawa T; Ukena D; Kroegel C; Chanez P; Dent G; Chung KF; Barnes PJ. (Jun 1990). Beta 2-adrenergic receptors on eosinophils. Binding and functional studies. Am Rev Respir Dis. 141:1446-1452.
  • Barnes PJ. (Jun 1990). Molecular biology and respiratory disease. 5. Molecular biology of receptors: implications for lung disease. Thorax. 45:482-488.
  • Mak JC; Barnes PJ. (Jun 1990). Autoradiographic visualization of muscarinic receptor subtypes in human and guinea pig lung. Am Rev Respir Dis. 141:1559-1568.
  • Ventresca PG; Nichol GM; Barnes PJ; Chung KF. (Jul 1990). Inhaled furosemide inhibits cough induced by low chloride content solutions but not by capsaicin. Am Rev Respir Dis. 142:143-146.
  • Liu SF; Yacoub M; Barnes PJ. (Jul 1990). Effect of histamine on human bronchial arteries in vitro. Naunyn Schmiedebergs Arch Pharmacol. 342:90-93.
  • Tokuyama K; Kuo HP; Rohde JA; Barnes PJ; Rogers DF. (Aug 1990). Neural control of goblet cell secretion in guinea pig airways. Am J Physiol. 259:L108-L115.
  • Stretton CD; Belvisi MG; Barnes PJ. (10 Aug 1990). Sensory nerve depletion potentiates inhibitory non-adrenergic, non-cholinergic nerves in guinea-pig airways. Eur J Pharmacol. 184:333-337.
  • Nichol G; Nix A; Barnes PJ; Chung KF. (Sep 1990). Prostaglandin F2 alpha enhancement of capsaicin induced cough in man: modulation by beta 2 adrenergic and anticholinergic drugs. Thorax. 45:694-698.
  • Nichol GM; Alton EW; Nix A; Geddes DM; Chung KF; Barnes PJ. (Sep 1990). Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis. 142:576-580.
  • Crawley DE; Liu SF; Evans TW; Barnes PJ. (Sep 1990). Inhibitory role of endothelium-derived relaxing factor in rat and human pulmonary arteries. Br J Pharmacol. 101:166-170.
  • Lötvall JO; Lemen RJ; Hui KP; Barnes PJ; Chung KF. (Oct 1990). Airflow obstruction after substance P aerosol: contribution of airway and pulmonary edema. J Appl Physiol. 69:1473-1478.
  • Rogers DF; Dijk S; Barnes PJ. (Nov 1990). Bradykinin-induced plasma exudation in guinea-pig airways: involvement of platelet activating factor. Br J Pharmacol. 101:739-745.
  • Stretton CD; Mak JC; Belvisi MG; Yacoub MH; Barnes PJ. (Nov 1990). Cholinergic control of human airways in vitro following extrinsic denervation of the human respiratory tract by heart-lung transplantation. Am Rev Respir Dis. 142:1030-1033.
  • Stretton CD; Belvisi MG; Barnes PJ. (Dec 1990). Neuropeptide Y modulates non-adrenergic, non-cholinergic neural bronchoconstriction in vivo and in vitro. Neuropeptides. 17:163-170.
  • Barnes PJ; Boschetto P; Rogers DF; Belvisi M; Roberts N; Chung KF; Evans TW. (Dec 1990). Effects of treatment on airway microvascular leakage. Eur Respir J Suppl. 12:663s-670s.
  • McCormack DG; Barnes PJ; Evans TW. (Dec 1990). Platelet-activating factor: evidence against a role in hypoxic pulmonary vasoconstriction. Crit Care Med. 18:1398-1402.
  • Lötvall JO; Skoogh BE; Lemen RJ; Elwood W; Barnes PJ; Chung KF. (Dec 1990). Bronchoconstriction induced by inhaled sodium metabisulfite in the guinea pig. Effect of capsaicin pretreatment and of neutral endopeptidase inhibition. Am Rev Respir Dis. 142:1390-1395.
  • Liu SF; Cai YN; Evans TW; McCormack DG; Barer GR; Barnes PJ. (4 Dec 1990). Ligustrazine is a vasodilator of human pulmonary and bronchial arteries. Eur J Pharmacol. 191:345-350.
  • Barnes PJ. (1991). Histamine receptors in the lung. Agents Actions Suppl. 33:103-122.
  • Barnes PJ. (1991). Platelet activating factor and asthma. Ann N Y Acad Sci. 629:193-204.
  • Barnes PJ. (Jan 1991). Future drug therapy for asthma. Clin Exp Allergy. 21 Suppl 1:80-85.
  • Verleden GM; Belvisi MG; Stretton CD; Barnes PJ. (Jan 1991). Nedocromil sodium modulates nonadrenergic, noncholinergic bronchoconstrictor nerves in guinea pig airways in vitro. Am Rev Respir Dis. 143:114-118.
  • Liu SF; Crawley DE; Barnes PJ; Evans TW. (Jan 1991). Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats. Am Rev Respir Dis. 143:32-37.
  • Tokuyama K; Lötvall JO; Löfdahl CG; Barnes PJ; Chung KF. (25 Jan 1991). Inhaled formoterol inhibits histamine-induced airflow obstruction and airway microvascular leakage. Eur J Pharmacol. 193:35-39.
  • Lötvall JO; Hui KP; Löfdahl CG; Barnes PJ; Chung KF. (Feb 1991). Capsaicin pretreatment does not inhibit allergen-induced airway microvascular leakage in guinea pig. Allergy. 46:105-108.
  • Hamid QA; Mak JC; Sheppard MN; Corrin B; Venter JC; Barnes PJ. (25 Feb 1991). Localization of beta 2-adrenoceptor messenger RNA in human and rat lung using in situ hybridization: correlation with receptor autoradiography. Eur J Pharmacol. 206:133-138.
  • Mak JC; Barnes PJ. (26 Feb 1991). Autoradiographic visualization of bradykinin receptors in human and guinea pig lung. Eur J Pharmacol. 194:37-43.
  • Barnes PJ. (Mar 1991). Neuropeptides and asthma. Am Rev Respir Dis. 143:S28-S32.
  • Stretton CD; Belvisi MG; Barnes PJ. (Mar 1991). Modulation of neural bronchoconstrictor responses in the guinea pig respiratory tract by vasoactive intestinal peptide. Neuropeptides. 18:149-157.
  • Chung KF; Podgorski MR; Goulding NJ; Godolphin JL; Sharland PR; O'Connor B; Flower RJ; Barnes PJ. (Mar 1991). Circulating autoantibodies to recombinant lipocortin-1 in asthma. Respir Med. 85:121-124.
  • Hui KP; Taylor IK; Taylor GW; Rubin P; Kesterson J; Barnes NC; Barnes PJ. (Mar 1991). Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. Thorax. 46:184-189.
  • Dent G; Giembycz MA; Rabe KF; Barnes PJ. (Jun 1991). Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors. Br J Pharmacol. 103:1339-1346.
  • O'Connor BJ; Chung KF; Chen-Worsdell YM; Fuller RW; Barnes PJ. (Jun 1991). Effect of inhaled furosemide and bumetanide on adenosine 5'-monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 143:1329-1333.
  • Elwood W; Lötvall JO; Barnes PJ; Chung KF. (Jun 1991). Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways. Am Rev Respir Dis. 143:1340-1344.
  • Belvisi MG; Stretton D; Barnes PJ. (6 Jun 1991). Nitric oxide as an endogenous modulator of cholinergic neurotransmission in guinea-pig airways. Eur J Pharmacol. 198:219-221.
  • Belvisi MG; Stretton CD; Barnes PJ. (1 Jul 1991). Bombesin-induced bronchoconstriction in the guinea pig: mode of action. J Pharmacol Exp Ther. 258:36-41.
  • Barnes PJ. (Sep 1991). Preventative therapy in adults with asthma. Respir Med. 85:355-357.
  • Barnes PJ. (Oct 1991). Biochemistry of asthma. Trends Biochem Sci. 16:365-369.
  • Shock A; Rabe KF; Dent G; Chambers RC; Gray AJ; Chung KF; Barnes PJ; Laurent GJ. (Oct 1991). Eosinophils adhere to and stimulate replication of lung fibroblasts 'in vitro'. Clin Exp Immunol. 86:185-190.
  • Barnes PJ; Baraniuk JN; Belvisi MG. (Nov 1991). Neuropeptides in the respiratory tract. Part I. Am Rev Respir Dis. 144:1187-1198.
  • Hamid Q; Belvisi MG; Stretton D; Rohde J; Harmar AJ; Barnes PJ. (Nov 1991). Localization of beta pre-protachykinin mRNA in nodose ganglion. Neuropeptides. 20:145-150.
  • Tokuyama K; Lötvall JO; Morikawa A; Barnes PJ; Chung KF. (Nov 1991). Role of thromboxane A2 in airway microvascular leakage induced by inhaled platelet-activating factor. J Appl Physiol. 71:1729-1734.
  • Lötvall JO; Elwood W; Tokuyama K; Barnes PJ; Chung KF. (Dec 1991). Differential effects of phosphoramidon on neurokinin A- and substance P-induced airflow obstruction and airway microvascular leakage in guinea-pig. Br J Pharmacol. 104:945-949.
  • Barnes PJ; Baraniuk JN; Belvisi MG. (Dec 1991). Neuropeptides in the respiratory tract. Part II. Am Rev Respir Dis. 144:1391-1399.
  • Rabe KF; Giembycz MA; Dent G; Barnes PJ. (1992). Activation of guinea pig eosinophil respiratory burst by leukotriene B4: role of protein kinase C. Fundam Clin Pharmacol. 6:353-358.
  • Barnes PJ; Chung KF. (Jan 1992). Questions about inhaled beta 2-adrenoceptor agonists in asthma. Trends Pharmacol Sci. 13:20-23.
  • Barnes PJ. (1992). Neurogenic inflammation and asthma. J Asthma. 29:165-180.
  • Barnes PJ. (Jan 1992). Asthma. New therapeutic approaches. Br Med Bull. 48:231-247.
  • Barnes PJ. (1992). Effect of bradykinin on airway function. Agents Actions Suppl. 38 ( Pt 3):432-438.
  • Baraniuk JN; Silver PB; Lundgren JD; Cole P; Kaliner MA; Barnes PJ. (Jan 1992). Bombesin stimulates human nasal mucous and serous cell secretion in vivo. Am J Physiol. 262:L48-L52.
  • Belvisi MG; Stretton CD; Yacoub M; Barnes PJ. (14 Jan 1992). Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. Eur J Pharmacol. 210:221-222.
  • Liu SF; Crawley DE; Evans TW; Barnes PJ. (Feb 1992). Endothelium-dependent nonadrenergic, noncholinergic neural relaxation in guinea pig pulmonary artery. J Pharmacol Exp Ther. 260:541-548.
  • Stretton D; Miura M; Belvisi MG; Barnes PJ. (15 Feb 1992). Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves. Proc Natl Acad Sci U S A. 89:1325-1329.
  • Stretton D; Belvisi MG; Barnes PJ. (Mar 1992). The effect of sensory nerve depletion on cholinergic neurotransmission in guinea pig airways. J Pharmacol Exp Ther. 260:1073-1080.
  • Belvisi MG; Stretton CD; Verleden GM; Ledingham SJ; Yacoub MH; Barnes PJ. (Mar 1992). Inhibition of cholinergic neurotransmission in human airways by opioids. J Appl Physiol. 72:1096-1100.
  • McCormack DG; Crawley DE; Barnes PJ; Evans TW. (Mar 1992). Bleomycin-induced lung injury in rats selectively abolishes hypoxic pulmonary vasoconstriction: evidence against a role for platelet-activating factor. Clin Sci (Lond). 82:259-264.
  • Liu SF; Dewar A; Crawley DE; Barnes PJ; Evans TW. (Mar 1992). Effect of tumor necrosis factor on hypoxic pulmonary vasoconstriction. J Appl Physiol. 72:1044-1049.
  • Madden BP; Hodson ME; Yacoub MH; Alton EW; Barnes PJ; Denison DM; Kay AB; Newman-Taylor A; et alGeddes DM. (28 Mar 1992). Heart-lung transplantation for cystic fibrosis. BMJ. 304:835-836.
  • Sakamoto T; Elwood W; Barnes PJ; Chung KF. (31 Mar 1992). Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig. Eur J Pharmacol. 213:367-373.
  • Crawley DE; Liu SF; Barnes PJ; Evans TW. (Apr 1992). Endothelin-3 is a potent pulmonary vasodilator in the rat. J Appl Physiol. 72:1425-1431.
  • Barnes PJ. (May 1992). New aspects of asthma. J Intern Med. 231:453-461.
  • Kuo HP; Rohde JA; Barnes PJ; Rogers DF. (14 May 1992). K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea. Eur J Pharmacol. 215:297-299.
  • Belvisi MG; Miura M; Stretton D; Barnes PJ. (14 May 1992). Capsazepine as a selective antagonist of capsaicin-induced activation of C-fibres in guinea-pig bronchi. Eur J Pharmacol. 215:341-344.
  • Liu SF; Hislop AA; Haworth SG; Barnes PJ. (Jun 1992). Developmental changes in endothelium-dependent pulmonary vasodilatation in pigs. Br J Pharmacol. 106:324-330.
  • Barnes PJ. (Jun 1992). PAF, eosinophils and asthma. J Lipid Mediat. 5:155-158.
  • Perkins RS; Dent G; Chung KF; Barnes PJ. (9 Jun 1992). The effect of anion transport inhibitors and extracellular Cl- concentration on eosinophil respiratory burst activity. Biochem Pharmacol. 43:2480-2483.
  • Barnes PJ. (Jul 1992). Modulation of neurotransmission in airways. Physiol Rev. 72:699-729.
  • Miura M; Belvisi MG; Stretton CD; Yacoub MH; Barnes PJ. (Jul 1992). Role of potassium channels in bronchodilator responses in human airways. Am Rev Respir Dis. 146:132-136.
  • Stone R; Barnes PJ; Fuller RW. (Aug 1992). Contrasting effects of prostaglandins E2 and F2 alpha on sensitivity of the human cough reflex. J Appl Physiol. 73:649-653.
  • Kuo HP; Rohde JA; Barnes PJ; Rogers DF. (Aug 1992). Cigarette smoke-induced airway goblet cell secretion: dose-dependent differential nerve activation. Am J Physiol. 263:L161-L167.
  • Miura M; Belvisi MG; Stretton CD; Yacoub MH; Barnes PJ. (Sep 1992). Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways. J Physiol. 455:1-15.
  • Crawley DE; Zhao L; Giembycz MA; Liu S; Barnes PJ; Winter RJ; Evans TW. (Sep 1992). Chronic hypoxia impairs soluble guanylyl cyclase-mediated pulmonary arterial relaxation in the rat. Am J Physiol. 263:L325-L332.
  • Miura M; Belvisi MG; Barnes PJ. (Oct 1992). Effect of bradykinin on airway neural responses in vitro. J Appl Physiol. 73:1537-1541.
  • Stone RA; Barnes PJ; Fuller RW. (Oct 1992). The low-chloride cough response is not inhibited by a single, high dose of aspirin. Br J Clin Pharmacol. 34:370-372.
  • Barnes PJ. (Oct 1992). New drugs for asthma. Eur Respir J. 5:1126-1136.
  • Hui KP; Lötvall J; Rogers DF; Barnes PJ; Chung FK. (Oct 1992). Ovalbumin aerosol challenge in actively sensitized guinea pigs: relationship between airway microvascular leakage and airflow obstruction. Allergy. 47:527-531.
  • Kuo HP; Liu S; Barnes PJ. (20 Oct 1992). The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways. Eur J Pharmacol. 221:385-388.
  • O'Connor BJ; Aikman SL; Barnes PJ. (22 Oct 1992). Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma. N Engl J Med. 327:1204-1208. DOI.
  • Liu SF; Crawley DE; Rohde JA; Evans TW; Barnes PJ. (Nov 1992). Role of nitric oxide and guanosine 3',5'-cyclic monophosphate in mediating nonadrenergic, noncholinergic relaxation in guinea-pig pulmonary arteries. Br J Pharmacol. 107:861-866.
  • Hayes JP; Lotvall JO; Baraniuk J; Daniel R; Barnes PJ; Taylor AJ; Chung KF. (Nov 1992). Bronchoconstriction and airway microvascular leakage in guinea pigs sensitized with trimellitic anhydride. Am Rev Respir Dis. 146:1306-1310.
  • Barnes PJ. (Nov 1992). Bradykinin and asthma. Thorax. 47:979-983.
  • Belvisi MG; Stretton CD; Miura M; Verleden GM; Tadjkarimi S; Yacoub MH; Barnes PJ. (Dec 1992). Inhibitory NANC nerves in human tracheal smooth muscle: a quest for the neurotransmitter. J Appl Physiol. 73:2505-2510.
  • Barnes PJ; Lee TH. (Dec 1992). Recent advances in asthma. Postgrad Med J. 68:942-953.
  • Alton EW; Rogers DF; Logan-Sinclair R; Yacoub M; Barnes PJ; Geddes DM. (Dec 1992). Bioelectric properties of cystic fibrosis airways obtained at heart-lung transplantation. Thorax. 47:1010-1014.
  • Rogers DF; Alton EW; Dewar A; Lethem MI; Barnes PJ. (Jan 1993). Impaired stimulus-evoked mucus secretion in cystic fibrosis bronchi. Exp Lung Res. 19:37-53.
  • Dent G; Barnes PJ. (1993). Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils. Life Sci. 52:1633-1640.
  • Barnes PJ. (1993). Beta-adrenoceptors on smooth muscle, nerves and inflammatory cells. Life Sci. 52:2101-2109.
  • Mak JC; Haddad EB; Buckley NJ; Barnes PJ. (1993). Visualization of muscarinic m4 mRNA and M4 receptor subtype in rabbit lung. Life Sci. 53:1501-1508.
  • Stone RA; Worsdell YM; Fuller RW; Barnes PJ. (Jan 1993). Effects of 5-hydroxytryptamine and 5-hydroxytryptophan infusion on the human cough reflex. J Appl Physiol. 74:396-401.
  • Barnes PJ. (1993). Anti-inflammatory therapy for asthma. Annu Rev Med. 44:229-242. DOI.
  • Sakamoto T; Barnes PJ; Chung KF. (26 Jan 1993). Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-, bradykinin- and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig. Eur J Pharmacol. 231:31-38.
  • Belvisi MG; Miura M; Stretton D; Barnes PJ. (26 Jan 1993). Endogenous vasoactive intestinal peptide and nitric oxide modulate cholinergic neurotransmission in guinea-pig trachea. Eur J Pharmacol. 231:97-102.
  • Kidney JC; Fuller RW; Worsdell YM; Lavender EA; Chung KF; Barnes PJ. (Feb 1993). Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic patients: comparison with oral salbutamol. Thorax. 48:130-133.
  • Verleden GM; Belvisi MG; Rabe KF; Miura M; Barnes PJ. (Mar 1993). Beta 2-adrenoceptor agonists inhibit NANC neural bronchoconstrictor responses in vitro. J Appl Physiol. 74:1195-1199.
  • Watson N; Maclagan J; Barnes PJ. (Apr 1993). Vagal control of guinea pig tracheal smooth muscle: lack of involvement of VIP or nitric oxide. J Appl Physiol. 74:1964-1971.
  • McCormack DG; Rees RG; Crawley D; Barnes PJ; Evans TW. (May 1993). Sensory neuropeptides and hypoxic pulmonary vasoconstriction in the rat. Thorax. 48:554-557.
  • Stone RA; Barnes PJ; Chung KF. (Jun 1993). Effect of frusemide on cough responses to chloride-deficient solution in normal and mild asthmatic subjects. Eur Respir J. 6:862-867.
  • Watson N; Maclagan J; Barnes PJ. (Jul 1993). Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig trachea. Br J Pharmacol. 109:751-759.
  • Sakamoto T; Tsukagoshi H; Barnes PJ; Chung KF. (Jul 1993). Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs. Agents Actions. 39:111-117.
  • Barnes PJ. (Jul 1993). Effect of nedocromil sodium on airway sensory nerves. J Allergy Clin Immunol. 92:182-186.
  • Barnes PJ. (Jul 1993). Effect of nedocromil sodium on platelet-activating factor-induced airway responses. J Allergy Clin Immunol. 92:187-189.
  • Barnes PJ. (Jul 1993). Effect of nedocromil sodium on microvascular leakage. J Allergy Clin Immunol. 92:197-199.
  • Adcock IM; Peters M; Gelder C; Shirasaki H; Brown CR; Barnes PJ. (Aug 1993). Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids. J Mol Endocrinol. 11:1-7.
  • Miyayasu K; Mak JC; Nishikawa M; Barnes PJ. (Sep 1993). Characterization of guinea pig pulmonary neurokinin type 1 receptors using a novel antagonist ligand, [3H]FK888. Mol Pharmacol. 44:539-544.
  • Sakamoto T; Barnes PJ; Chung KF. (Sep 1993). Effect of beta 2-adrenoceptor agonists against platelet-activating factor-induced airway microvascular leakage and bronchoconstriction in the guinea pig. Agents Actions. 40:50-56.
  • Fox AJ; Barnes PJ; Urban L; Dray A. (Sep 1993). An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J Physiol. 469:21-35.
  • Crompton GK; Barnes PJ. (May 2006). Aerosol delivery devices. Chest. 129:1388-1389. DOI.
  • Catley MC; Sukkar MB; Chung KF; Jaffee B; Liao SM; Coyle AJ; Haddad EL-B; Barnes PJ; et alNewton R. (Aug 2006). Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol Pharmacol. 70:697-705. DOI.
  • Barnes PJ. (May 2006). Receptor heterodimerization: a new level of cross-talk. J Clin Invest. 116:1210-1212. DOI.
  • Paraskakis E; Brindicci C; Fleming L; Krol R; Kharitonov SA; Wilson NM; Barnes PJ; Bush A. (1 Aug 2006). Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma. Am J Respir Crit Care Med. 174:260-267. DOI.
  • Barnes PJ. (Jun 2006). How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br J Pharmacol. 148:245-254. DOI.
  • Hew M; Bhavsar P; Torrego A; Meah S; Khorasani N; Barnes PJ; Adcock I; Chung KF. (15 Jul 2006). Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am J Respir Crit Care Med. 174:134-141. DOI.
  • Erin EM; Leaker BR; Zacharasiewicz A; Higgins LA; Nicholson GC; Boyce MJ; de Boer P; Jones RC; et alDurham SR; Barnes PJ; Hansel TT. (Apr 2006). Effects of a reversible beta-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses. CLIN EXP ALLERGY. 36:458-464.
  • Rogers DF; Barnes PJ. (2006). Treatment of airway mucus hypersecretion. Ann Med. 38:116-125. DOI.
  • Adcock IM; Ford P; Ito K; Barnes PJ. (6 Feb 2006). Epigenetics and airways disease. RESP RES. 7. DOI.
  • Barnes PJ; Chowdhury B; Kharitonov SA; Magnussen H; Page CP; Postma D; Saetta M. (1 Jul 2006). Pulmonary biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 174:6-14. DOI.
  • Barnes PJ. (Feb 2006). Corticosteroid effects on cell signalling. Eur Respir J. 27:413-426. DOI.
  • Barnes PJ. (8 Mar 2006). Corticosteroids: the drugs to beat. Eur J Pharmacol. 533:2-14. DOI.
  • Barnes PJ. (Jan 2006). Reduced histone deacetylase in COPD: clinical implications. Chest. 129:151-155. DOI.
  • Barnes PJ. (Aug 1996). Mechanisms of action of glucocorticoids in asthma. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 154:S21-S26.
  • Barnes PJ. (Feb 2000). Inhaled corticosteroids are not beneficial in chronic obstructive pulmonary disease. AM J RESP CRIT CARE. 161:342-344.
  • Andersson F; Borg S; Barnes PJ; Lofdahl CG; O'Byrne P; Postma D; Pauwels RA; Tattersfield A; et alUllman A. (Jan 2000). A high dose of inhaled budesonide is more cost-effective than a low dose in moderate asthma. J ALLERGY CLIN IMMUN. 105:S102-S103.
  • Montuschi P; Kharitonov SA; Ciabattoni G; Corradi M; van Rensen L; Geddes DM; Hodson ME; Barnes PJ. (Mar 2000). Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis. THORAX. 55:205-209.
  • Woolcock AJ; Barnes PJ. (Mar 2000). Asthma: The important questions Part 4 - Introduction. AM J RESP CRIT CARE. 161:S157-S157.
  • Barnes PJ. (27 Jul 2000). Medical progress: Chronic obstructive pulmonary disease. NEW ENGL J MED. 343:269-280.
  • Barnes PJ. (Aug 2001). Clinical outcome of adding long-acting beta-agonists to inhaled corticosteroids. RESPIRATORY MEDICINE. 95:S12-S16.
  • Barnes PJ. (Oct 2001). Allergy review series VII: Intracellular signaling and regulation of allergic reactions - Molecular mechanisms of corticosteroids in allergic diseases. ALLERGY. 56:928-936.
  • de Graaf W; Smith AK; Barnes PJ; Rogers DF. (Mar 2002). Mucin gene expression in human respiratory epithelial cell lines: Activation by phorbol esters and effect of a corticosteroid and cyclic AMP activating agents. BRIT J PHARMACOL. 135.
  • Smith SJ; Brookes-Fazakerley S; Barnes PJ; Giembycz MA. (Mar 2002). Determination of phosphodiesterase 7A protein expression in human immune and proinflammatory cells. BRIT J PHARMACOL. 135.
  • Paredi P; Kharitonov SA; Barnes PJ. (Jan 2003). Exhaled carbon monoxide in lung disease. EUR RESPIR J. 21:197-197.
  • Paredi P; Kharitonov SA; Barnes PJ. (Jan 2003). Exhaled breath temperature in asthma. EUR RESPIR J. 21:195-195. DOI.
  • Paredi P; Kharitonov SA; Barnes PJ. (Aug 2003). Exhaled breath temperature in airways disease. EUR RESPIR J. 22:394-395.
  • Carpagnano GE; Barnes PJ. (Oct 2003). Interleukin-6, obstructive sleep apnea, and obesity. CHEST. 124:1622-+.
  • Barnes PJ. (Apr 2004). Ashma guidelines: recommendations versus reality. RESPIRATORY MEDICINE. 98:S1-S7. DOI.
  • Barnes PJ. (Oct 2004). Decision making in asthma therapy - what is important in clinical practice?. RESP MED. 98:S1-S3. DOI.
  • Kankaanranta H; Lahdensuo A; Moilanen E; Barnes PJ. (27 Oct 2004). Add-on therapy options in asthma not adequately controlled by inhaled corticosteroids: a comprehensive review. RESP RES. 5. DOI.
  • Barnes PJ. (20 Dec 2004). Chronic obstructive pulmonary disease: New thinking, new treatment - Introduction. AM J MED. 117:1S-2S. DOI.
  • Barnes PJ; Cosio MG. (Oct 2004). Characterization of T lymphocytes in chronic obstructive pulmonary disease. PLOS MED. 1:25-27. DOI.
  • Birrell MA; McCluskie K; Wong SS; Donnelly LE; Barnes PJ; Belvisi MG. (Feb 2005). Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-kappa B-independent mechanism. FASEB J. 19:840-+. DOI.
  • Bucchioni E; Allegra L; Barnes PJ; Csoma Z; Kharitonov SA. (Apr 2005). Histamine levels following adenosine monophosphate challenge. RESP MED. 99:516-516.
  • Barnes PJ. (2005). Achieving asthma control. CURRENT MEDICAL RESEARCH AND OPINION. 21:S5-S9. DOI.
  • Barnes PJ. (2005). Introduction: how can we improve asthma management?. CURR MED RES OPIN. 21:S1-S3. DOI.
  • Montuschi P; Martello S; Felli M; Mondino C; Barnes PJ; Chiarotti M. (19 Oct 2005). Liquid chromatography/mass spectrometry analysis of exhaled leukotriene B-4 in asthmatic children. RESP RES. 6. DOI.
  • Barnes PJ. (Jan 2006). Drugs for asthma. Br J Pharmacol. 147 Suppl 1:S297-S303. DOI.
  • Nicholson GC; Tennant RC; Carpenter DC; Sarau HM; Kon OM; Barnes PJ; Salmon M; Vessey RS; et alTal-Singer R; Hansel TT. (2007). A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist. Pulm Pharmacol Ther. 20:52-59. DOI.
  • Lee KY; Ito K; Hayashi R; Jazrawi EP; Barnes PJ; Adcock IM. (1 Jan 2006). NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. J Immunol. 176:603-615.
  • Barnes PJ. (Jan 2006). Novel signal transduction modulators for the treatment of airway diseases. Pharmacol Ther. 109:238-245. DOI.
  • Ito K; Yamamura S; Essilfie-Quaye S; Cosio B; Ito M; Barnes PJ; Adcock IM. (23 Jan 2006). Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med. 203:7-13. DOI.
  • Usmani OS; Biddiscombe MF; Barnes PJ. (15 Dec 2005). Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. Am J Respir Crit Care Med. 172:1497-1504. DOI.
  • Varani K; Caramori G; Vincenzi F; Adcock I; Casolari P; Leung E; Maclennan S; Gessi S; et alMorello S; Barnes PJ; Ito K; Chung KF; Cavallesco G; Azzena G; Papi A; Borea PA. (15 Feb 2006). Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 173:398-406. DOI.
  • Erin EM; Leaker BR; Zacharasiewicz AS; Higgins LA; Williams TJ; Boyce MJ; de Boer P; Durham SR; et alBarnes PJ; Hansel TT. (Dec 2005). Single dose topical corticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challenge. Allergy. 60:1524-1529. DOI.
  • Barnes PJ. (Dec 2005). Targeting histone deacetylase 2 in chronic obstructive pulmonary disease treatment. Expert Opin Ther Targets. 9:1111-1121. DOI.
  • Erin EM; Zacharasiewicz AS; Nicholson GC; Tan AJ; Higgins LA; Williams TJ; Murdoch RD; Durham SR; et alBarnes PJ; Hansel TT. (Dec 2005). Topical corticosteroid inhibits interleukin-4,-5 and-13 in nasal secretions following allergen challenge. CLIN EXP ALLERGY. 35:1608-1614. DOI.
  • Antczak A; Kharitonov SA; Montuschi P; Gorski P; Barnes PJ. (Nov 2005). Inflammatory response to sputum induction measured by exhaled markers. Respiration. 72:594-599. DOI.
  • Ricciardolo FL; Caramori G; Ito K; Capelli A; Brun P; Abatangelo G; Papi A; Chung KF; et alAdcock I; Barnes PJ; Donner CF; Rossi A; Di Stefano A. (Nov 2005). Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J Allergy Clin Immunol. 116:1028-1035. DOI.
  • Biernacki WA; Kharitonov SA; Biernacka HM; Barnes PJ. (Oct 2005). Effect of montelukast on exhaled leukotrienes and quality of life in asthmatic patients. Chest. 128:1958-1963. DOI.
  • Basoglu OK; Pelleg A; Essilfie-Quaye S; Brindicci C; Barnes PJ; Kharitonov SA. (Oct 2005). Effects of aerosolized adenosine 5'-triphosphate vs adenosine 5'-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma. Chest. 128:1905-1909. DOI.
  • Montuschi P; Macagno F; Parente P; Valente S; Lauriola L; Ciappi G; Kharitonov SA; Barnes PJ; et alCiabattoni G. (Oct 2005). Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD. Thorax. 60:827-833. DOI.
  • Maneechotesuwan K; Essilfie-Quaye S; Meah S; Kelly C; Kharitonov SA; Adcock IM; Barnes PJ. (Oct 2005). Formoterol attenuates neutrophilic airway inflammation in asthma. Chest. 128:1936-1942. DOI.
  • Hansel TT; Neighbour H; Erin EM; Tan AJ; Tennant RC; Maus JG; Barnes PJ. (Oct 2005). Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma. Chest. 128:1974-1979. DOI.
  • Usmani OS; Ito K; Maneechotesuwan K; Ito M; Johnson M; Barnes PJ; Adcock IM. (15 Sep 2005). Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med. 172:704-712. DOI.
  • Barnes PJ. (Sep 2005). [How should clinical practice guidelines be implemented? Conclusion]. Rev Pneumol Clin. 61:3S29-3S30.
  • Horváth I; Hunt J; Barnes PJ; Alving K; Antczak A; Baraldi E; Becher G; van Beurden WJ; et alCorradi M; Dekhuijzen R; Dweik RA; Dwyer T; Effros R; Erzurum S; Gaston B; Gessner C; Greening A; Ho LP; Hohlfeld J; Jöbsis Q; Laskowski D; Loukides S; Marlin D; Montuschi P; Olin AC; Redington AE; Reinhold P; van Rensen EL; Rubinstein I; Silkoff P; Toren K; Vass G; Vogelberg C; Wirtz H; ATS/ERS Task Force on Exhaled Breath Condensate. (Sep 2005). Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J. 26:523-548. DOI.
  • Kharitonov SA; Walker L; Barnes PJ. (Sep 2005). Repeatability of standardised nasal nitric oxide measurements in healthy and asthmatic adults and children. Respir Med. 99:1105-1114. DOI.
  • Sharma R; Bolger AP; Rauchhaus M; von Haehling S; Doehner W; Adcock IM; Barnes PJ; Poole-Wilson PA; et alVolk HD; Coats AJ; Lim S; Anker SD. (Aug 2005). Cellular endotoxin desensitization in patients with severe chronic heart failure. Eur J Heart Fail. 7:865-868. DOI.
  • Barnes PJ. (Aug 2005). Molecular mechanisms and cellular effects of glucocorticosteroids. Immunol Allergy Clin North Am. 25:451-468. DOI.
  • Shahid SK; Kharitonov SA; Wilson NM; Bush A; Barnes PJ. (21 Jul 2005). Exhaled 8-isoprostane in childhood asthma. RESP RES. 6. DOI.
  • Brindicci C; Ito K; Resta O; Pride NB; Barnes PJ; Kharitonov SA. (Jul 2005). Exhaled nitric oxide from lung periphery is increased in COPD. Eur Respir J. 26:52-59. DOI.
  • Barnes PJ. (Jul 2005). Will it be steroids for ever?. Clin Exp Allergy. 35:843-845. DOI.
  • Caramori G; Fabbri M; Paioli D; Falcone F; Severino C; Felisatti G; Arar O; Adcock IM; et alFan Chung K; Barnes PJ; Ciaccia A; Papi A. (Jun 2005). Asthma is not a common cause of severe chronic respiratory failure in non-smokers: ALOT study. Monaldi Arch Chest Dis. 63:84-87.
  • Barnes PJ; Stockley RA. (Jun 2005). COPD: current therapeutic interventions and future approaches. Eur Respir J. 25:1084-1106. DOI.
  • Carpagnano GE; Foschino-Barbaro MP; Resta O; Barnes PJ. (Jun 2005). Oxidative stress and cardiovascular complications in sleep apnea. Chest. 127:2294. DOI.
  • Culpitt SV; Rogers DF; Traves SL; Barnes PJ; Donnelly LE. (Jun 2005). Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma. Respir Med. 99:703-710. DOI.
  • Wada H; Kagoshima M; Ito K; Barnes PJ; Adcock IM. (27 May 2005). 5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene. Biochem Biophys Res Commun. 331:93-99. DOI.
  • Ito K; Ito M; Elliott WM; Cosio B; Caramori G; Kon OM; Barczyk A; Hayashi S; et alAdcock IM; Hogg JC; Barnes PJ. (12 May 2005). Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med. 352:1967-1976. DOI.
  • Haque RA; Usmani OS; Barnes PJ. (May 2005). Chronic idiopathic cough: a discrete clinical entity?. Chest. 127:1710-1713. DOI.
  • Catley MC; Chivers JE; Holden NS; Barnes PJ; Newton R. (May 2005). Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. Br J Pharmacol. 145:114-122. DOI.
  • Barnes PJ; Adcock IM; Ito K. (Mar 2005). Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J. 25:552-563. DOI.
  • Paredi P; Kharitonov SA; Barnes PJ. (2005). Correlation of exhaled breath temperature with bronchial blood flow in asthma. Respir Res. 6:15. DOI.
  • Usmani OS; Belvisi MG; Patel HJ; Crispino N; Birrell MA; Korbonits M; Korbonits D; Barnes PJ. (Feb 2005). Theobromine inhibits sensory nerve activation and cough. FASEB J. 19:231-233. DOI.
  • Barnes PJ. (15 Jan 2005). A single inhaler for asthma?. Am J Respir Crit Care Med. 171:95-96. DOI.
  • Adcock IM; Cosio B; Tsaprouni L; Barnes PJ; Ito K. (Jan 2005). Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response. Antioxid Redox Signal. 7:144-152. DOI.
  • Barnes PJ. (2005). Theophylline in chronic obstructive pulmonary disease: new horizons. Proc Am Thorac Soc. 2:334-339. DOI.
  • Barnes PJ. (20 Dec 2004). The role of anticholinergics in chronic obstructive pulmonary disease. Am J Med. 117 Suppl 12A:24S-32S.
  • Smith SJ; Cieslinski LB; Newton R; Donnelly LE; Fenwick PS; Nicholson AG; Barnes PJ; Barnette MS; et alGiembycz MA. (Dec 2004). Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol. 66:1679-1689. DOI.
  • Montuschi P; Barnes PJ; Roberts LJ. (Dec 2004). Isoprostanes: markers and mediators of oxidative stress. FASEB J. 18:1791-1800. DOI.
  • Barnes PJ. (Dec 2004). Mediators of chronic obstructive pulmonary disease. Pharmacol Rev. 56:515-548. DOI.
  • Carpagnano GE; Kharitonov SA; Foschino-Barbaro MP; Resta O; Gramiccioni E; Barnes PJ. (Dec 2004). Supplementary oxygen in healthy subjects and those with COPD increases oxidative stress and airway inflammation. Thorax. 59:1016-1019. DOI.
  • Caramori G; Di Gregorio C; Carlstedt I; Casolari P; Guzzinati I; Adcock IM; Barnes PJ; Ciaccia A; et alCavallesco G; Chung KF; Papi A. (Nov 2004). Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease. Histopathology. 45:477-484. DOI.
  • Donnelly LE; Barnes PJ. (Oct 2004). Acidic mammalian chitinase--a potential target for asthma therapy. Trends Pharmacol Sci. 25:509-511. DOI.
  • Donnelly LE; Newton R; Kennedy GE; Fenwick PS; Leung RH; Ito K; Russell RE; Barnes PJ. (Oct 2004). Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol. 287:L774-L783. DOI.
  • Chivers JE; Cambridge LM; Catley MC; Mak JC; Donnelly LE; Barnes PJ; Newton R. (Oct 2004). Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release. Eur J Biochem. 271:4042-4052. DOI.
  • Mondino C; Ciabattoni G; Koch P; Pistelli R; Trové A; Barnes PJ; Montuschi P. (Oct 2004). Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children. J Allergy Clin Immunol. 114:761-767. DOI.
  • Barnes PJ. (Oct 2004). New drugs for asthma. Nat Rev Drug Discov. 3:831-844. DOI.
  • Barnes PJ; Hansel TT. (11 Sep 2004). Prospects for new drugs for chronic obstructive pulmonary disease. Lancet. 364:985-996. DOI.
  • Cosio BG; Tsaprouni L; Ito K; Jazrawi E; Adcock IM; Barnes PJ. (6 Sep 2004). Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med. 200:689-695. DOI.
  • Ichinose M; Barnes PJ. (Sep 2004). Cytokine-directed therapy in asthma. Curr Drug Targets Inflamm Allergy. 3:263-269.
  • Horváth I; Donnelly LE; Kiss A; Balint B; Kharitonov SA; Barnes PJ. (Sep 2004). Exhaled nitric oxide and hydrogen peroxide concentrations in asthmatic smokers. Respiration. 71:463-468. DOI.
  • Barnes PJ; Kleinert S. (14 Aug 2004). COPD--a neglected disease. Lancet. 364:564-565. DOI.
  • Traves SL; Smith SJ; Barnes PJ; Donnelly LE. (Aug 2004). Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2. J Leukoc Biol. 76:441-450. DOI.
  • Cosío BG; Mann B; Ito K; Jazrawi E; Barnes PJ; Chung KF; Adcock IM. (15 Jul 2004). Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. Am J Respir Crit Care Med. 170:141-147. DOI.
  • Bucchioni E; Csoma Z; Allegra L; Chung KF; Barnes PJ; Kharitonov SA. (Jul 2004). Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma. Respir Med. 98:651-655.
  • Bumbacea D; Campbell D; Nguyen L; Carr D; Barnes PJ; Robinson D; Chung KF. (Jul 2004). Parameters associated with persistent airflow obstruction in chronic severe asthma. Eur Respir J. 24:122-128.
  • Di Stefano A; Caramori G; Capelli A; Gnemmi I; Ricciardolo FL; Oates T; Donner CF; Chung KF; et alBarnes PJ; Adcock IM. (Jul 2004). STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. Eur Respir J. 24:78-85.
  • Barnes PJ. (24 Jun 2004). Small airways in COPD. N Engl J Med. 350:2635-2637. DOI.
  • Leckie MJ; Gomma AH; Purcell IF; Nyawo B; Dewar A; Okrongly D; Burman JF; Hooper J; et alBarnes PJ; Clague JR; Hansel TT. (Jun 2004). Automated quantitation of peripheral blood neutrophil activation in patients with myocardial ischaemia. Int J Cardiol. 95:307-313. DOI.
  • Carpagnano GE; Barnes PJ; Francis J; Wilson N; Bush A; Kharitonov SA. (Jun 2004). Breath condensate pH in children with cystic fibrosis and asthma: a new noninvasive marker of airway inflammation?. Chest. 125:2005-2010.
  • Barnes PJ. (Jun 2004). COPD: is there light at the end of the tunnel?. Curr Opin Pharmacol. 4:263-272. DOI.
  • Matthews JG; Ito K; Barnes PJ; Adcock IM. (Jun 2004). Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol. 113:1100-1108. DOI.
  • Atzori L; Caramori G; Lim S; Jazrawi E; Donnelly L; Adcock I; Barnes PJ; Chung KF. (Jun 2004). Effect of cigarette smoking on haem-oxygenase expression in alveolar macrophages. Respir Med. 98:530-535.
  • Cáp P; Chládek J; Pehal F; Malý M; Petrů V; Barnes PJ; Montuschi P. (Jun 2004). Gas chromatography/mass spectrometry analysis of exhaled leukotrienes in asthmatic patients. Thorax. 59:465-470.
  • Meja KK; Catley MC; Cambridge LM; Barnes PJ; Lum H; Newton R; Giembycz MA. (May 2004). Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89. J Pharmacol Exp Ther. 309:833-844. DOI.
  • Lim S; Caramori G; Tomita K; Jazrawi E; Oates T; Chung KF; Barnes PJ; Adcock IM. (May 2004). Differential expression of IL-10 receptor by epithelial cells and alveolar macrophages. Allergy. 59:505-514. DOI.
  • Catley MC; Cambridge LM; Nasuhara Y; Ito K; Chivers JE; Beaton A; Holden NS; Bergmann MW; et alBarnes PJ; Newton R. (30 Apr 2004). Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding. J Biol Chem. 279:18457-18466. DOI.
  • Barnes PJ. (Apr 2004). Asthma management: can we further improve compliance and outcomes?. Respir Med. 98 Suppl A:S8-S9.
  • Bergmann MW; Staples KJ; Smith SJ; Barnes PJ; Newton R. (Apr 2004). Glucocorticoid inhibition of granulocyte macrophage-colony-stimulating factor from T cells is independent of control by nuclear factor-kappaB and conserved lymphokine element 0. Am J Respir Cell Mol Biol. 30:555-563. DOI.
  • Bergmann MW; Staples KJ; Barnes PJ; Newton R. (Apr 2004). Nuclear factor-kappaB does not mediate the inhibitory effects of dexamethasone on granulocyte-macrophage colony-stimulating factor expression. Immunology. 111:430-434. DOI.
  • Yuda H; Adachi Y; Taguchi O; Gabazza EC; Hataji O; Fujimoto H; Tamaki S; Nishikubo K; et alFukudome K; D'Alessandro-Gabazza CN; Maruyama J; Izumizaki M; Iwase M; Homma I; Inoue R; Kamada H; Hayashi T; Kasper M; Lambrecht BN; Barnes PJ; Suzuki K. (15 Mar 2004). Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice. Blood. 103:2196-2204. DOI.
  • Koch A; Giembycz M; Ito K; Lim S; Jazrawi E; Barnes PJ; Adcock I; Erdmann E; et alChung KF. (Mar 2004). Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. Am J Respir Cell Mol Biol. 30:342-349. DOI.
  • Barnes PJ; Ito K; Adcock IM. (28 Feb 2004). Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet. 363:731-733. DOI.
  • Ito K; Hanazawa T; Tomita K; Barnes PJ; Adcock IM. (27 Feb 2004). Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem Biophys Res Commun. 315:240-245. DOI.
  • Barnes PJ. (Feb 2004). Ceramide lances the lungs. Nat Med. 10:130-131. DOI.
  • Holden NS; Catley MC; Cambridge LM; Barnes PJ; Newton R. (Feb 2004). ICAM-1 expression is highly NF-kappaB-dependent in A549 cells. No role for ERK and p38 MAPK. Eur J Biochem. 271:785-791.
  • Barnes PJ. (2004). Alveolar macrophages in chronic obstructive pulmonary disease (COPD). Cell Mol Biol (Noisy-le-grand). 50 Online Pub:OL627-OL637.
  • Usmani OS; Biddiscombe MF; Underwood SR; Barnes PJ. (Jan 2004). Characterization of the generation of radiolabeled monodisperse albuterol particles using the spinning-top aerosol generator. J Nucl Med. 45:69-73.
  • Barnes PJ. (2004). Corticosteroid resistance in airway disease. Proc Am Thorac Soc. 1:264-268. DOI.
  • Barnes PJ. (2004). Distribution of receptor targets in the lung. Proc Am Thorac Soc. 1:345-351. DOI.
  • Kharitonov SA; Barnes PJ. (2004). Effects of corticosteroids on noninvasive biomarkers of inflammation in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 1:191-199. DOI.
  • Adcock IM; Ito K; Barnes PJ. (2004). Glucocorticoids: effects on gene transcription. Proc Am Thorac Soc. 1:247-254. DOI.
  • Hansel TT; Tennant RC; Tan AJ; Higgins LA; Neighbour H; Erin EM; Barnes PJ. (Jan 2004). Theophylline: mechanism of action and use in asthma and chronic obstructive pulmonary disease. Drugs Today (Barc). 40:55-69.
  • Barnes PJ. (Dec 2003). Cytokine-directed therapies for the treatment of chronic airway diseases. Cytokine Growth Factor Rev. 14:511-522.
  • Bucchioni E; Kharitonov SA; Allegra L; Barnes PJ. (Dec 2003). High levels of interleukin-6 in the exhaled breath condensate of patients with COPD. Respir Med. 97:1299-1302.
  • Usmani OS; Biddiscombe MF; Nightingale JA; Underwood SR; Barnes PJ. (Nov 2003). Effects of bronchodilator particle size in asthmatic patients using monodisperse aerosols. J Appl Physiol. 95:2106-2112. DOI.
  • Culpitt SV; Rogers DF; Fenwick PS; Shah P; De Matos C; Russell RE; Barnes PJ; Donnelly LE. (Nov 2003). Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD. Thorax. 58:942-946.
  • Allen M; Heinzmann A; Noguchi E; Abecasis G; Broxholme J; Ponting CP; Bhattacharyya S; Tinsley J; et alZhang Y; Holt R; Jones EY; Lench N; Carey A; Jones H; Dickens NJ; Dimon C; Nicholls R; Baker C; Xue L; Townsend E; Kabesch M; Weiland SK; Carr D; von Mutius E; Adcock IM; Barnes PJ; Lathrop GM; Edwards M; Moffatt MF; Cookson WO. (Nov 2003). Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet. 35:258-263. DOI.
  • Carpagnano GE; Kharitonov SA; Resta O; Foschino-Barbaro MP; Gramiccioni E; Barnes PJ. (Oct 2003). 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy. Chest. 124:1386-1392.
  • Barnes PJ; Shapiro SD; Pauwels RA. (Oct 2003). Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J. 22:672-688.
  • Barnes PJ; Adcock IM. (2 Sep 2003). How do corticosteroids work in asthma?. Ann Intern Med. 139:359-370.
  • Barnes PJ. (Sep 2003). Chronic obstructive pulmonary disease * 12: New treatments for COPD. Thorax. 58:803-808.
  • Patel HJ; Birrell MA; Crispino N; Hele DJ; Venkatesan P; Barnes PJ; Yacoub MH; Belvisi MG. (Sep 2003). Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation. Br J Pharmacol. 140:261-268. DOI.
  • Robinson DS; Campbell DA; Durham SR; Pfeffer J; Barnes PJ; Chung KF; Asthma and Allergy Research Group of the National Heart and Lung Institute. (Sep 2003). Systematic assessment of difficult-to-treat asthma. Eur Respir J. 22:478-483.
  • Ichinose M; Sugiura H; Yamagata S; Koarai A; Tomaki M; Ogawa H; Komaki Y; Barnes PJ; et alShirato K; Hattori T. (Sep 2003). Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways. Eur Respir J. 22:457-461.
  • Staples KJ; Bergmann MW; Barnes PJ; Newton R. (Aug 2003). Evidence for post-transcriptional regulation of interleukin-5 by dexamethasone. Immunology. 109:527-535.
  • Csoma Z; Bush A; Wilson NM; Donnelly L; Balint B; Barnes PJ; Kharitonov SA. (Aug 2003). Nitric oxide metabolites are not reduced in exhaled breath condensate of patients with primary ciliary dyskinesia. Chest. 124:633-638.
  • von Haehling S; Genth-Zotz S; Sharma R; Bolger AP; Doehner W; Barnes PJ; Coats AJ; Anker SD. (Aug 2003). The relationship between age and production of tumour necrosis factor-alpha in healthy volunteers and patients with chronic heart failure. Int J Cardiol. 90:197-204.
  • Catley MC; Chivers JE; Cambridge LM; Holden N; Slater DM; Staples KJ; Bergmann MW; Loser P; et alBarnes PJ; Newton R. (17 Jul 2003). IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. FEBS Lett. 547:75-79.
  • Hansel TT; Kharitonov SA; Donnelly LE; Erin EM; Currie MG; Moore WM; Manning PT; Recker DP; et alBarnes PJ. (Jul 2003). A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J. 17:1298-1300. DOI.
  • Montuschi P; Kharitonov SA; Ciabattoni G; Barnes PJ. (Jul 2003). Exhaled leukotrienes and prostaglandins in COPD. Thorax. 58:585-588.
  • Baraldi E; Ghiro L; Piovan V; Carraro S; Ciabattoni G; Barnes PJ; Montuschi P. (Jul 2003). Increased exhaled 8-isoprostane in childhood asthma. Chest. 124:25-31.
  • Zhang X; Msc; Moilanen E; Lahti A; Hämäläinen M; Giembycz MA; Barnes PJ; Lindsay MA; et alKankaanranta H. (Jul 2003). Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5. J Allergy Clin Immunol. 112:93-101.
  • Barnes PJ. (Jun 2003). Anti-leukotrienes: here to stay?. Curr Opin Pharmacol. 3:257-263.
  • Tennant RC; Erin EM; Barnes PJ; Hansel TT. (Jun 2003). Long-acting beta 2-adrenoceptor agonists or tiotropium bromide for patients with COPD: is combination therapy justified?. Curr Opin Pharmacol. 3:270-276.
  • Nabeyrat E; Jones GE; Fenwick PS; Barnes PJ; Donnelly LE. (Jun 2003). Mitogen-activated protein kinases mediate peroxynitrite-induced cell death in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 284:L1112-L1120. DOI.
  • Zhang Y; Leaves NI; Anderson GG; Ponting CP; Broxholme J; Holt R; Edser P; Bhattacharyya S; et alDunham A; Adcock IM; Pulleyn L; Barnes PJ; Harper JI; Abecasis G; Cardon L; White M; Burton J; Matthews L; Mott R; Ross M; Cox R; Moffatt MF; Cookson WO. (Jun 2003). Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet. 34:181-186. DOI.
  • Carpagnano GE; Barnes PJ; Geddes DM; Hodson ME; Kharitonov SA. (15 Apr 2003). Increased leukotriene B4 and interleukin-6 in exhaled breath condensate in cystic fibrosis. Am J Respir Crit Care Med. 167:1109-1112. DOI.
  • Carpagnano GE; Kharitonov SA; Foschino-Barbaro MP; Resta O; Gramiccioni E; Barnes PJ. (Apr 2003). Increased inflammatory markers in the exhaled breath condensate of cigarette smokers. Eur Respir J. 21:589-593.
  • Biernacki WA; Kharitonov SA; Barnes PJ. (Apr 2003). Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD. Thorax. 58:294-298.
  • Beeh KM; Kornmann O; Buhl R; Culpitt SV; Giembycz MA; Barnes PJ. (Apr 2003). Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. Chest. 123:1240-1247.
  • Caramori G; Romagnoli M; Casolari P; Bellettato C; Casoni G; Boschetto P; Chung KF; Barnes PJ; et alAdcock IM; Ciaccia A; Fabbri LM; Papi A. (Apr 2003). Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. Thorax. 58:348-351.
  • Biddiscombe MF; Usmani OS; Barnes PJ. (26 Mar 2003). A system for the production and delivery of monodisperse salbutamol aerosols to the lungs. Int J Pharm. 254:243-253.
  • Barnes PJ. (15 Mar 2003). Theophylline: new perspectives for an old drug. Am J Respir Crit Care Med. 167:813-818. DOI.
  • Carpagnano GE; Kharitonov SA; Wells AU; Pantelidis P; Du Bois RM; Barnes PJ. (Mar 2003). Increased vitronectin and endothelin-1 in the breath condensate of patients with fibrosing lung disease. Respiration. 70:154-160. DOI.
  • Kharitonov SA; Barnes PJ. (Mar 2003). Nitric oxide, nitrotyrosine, and nitric oxide modulators in asthma and chronic obstructive pulmonary disease. Curr Allergy Asthma Rep. 3:121-129.
  • Kharitonov SA; Gonio F; Kelly C; Meah S; Barnes PJ. (Mar 2003). Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur Respir J. 21:433-438.
  • Paredi P; Caramori G; Cramer D; Ward S; Ciaccia A; Papi A; Kharitonov SA; Barnes PJ. (Mar 2003). Slower rise of exhaled breath temperature in chronic obstructive pulmonary disease. Eur Respir J. 21:439-443.
  • Tomita K; Barnes PJ; Adcock IM. (7 Feb 2003). The effect of oxidative stress on histone acetylation and IL-8 release. Biochem Biophys Res Commun. 301:572-577.
  • Smith SJ; Brookes-Fazakerley S; Donnelly LE; Barnes PJ; Barnette MS; Giembycz MA. (Feb 2003). Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells. Am J Physiol Lung Cell Mol Physiol. 284:L279-L289. DOI.
  • Montuschi P; Ragazzoni E; Valente S; Corbo G; Mondino C; Ciappi G; Barnes PJ; Ciabattoni G. (Feb 2003). Validation of leukotriene B4 measurements in exhaled breath condensate. Inflamm Res. 52:69-73.
  • Horváth I; Loukides S; Wodehouse T; Csiszér E; Cole PJ; Kharitonov SA; Barnes PJ. (Jan 2003). Comparison of exhaled and nasal nitric oxide and exhaled carbon monoxide levels in bronchiectatic patients with and without primary ciliary dyskinesia. Thorax. 58:68-72.
  • Paredi P; Kharitonov SA; Barnes PJ. (Jan 2003). Exhaled breath temperature in asthma. Eur Respir J. 21:195.
  • Paredi P; Kharitonov SA; Barnes PJ. (Jan 2003). Exhaled carbon monoxide in lung disease. Eur Respir J. 21:197.
  • Culpitt SV; Rogers DF; Shah P; De Matos C; Russell RE; Donnelly LE; Barnes PJ. (1 Jan 2003). Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 167:24-31. DOI.
  • Wodehouse T; Kharitonov SA; Mackay IS; Barnes PJ; Wilson R; Cole PJ. (Jan 2003). Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia. Eur Respir J. 21:43-47.
  • Barnes PJ. (2003). New concepts in chronic obstructive pulmonary disease. Annu Rev Med. 54:113-129. DOI.
  • Barnes PJ. (2003). New treatments for chronic obstructive pulmonary disease. Ann Ist Super Sanita. 39:573-582.
  • Leckie MJ; Jenkins GR; Khan J; Smith SJ; Walker C; Barnes PJ; Hansel TT. (Jan 2003). Sputum T lymphocytes in asthma, COPD and healthy subjects have the phenotype of activated intraepithelial T cells (CD69+ CD103+). Thorax. 58:23-29.
  • Barnes PJ. (Jan 2003). Therapy of chronic obstructive pulmonary disease. Pharmacol Ther. 97:87-94.
  • Barnes PJ. (Jan 2003). Update on asthma. Isr Med Assoc J. 5:68-72.
  • Paredi P; Kharitonov SA; Barnes PJ. (15 Dec 2002). Analysis of expired air for oxidation products. Am J Respir Crit Care Med. 166:S31-S37. DOI.
  • Csoma Z; Kharitonov SA; Balint B; Bush A; Wilson NM; Barnes PJ. (15 Nov 2002). Increased leukotrienes in exhaled breath condensate in childhood asthma. Am J Respir Crit Care Med. 166:1345-1349. DOI.
  • Montuschi P; Nightingale JA; Kharitonov SA; Barnes PJ. (15 Nov 2002). Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide. Free Radic Biol Med. 33:1403-1408.
  • Mattos W; Lim S; Russell R; Jatakanon A; Chung KF; Barnes PJ. (Nov 2002). Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids. Chest. 122:1543-1552.
  • Russell RE; Thorley A; Culpitt SV; Dodd S; Donnelly LE; Demattos C; Fitzgerald M; Barnes PJ. (Oct 2002). Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases. Am J Physiol Lung Cell Mol Physiol. 283:L867-L873. DOI.
  • Kharitonov SA; Donnelly LE; Montuschi P; Corradi M; Collins JV; Barnes PJ. (Oct 2002). Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma. Thorax. 57:889-896.
  • Carpagnano GE; Kharitonov SA; Resta O; Foschino-Barbaro MP; Gramiccioni E; Barnes PJ. (Oct 2002). Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest. 122:1162-1167.
  • Eynott PR; Groneberg DA; Caramori G; Adcock IM; Donnelly LE; Kharitonov S; Barnes PJ; Chung KF. (27 Sep 2002). Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness. Eur J Pharmacol. 452:123-133.
  • Di Stefano A; Caramori G; Oates T; Capelli A; Lusuardi M; Gnemmi I; Ioli F; Chung KF; et alDonner CF; Barnes PJ; Adcock IM. (Sep 2002). Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD. Eur Respir J. 20:556-563.
  • Tomita K; Caramori G; Lim S; Ito K; Hanazawa T; Oates T; Chiselita I; Jazrawi E; et alChung KF; Barnes PJ; Adcock IM. (1 Sep 2002). Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers. Am J Respir Crit Care Med. 166:724-731.
  • Hansel TT; Barnes PJ. (Sep 2002). Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD. Drugs Today (Barc). 38:585-600.
  • Emelyanov A; Fedoseev G; Krasnoschekova O; Abulimity A; Trendeleva T; Barnes PJ. (Sep 2002). Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial. Eur Respir J. 20:596-600.
  • Chung KF; van Rennen EL; Stirling RG; Barnes PJ. (15 Aug 2002). Duplicate publication. Am J Respir Crit Care Med. 166:625.
  • Ito K; Caramori G; Lim S; Oates T; Chung KF; Barnes PJ; Adcock IM. (1 Aug 2002). Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med. 166:392-396.
  • Chung KF; van Rensen E; Stirling R; Barnes PJ. (Aug 2002). IL-5 in asthma. Thorax. 57:751.
  • Antczak A; Montuschi P; Kharitonov S; Gorski P; Barnes PJ. (1 Aug 2002). Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma. Am J Respir Crit Care Med. 166:301-306.
  • Traves SL; Culpitt SV; Russell RE; Barnes PJ; Donnelly LE. (Jul 2002). Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD. Thorax. 57:590-595.
  • Ito K; Lim S; Caramori G; Cosio B; Chung KF; Adcock IM; Barnes PJ. (25 Jun 2002). A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 99:8921-8926. DOI.
  • Bryan SA; Jose PJ; Topping JR; Wilhelm R; Soderberg C; Kertesz D; Barnes PJ; Williams TJ; et alHansel TT; Sabroe I. (15 Jun 2002). Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 165:1602-1609.
  • Birrell MA; Crispino N; Hele DJ; Patel HJ; Yacoub MH; Barnes PJ; Belvisi MG. (Jun 2002). Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD. Br J Pharmacol. 136:620-628. DOI.
  • Erin EM; Williams TJ; Barnes PJ; Hansel TT. (Jun 2002). Eotaxin receptor (CCR3) antagonism in asthma and allergic disease. Curr Drug Targets Inflamm Allergy. 1:201-214.
  • Barnes PJ. (Jun 2002). New treatments for COPD. Nat Rev Drug Discov. 1:437-446. DOI.
  • Culpitt SV; de Matos C; Russell RE; Donnelly LE; Rogers DF; Barnes PJ. (15 May 2002). Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 165:1371-1376.
  • Montuschi P; Barnes PJ. (May 2002). Analysis of exhaled breath condensate for monitoring airway inflammation. Trends Pharmacol Sci. 23:232-237.
  • De Souza PM; Kankaanranta H; Michael A; Barnes PJ; Giembycz MA; Lindsay MA. (1 May 2002). Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis. Blood. 99:3432-3438.
  • Nightingale JA; Rogers DF; Barnes PJ. (May 2002). Comparison of the effects of salmeterol and formoterol in patients with severe asthma. Chest. 121:1401-1406.
  • Shahid SK; Kharitonov SA; Wilson NM; Bush A; Barnes PJ. (1 May 2002). Increased interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma. Am J Respir Crit Care Med. 165:1290-1293.
  • Erin EM; Barnes PJ; Hansel TT. (May 2002). Optimizing sputum methodology. Clin Exp Allergy. 32:653-657.
  • Russell RE; Culpitt SV; DeMatos C; Donnelly L; Smith M; Wiggins J; Barnes PJ. (May 2002). Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 26:602-609.
  • Ravenna F; Caramori G; Panella GL; Papi A; Benea G; Adcock IM; Barnes PJ; Ciaccia A. (Apr 2002). An unusual case of congenital short trachea with very long bronchi mimicking bronchial asthma. Thorax. 57:372-373.
  • Montuschi P; Barnes PJ. (Apr 2002). Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol. 109:615-620.
  • Irusen E; Matthews JG; Takahashi A; Barnes PJ; Chung KF; Adcock IM. (Apr 2002). p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol. 109:649-657.
  • Tomita K; Lim S; Hanazawa T; Usmani O; Stirling R; Chung KF; Barnes PJ; Adcock IM. (Mar 2002). Attenuated production of intracellular IL-10 and IL-12 in monocytes from patients with severe asthma. Clin Immunol. 102:258-266. DOI.
  • Hislop AA; Mak JC; Kelly D; Reader JA; Barnes PJ; Haworth SG. (Mar 2002). Postnatal changes in beta-adrenoceptors in the lung and the effect of hypoxia induced pulmonary hypertension of the newborn. Br J Pharmacol. 135:1415-1424. DOI.
  • Hansel TT; Sterk PJ; Holgate ST; Barnes PJ. (Mar 2002). The trials and tribulations of anti-IL-5 em leader. J Allergy Clin Immunol. 109:575-576.
  • Mak JC; Chuang TT; Harris CA; Barnes PJ. (2 Feb 2002). Increased expression of G protein-coupled receptor kinases in cystic fibrosis lung. Eur J Pharmacol. 436:165-172.
  • Mak JC; Hisada T; Salmon M; Barnes PJ; Chung KF. (Feb 2002). Glucocorticoids reverse IL-1beta-induced impairment of beta-adrenoceptor-mediated relaxation and up-regulation of G-protein-coupled receptor kinases. Br J Pharmacol. 135:987-996. DOI.
  • Hansel TT; Erin EM; Barnes PJ. (Feb 2002). The allergen challenge. Clin Exp Allergy. 32:162-167.
  • Barnes PJ. (Feb 2002). The role of inflammation and anti-inflammatory medication in asthma. Respir Med. 96 Suppl A:S9-15.
  • Paredi P; Kharitonov SA; Barnes PJ. (15 Jan 2002). Faster rise of exhaled breath temperature in asthma: a novel marker of airway inflammation?. Am J Respir Crit Care Med. 165:181-184.
  • Kharitonov SA; Barnes PJ. (Jan 2002). Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers. 7:1-32. DOI.
  • Barnes PJ. (2002). Current and future therapies for airway mucus hypersecretion. Novartis Found Symp. 248:237-249.
  • Barnes PJ. (2002). Cytokine modulators as novel therapies for asthma. Annu Rev Pharmacol Toxicol. 42:81-98. DOI.
  • Groneberg DA; Eynott PR; Döring F; Dinh QT; Oates T; Barnes PJ; Chung KF; Daniel H; et alFischer A. (Jan 2002). Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung. Thorax. 57:55-60.
  • Donnelly LE; Barnes PJ. (Jan 2002). Expression and regulation of inducible nitric oxide synthase from human primary airway epithelial cells. Am J Respir Cell Mol Biol. 26:144-151.
  • Kankaanranta H; Giembycz MA; Barnes PJ; Haddad EL-B; Saarelainen S; Zhang X; Moilanen E; Lindsay MA. (Jan 2002). Hydrogen peroxide reverses IL-5 afforded eosinophil survival and promotes constitutive human eosinophil apoptosis. Int Arch Allergy Immunol. 127:73-78.
  • Barnes PJ. (Jan 2002). Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids. Eur Respir J. 19:182-191.
  • Barnes PJ. (Dec 2001). Cytokine modulators as novel therapies for airway disease. Eur Respir J Suppl. 34:67s-77s.
  • van Rensen EL; Stirling RG; Scheerens J; Staples K; Sterk PJ; Barnes PJ; Chung KF. (Dec 2001). Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma. Thorax. 56:935-940.
  • Biernacki WA; Kharitonov SA; Barnes PJ. (Dec 2001). Exhaled carbon monoxide in patients with lower respiratory tract infection. Respir Med. 95:1003-1005. DOI.
  • Barnes PJ. (Dec 2001). Molecular mechanisms of atopy. Mediators Inflamm. 10:285-288. DOI.
  • Pulleyn LJ; Newton R; Adcock IM; Barnes PJ. (Dec 2001). TGFbeta1 allele association with asthma severity. Hum Genet. 109:623-627. DOI.
  • Oliver B; Tomita K; Keller A; Caramori G; Adcock I; Chung KF; Barnes PJ; Lim S. (Nov 2001). Low-dose theophylline does not exert its anti-inflammatory effects in mild asthma through upregulation of interleukin-10 in alveolar macrophages. Allergy. 56:1087-1090.
  • Kagoshima M; Wilcke T; Ito K; Tsaprouni L; Barnes PJ; Punchard N; Adcock IM. (19 Oct 2001). Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation. Eur J Pharmacol. 429:327-334.
  • Stirling RG; van Rensen EL; Barnes PJ; Chung KF. (15 Oct 2001). Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma. Am J Respir Crit Care Med. 164:1403-1409.
  • O'Byrne PM; Barnes PJ; Rodriguez-Roisin R; Runnerstrom E; Sandstrom T; Svensson K; Tattersfield A. (15 Oct 2001). Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial. Am J Respir Crit Care Med. 164:1392-1397.
  • Emelyanov A; Fedoseev G; Abulimity A; Rudinski K; Fedoulov A; Karabanov A; Barnes PJ. (Oct 2001). Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. Chest. 120:1136-1139.
  • Barnes PJ. (Oct 2001). Molecular mechanisms of corticosteroids in allergic diseases. Allergy. 56:928-936.
  • Lynch OT; Giembycz MA; Barnes PJ; Lindsay MA. (Oct 2001). Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils. Br J Pharmacol. 134:797-806. DOI.
  • Newton R; Staples KJ; Hart L; Barnes PJ; Bergmann MW. (14 Sep 2001). GM-CSF expression in pulmonary epithelial cells is regulated negatively by posttranscriptional mechanisms. Biochem Biophys Res Commun. 287:249-253. DOI.
  • Kharitonov SA; Barnes PJ. (1 Sep 2001). Does exhaled nitric oxide reflect asthma control? Yes, it does!. Am J Respir Crit Care Med. 164:727-728.
  • Caramori G; Lim S; Ito K; Tomita K; Oates T; Jazrawi E; Chung KF; Barnes PJ; et alAdcock IM. (Sep 2001). Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies. Eur Respir J. 18:466-473.
  • Staples KJ; Bergmann M; Tomita K; Houslay MD; McPhee I; Barnes PJ; Giembycz MA; Newton R. (15 Aug 2001). Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A. J Immunol. 167:2074-2080.
  • Ito K; Jazrawi E; Cosio B; Barnes PJ; Adcock IM. (10 Aug 2001). p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex. J Biol Chem. 276:30208-30215. DOI.
  • Horváth I; MacNee W; Kelly FJ; Dekhuijzen PN; Phillips M; Döring G; Choi AM; Yamaya M; et alBach FH; Willis D; Donnelly LE; Chung KF; Barnes PJ. (Aug 2001). "Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases", summary of the ERS Research Seminar in Budapest, Hungary, September, 1999. Eur Respir J. 18:420-430.
  • Barnes PJ. (Aug 2001). Cytokine-directed therapies for asthma. J Allergy Clin Immunol. 108:S72-S76.
  • Spicuzza L; Belvisi MG; Birrell MA; Barnes PJ; Hele DJ; Giembycz MA. (Aug 2001). Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol. 133:1201-1212. DOI.
  • Montuschi P; Kharitonov SA; Barnes PJ. (Aug 2001). Exhaled carbon monoxide and nitric oxide in COPD. Chest. 120:496-501.
  • Fox AJ; Patel HJ; Barnes PJ; Belvisi MG. (20 Jul 2001). Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases. Eur J Pharmacol. 424:159-162.
  • Lim S; Tomita K; Caramori G; Jatakanon A; Oliver B; Keller A; Adcock I; Chung KF; et alBarnes PJ. (15 Jul 2001). Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma. Am J Respir Crit Care Med. 164:273-276.
  • Robinson DS; Campbell D; Barnes PJ. (23 Jun 2001). Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial. Lancet. 357:2007-2011. DOI.
  • Andersson F; Stahl E; Barnes PJ; Löfdahl CG; O'Byrne PM; Pauwels RA; Postma DS; Tattersfield AE; et alUllman A; Formoterol and Corticosteroid Establishing Therapy. International Study Group. (Jun 2001). Adding formoterol to budesonide in moderate asthma--health economic results from the FACET study. Respir Med. 95:505-512.
  • Di Stefano A; Capelli A; Lusuardi M; Caramori G; Balbo P; Ioli F; Sacco S; Gnemmi I; et alBrun P; Adcock IM; Balbi B; Barnes PJ; Chung KF; Donner CF. (Jun 2001). Decreased T lymphocyte infiltration in bronchial biopsies of subjects with severe chronic obstructive pulmonary disease. Clin Exp Allergy. 31:893-902.
  • Kharitonov SA; Barnes PJ. (Jun 2001). Exhaled markers of inflammation. Curr Opin Allergy Clin Immunol. 1:217-224.
  • Kharitonov SA; Barnes PJ. (Jun 2001). Exhaled markers of pulmonary disease. Am J Respir Crit Care Med. 163:1693-1722.
  • Balint B; Donnelly LE; Hanazawa T; Kharitonov SA; Barnes PJ. (Jun 2001). Increased nitric oxide metabolites in exhaled breath condensate after exposure to tobacco smoke. Thorax. 56:456-461.
  • Balint B; Kharitonov SA; Hanazawa T; Donnelly LE; Shah PL; Hodson ME; Barnes PJ. (Jun 2001). Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis. Eur Respir J. 17:1201-1207.
  • Barnes PJ. (Jun 2001). New treatments for chronic obstructive pulmonary disease. Curr Opin Pharmacol. 1:217-222.
  • de Souza PM; Kankaanranta H; Barnes PJ; Giembycz MA; Lindsay MA. (May 2001). Caspase-mediated cleavage of MST1 during apoptosis of human eosinophils. BRIT J PHARMACOL. 133:U25-U25.
  • Barnes PJ. (May 2001). IL-10: a key regulator of allergic disease. Clin Exp Allergy. 31:667-669.
  • Ito K; Lim S; Caramori G; Chung KF; Barnes PJ; Adcock IM. (Apr 2001). Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J. 15:1110-1112.
  • Fujita K; Kasayama S; Hashimoto J; Nagasaka Y; Nakano N; Morimoto Y; Barnes PJ; Miyatake A. (Apr 2001). Inhaled corticosteroids reduce bone mineral density in early postmenopausal but not premenopausal asthmatic women. J Bone Miner Res. 16:782-787. DOI.
  • Barnes PJ. (Apr 2001). Tiotropium bromide. Expert Opin Investig Drugs. 10:733-740. DOI.
  • Spicuzza L; Barnes PJ; Di Maria GU; Belvisi MG. (30 Mar 2001). Effect of 8-iso-prostaglandin F(2 alpha) on acetylcholine release from parasympathetic nerves in guinea pig airways. Eur J Pharmacol. 416:231-234.
  • Finney PA; Donnelly LE; Belvisi MG; Chuang TT; Birrell M; Harris A; Mak JC; Scorer C; et alBarnes PJ; Adcock IM; Giembycz MA. (Mar 2001). Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha). Br J Pharmacol. 132:1261-1270. DOI.
  • Donnelly LE; Barnes PJ. (Mar 2001). Expression of heme oxygenase in human airway epithelial cells. Am J Respir Cell Mol Biol. 24:295-303.
  • Corradi M; Montuschi P; Donnelly LE; Pesci A; Kharitonov SA; Barnes PJ. (Mar 2001). Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases. Am J Respir Crit Care Med. 163:854-858.
  • Pype JL; Xu H; Schuermans M; Dupont LJ; Wuyts W; Mak JC; Barnes PJ; Demedts MG; et alVerleden GM. (Mar 2001). Mechanisms of interleukin 1beta-induced human airway smooth muscle hyporesponsiveness to histamine. Involvement of p38 MAPK NF-kappaB. Am J Respir Crit Care Med. 163:1010-1017.
  • Barnes PJ. (Mar 2001). Neurogenic inflammation in the airways. Respir Physiol. 125:145-154.
  • Hansel TT; Barnes PJ. (Mar 2001). Novel drugs for treating asthma. Curr Allergy Asthma Rep. 1:164-173.
  • Barnes PJ. (Feb 2001). Corticosteroids, IgE, and atopy. J Clin Invest. 107:265-266. DOI.
  • Paredi P; Kharitonov SA; Barnes PJ. (Feb 2001). Direct methods for the measurement of nitric oxide. Monaldi Arch Chest Dis. 56:88-90.
  • Barnes PJ. (2001). Future Advances in COPD Therapy. Respiration. 68:441-448.
  • Barnes PJ. (2001). Histamine and serotonin. Pulm Pharmacol Ther. 14:329-339. DOI.
  • Paredi P; Kharitonov SA; Hanazawa T; Barnes PJ. (Jan 2001). Local vasodilator response to mobile phones. Laryngoscope. 111:159-162. DOI.
  • Barnes PJ; Page C. (2001). Mediators of asthma: a new series. Pulm Pharmacol Ther. 14:1-2. DOI.
  • Barnes PJ. (2001). Potential novel therapies for chronic obstructive pulmonary disease. Novartis Found Symp. 234:255-267.
  • Barnes PJ. (2001). Th2 cytokines and asthma: an introduction. Respir Res. 2:64-65.
  • Leckie MJ; ten Brinke A; Khan J; Diamant Z; O'Connor BJ; Walls CM; Mathur AK; Cowley HC; et alChung KF; Djukanovic R; Hansel TT; Holgate ST; Sterk PJ; Barnes PJ. (23 Dec 2000). Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 356:2144-2148.
  • Bryan SA; O'Connor BJ; Matti S; Leckie MJ; Kanabar V; Khan J; Warrington SJ; Renzetti L; et alRames A; Bock JA; Boyce MJ; Hansel TT; Holgate ST; Barnes PJ. (23 Dec 2000). Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 356:2149-2153. DOI.
  • Mak JC; Rousell J; Haddad EB; Barnes PJ. (Dec 2000). Transforming growth factor-beta1 inhibits beta2-adrenoceptor gene transcription. Naunyn Schmiedebergs Arch Pharmacol. 362:520-525.
  • Newton R; Hart L; Chung KF; Barnes PJ. (2 Nov 2000). Ceramide induction of COX-2 and PGE(2) in pulmonary A549 cells does not involve activation of NF-kappaB. Biochem Biophys Res Commun. 277:675-679. DOI.
  • Barnes PJ. (Nov 2000). Anti-IgE therapy in asthma: rationale and therapeutic potential. Int Arch Allergy Immunol. 123:196-204.
  • Lim S; Groneberg D; Fischer A; Oates T; Caramori G; Mattos W; Adcock I; Barnes PJ; et alChung KF. (Nov 2000). Expression of heme oxygenase isoenzymes 1 and 2 in normal and asthmatic airways: effect of inhaled corticosteroids. Am J Respir Crit Care Med. 162:1912-1918.
  • Koch A; Nasuhara Y; Barnes PJ; Lindsay MA; Giembycz MA. (Nov 2000). Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle. Br J Pharmacol. 131:981-989. DOI.
  • Meja KK; Seldon PM; Nasuhara Y; Ito K; Barnes PJ; Lindsay MA; Giembycz MA. (Nov 2000). p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism. Br J Pharmacol. 131:1143-1153. DOI.
  • Lim S; Roche N; Oliver BG; Mattos W; Barnes PJ; Chung KF. (Oct 2000). Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10. Am J Respir Crit Care Med. 162:1355-1360.
  • Kharitonov SA; Barnes PJ. (Oct 2000). Clinical aspects of exhaled nitric oxide. Eur Respir J. 16:781-792.
  • Lim S; Jatakanon A; Gordon D; Macdonald C; Chung KF; Barnes PJ. (Oct 2000). Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice. Thorax. 55:837-841.
  • Paredi P; Kharitonov SA; Barnes PJ. (Oct 2000). Elevation of exhaled ethane concentration in asthma. Am J Respir Crit Care Med. 162:1450-1454.
  • Hanazawa T; Kharitonov SA; Barnes PJ. (Oct 2000). Increased nitrotyrosine in exhaled breath condensate of patients with asthma. Am J Respir Crit Care Med. 162:1273-1276.
  • Montuschi P; Collins JV; Ciabattoni G; Lazzeri N; Corradi M; Kharitonov SA; Barnes PJ. (Sep 2000). Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med. 162:1175-1177.
  • Ito K; Barnes PJ; Adcock IM. (Sep 2000). Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol. 20:6891-6903.
  • Spicuzza L; Haddad EB; Birrell M; Ling A; Clarke D; Venkatesan P; Barnes PJ; Belvisi MG. (Aug 2000). Characterization of the effects of cannabinoids on guinea-pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves. Br J Pharmacol. 130:1720-1726. DOI.
  • Paredi P; Kharitonov SA; Leak D; Ward S; Cramer D; Barnes PJ. (Aug 2000). Exhaled ethane, a marker of lipid peroxidation, is elevated in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 162:369-373.
  • Barnes PJ. (27 Jul 2000). Chronic obstructive pulmonary disease. N Engl J Med. 343:269-280. DOI.
  • Staples KJ; Bergmann M; Barnes PJ; Newton R. (14 Jul 2000). Stimulus-specific inhibition of IL-5 by cAMP-elevating agents and IL-10 reveals differential mechanisms of action. Biochem Biophys Res Commun. 273:811-815. DOI.
  • Nightingale JA; Maggs R; Cullinan P; Donnelly LE; Rogers DF; Kinnersley R; Chung KF; Barnes PJ; et alAshmore M; Newman-Taylor A. (Jul 2000). Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med. 162:161-166.
  • Finney PA; Belvisi MG; Donnelly LE; Chuang TT; Mak JC; Scorer C; Barnes PJ; Adcock IM; et alGiembycz MA. (Jul 2000). Albuterol-induced downregulation of Gsalpha accounts for pulmonary beta(2)-adrenoceptor desensitization in vivo. J Clin Invest. 106:125-135. DOI.
  • Kankaanranta H; Lindsay MA; Giembycz MA; Zhang X; Moilanen E; Barnes PJ. (Jul 2000). Delayed eosinophil apoptosis in asthma. J Allergy Clin Immunol. 106:77-83. DOI.
  • Barnes PJ. (Jul 2000). New directions in allergic diseases: mechanism-based anti-inflammatory therapies. J Allergy Clin Immunol. 106:5-16. DOI.
  • Newton R; Cambridge L; Hart LA; Stevens DA; Lindsay MA; Barnes PJ. (Jul 2000). The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes. Br J Pharmacol. 130:1353-1361. DOI.
  • Leckie MJ; Bryan SA; Khan J; Dewar A; Aikman SL; McGrath J; Okrongly DA; Burman JF; et alBarnes PJ; Hansel TT. (Jun 2000). Automated quantitation of circulating neutrophil and eosinophil activation in asthmatic patients. Thorax. 55:471-477.
  • Ranu HK; Mak JC; Barnes PJ; Harding SE. (Jun 2000). G(i)-dependent suppression of beta(1)-adrenoceptor effects in ventricular myocytes from NE-treated guinea pigs. Am J Physiol Heart Circ Physiol. 278:H1807-H1814.
  • Lynch OT; Giembycz MA; Daniels I; Barnes PJ; Lindsay MA. (1 Jun 2000). Pleiotropic role of lyn kinase in leukotriene B(4)-induced eosinophil activation. Blood. 95:3541-3547.
  • Haddad EB; Fox AJ; Rousell J; Burgess G; McIntyre P; Barnes PJ; Chung KF. (Jun 2000). Post-transcriptional regulation of bradykinin B1 and B2 receptor gene expression in human lung fibroblasts by tumor necrosis factor-alpha: modulation by dexamethasone. Mol Pharmacol. 57:1123-1131.
  • Lim S; John M; Seybold J; Taylor D; Witt C; Barnes PJ; Chung KF. (May 2000). Increased interleukin-10 and macrophage inflammatory protein-1 alpha release from blood monocytes ex vivo during late-phase response to allergen in asthma. Allergy. 55:489-495.
  • Mak JC; Roffel AF; Katsunuma T; Elzinga CR; Zaagsma J; Barnes PJ. (May 2000). Up-regulation of airway smooth muscle histamine H(1) receptor mRNA, protein, and function by beta(2)-adrenoceptor activation. Mol Pharmacol. 57:857-864.
  • Paredi P; Kharitonov SA; Leak D; Shah PL; Cramer D; Hodson ME; Barnes PJ. (Apr 2000). Exhaled ethane is elevated in cystic fibrosis and correlates with carbon monoxide levels and airway obstruction. Am J Respir Crit Care Med. 161:1247-1251.
  • Thomas SR; Kharitonov SA; Scott SF; Hodson ME; Barnes PJ. (Apr 2000). Nasal and exhaled nitric oxide is reduced in adult patients with cystic fibrosis and does not correlate with cystic fibrosis genotype. Chest. 117:1085-1089.
  • Barnes PJ. (Mar 2000). Endogenous inhibitory mechanisms in asthma. Am J Respir Crit Care Med. 161:S176-S181.
  • Barnes PJ. (Mar 2000). Nonantimicrobial aspects of therapy. Semin Respir Infect. 15:52-58.
  • Lim S; Jatakanon A; Meah S; Oates T; Chung KF; Barnes PJ. (Mar 2000). Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma. Thorax. 55:184-188.
  • Antuni JD; Kharitonov SA; Hughes D; Hodson ME; Barnes PJ. (Feb 2000). Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis. Thorax. 55:138-142.
  • Barnes PJ. (Feb 2000). Mechanisms in COPD: differences from asthma. Chest. 117:10S-14S.
  • Nightingale JA; Rogers DF; Chung KF; Barnes PJ. (Feb 2000). No effect of inhaled budesonide on the response to inhaled ozone in normal subjects. Am J Respir Crit Care Med. 161:479-486.
  • Barnes PJ. (Feb 2000). The pharmacological properties of tiotropium. Chest. 117:63S-66S.
  • Jatakanon A; Lim S; Barnes PJ. (Jan 2000). Changes in sputum eosinophils predict loss of asthma control. Am J Respir Crit Care Med. 161:64-72.
  • Hart L; Lim S; Adcock I; Barnes PJ; Chung KF. (Jan 2000). Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma. Am J Respir Crit Care Med. 161:224-231.
  • Hanazawa T; Antuni JD; Kharitonov SA; Barnes PJ. (Jan 2000). Intranasal administration of eotaxin increases nasal eosinophils and nitric oxide in patients with allergic rhinitis. J Allergy Clin Immunol. 105:58-64.
  • Barnes PJ. (2000). Molecular basis for corticosteroid action in asthma. Chem Immunol. 78:72-80.
  • Bryan SA; Leckie MJ; Hansel TT; Barnes PJ. (Jan 2000). Novel therapy for asthma. Expert Opin Investig Drugs. 9:25-42. DOI.
  • Leckie MJ; Bryan SA; Hansel TT; Barnes PJ. (Jan 2000). Novel therapy for COPD. Expert Opin Investig Drugs. 9:3-23. DOI.
  • Adcock IM; Nasuhari Y; Barnes PJ. (Aug 1998). Role of CBP in glucocorticoid-induced gene repression. Biochem Soc Trans. 26:S255.
  • Barnes PJ. (1997). Neural mechanisms in asthma: new developments. Pediatr Pulmonol Suppl. 16:82-83.
  • Barnes PJ; Haddad EB; Rousell J. (1997). Regulation of muscarinic M2 receptors. Life Sci. 60:1015-1021.
  • Barnes PJ. (Jul 1996). Pathophysiology of asthma. Br J Clin Pharmacol. 42:3-10.
  • BARNES PJ. (31 Jul 1991). SENSORY NERVES, NEUROPEPTIDES, AND ASTHMA. ANN NY ACAD SCI. 629:359-370.
  • BARNES PJ. (1991). NEUROGENIC INFLAMMATION IN AIRWAYS. INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY. 94:303-309.

Books

  • Barnes PJ. New drugs for asthma, allergy and COPD. 31. (2001).
  • Barnes PJ. Asthma and COPD: basic mechanisms and clinical management. (2002).
  • Marczin N; Kharitonov SA; Yacoub MH; Barnes PJ. Disease markers in exhaled breath. 1-560. (2002).
  • Barnes PJ. Managing chronic obstructive pulmonary disease. (2001).
  • Hansel T; Barnes PJ. Hansel T (ed); Barnes PJ (ed). Recent Advances in the Pathophysiology of COPD. 1-231. Birkhauser Verlag (2003).
  • Hansel TT; Barnes PJ. An Atlas of Chronic Obstructive Pulmonary Disease. 1-290. Parthenon Publishing, New York (2004).
  • Barnes PJ. Page CP (ed); Barnes PJ (ed). Pharmacology and Therapeutics of Asthma and COPD. 1-376. Springer, Berlin (2004).

Chapters in books

  • Barnes PJ. Asthma. In Pulmonary biology in health and disease. 364-380. (2002).
  • Barnes PJ. Autonomic control of the airways. In Handbook of the autonomic nervous system in health and disease. 439-462. (2002).
  • Barnes PJ. Biology of asthma. In Disease markers in exhaled breath: Basic mechanisms and clinical applications. 133-142. (2002).
  • Barnes PJ. Corticosteroids. In Asthma and COPD: basic mechanisms and clinical management. 547-564. (2002).
  • Barnes PJ. Future therapies. In Asthma and COPD: basic mechanisms and clinical management. 641-656. (2002).
  • Barnes PJ. Future therapies for asthma. In Biotherapeutic approaches to asthma. 352-382. (2002).
  • Barnes PJ. Gene regulation of muscarinic receptor subtypes. 159-174. (2001).
  • Barnes PJ. Neural and humoral control. In Asthma and COPD: basic mechanisms and clinical management. 323-340. (2002).
  • Barnes PJ. New treatments for COPD. In Clinical management of chronic obstructive pulmonary disease. 943-963. (2002).
  • Barnes PJ. Other mediators of airway disease. In Asthma and COPD: basic mechanisms and clinical management. 291-305. (2002).
  • Barnes PJ. Inflammatory mediators and neural mechanisms in severe asthma. 2nd:67-87. (2001).
  • Barnes PJ. What are the mechanisms of corticosteroids resistance in asthma?. In Asthma: Critical debates. 241-254. (2002).
  • Barnes PJ. The pathogenesis and treatment of asthma as an inflammatory disease. 221-236. (2001).
  • Barnes PJ. Theophylline. In Asthma and COPD: basic mechanisms and clinical management. 535-545. (2002).
  • Barnes PJ; Drazen JM. Pathophysiology of asthma. In Asthma and COPD: basic mechanical and clinical management. 343-359. (2002).
  • Brown TJ; Belvisi MG; Foster ML. Dissociated steroids. 98-101. (2001).
  • Bryan SA; Leckie MJ; Jenkins G; Barnes PJ; Williams TJ; Sabroe I; Hansel TT. Measurement of granulocyte pharmacodynamics in whole blood by flow cytometry. (2001).
  • Chung KF. Cytokines in asthma and COPD. In Asthma and COPD. 261-271. (2002).
  • Chung KF; Barnes PJ. Mediator antagonists. In Asthma and COPD: basic mechanical and clinical management. 565-571. (2002).
  • Desai SR; Hansell DM. Imaging. In Asthma and COPD: basic mechanisms and clinical management. 465-480. (2002).
  • Hansel TT; Barnes PJ. Scientific evidence and expert opinion for the selection and use of long-acting ß2 agonists: central considerations of safety and effectiveness. In The Effective Management of Asthma. 61-73. (2002).
  • Kharitonov SA; Barnes PJ. Use of exhaled nitric oxide as readout for inhaled corticosteroids efficacy. 441-463. (2001).
  • Kharitonov SA; Barnes PJ. Measurement of exhaled nitric oxide and carbon monoxide. 44-47. (2001).
  • Message SD; Johnston SL. Infections. In Asthma and COPD: basic mechanisms and clinical management. 407-420. (2002).
  • Partridge MR. Education and self management. In Asthma and COPD: basic mechanisms and clinical management. 737-742. (2002).
  • Pride NB. Monitoring lung function. 30-34. (2001).
  • Pride NB. Pulmonary physiology. In Asthma and COPD: basic mechanisms and clinical management. 43-56. (2002).
  • Rennard SI; Barnes PJ. Pathogenesis of COPD. In Asthma and COPD: basic mechanisms and clinical management. 361-379. (2002).
  • Rogers DF; Barnes PJ. Mucus regulation. 160-164. (2001).

Conferences

  • Kizawa Y; Kimura G; Ueda K; Ito K; Barnes PJ; Kusama T. p38MAPK gamma is involved in the corticosteroid refractory airway inflammation and AHR in cigarette smoke exposed and poly(I:C) treated mice. 115:215P-215P. (2011).
  • Barnes PJ. Oxidative stress and corticosteroid resistance. 22:S38-S38. (Jun 2010). DOI.
  • Barnes PJ. Role of NO in the pathogenesis of asthma and COPD. 22:S33-S34. (Jun 2010). DOI.
  • Kizawa Y; Eto S; Ueda K; Ito K; Barnes PJ; Kusama T. Possible involvement of TLR3 pathway on corticosteroid refractory airway inflammation in mice. 112:205P-205P. (2010).
  • Biddiscombe MF; Meah S; Sadler R; Barnes PJ; Usmani OS. IN VITRO VALIDATION OF RADIOLABELLED INHALED CORTICOSTEROID FOR IN VIVO LUNG DELIVERY USING GAMMA SCINTIGRAPHY. 64:A131-A132. (Dec 2009). DOI.
  • de Matas M; Shao Q; Biddiscombe M; Chrystyn H; Barnes PJ; Usmani OS. MODELLING THE IMPACT OF INHALED DRUG PARTICLE SIZE OF SALBUTAMOL ON BRONCHODILATOR RESPONSE USING ARTIFICIAL INTELLIGENCE. 64:A131-A131. (Dec 2009). DOI.
  • Biddiscombe MF; Verbanck S; Meah S; Barnes PJ; Usmani OS. REPRODUCIBILITY OF THE MULTIPLE BREATH NITROGEN WASHOUT TEST IN HEALTHY VOLUNTEERS AND SUBJECTS WITH MILD TO MODERATE ASTHMA. 64:A128-A128. (Dec 2009). DOI.
  • Biddiscombe MF; Meah S; Barnes PJ; Usmani OS. GAMMA SCINTIGRAPHY: REGIONS OF INTEREST IN THE LUNGS. ARE WE BEING CONSISTENT IN WHAT WE ARE MEASURING?. 64:A153-A154. (Dec 2009). DOI.
  • Thomas CMR; Saunders MA; Wedzicha JA; Barnes PJ; Donnelly LE. DECREASED MACROPHAGE FUNCTION IN COPD. 64:A55-A56. (Dec 2009). DOI.
  • Barnes PJ; Celli BR. Systemic manifestations and comorbidities of COPD. 33:1165-1185. (May 2009). DOI.
  • Kizawa Y; Watanabe Y; Eto S; Kimura G; Saito R; Ito K; Barnes PJ; Kusama T. PI3kinase signalling is more important than p38MAPkinase signalling for steroid-resistant airway inflammation in a cigarette smoking murine model. 109:239P-239P. (2009).
  • BARNES PJ. SENSORY NERVES, NEUROPEPTIDES, AND ASTHMA. 629:359-370. (1991).
  • Adcock IM; Barnes PJ. Transcription factors in asthma. 25-45. (1998).
  • Kizawa Y; Kimura G; Saito R; Watanabe Y; Ito K; Barnes PJ; Kusama T. Effects of dexamethasone and theophylline on airway inflammation induced by cigarette smoke and lipopolysaccharide in mice. 106:158P-158P. (2008).
  • Kumar V; Charron CE; Barnes PJ; Ito K. Hypoxia decreases HDAC2 in U937 cells as a possible mechanism for glucocorticoid resistance in COPD. Winter Meeting of the British-Thoracic-Society. 62:A27-A27. (Dec 2007).
  • Coutts D; To Y; Ito M; Ito K; Barnes PJ. Theophylline restores corticosteroid sensitivity in COPD cells via an inhibitory effect on PI3K signalling. 62:A28-A28. (Dec 2007).
  • Nakamaru Y; Takagi D; Maeda M; Barnes PJ; Fukuda S; Ito K. Oxidative stress regulates IL-4 gene expression in mast cells through reduction of histone deacetylase (HDAC). 119:S138-S138. (Jan 2007).
  • Usmani OS; Biddiscombe MF; Barnes PJ. Airway drug delivery: Size matters - Bigger is indeed better. Winter Meeting of the British-Thoracic-Society. 57:U89-U89. (Dec 2002).
  • Usmani OS; Maneechotesuwan K; Adcock IM; Barnes PJ. Glucocorticoid receptor activation in induced sputum following inhaled long-acting beta 2-agonist and glucocorticoid treatment. Winter Meeting of the British-Thoracic-Society. 57:U10-U10. (Dec 2002).
  • Uasuf C; Barnes PJ. Is exhaled carbon monoxide related with atopy in asthmatic children?. 21st Congress of the European-Academy-of-Allergology-and-Clinical-Immunology. 57:200-201. (Jul 2002).
  • Balint B; Kharitonov SA; Horvath I; Barnes PJ. Exhaled markers in cystic fibrosis. Conference of the NATO-Advanced-Study-Institute on Disease Markers in Exhaled Breath. 346:234-241. (2002).
  • Barnes PJ. Biology of asthma. Conference of the NATO-Advanced-Study-Institute on Disease Markers in Exhaled Breath. 346:133-142. (2002).
  • Katsunuma T; Fujita K; Mak JCW; Barnes PJ; Ueno K; Iikura Y. beta-Adrenergic agonists and bronchial hyperreactivity: Role of beta(2)-adrenergic and tachykinin neurokinin-2 receptors. 106:S104-S108. (Jul 2000).
  • Barnes PJ. Cytokine modulators as novel therapies for airway disease. 18:67S-77S. (Dec 2001). DOI.
  • Patel HJ; Birrell MA; Crispino N; Hele DJ; Yacoub MH; Venkatesan P; Barnes PJ; Belvisi MG. The effect of a cannabinoid (CB2) agonist on activation of airway sensory nerves in vitro and the cough reflex. 138:U37-U37. (Apr 2003).
  • Usmani OS; Patel HJ; Belvisi MG; Barnes PJ. Chocolate, chilli pepper, and cough. 57. (Dec 2002).
  • Kizawa Y; deSouza PM; Smith SJ; Kusama T; Barnes PJ; Giembycz MA; Lindsay MA. Possible involvement of Mst1 in the mediation of Fas-induced apoptosis of human CD4(+) T-cells. 91:251P-251P. (2003).
  • Carpagnano GE; Bucchioni E; Kharitonov SA; Barnes PJ. IL-6 in exhaled breath condensate as an inflammatory marker in pulmonary diseases. 22:44S-44S. (Sep 2003).
  • Zhang XZ; Moilanen E; Adcock I; Giembycz MA; Barnes PJ; Kankaanranta H. Histone acetylation status regulates eosinophil and neutrophil apoptosis. 197:309-309. (15 Jun 2004).
  • Smith SF; Barnes PJ; OConnor BJ; Lim S. Evidence for secretion of lipocortin 1 into the upper and central airways of human subjects. 42:P658-P659. (Nov 1996).
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