Professor Peter J Openshaw MB BS PhD FMedSci
Head of Section; Prof of Experimental Medicine
National Heart & Lung Institute
St Mary's Campus
Tel: +44 (0)20 7594 3854
Professor Peter Openshaw
Peter Openshaw is the Director of the Centre for Respiratory Infection (CRI) at the National Heart and Lung Institute, Imperial College London. He is also Professor of Experimental Medicine and an Honorary Physician in the Department of Respiratory Medicine at the St Mary's Campus of the Imperial College NHS Trust.
Peter trained at Guy's Hospital, the Brompton and the Royal Postgraduate Medical School (Hammersmith). His PhD training (with Ita Askonas FRS at the National Institute for Medical Research, 1985-1988) led to a Wellcome Senior Fellowship and the creation of the Academic Department of Respiratory Medicine at St Mary's. The department now has three professors (Peter Openshaw, Sebastian Johnston and Ajit Lalvani) and over 60 members of staff. It was completely refurbished in 2002-2003 (JIF award). He was the Principal Applicant on a strategic award for a Centre in Respiratory Infection (Wellcome Trust, £3.4m, 2008-2010).
His research is on the immunology of the lung, viral lung disease, vaccination and immunopathogenesis of viral disease. He was among the first 100 elected Fellows of the Academy of Medical Sciences (1999). He served on Wellcome Trust's Clinical Interest Group (1997-2003), Infection and Immunity (2002-2004) and the Tropical and Clinical Panels (2006-2008) and is now on the Immunology and Infectious Diseases panel. He has served on many other national and international grant bodies. He became a member of British Society for Immunology's Council in 2006 and a member of the Department of Health's Scientific Advisory Group on Pandemic Influenza in December 2007.
In 2009 Peter was invited by the Department of Health to became a member of the Scientific Advisory Group in Emergencies (SAGE), chaired by the Chief Government Scientist, which advised the UK Government on pandemic influenza.
In May 2009, he was invited by the Department of Health, to convene a UK-wide consortium of research groups to study hospitalised patients with H1N1/09 infection, Mechanisms of Severe Accute Influenza Consortium (MOSAIC). This involved 45 co-investigators in 8 cities, focusing on a comprehensive investigation of hospitalised patients with influenza.
- Tregoning JS; Wang BL; McDonald JU; Yamaguchi Y; Harker JA; Goritzka M; Johansson C; Bukreyev A; et alCollins PL; Openshaw PJ. (2 Apr 2013). Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection. Proc Natl Acad Sci U S A. 110:5576-5581. Author weblink DOI.
- Loebbermann J; Durant L; Thornton H; Johansson C; Openshaw PJ. (19 Feb 2013). Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells. Proc Natl Acad Sci U S A. 110:2987-2992. Author weblink DOI.
- Dodd JS; Clark D; Muir R; Korpis C; Openshaw PJ. (21 Nov 2012). Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV disease in mice. Mucosal Immunol. Author weblink DOI.
- Loebbermann J; Thornton H; Durant L; Sparwasser T; Webster KE; Sprent J; Culley FJ; Johansson C; et alOpenshaw PJ. (Mar 2012). Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol. 5:161-172. Author weblink DOI.
- Everitt AR; Clare S; Pertel T; John SP; Wash RS; Smith SE; Chin CR; Feeley EM; et alSims JS; Adams DJ; Wise HM; Kane L; Goulding D; Digard P; Anttila V; Baillie JK; Walsh TS; Hume DA; Palotie A; Xue Y; Colonna V; Tyler-Smith C; Dunning J; Gordon SB; GenISIS Investigators; MOSAIC Investigators; Smyth RL; Openshaw PJ; Dougan G; Brass AL; Kellam P. (26 Apr 2012). IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 484:519-523. Author weblink DOI.
- Pribul PK; Harker J; Wang B; Wang H; Tregoning JS; Schwarze J; Openshaw PJM. (1 May 2008). Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development. JOURNAL OF VIROLOGY. 82:4441-4448. Author weblink DOI.