Professor Peter Openshaw

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Professor Peter J Openshaw MB BS PhD FMedSci

Head of Section; Prof of Experimental Medicine
National Heart & Lung Institute

Norfolk Place
St Mary's Campus

Tel: +44 (0)20 7594 3854
Email: Email address for Professor Peter J Openshaw MB BS PhD FMedSci

Professor Peter Openshaw

Peter Openshaw is the Director of the Centre for Respiratory Infection (CRI) at the National Heart and Lung Institute, Imperial College London.  He is also Professor of Experimental Medicine and an Honorary Physician in the Department of Respiratory Medicine at the St Mary's Campus of the Imperial College NHS Trust.

Peter trained at Guy's Hospital, the Brompton and the Royal Postgraduate Medical School (Hammersmith).  His PhD training (with Ita Askonas FRS at the National Institute for Medical Research, 1985-1988) led to a Wellcome Senior Fellowship and the creation of the Academic Department of Respiratory Medicine at St Mary's.  The department now has three professors (Peter Openshaw, Sebastian Johnston and Ajit Lalvani) and over 60 members of staff.  It was completely refurbished in 2002-2003 (JIF award).  He was the Principal Applicant on a strategic award for a Centre in Respiratory Infection (Wellcome Trust, £3.4m, 2008-2010).

His research is on the immunology of the lung, viral lung disease, vaccination and immunopathogenesis of viral disease.  He was among the first 100 elected Fellows of the Academy of Medical Sciences (1999).  He served on Wellcome Trust's Clinical Interest Group (1997-2003), Infection and Immunity (2002-2004) and the Tropical and Clinical Panels (2006-2008) and is now on the Immunology and Infectious Diseases panel.  He has served on many other national and international grant bodies.  He became a member of British Society for Immunology's Council in 2006 and a member of the Department of Health's Scientific Advisory Group on Pandemic Influenza in December 2007.

In 2009 Peter was invited by the Department of Health to became a member of the Scientific Advisory Group in Emergencies (SAGE), chaired by the Chief Government Scientist, which advised the UK Government on pandemic influenza.

In May 2009, he was invited by the Department of Health, to convene a UK-wide consortium of research groups to study hospitalised patients with H1N1/09 infection, Mechanisms of Severe Accute Influenza Consortium (MOSAIC). This involved 45 co-investigators in 8 cities, focusing on a comprehensive investigation of hospitalised patients with influenza.

 

Selected Publications


Journals

  • everitt A. (2012). IFITM3 restricts the morbidity and mortality associated with influenza. Nature.
  • Nguyen-Van-Tam JS; Openshaw PJ; Hashim A; Gadd EM; Lim WS; Semple MG; Read RC; Taylor BL; et alBrett SJ; McMenamin J; Enstone JE; Armstrong C; Nicholson KG; Influenza Clinical Information Network (FLU-CIN). (Jul 2010). Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009). Thorax. 65:645-651. DOI.
  • Lee DC; Harker JA; Tregoning JS; Atabani SF; Johansson C; Schwarze J; Openshaw PJ. (Sep 2010). CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection. J Virol. 84:8790-8798. DOI.
  • Openshaw PJ; Dunning J. (Sep 2010). Influenza vaccination: lessons learned from the pandemic (H1N1) 2009 influenza outbreak. Mucosal Immunol. 3:422-424. DOI.
  • Dunning J; Openshaw PJ. (Jun 2010). Impact of the 2009 influenza pandemic. Thorax. 65:471-472. DOI.
  • Harker JA; Lee DC; Yamaguchi Y; Wang B; Bukreyev A; Collins PL; Tregoning JS; Openshaw PJ. (May 2010). Delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection. J Virol. 84:5294-5302. DOI.
  • Tregoning JS; Pribul PK; Pennycook AM; Hussell T; Wang B; Lukacs N; Schwarze J; Culley FJ; et alOpenshaw PJ. (2010). The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung. PLoS One. 5:e9381. DOI Open Access copy.
  • Dodd JS; Lum E; Goulding J; Muir R; Van Snick J; Openshaw PJ. (1 Dec 2009). IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection. J Immunol. 183:7006-7013. DOI.
  • Olszewska W; Openshaw P. (1 Jun 2009). Emerging drugs for respiratory syncytial virus infection. EXPERT OPINION ON EMERGING DRUGS. 14:207-217. Author weblink DOI.
  • Dodd J; Riffault S; Kodituwakku JS; Hayday AC; Openshaw PJ. (15 Jan 2009). Pulmonary V gamma 4+ gamma delta T cells have proinflammatory and antiviral effects in viral lung disease. J Immunol. 182:1174-1181.
  • Pribul PK; Harker J; Wang B; Wang H; Tregoning JS; Schwarze J; Openshaw PJM. (1 May 2008). Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development. JOURNAL OF VIROLOGY. 82:4441-4448. Author weblink DOI.
  • Tregoning JS; Yamaguchi Y; Harker J; Wang B; Openshaw PJ. (Apr 2008). The role of T cells in the enhancement of respiratory syncytial virus infection severity during adult reinfection of neonatally sensitized mice. J Virol. 82:4115-4124. DOI.
  • Harker J; Bukreyev A; Collins PL; Wang B; Openshaw PJM; Tregoning JS. (1 Dec 2007). Virally delivered Cytokines alter the immune response to future lung infections. JOURNAL OF VIROLOGY. 81:13105-13111. Author weblink DOI.
  • Moghaddam A; Olszewska W; Wang B; Tregoning JS; Helson R; Sattentau QJ; Openshaw PJ. (Aug 2006). A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines. Nat Med. 12:905-907. DOI.
  • Smyth RL; Openshaw PJ. (22 Jul 2006). Bronchiolitis. Lancet. 368:312-322. DOI.
  • Culley FJ; Pennycook AM; Tregoning JS; Hussell T; Openshaw PJ. (May 2006). Differential chemokine expression following respiratory virus infection reflects Th1- or Th2-biased immunopathology. J Virol. 80:4521-4527. DOI.
  • Wilkinson TM; Donaldson GC; Johnston SL; Openshaw PJ; Wedzicha JA. (15 Apr 2006). Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 173:871-876. DOI.
  • Openshaw PJ; Tregoning JS. (Jul 2005). Immune responses and disease enhancement during respiratory syncytial virus infection. Clin Microbiol Rev. 18:541-555. DOI.
  • Openshaw PJ. (2005). Antiviral immune responses and lung inflammation after respiratory syncytial virus infection. Proc Am Thorac Soc. 2:121-125. DOI.
  • Openshaw PJ; Yamaguchi Y; Tregoning JS. (Dec 2004). Childhood infections, the developing immune system, and the origins of asthma. J Allergy Clin Immunol. 114:1275-1277. DOI.
  • Schwarze J; O'Donnell DR; Rohwedder A; Openshaw PJ. (1 Apr 2004). Latency and persistence of respiratory syncytial virus despite T cell immunity. Am J Respir Crit Care Med. 169:801-805. DOI.
  • Culley FJ; Pollott J; Openshaw PJ. (18 Nov 2002). Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood. J Exp Med. 196:1381-1386.
  • Godkin AJ; Thomas HC; Openshaw PJ. (15 Aug 2002). Evolution of epitope-specific memory CD4(+) T cells after clearance of hepatitis C virus. J Immunol. 169:2210-2214.
  • Pala P; Bjarnason R; Sigurbergsson F; Metcalfe C; Sigurs N; Openshaw PJ. (Aug 2002). Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy. Eur Respir J. 20:376-382.
  • Openshaw PJ; Culley FJ; Olszewska W. (15 Oct 2001). Immunopathogenesis of vaccine-enhanced RSV disease. Vaccine. 20 Suppl 1:S27-S31.
  • Hussell T; Pennycook A; Openshaw PJ. (Sep 2001). Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology. Eur J Immunol. 31:2566-2573. DOI.
  • Walzl G; Matthews S; Kendall S; Gutierrez-Ramos JC; Coyle AJ; Openshaw PJ; Hussell T. (2 Apr 2001). Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology. J Exp Med. 193:785-792.
  • Simmons CP; Hussell T; Sparer T; Walzl G; Openshaw P; Dougan G. (15 Jan 2001). Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8+ T cell responses. J Immunol. 166:1106-1113.
  • Hussell T; Openshaw PJ. (15 Dec 2000). IL-12-activated NK cells reduce lung eosinophilia to the attachment protein of respiratory syncytial virus but do not enhance the severity of illness in CD8 T cell-immunodeficient conditions. J Immunol. 165:7109-7115.
  • Walzl G; Tafuro S; Moss P; Openshaw PJ; Hussell T. (6 Nov 2000). Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology. J Exp Med. 192:1317-1326.
  • Pala P; Hussell T; Openshaw PJ. (21 Sep 2000). Flow cytometric measurement of intracellular cytokines. J Immunol Methods. 243:107-124.
  • O'Donnell DR; Openshaw PJ. (Dec 1998). Anaphylactic sensitization to aeroantigen during respiratory virus infection. Clin Exp Allergy. 28:1501-1508.
  • Hussell T; Openshaw PJ. (Nov 1998). Intracellular IFN-gamma expression in natural killer cells precedes lung CD8+ T cell recruitment during respiratory syncytial virus infection. J Gen Virol. 79 ( Pt 11):2593-2601.
  • O'Donnell DR; McGarvey MJ; Tully JM; Balfour-Lynn IM; Openshaw PJ. (Aug 1998). Respiratory syncytial virus RNA in cells from the peripheral blood during acute infection. J Pediatr. 133:272-274.
  • Spender LC; Hussell T; Openshaw PJ. (Jul 1998). Abundant IFN-gamma production by local T cells in respiratory syncytial virus-induced eosinophilic lung disease. J Gen Virol. 79 ( Pt 7):1751-1758.
  • Sparer TE; Matthews S; Hussell T; Rae AJ; Garcia-Barreno B; Melero JA; Openshaw PJ. (1 Jun 1998). Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia. J Exp Med. 187:1921-1926.
  • Murphy E; Shibuya K; Hosken N; Openshaw P; Maino V; Davis K; Murphy K; O'Garra A. (1 Mar 1996). Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J Exp Med. 183:901-913.
  • Openshaw P; Murphy EE; Hosken NA; Maino V; Davis K; Murphy K; O'Garra A. (1 Nov 1995). Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med. 182:1357-1367.
  • Alwan WH; Kozlowska WJ; Openshaw PJ. (1 Jan 1994). Distinct types of lung disease caused by functional subsets of antiviral T cells. J Exp Med. 179:81-89.
  • Alwan WH; Openshaw PJ. (1993). Distinct patterns of T- and B-cell immunity to respiratory syncytial virus induced by individual viral proteins. Vaccine. 11:431-437.
  • Alwan WH; Record FM; Openshaw PJ. (Jun 1992). CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells. Clin Exp Immunol. 88:527-536.
  • Cherrie AH; Anderson K; Wertz GW; Openshaw PJ. (Apr 1992). Human cytotoxic T cells stimulated by antigen on dendritic cells recognize the N, SH, F, M, 22K, and 1b proteins of respiratory syncytial virus. J Virol. 66:2102-2110.
  • Openshaw PJ; Clarke SL; Record FM. (Apr 1992). Pulmonary eosinophilic response to respiratory syncytial virus infection in mice sensitized to the major surface glycoprotein G. Int Immunol. 4:493-500.
  • Openshaw PJ. (Feb 1989). Flow cytometric analysis of pulmonary lymphocytes from mice infected with respiratory syncytial virus. Clin Exp Immunol. 75:324-328.
  • Cannon MJ; Openshaw PJ; Askonas BA. (1 Sep 1988). Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. J Exp Med. 168:1163-1168.
  • Bangham CR; Openshaw PJ; Ball LA; King AM; Wertz GW; Askonas BA. (15 Dec 1986). Human and murine cytotoxic T cells specific to respiratory syncytial virus recognize the viral nucleoprotein (N), but not the major glycoprotein (G), expressed by vaccinia virus recombinants. J Immunol. 137:3973-3977.
  • Openshaw P; Edwards S; Helms P. (Aug 1984). Changes in rib cage geometry during childhood. Thorax. 39:624-627.
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