Dr Petr Vikhorev

My research interests focus on the mechanisms and regulation of muscle contraction. I jointed the Laboratory of Muscle Biophysics in 2009. My current research project is to build and set up instrumentation, computer controlled with LabVIEW software, for investigation of the myofibril contractile dynamics, and applied this technique to the study of myopathic heart muscle and transgenic mouse models.

 Career Outline

1997 BSc in Biology, St. Petersburg State University. 1999 MSc in Biology (Biophysics), St. Petersburg State University. 1999-2001 (7 months) Visiting researcher, Nencki Institute of Experimental Biology of the Polish Academy of Sciences. 2003 PhD in Histology, Cytology and Cellular Biology, Institute of Cytology of the Russian Academy of Sciences. 2004-2005  Post-doctoral researcher, University of York. 2006-2009 Post-doctoral researcher, University of Kalmar, Sweden. 2009-present, Research associate, London Imperial College.

 List of Publications

1. Vikhorev P.G., Vikhoreva N.N., Cammarato A., Sparrow J.C. (2010) In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation. J Muscle Res Cell Motil. 31(3):171-179.
2. Vikhoreva N.N., Vikhorev P.G., Fedorova M.A., Hoffmann R., Månsson A., Kuleva N.V. (2009)The in vitro motility assay parameters of actin filaments from Mytilus edulis exposed in vivo to copper ions. Archiv. Bioch. Biophys. 491(1-2): 32-38.
3. Vikhorev P.G, Vikhoreva N.N, Månsson A. (2008) Bending flexibility of actin filaments during motor induced sliding. Biophysical J. 95(12):5809-5819.
4. Vikhorev P.G, Vikhoreva N., Mark Sundberg M., Balaz M., Nuria Albet-Torres N., Bunk R., Kvennefors A., Liljesson K., Nicholls I., Nilsson L., Omling P., Tågerud S., Montelius L., Månsson A. (2008) Motor propelled proteins display diffusion dynamics. Langmuir. 24(23):13509-13517.
5. Dedova I.V., Avrova S.V., Vikhoreva N.N., Vikhorev P.G., Hazlett T.L., Van der Meer W., Dos Remedios C.G., Borovikov Iu.S. (2004) Conformational changes of actin induced by strong or weak myosin subfragment-1 binding] Tsitologiia. 46(8):719-34.
6. Borovikov Yu.S., Wrzosek A., Kulikova N., Vikhorev P.G, Vikhoreva N.N, Dabrowska R. (2004) Behavior of caldesmon upon interaction of thin filaments with myosin subfragment 1 in ghost fibers. Biochim. Biophys. Acta. 1699:183-189.
7. Borovikov Yu.S., Dedova I.V., Dos Remedios C.G., Vikhoreva N.N., Vikhorev P.G., Avrova S.V., Hazlett T.L., Van Der Meer B.W. (2004) Fluorescence depolarization of actin filaments in reconstructed myofibers: The effect of S1 or pPDM-S1 on Movements of distinct areas of actin. Biophysical J. 86:3020-3029.
8. Borovikov Yu.S., Avrova S.V., Vikhoreva N.N., Vikhorev P.G., Ermakov V.S., Copeland O., Marston S. (2001) C-terminal actin-binding sites of smooth muscle caldesmon switch actin between conformational states. Int. J. of Biochem. Cell Biol. 33:1151-1159.
9. Vikhorev P.G., Avrova S.V., Ermakov V.S., Copeland O., Marston S.B., Borovikov Iu.S. (2000) Effect of the C-terminal actin-binding sites of caldesmon on the interaction of actin with myosin. Tsitologiia. 42(11):1069-74.
10. Vikhorev P.G., Vikhoreva N.N., Rosliakova M.A., Chacko S., Borovikov Iu.S. (2000). Caldesmon inhibits formation of strongly bound myosin cross-bridges and activates an ability of weakly bound cross-bridges to transform actin monomers to the off-conformation. Tsitologiia. 42(5):444-53.