Professor Peter Openshaw

Publications


Journals

  • Wythe SE; Dodd JS; Openshaw PJ; Schwarze J. (15 Feb 2012). OX40 Ligand and Programmed Cell Death 1 Ligand 2 Expression on Inflammatory Dendritic Cells Regulates CD4 T Cell Cytokine Production in the Lung during Viral Disease. J Immunol. 188:1647-1655. DOI.
  • Loebbermann J; Thornton H; Durant L; Sparwasser T; Webster KE; Sprent J; Culley FJ; Johansson C; et alOpenshaw PJ. (11 Jan 2012). Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol. DOI.
  • Lim WS; Bewick T; Myles P; Greenwood S; Nguyen-Van-Tam JS; Brett S; Semple MG; Openshaw PJ; et alBannister B; Read RC; Taylor B; McMenamin J; Enstone JE; Nicholson KG; Influenza Clinical Information. (Dec 2011). The increasing importance of innate antimicrobials response. THORAX. 66:1091-1091. DOI.
  • Dunning J; Nguyen-Van-Tam J; Nicholson K; Openshaw P. (8 Nov 2011). Doctors accepting flu vaccination is the sensible and responsible choice. BMJ: British Medical Journal. 343. DOI.
  • Dunning J; Nguyen-Van-Tam J; Nicholson K; Openshaw P. (2011). Doctors accepting flu vaccination is the sensible and responsible choice. BMJ. 343:d7199.
  • Brett SJ; Myles P; Lim WS; Enstone JE; Bannister B; Semple MG; Read RC; Taylor BL; et alMcMenamin J; Nicholson KG; Nguyen-Van-Tam JS; Openshaw PJ; Influenza Clinical Information Network (FLU-CIN). (2011). Pre-admission statin use and in-hospital severity of 2009 pandemic influenza A(H1N1) disease. PLoS One. 6:e18120. DOI.
  • Enstone JE; Myles PR; Openshaw PJ; Gadd EM; Lim WS; Semple MG; Read RC; Taylor BL; et alMcMenamin J; Armstrong C; Bannister B; Nicholson KG; Nguyen-Van-Tam JS. (Apr 2011). Nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010. Emerg Infect Dis. 17:592-598. DOI.
  • Habibi MS; Patel S; Openshaw P. (Mar 2011). Hot topics in the prevention of respiratory syncytial virus disease. Expert Rev Vaccines. 10:291-293. DOI.
  • Bewick T; Myles P; Greenwood S; Nguyen-Van-Tam JS; Brett SJ; Semple MG; Openshaw PJ; Bannister B; et alRead RC; Taylor BL; McMenamin J; Enstone JE; Nicholson KG; Lim WS; Influenza Clinical Information Network. (Mar 2011). Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults. Thorax. 66:247-252. DOI.
  • Telcian AG; Laza-Stanca V; Edwards MR; Harker JA; Wang H; Bartlett NW; Mallia P; Zdrenghea MT; et alKebadze T; Coyle AJ; Openshaw PJ; Stanciu LA; Johnston SL. (1 Jan 2011). RSV-induced bronchial epithelial cell PD-L1 expression inhibits CD8+ T cell nonspecific antiviral activity. J Infect Dis. 203:85-94. DOI.
  • Olszewska W; Ispas G; Schnoeller C; Sawant D; Van de Casteele T; Nauwelaers D; Van Kerckhove B; Roymans D; et alDe Meulder M; Rouan MC; Van Remoortere P; Bonfanti JF; Van Velsen F; Koul A; Vanstockem M; Andries K; Sowinski P; Wang B; Openshaw P; Verloes R. (Aug 2011). Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model. Eur Respir J. 38:401-408. DOI.
  • Tregoning JS; Yamaguchi Y; Wang B; Mihm D; Harker JA; Bushell ES; Zheng M; Liao G; et alPeltz G; Openshaw PJ. (1 Nov 2010). Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent. J Immunol. 185:5384-5391. DOI.
  • Nguyen-Van-Tam JS; Openshaw PJ; Hashim A; Gadd EM; Lim WS; Semple MG; Read RC; Taylor BL; et alBrett SJ; McMenamin J; Enstone JE; Armstrong C; Nicholson KG; Influenza Clinical Information Network (FLU-CIN). (Jul 2010). Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009). Thorax. 65:645-651. DOI.
  • Lee DC; Harker JA; Tregoning JS; Atabani SF; Johansson C; Schwarze J; Openshaw PJ. (Sep 2010). CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection. J Virol. 84:8790-8798. DOI.
  • Openshaw PJ; Dunning J. (Sep 2010). Influenza vaccination: lessons learned from the pandemic (H1N1) 2009 influenza outbreak. Mucosal Immunol. 3:422-424. DOI.
  • Dunning J; Openshaw PJ. (Jun 2010). Impact of the 2009 influenza pandemic. Thorax. 65:471-472. DOI.
  • Harker JA; Lee DC; Yamaguchi Y; Wang B; Bukreyev A; Collins PL; Tregoning JS; Openshaw PJ. (May 2010). Delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection. J Virol. 84:5294-5302. DOI.
  • Harker JA; Godlee A; Wahlsten JL; Lee DC; Thorne LG; Sawant D; Tregoning JS; Caspi RR; et alBukreyev A; Collins PL; Openshaw PJ. (Apr 2010). Interleukin 18 coexpression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells. J Virol. 84:4073-4082. DOI.
  • Samarasinghe S; Mancao C; Pule M; Nawroly N; Karlsson H; Brewin J; Openshaw P; Gaspar HB; et alVeys P; Amrolia PJ. (14 Jan 2010). Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy. Blood. 115:396-407. DOI.
  • Tregoning JS; Pribul PK; Pennycook AM; Hussell T; Wang B; Lukacs N; Schwarze J; Culley FJ; et alOpenshaw PJ. (2010). The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung. PLoS One. 5:e9381. DOI Open Access copy.
  • Openshaw P. (Jan 2010). BRONCHIOLITIS. CHILD CARE HLTH DEV. 36:8-8.
  • Dodd JS; Lum E; Goulding J; Muir R; Van Snick J; Openshaw PJ. (1 Dec 2009). IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection. J Immunol. 183:7006-7013. DOI.
  • Olszewska W; Openshaw P. (Jun 2009). Emerging drugs for respiratory syncytial virus infection. EXPERT OPIN EMERG DR. 14:207-217. DOI.
  • Openshaw PJ. (Mar 2009). Crossing barriers: infections of the lung and the gut. MUCOSAL IMMUNOL. 2:100-102. DOI.
  • Dodd J; Riffault S; Kodituwakku JS; Hayday AC; Openshaw PJ. (15 Jan 2009). Pulmonary V gamma 4+ gamma delta T cells have proinflammatory and antiviral effects in viral lung disease. J Immunol. 182:1174-1181.
  • Tourdot S; Mathie S; Hussell T; Edwards L; Wang H; Openshaw PJM; Schwarze J; Lloyd CM. (Jul 2008). Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization (vol 38, pg 1016, 2008). CLIN EXP ALLERGY. 38:1241-1241.
  • Pollock K; Openshaw P. (May 2008). World Immune Regulation Meeting II. IDrugs. 11:312-314.
  • Pribul PK; Harker J; Wang B; Wang H; Tregoning JS; Schwarze J; Openshaw PJM. (May 2008). Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development. J VIROL. 82:4441-4448. DOI.
  • Tregoning JS; Yamaguchi Y; Harker J; Wang B; Openshaw PJ. (Apr 2008). The role of T cells in the enhancement of respiratory syncytial virus infection severity during adult reinfection of neonatally sensitized mice. J Virol. 82:4115-4124. DOI.
  • Helson R; Olszewska W; Singh M; Megede JZ; Melero JA; O'Hagan D; Openshaw PJ. (6 Feb 2008). Polylactide-co-glycolide (PLG) microparticles modify the immune response to DNA vaccination. Vaccine. 26:753-761. DOI.
  • Harker J; Bukreyev A; Collins PL; Wang B; Openshaw PJM; Tregoning JS. (Dec 2007). Virally delivered Cytokines alter the immune response to future lung infections. J VIROL. 81:13105-13111. DOI.
  • Culley FJ; Pennycook AM; Tregoning JS; Dodd JS; Walzl G; Wells TN; Hussell T; Openshaw PJ. (Aug 2006). Role of CCL5 (RANTES) in viral lung disease. J Virol. 80:8151-8157. DOI.
  • Moghaddam A; Olszewska W; Wang B; Tregoning JS; Helson R; Sattentau QJ; Openshaw PJ. (Aug 2006). A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines. Nat Med. 12:905-907. DOI.
  • Smyth RL; Openshaw PJ. (22 Jul 2006). Bronchiolitis. Lancet. 368:312-322. DOI.
  • OPENSHAW PJM; ASKONAS BA. (1987). LYMPHOCYTOSIS IN CELLS RECOVERED BY BRONCHOALVEOLAR LAVAGE FROM MICE INFECTED WITH HUMAN RESPIRATORY SYNCYTIAL VIRUS. CLIN SCI. 72:P35-P35.
  • OPENSHAW PJM; JONES HA; HUGHES JMB. (1986). THE EFFECT OF SALBUTAMOL IN CHRONIC AIR-FLOW OBSTRUCTION. CLIN SCI. 70:P69-P69.
  • Openshaw P. (Jun 2006). T cells take the inside track. Nat Med. 12:614-615. DOI.
  • Culley FJ; Pennycook AM; Tregoning JS; Hussell T; Openshaw PJ. (May 2006). Differential chemokine expression following respiratory virus infection reflects Th1- or Th2-biased immunopathology. J Virol. 80:4521-4527. DOI.
  • Wilkinson TM; Donaldson GC; Johnston SL; Openshaw PJ; Wedzicha JA. (15 Apr 2006). Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 173:871-876. DOI.
  • Harker J; Tregoning JS; Bukreyev A; Yamaguchi Y; Mihm D; Collins P; Openshaw PJM. (Dec 2005). Contrasting effects of virally expressed IFN-gamma and IL-4 in neonatal and adult mice. IMMUNOLOGY. 116:25-25.
  • Tourdot S; Hussell T; Openshaw PJM; Edwards L; Lloyd CM. (Dec 2005). RSV infection provokes airway remodelling in non-sensitised allergen challenged mice. IMMUNOLOGY. 116:53-53.
  • Dodd JS; Korpis C; Openshaw PJM. (Dec 2005). IL-21 reduces immunopathology in respiratory viral disease in a T cell-dependent manner. IMMUNOLOGY. 116:84-84.
  • Godkin A; Openshaw P; Thomas HC. (Nov 2005). Immune tolerance to hepatitis C virus acquired during engraftment of bone marrow transplant. J Viral Hepat. 12:604-608. DOI.
  • Openshaw PJ; Tregoning JS. (Jul 2005). Immune responses and disease enhancement during respiratory syncytial virus infection. Clin Microbiol Rev. 18:541-555. DOI.
  • Matthews SP; Tregoning JS; Coyle AJ; Hussell T; Openshaw PJ. (Feb 2005). Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection. J Virol. 79:2050-2057. DOI.
  • Openshaw PJ. (2005). Antiviral immune responses and lung inflammation after respiratory syncytial virus infection. Proc Am Thorac Soc. 2:121-125. DOI.
  • Openshaw PJ; Tregoning J; Harker J. (2005). RSV 2005: Global impact, changing concepts, and new challenges. Viral Immunol. 18:749-751. DOI.
  • Beyer M; Wang H; Peters N; Doths S; Koerner-Rettberg C; Openshaw PJ; Schwarze J. (2005). The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo. Respir Res. 6:70. DOI.
  • Openshaw PJ; Yamaguchi Y; Tregoning JS. (Dec 2004). Childhood infections, the developing immune system, and the origins of asthma. J Allergy Clin Immunol. 114:1275-1277. DOI.
  • Olszewska W; Suezer Y; Sutter G; Openshaw PJ. (25 Nov 2004). Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins. Vaccine. 23:215-221. DOI.
  • Schmidt AC; Johnson TR; Openshaw PJ; Braciale TJ; Falsey AR; Anderson LJ; Wertz GW; Groothuis JR; et alPrince GA; Melero JA; Graham BS. (Nov 2004). Respiratory syncytial virus and other pneumoviruses: a review of the international symposium--RSV 2003. Virus Res. 106:1-13. DOI.
  • Maher CF; Hussell T; Blair E; Ring CJ; Openshaw PJ. (Oct 2004). Recombinant respiratory syncytial virus lacking secreted glycoprotein G is attenuated, non-pathogenic but induces protective immunity. Microbes Infect. 6:1049-1055. DOI.
  • Bartholdy C; Olszewska W; Stryhn A; Thomsen AR; Openshaw PJ. (Oct 2004). Gene-gun DNA vaccination aggravates respiratory syncytial virus-induced pneumonitis. J Gen Virol. 85:3017-3026. DOI.
  • Ison MG; Johnston SL; Openshaw P; Murphy B; Hayden F. (Jun 2004). Current research on respiratory viral infections: Fifth International Symposium. Antiviral Res. 62:75-110.
  • Olszewska W; Helson R; Openshaw PJ. (Jun 2004). Vaccines for the prevention of respiratory viral infections: problems and current status. Expert Opin Investig Drugs. 13:681-689. DOI.
  • Regner M; Culley F; Fontannaz P; Hu K; Morein B; Lambert PH; Openshaw P; Siegrist CA. (Jun 2004). Safety and efficacy of immune-stimulating complex-based antigen delivery systems for neonatal immunisation against respiratory syncytial virus infection. Microbes Infect. 6:666-675. DOI.
  • Schwarze J; O'Donnell DR; Rohwedder A; Openshaw PJ. (1 Apr 2004). Latency and persistence of respiratory syncytial virus despite T cell immunity. Am J Respir Crit Care Med. 169:801-805. DOI.
  • Openshaw PJ. (Apr 2004). What does the peripheral blood tell you in SARS?. Clin Exp Immunol. 136:11-12. DOI.
  • Olszewska W; Openshaw P. (Dec 2003). Viral Vaccine Meeting 2003 - 25-28 October, 2003, Barcelona, Spain. IDRUGS. 6:1127-1129.
  • Openshaw PJ. (Aug 2003). Where is SARS now?. Thorax. 58:650-651.
  • Olszewska W; Openshaw P. (Jun 2003). The future of vaccines--cancer meets infectious diseases: immune mechanisms. 10-13 April 2003, Semmering, Austria. IDrugs. 6:522-524.
  • Walzl G; Humphreys IR; Marshall BG; Edwards L; Openshaw PJ; Shaw RJ; Hussell T. (Jun 2003). Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner. Infect Immun. 71:3384-3391.
  • Openshaw PJ. (Feb 2003). RSV bronchiolitis, gammadelta T cells and asthma: are they linked?. Clin Exp Immunol. 131:197-198.
  • Openshaw PJ; Dean GS; Culley FJ. (Feb 2003). Links between respiratory syncytial virus bronchiolitis and childhood asthma: clinical and research approaches. Pediatr Infect Dis J. 22:S58-S64. DOI.
  • Pala P; Message SD; Johnston SL; Openshaw PJ. (Dec 2002). Increased aeroallergen-specific interleukin-4-producing T cells in asthmatic adults. Clin Exp Allergy. 32:1739-1744.
  • Culley FJ; Pollott J; Openshaw PJ. (18 Nov 2002). Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood. J Exp Med. 196:1381-1386.
  • Godkin AJ; Thomas HC; Openshaw PJ. (15 Aug 2002). Evolution of epitope-specific memory CD4(+) T cells after clearance of hepatitis C virus. J Immunol. 169:2210-2214.
  • Ison MG; Mills J; Openshaw P; Zambon M; Osterhaus A; Hayden F. (Aug 2002). Current research on respiratory viral infections: Fourth International Symposium. Antiviral Res. 55:227-278.
  • Pala P; Bjarnason R; Sigurbergsson F; Metcalfe C; Sigurs N; Openshaw PJ. (Aug 2002). Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy. Eur Respir J. 20:376-382.
  • Openshaw PJ. (2002). Potential therapeutic implications of new insights into respiratory syncytial virus disease. Respir Res. 3 Suppl 1:S15-S20.
  • Godkin A; Openshaw P; Thomas H. (Apr 2002). Characterisation of epitope-specific functionally distinct CD4+memory cell populations after clearance of hepatitis C virus (HCV). GASTROENTEROLOGY. 122:A640-A640.
  • Olszewska W; Zambon M; Openshaw PJ. (2002). Development of vaccines against common colds. Br Med Bull. 62:99-111.
  • Boyton RJ; Openshaw PJ. (2002). Pulmonary defences to acute respiratory infection. Br Med Bull. 61:1-12.
  • Ostler T; Schamel K; Hussell T; Openshaw P; Hausmann J; Ehl S. (1 Nov 2001). An improved protocol for measuring cytotoxic T cell activity in anatomic compartments with low cell numbers. J Immunol Methods. 257:155-161.
  • Openshaw PJ; Culley FJ; Olszewska W. (15 Oct 2001). Immunopathogenesis of vaccine-enhanced RSV disease. Vaccine. 20 Suppl 1:S27-S31.
  • Hussell T; Pennycook A; Openshaw PJ. (Sep 2001). Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology. Eur J Immunol. 31:2566-2573. DOI.
  • Ostler T; Hussell T; Surh CD; Openshaw P; Ehl S. (Sep 2001). Long-term persistence and reactivation of T cell memory in the lung of mice infected with respiratory syncytial virus. Eur J Immunol. 31:2574-2582. DOI.
  • Wachholz PA; Verhoef A; Walker S; Pala P; Openshaw P; Till SJ; Durham SR. (Jul 2001). Subcutaneous grass pollen immunotherapy (it): influence on immunological responses in the peripheral blood. CLIN EXP ALLERGY. 31:1157-1158.
  • Godkin A; Jeanguet N; Thursz M; Openshaw P; Thomas H. (May 2001). Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients. Eur J Immunol. 31:1438-1446. DOI.
  • Walzl G; Matthews S; Kendall S; Gutierrez-Ramos JC; Coyle AJ; Openshaw PJ; Hussell T. (2 Apr 2001). Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology. J Exp Med. 193:785-792.
  • Openshaw PJ. (Mar 2001). Potential mechanisms causing delayed effects of respiratory syncytial virus infection. Am J Respir Crit Care Med. 163:S10-S13.
  • Johnston SL; Openshaw PJ. (17 Feb 2001). The protective effect of childhood infections. BMJ. 322:376-377.
  • Simmons CP; Hussell T; Sparer T; Walzl G; Openshaw P; Dougan G. (15 Jan 2001). Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8+ T cell responses. J Immunol. 166:1106-1113.
  • Hussell T; Openshaw PJ. (15 Dec 2000). IL-12-activated NK cells reduce lung eosinophilia to the attachment protein of respiratory syncytial virus but do not enhance the severity of illness in CD8 T cell-immunodeficient conditions. J Immunol. 165:7109-7115.
  • Pennycook A; Openshaw P; Hussell T. (Dec 2000). Partners in crime: co-infections in the developing world. Clin Exp Immunol. 122:296-299.
  • Walzl G; Tafuro S; Moss P; Openshaw PJ; Hussell T. (6 Nov 2000). Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology. J Exp Med. 192:1317-1326.
  • Godkin AJ; Thursz M; Openshaw P; Thomas HC. (Oct 2000). Identification of HLA-DR11-restricted CD4+T cell epitopes derived from hepatitis C virus. HEPATOLOGY. 32:271A-271A.
  • Pala P; Hussell T; Openshaw PJ. (21 Sep 2000). Flow cytometric measurement of intracellular cytokines. J Immunol Methods. 243:107-124.
  • Openshaw PJ; Hewitt C. (Aug 2000). Protective and harmful effects of viral infections in childhood on wheezing disorders and asthma. Am J Respir Crit Care Med. 162:S40-S43.
  • Pala P; Verhoef A; Lamb JR; Openshaw PJ. (Jun 2000). Single cell analysis of cytokine expression kinetics by human CD4+ T-cell clones during activation or tolerance induction. Immunology. 100:209-216.
  • Folkerts G; Walzl G; Openshaw P. (May 2000). Clean living increases more than just atopic disease - Reply. IMMUNOL TODAY. 21:249-250.
  • Folkerts G; Walzl G; Openshaw P. (May 2000). Reply to rook. Immunol Today. 21:249-250.
  • Folkerts G; Walzl G; Openshaw PJ. (Mar 2000). Do common childhood infections 'teach' the immune system not to be allergic?. Immunol Today. 21:118-120.
  • Smyth RL; Fletcher JN; Thomas HM; Hart CA; Openshaw PJ. (4 Dec 1999). Respiratory syncytial virus and wheeze. Lancet. 354:1997-1998.
  • Openshaw PJ; Walzl G. (Oct 1999). Infections prevent the development of asthma--true, false or both?. J R Soc Med. 92:495-499.
  • Hussell T; Openshaw P. (Aug 1999). Recent developments in the biology of respiratory syncytial virus: are vaccines and new treatments just round the corner?. Curr Opin Microbiol. 2:410-414. DOI.
  • Openshaw PJ. (6 Mar 1999). Nature medicine . BMJ. 318:677.
  • Marshall BG; Hussell T; Matthews S; Sparer T; Young DB; Shaw RJ; Openshaw PJM. (Mar 1999). Immune deviation by BCG in a susceptible murine model of Cryptococcus neoformans infection. AM J RESP CRIT CARE. 159:A869-A869.
  • O'Donnell DR; Openshaw PJ. (Dec 1998). Anaphylactic sensitization to aeroantigen during respiratory virus infection. Clin Exp Allergy. 28:1501-1508.
  • Hussell T; Georgiou A; Sparer TE; Matthews S; Pala P; Openshaw PJ. (1 Dec 1998). Host genetic determinants of vaccine-induced eosinophilia during respiratory syncytial virus infection. J Immunol. 161:6215-6222.
  • Hussell T; Openshaw PJ. (Nov 1998). Intracellular IFN-gamma expression in natural killer cells precedes lung CD8+ T cell recruitment during respiratory syncytial virus infection. J Gen Virol. 79 ( Pt 11):2593-2601.
  • O'Donnell DR; McGarvey MJ; Tully JM; Balfour-Lynn IM; Openshaw PJ. (Aug 1998). Respiratory syncytial virus RNA in cells from the peripheral blood during acute infection. J Pediatr. 133:272-274.
  • Openshaw PJ; Lemanske RF. (Jul 1998). Respiratory viruses and asthma: can the effects be prevented?. Eur Respir J Suppl. 27:35s-39s.
  • Spender LC; Hussell T; Openshaw PJ. (Jul 1998). Abundant IFN-gamma production by local T cells in respiratory syncytial virus-induced eosinophilic lung disease. J Gen Virol. 79 ( Pt 7):1751-1758.
  • Sparer TE; Matthews S; Hussell T; Rae AJ; Garcia-Barreno B; Melero JA; Openshaw PJ. (1 Jun 1998). Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia. J Exp Med. 187:1921-1926.
  • Openshaw PJ; Hussell T. (1998). The effect of IL-12 treatment on vaccine-enhanced illness during infection with respiratory syncytial virus. Dev Biol Stand. 92:179-185.
  • Hussell T; Baldwin CJ; O'Garra A; Openshaw PJ. (Dec 1997). CD8+ T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection. Eur J Immunol. 27:3341-3349. DOI.
  • Hussell T; Khan U; Openshaw P. (1 Jul 1997). IL-12 treatment attenuates T helper cell type 2 and B cell responses but does not improve vaccine-enhanced lung illness. J Immunol. 159:328-334.
  • Openshaw P; Khan U; Hussell T. (Jan 1997). IL-12 induces Th1 responses but does not prevent vaccine-enhanced illness during viral challenge. J ALLERGY CLIN IMMUN. 99:1496-1496.
  • Hussell T; Spender LC; Georgiou A; O'Garra A; Openshaw PJ. (Oct 1996). Th1 and Th2 cytokine induction in pulmonary T cells during infection with respiratory syncytial virus. J Gen Virol. 77 ( Pt 10):2447-2455.
  • Hussell T; Openshaw PJ. (Aug 1996). Immunological determinants of disease caused by respiratory syncytial virus. Trends Microbiol. 4:299-300.
  • MireSluis AR; Das RG; Thorpe R; Thomas S; Maher D; Valent P; Payer E; Groote D; et alHayglass K; Ziltener H; Poulsen LK; Miossec P; Chomarat P; Grassi J; Pawelec G; Fritzsche U; Falk M; Topp M; Reisbach G; Sidiropoulos J; BenSasson SZ; EvenChen Z; Pegoraro L; Barboni F; Sugimoto R; Tsuji K; Arai K; Yokota T; Olobo J; Wagemaker G; VanDerPouwKraan T; Sheth KV; Gutierrez C; Rivas D; Lycke N; Schon K; Bews JPA; Tullberg K; Klotzbucher R; Page L; Bird C; McGuckin CP; Gordon J; Katira A; Openshaw P; Georgiou A; Testa NG; Callard R; Paik K; McKearn J; Rock M; Harper K; Swanson SJ; Siegel JP; Spiegelberg HL; Geigert J; Carter K; Paul WE; Watson C; Tsang M; Zhou L; Westreich L; Chao CC; Riss TL; Moravec R. (17 Jul 1996). Implications for the assay and biological properties of interleukin-3 - Results of a WHO international collaborative study. J IMMUNOL METHODS. 194:1-12.
  • MireSluis AR; Das RG; Thorpe R; Thomas S; Maher D; Valent P; Groote D; Hayglass K; et alZiltener H; Poulsen LK; Miossec P; Chomarat P; Grassi J; Pawelec G; Fritzsche U; Falk M; Topp M; Reisbach G; Sidiropoulos J; BenSasson SZ; EvenChen Z; Pegoraro L; Barboni F; Sugimoto K; Tsuji K; Matsumoto T; Arai K; Yokota T; Olobo J; Wagemaker G; VanDerPouwKraan T; Sheth KV; Gutierrez C; Rivas D; Lycke N; Schon K; Bews JPA; Tullberg K; Klotzbucher R; Page L; Bird C; McGuckin CP; Gordon J; Katira A; Openshaw P; Georgiou A; Testa NG; Callard R; Paik K; McKearn J; Rock M; Harper K; Swanson SJ; Siegel JP; Speigelberg HL; Geigert J; Carter K; Paul WE; Watson C; Tsang M; Zhou L; Westreich L; Chao CC; Riss TL; Moravec R. (17 Jul 1996). Implications for the assay and biological activity of interleukin-4 - Results of a WHO international collaborative study. J IMMUNOL METHODS. 194:13-25.
  • Vicari AP; Mocci S; Openshaw P; O'Garra A; Zlotnik A. (Jul 1996). Mouse gamma delta TCR+NK1.1+ thymocytes specifically produce interleukin-4, are major histocompatibility complex class I independent, and are developmentally related to alpha beta TCR+NK1.1+ thymocytes. Eur J Immunol. 26:1424-1429. DOI.
  • Murphy E; Shibuya K; Hosken N; Openshaw P; Maino V; Davis K; Murphy K; O'Garra A. (1 Mar 1996). Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J Exp Med. 183:901-913.
  • Openshaw P; Murphy EE; Hosken NA; Maino V; Davis K; Murphy K; O'Garra A. (1 Nov 1995). Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med. 182:1357-1367.
  • Openshaw PJ. (Oct 1995). Immunity and immunopathology to respiratory syncytial virus. The mouse model. Am J Respir Crit Care Med. 152:S59-S62.
  • Openshaw PJ. (1995). Immunopathological mechanisms in respiratory syncytial virus disease. Springer Semin Immunopathol. 17:187-201.
  • OPENSHAW PJM. (5 Jan 1995). DISEASE ENHANCEMENT BY IMMUNITY TO RESPIRATORY SYNCYTIAL (RS) VIRUS. J CELL BIOCHEM. 275-275.
  • ODONNELL DR; GEORGIOU A; MEE PJ; TYBULEWICZ VLJ; OPENSHAW PJM. (5 Jan 1995). NORMAL PATTERNS OF LUNG-DISEASE AND VIRUS CLEARANCE IN RESPIRATORY SYNCYTIAL VIRUS-INFECTED MICE DEFICIENT OF IL-3. J CELL BIOCHEM. 284-284.
  • Openshaw PJ; O'Donnell DR. (Feb 1994). Asthma and the common cold: can viruses imitate worms?. Thorax. 49:101-103.
  • Alwan WH; Kozlowska WJ; Openshaw PJ. (1 Jan 1994). Distinct types of lung disease caused by functional subsets of antiviral T cells. J Exp Med. 179:81-89.
  • Alwan WH; Record FM; Openshaw PJ. (15 Jun 1993). Phenotypic and functional characterization of T cell lines specific for individual respiratory syncytial virus proteins. J Immunol. 150:5211-5218.
  • RAPECKI S; MCILROY D; OPENSHAW P. (13 Mar 1993). T-LYMPHOCYTE SUBSETS IN LUNG INFECTIONS - GAMMA-DELTA T-CELLS ARE INDUCED BY NONVIRAL PATHOGENS. J CELL BIOCHEM. 53-53.
  • OPENSHAW PJM; KOZLOWSKA W; ALWAN WH. (13 Mar 1993). T-CELLS SPECIFIC TO SINGLE VIRAL-PROTEINS CAUSE DISTINCT PATTERNS OF PROTECTION AND DISEASE. J CELL BIOCHEM. 68-68.
  • Alwan WH; Openshaw PJ. (1993). Distinct patterns of T- and B-cell immunity to respiratory syncytial virus induced by individual viral proteins. Vaccine. 11:431-437.
  • Openshaw P. (Aug 1992). Barcelona's asthma epidemics. Thorax. 47:668.
  • Alwan WH; Record FM; Openshaw PJ. (Jun 1992). CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells. Clin Exp Immunol. 88:527-536.
  • Openshaw PJ; Clarke SL; Record FM. (Apr 1992). Pulmonary eosinophilic response to respiratory syncytial virus infection in mice sensitized to the major surface glycoprotein G. Int Immunol. 4:493-500.
  • Cherrie AH; Anderson K; Wertz GW; Openshaw PJ. (Apr 1992). Human cytotoxic T cells stimulated by antigen on dendritic cells recognize the N, SH, F, M, 22K, and 1b proteins of respiratory syncytial virus. J Virol. 66:2102-2110.
  • OPENSHAW PJM; RECORD FM. (Mar 1992). EPITHELIAL GAMMA-DELTA T-CELLS IN LUNG INFECTIONS. THORAX. 47:P253-P253.
  • Openshaw PJ. (19 Oct 1991). When we sneeze, does the immune system catch a cold?. BMJ. 303:935-936.
  • Openshaw PJ; Alwan WH; Cherrie AH; Record FM. (17 Aug 1991). Accidental infection of laboratory worker with recombinant vaccinia virus. Lancet. 338:459.
  • Openshaw PJ. (Mar 1991). Pulmonary epithelial T cells induced by viral infection express T cell receptors alpha/beta. Eur J Immunol. 21:803-806. DOI.
  • Openshaw PJ; Anderson K; Wertz GW; Askonas BA. (Apr 1990). The 22,000-kilodalton protein of respiratory syncytial virus is a major target for Kd-restricted cytotoxic T lymphocytes from mice primed by infection. J Virol. 64:1683-1689.
  • Askonas BA; Openshaw PJ. (Dec 1989). MHC and antigen presentation. Immunol Today. 10:396-397.
  • Openshaw PJ. (Feb 1989). Flow cytometric analysis of pulmonary lymphocytes from mice infected with respiratory syncytial virus. Clin Exp Immunol. 75:324-328.
  • Openshaw PJ; Turner-Warwick M. (Jan 1989). Observations on sputum production in patients with variable airflow obstruction; implications for the diagnosis of asthma and chronic bronchitis. Respir Med. 83:25-31.
  • Askonas BA; Openshaw P; Cannon M. (1989). T-cells in respiratory syncytial virus (RSV) infection. Adv Exp Med Biol. 257:9-17.
  • Cannon MJ; Openshaw PJ; Askonas BA. (1 Sep 1988). Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. J Exp Med. 168:1163-1168.
  • Openshaw PJ; Pemberton RM; Ball LA; Wertz GW; Askonas BA. (Feb 1988). Helper T cell recognition of respiratory syncytial virus in mice. J Gen Virol. 69 ( Pt 2):305-312.
  • OPENSHAW PJM; CANNON MJ; ASKONAS BA. (Sep 1987). INJECTION OF VIRUS-SPECIFIC CYTOTOXIC T-CELLS CAN ENHANCE DISEASE IN MICE INFECTED WITH RESPIRATORY SYNCYTIAL VIRUS. THORAX. 42:710-711.
  • Pemberton RM; Cannon MJ; Openshaw PJ; Ball LA; Wertz GW; Askonas BA. (Aug 1987). Cytotoxic T cell specificity for respiratory syncytial virus proteins: fusion protein is an important target antigen. J Gen Virol. 68 ( Pt 8):2177-2182.
  • OPENSHAW PJM; ASKONAS BA. (Mar 1987). RESPIRATORY SYNCYTIAL VIRUS (RSV) SPECIFIC HELPER T-CELL FUNCTION IN MICE PRIMED WITH RECOMBINANT VACCINIA VIRUSES EXPRESSING SINGLE RSV PROTEINS. THORAX. 42:213-213.
  • Turner-Warwick M; Openshaw P. (1987). Sputum in asthma. Postgrad Med J. 63 Suppl 1:79-82.
  • Bangham CR; Openshaw PJ; Ball LA; King AM; Wertz GW; Askonas BA. (15 Dec 1986). Human and murine cytotoxic T cells specific to respiratory syncytial virus recognize the viral nucleoprotein (N), but not the major glycoprotein (G), expressed by vaccinia virus recombinants. J Immunol. 137:3973-3977.
  • OPENSHAW PJM; CANNON MJ; ASKONAS BA. (Sep 1986). SPECIFICITY OF MURINE CYTOTOXIC T-CELLS TO RESPIRATORY SYNCYTIAL VIRUS. THORAX. 41:730-730.
  • OPENSHAW PJM; WINTERTON SJ. (Jun 1986). LATE RESULTS OF PLOMBAGE. THORAX. 41:494-494.
  • OPENSHAW PJM; HUGHES JMB; CARR D; VALIND S; LAVENDER JP; PRIDE NB. (1985). STRUCTURE AND FUNCTION IN BULLOUS LUNG-DISEASE. THORAX. 40:710-710.
  • Openshaw P; Edwards S; Helms P. (Aug 1984). Changes in rib cage geometry during childhood. Thorax. 39:624-627.
  • Cochrane GM; Newstead CG; Nowell RV; Openshaw P; Wolff CB. (Dec 1982). The rate of rise of alveolar carbon dioxide pressure during expiration in man. J Physiol. 333:17-27.
  • OPENSHAW P. (1982). THE CAUSE OF VENOUS ULCERATION. LANCET. 2:437-438.
  • Davis C; Campbell EJ; Openshaw P; Pride NB; Woodroof G. (Apr 1980). Importance of airway closure in limiting maximal expiration in normal man. J Appl Physiol. 48:695-701.
  • Openshaw P. (20 Jan 1979). Breathing and control of heart rate. Br Med J. 1:199.
  • Pearson S; Openshaw P. (25 Nov 1978). Towards positive diagnosis of the irritable bowel. Br Med J. 2:1496.
  • Openshaw PJ; Woodroof GM. (Nov 1978). Effect of lung volume on the diving response in man. J Appl Physiol. 45:783-785.
  • CAMPBELL EJM; DAVIS C; OPENSHAW P; WOODROOF G; PRIDE NB. (1976). DETERMINANTS OF RESIDUAL VOLUME IN NORMAL SUBJECTS. CLIN RES. 24:A689-A689.
  • DAVIS C; OPENSHAW P; WOODROOF G; CAMPBELL EJM; PRIDE NB. (1976). DETERMINANTS OF RESIDUAL VOLUME IN NORMAL SUBJECTS. CLIN SCI MOL MED. 51:P4-P4.

Chapters in books

  • Openshaw PJM; Matthews S; Pala P; Hussell T; Walzi G. Immunopathogenesis of viral infections in children. In Textbook of respiratory cell and molecular biology. 283-298. (2002).

Conferences

  • Loebbermann J; Thornton H; Sparwasser T; Webster K; Sprent J; Culley F; Johansson C; Openshaw P. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. 135:181-181. (Dec 2011).
  • Dodd J; Muir R; Affendi S; Nickson E; Openshaw P. Lung NKT cells modulate NK and T cell activity to drive Th2 responses during respiratory viral infection. 135:98-98. (Dec 2011).
  • Sridhar S; Begom S; Bermingham A; Roberts K; Barclay W; Openshaw P; Lalvani A. Predominance of heterosubtypic IFN-gamma-only-secreting effector memory T cells in pandemic H1N1 naive adults. 135:65-65. (Dec 2011).
  • Dodd J; Clark D; Muir R; Korpis C; Openshaw P. Endogenous IL-21 regulates pathogenic CD4 T cell responses during respiratory viral infection. 135:164-164. (Dec 2011).
  • Dodd J; Nickson E; Openshaw P. IL-7 drives an early Th17 environment upon respiratory viral challenge. 135:123-123. (Dec 2011).
  • Schnoeller C; Loebbermann J; Durant L; Johansson C; Thornton H; O'Garra A; Openshaw P. Roles for IL-10 in RSV infection. 135:199-199. (Dec 2011).
  • Habibi MS; Durant L; Paras A; Thornton H; Openshaw PJM. Human protective and regulatory T cell responses during experimental respiratory syncytial virus infection. 135:199-199. (Dec 2011).
  • Schuijs M; Hartmann S; Openshaw P; Schnoeller C. Helminth-derived immunomodulator AvCystatin blocks Th2 driven lung eosinophillia in mice infected with respiratory syncytial virus. 135:185-185. (Dec 2011).
  • Loebbermann J; Thornton H; Sparwasser T; Johansson C; Openshaw P. Regulation of immunity during viral lung infection. 131:134-134. (Dec 2010).
  • Schnoeller C; Roux X; Sawant D; Raze D; Locht C; Olszewska W; Openshaw PJ. Live attenuated Bordetella pertussis vaccine candidate modulates viral lung inflammation. 131:138-138. (Dec 2010).
  • Dodd J; Cairns J; Openshaw P. Identifying factors that induce pulmonary NKT-cell-driven airway hyper responsiveness. 131:170-170. (Dec 2010).
  • Schnoeller C; Loebbermann J; Johansson C; Thornton H; Sawant D; Benjamin CA; O'Garra A; Openshaw PJ. The role of IL-10 in RSV infection. 131:176-176. (Dec 2010).
  • Sridhar S; Begom S; Bermingham A; Bremang S; Magtoto M; Grass L; Potiphar L; Openshaw P; et alLalvani A. Cross-reactive T cells to pandemic influenza H1N1 are predominantly of an effector phenotype. 131:176-176. (Dec 2010).
  • Openshaw PJ. Influenzas yesterday, today and tomorrow. 131:10-10. (Dec 2010).
  • Tregoning JS; Yamaguchi Y; Harker JA; Wang B; Lee DC; Nawroly N; Openshaw PJ. T cell derived interferon gamma inhibits antibody responses during early life. 131:52-52. (Dec 2010).
  • Wythe SE; Dodd JS; Openshaw PJ; Schwarze J. OX4oL and PDL-2 on lung dendritic cells differentially regulate Th1-and Th2-polarised effector responses in respiratory syncytial virus disease. 125:21-21. (Dec 2008).
  • Loebbermann J; Lee D; Webster K; Sprent J; Johansson C; Openshaw P. Contrasting effects of natural regulatory T cells at different sites during respiratory viral infection. 125:68-69. (Dec 2008).
  • Dodd JS; Muir R; Openshaw PJM. Lung, but not splenic, NKT cells drive Th2 responses during respiratory virus infection. 125:72-73. (Dec 2008).
  • Samarasinghe SR; Nawroly N; Karlsson H; Openshaw P; Vitteta E; Veys P; Amrolia P. Functional characterisaition of alloreactive T-Cells identifies CD25 and CD71 as the optimal targets for allodepletion strategies. 49th Annual Meeting of the American-Society-of-Hematology. 110:649A-649A. (16 Nov 2007).
  • Dodd JS; Clark D; O'Brien D; Korpis C; Openshaw PJM. IL-21 depletion exacerbates augmented respiratory syncytial virus (RSV) disease by deregulating control of dendritic cell: CD4 T cell stimulation. Annual Congress of the British-Society-of-Immunology. 120:14-14. (Mar 2007).
  • Wythe SE; Dodd JS; Openshaw PJ; Schwarze J. Differential expression of CD40, OX40L & PDL2 on lung dendritic cells in polarised immune responses to Respiratory Syncytial Virus (RSV). Annual Congress of the British-Society-of-Immunology. 120:15-15. (Mar 2007).
  • Samarasinghe S; Karlsson H; Nawroly N; Openshaw P; Veys P; Amrolia P. Enhanced depletion of alloreactive T cells using combined CD25/71 immunomagnetic selection. Tandem BMT Meeting 2007. 13:21-21. (Feb 2007).
  • Openshaw PJM. Potential mechanisms causing delayed effects of respiratory syncytial virus infection. 163:S10-S12. (Mar 2001).
  • Openshaw PJ; Lemanske RF. Respiratory viruses and asthma: can the effects be prevented?. Workshop on Early Intervention in Childhood Asthma. 12:35S-39S. (Jul 1998).
  • Openshaw PJM; Spender LC; Hussell T. Beneficial and harmful immune responses in the respiratory tract. 8th International Congress of Mucosal Immunology. 449-457. (1996).
  • ASKONAS BA; OPENSHAW P; CANNON M. T-CELLS IN RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION. INTERNATIONAL SYMP ON THE IMMUNE RESPONSE TO VIRAL INFECTIONS. 257:9-17. (1989).

Patents

  • Methods of modifying an antigen to modify the Th2-type bias of the Th1/Th2-type immune response of an animal International (PCT) patent with Publication Number (. Patent number: UK patent 0326439 (7WO2005/049074). Filed: 13 Nov 2003. Awarded: 15 Nov 2004. Published: 2 Jun 2005.
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