Contact details

Dr Paolo A Muraro

Clinical Reader in Neuroimmunology
Department of Medicine

Email: Email address for Dr Paolo A Muraro

Dr Paolo A Muraro

A medical graduate from University of Rome "La Sapienza", Dr Muraro trained in clinical neurology and neuroimmunology in Italy and at the National Institute of Neurological Disorders and Stroke, National Institutes of Health, United States.

Dr Muraro's research focuses on understanding the pathogenesis of inflammatory neurological diseases, particularly multiple sclerosis (MS), and on developing effective therapies.

His scientific contributions include the characterization of immune responses to myelin proteins, studies of T cell repertoire in health and autoimmune disease, and the elucidation of the mechanisms of action of immuno-modulatory treatments and haematopoietic stem cell transplantation (HSCT) in MS. A recent study providing the first demonstration of immune renewal in patients treated with HSCT has been highlighted in editorials and press commentaries including the Dana Foundation Progress Report on Brain Research 2006. http://www.dana.org/news/publications/detail.aspx?id=4226

Selected Publications

Journals

Dubinsky AN; Burt RK; Martin R; Muraro PA. (Feb 2010). T-cell clones persisting in the circulation after autologous hematopoietic SCT are undetectable in the peripheral CD34+ selected graft. Bone Marrow Transplant. 45:325-331. DOI.
Burt RK; Loh Y; Cohen B; Stefosky D; Balabanov R; Katsamakis G; Oyama Y; Russell EJ; et alStern J; Muraro P; Rose J; Testori A; Bucha J; Jovanovic B; Milanetti F; Storek J; Voltarelli JC; Burns WH. (Mar 2009). Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. LANCET NEUROL. 8:244-253. DOI.
Cassiani-Ingoni R; Muraro PA; Magnus T; Reichert-Scrivner S; Schmidt J; Huh J; Quandt JA; Bratincsak A; et alShahar T; Eusebi F; Sherman LS; Mattson MP; Martin R; Rao MS. (Jul 2007). Disease progression after bone marrow transplantation in a model of multiple sclerosis is associated with chronic microglial and glial progenitor response. J NEUROPATH EXP NEUR. 66:637-649.
Packer AN; Muraro PA. (Mar 2007). Optimized clonotypic analysis of T-cell receptor repertoire in immune reconstitution. Exp Hematol. 35:516-521. DOI.
Muraro PA; Cassiani-Ingoni R; Chung K; Packer AN; Sospedra M; Martin R. (Feb 2006). Clonotypic analysis of cerebrospinal fluid T cells during disease exacerbation and remission in a patient with multiple sclerosis. J Neuroimmunol. 171:177-183. DOI.
Muraro PA; Douek DC. (Feb 2006). Renewing the T cell repertoire to arrest autoimmune aggression. Trends Immunol. 27:61-67. DOI.
Muraro PA; Douek DC; Packer A; Chung K; Guenaga FJ; Cassiani-Ingoni R; Campbell C; Memon S; et alNagle JW; Hakim FT; Gress RE; McFarland HF; Burt RK; Martin R. (7 Mar 2005). Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J Exp Med. 201:805-816. DOI.
Muraro PA; Liberati L; Bonanni L; Pantalone A; Caporale CM; Iarlori C; De Luca G; Farina D; et alLugaresi A; Gambi D. (May 2004). Decreased integrin gene expression in patients with MS responding to interferon-beta treatment. J Neuroimmunol. 150:123-131. DOI.
Muraro PA; Cassiani Ingoni R; Martin R. (Jun 2003). Hematopoietic stem cell transplantation for multiple sclerosis: current status and future challenges. Curr Opin Neurol. 16:299-305. DOI.
Muraro PA; Wandinger KP; Bielekova B; Gran B; Marques A; Utz U; McFarland HF; Jacobson S; et alMartin R. (Jan 2003). Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders. Brain. 126:20-31.
Muraro PA; Bonanni L; Mazzanti B; Pantalone A; Traggiai E; Massacesi L; Vergelli M; Gambi D. (Jun 2002). Short-term dynamics of circulating T cell receptor V beta repertoire in relapsing-remitting MS. J Neuroimmunol. 127:149-159.
Muraro PA; Jacobsen M; Necker A; Nagle JW; Gaber R; Sommer N; Oertel WH; Martin R; et alHemmer B. (1 Dec 2000). Rapid identification of local T cell expansion in inflammatory organ diseases by flow cytometric T cell receptor Vbeta analysis. J Immunol Methods. 246:131-143.
Muraro PA; Leist T; Bielekova B; McFarland HF. (1 Nov 2000). VLA-4/CD49d downregulated on primed T lymphocytes during interferon-beta therapy in multiple sclerosis. J Neuroimmunol. 111:186-194.
Muraro PA; Pette M; Bielekova B; McFarland HF; Martin R. (15 May 2000). Human autoreactive CD4+ T cells from naive CD45RA+ and memory CD45RO+ subsets differ with respect to epitope specificity and functional antigen avidity. J Immunol. 164:5474-5481.
Muraro PA; Vergelli M; Kalbus M; Banks DE; Nagle JW; Tranquill LR; Nepom GT; Biddison WE; et alMcFarland HF; Martin R. (15 Jul 1997). Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire. J Clin Invest. 100:339-349. DOI.

Chapters in books

Muraro P; Van Laar J; Illei G; Pavletic S. Hematopoietic stem cell transplantation for autoimmune disorders. In Hematopoietic Stem Cell Transplantation in Clinical Practice. 197-210. Barrett AJ (ed); Treleaven J (ed). Churchill Livingstone/Elsevier Science, Edinburgh (2008).