Dr Becca Asquith

Publications


Journals

  • Olindo S; Belrose G; Gillet N; Rodriguez S; Boxus M; Verlaeten O; Asquith B; Bangham C; et alSignaté A; Smadja D; Lezin A; Césaire R; Willems L. (8 Dec 2011). Safety of long-term treatment of HAM/TSP patients with valproic acid. Blood. 118:6306-6309. DOI.
  • Florins A; de Brogniez A; Elemans M; Bouzar AB; François C; Reichert M; Asquith B; Willems L. (Jan 2012). Viral expression directs the fate of B cells in bovine leukemia virus-infected sheep. J Virol. 86:621-624. DOI.
  • Seich Al Basatena NK; Macnamara A; Vine AM; Thio CL; Astemborski J; Usuku K; Osame M; Kirk GD; et alDonfield SM; Goedert JJ; Bangham CR; Carrington M; Khakoo SI; Asquith B. (Oct 2011). KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection. PLoS Pathog. 7:e1002270. DOI.
  • Elemans M; al Basatena NKS; Klatt NR; Gkekas C; Silvestri G; Asquith B. (Sep 2011). Why Don't CD8+T Cells Reduce the Lifespan of SIV-Infected Cells In Vivo?. PLOS COMPUT BIOL. 7. DOI.
  • Best I; López G; Talledo M; MacNamara A; Verdonck K; González E; Tipismana M; Asquith B; et alGotuzzo E; Vanham G; Clark D. (Nov 2011). Short communication an interferon-γ ELISPOT assay with two cytotoxic T cell epitopes derived from HTLV-1 tax region 161-233 discriminates HTLV-1-associated myelopathy/tropical spastic paraparesis patients from asymptomatic HTLV-1 carriers in a Peruvian population. AIDS Res Hum Retroviruses. 27:1207-1212. DOI.
  • Elemans M; Thiébaut R; Kaur A; Asquith B. (Mar 2011). Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV-infection. PLoS Comput Biol. 7:e1001103. DOI.
  • Hilburn S; Rowan A; Demontis MA; MacNamara A; Asquith B; Bangham CR; Taylor GP. (15 Feb 2011). In vivo expression of human T-lymphotropic virus type 1 basic leucine-zipper protein generates specific CD8+ and CD4+ T-lymphocyte responses that correlate with clinical outcome. J Infect Dis. 203:529-536. DOI.
  • Macnamara A; Rowan A; Hilburn S; Kadolsky U; Fujiwara H; Suemori K; Yasukawa M; Taylor G; et alBangham CR; Asquith B. (2010). HLA class I binding of HBZ determines outcome in HTLV-1 infection. PLoS Pathog. 6:e1001117. DOI.
  • Kadolsky UD; Asquith B. (2010). Quantifying the impact of human immunodeficiency virus-1 escape from cytotoxic T-lymphocytes. PLoS Comput Biol. 6:e1000981. DOI Open Access copy.
  • Asquith B; Borghans JAM; Ganusov VV; Macallan DC. (Oct 2009). Lymphocyte kinetics in health and disease (vol 30, pg 182, 2009). TRENDS IMMUNOL. 30:467-467. DOI.
  • Kattan T; MacNamara A; Rowan AG; Nose H; Mosley AJ; Tanaka Y; Taylor GP; Asquith B; et alBangham CR. (1 May 2009). The avidity and lytic efficiency of the CTL response to HTLV-1. J Immunol. 182:5723-5729. DOI.
  • Asquith B; Borghans JA; Ganusov VV; Macallan DC. (Apr 2009). Lymphocyte kinetics in health and disease. Trends Immunol. 30:182-189. DOI.
  • MacNamara A; Kadolsky U; Bangham CRM; Asquith B. (Mar 2009). T-Cell Epitope Prediction: Rescaling Can Mask Biological Variation between MHC Molecules. PLOS COMPUT BIOL. 5. DOI.
  • Lezin A; Olindo S; Belrose G; Signate A; Cesaire R; Smadja D; Macallan D; Asquith B; et alBangham C; Bouzar A; Gillet N; Defoiche J; Florins A; Verlaeten O; Burny A; Willems L. (2009). Gene activation therapy: from the BLV model to HAM/TSP patients. Front Biosci (Schol Ed). 1:205-215.
  • Bangham CR; Meekings K; Toulza F; Nejmeddine M; Majorovits E; Asquith B; Taylor GP. (2009). The immune control of HTLV-1 infection: selection forces and dynamics. Front Biosci. 14:2889-2903.
  • Florins A; Reichert M; Asquith B; Bouzar AB; Jean G; François C; Jasik A; Burny A; et alKettmann R; Willems L. (2009). Earlier onset of delta-retrovirus-induced leukemia after splenectomy. PLoS One. 4:e6943. DOI.
  • Macallan DC; Asquith B; Zhang Y; de Lara C; Ghattas H; Defoiche J; Beverley PC. (2009). Measurement of proliferation and disappearance of rapid turnover cell populations in human studies using deuterium-labeled glucose. Nat Protoc. 4:1313-1327. DOI.
  • Defoiche J; Debacq C; Asquith B; Zhang Y; Burny A; Bron D; Lagneaux L; Macallan D; et alWillems L. (Oct 2008). Reduction of B cell turnover in chronic lymphocytic leukaemia. BRIT J HAEMATOL. 143:240-247. DOI.
  • Asquith B. (2008). The evolutionary selective advantage of HIV-1 escape variants and the contribution of escape to the HLA-associated risk of AIDS progression. PLoS One. 3:e3486. DOI.
  • Asquith B; Bangham CR. (Jan 2008). How does HTLV-I persist despite a strong cell-mediated immune response?. Trends Immunol. 29:4-11. DOI.
  • Lezin A; Gillet N; Olindo S; Signate A; Grandvaux N; Verlaeten O; Belrose G; Bittencourt MD; et alHiscott J; Asquith B; Burny A; Smadja D; Cesaire R; Willems L. (15 Nov 2007). Histone deacetylase-mediated transcriptional activation reduces proviral loads in HTLV-1-associated myelopathy/tropical spastic paraparesis patients. BLOOD. 110:3722-3728. DOI.
  • Zhang Y; Wallace DL; de Lara CM; Ghattas H; Asquith B; Worth A; Griffin GE; Taylor GP; et alTough DF; Beverley PC; Macallan DC. (Jun 2007). In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection. Immunology. 121:258-265. DOI.
  • Asquith B; Bangham CRM. (Jun 2007). Quantifying HTLV-I dynamics. IMMUNOL CELL BIOL. 85:280-286. DOI.
  • Asquith B; Zhang Y; Mosley AJ; de Lara CM; Wallace DL; Worth A; Kaftantzi L; Meekings K; et alGriffin GE; Tanaka Y; Tough DF; Beverley PC; Taylor GP; Macallan DC; Bangham CR. (8 May 2007). In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection. Proc Natl Acad Sci U S A. 104:8035-8040. DOI.
  • Asquith B; McLean AR. (10 Apr 2007). In vivo CD8+ T cell control of immunodeficiency virus infection in humans and macaques. Proc Natl Acad Sci U S A. 104:6365-6370. DOI.
  • Florins A; Gillet N; Asquith B; Boxus M; Burteau C; Twizere JC; Urbain P; Vandermeers F; et alDebacq C; Sanchez-Alcaraz MT; Schwartz-Cornil I; Kerkhofs P; Jean G; Théwis A; Hay J; Mortreux F; Wattel E; Reichert M; Burny A; Kettmann R; Bangham C; Willems L. (2007). Cell dynamics and immune response to BLV infection: a unifying model. Front Biosci. 12:1520-1531.
  • Florins A; Gillet N; Asquith B; Debacq C; Jean G; Schwartz-Cornil I; Bonneau M; Burny A; et alReichert M; Kettmann R; Willems L. (Dec 2006). Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leukemia virus-infected sheep. J Virol. 80:11998-12008. DOI.
  • Debacq C; Gillet N; Asquith B; Sanchez-Alcaraz MT; Florins A; Boxus M; Schwartz-Cornil I; Bonneau M; et alJean G; Kerkhofs P; Hay J; Théwis A; Kettmann R; Willems L. (Oct 2006). Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep. J Virol. 80:9710-9719. DOI.
  • Asquith B; Debacq C; Florins A; Gillet N; Sanchez-Alcaraz T; Mosley A; Willems L. (7 May 2006). Quantifying lymphocyte kinetics in vivo using carboxyfluorescein diacetate succinimidyl ester (CFSE). Proc Biol Sci. 273:1165-1171. DOI.
  • Asquith B; Edwards CTT; Lipsitch M; McLean AR. (Apr 2006). Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo. PLOS BIOL. 4:583-592. DOI.
  • Asquith B; Mosley AJ; Heaps A; Tanaka Y; Taylor GP; McLean AR; Bangham CRM. (9 Dec 2005). Quantification of the virus-host interaction in human T lymphotropic virus I infection. RETROVIROLOGY. 2. DOI.
  • Debacq C; Héraud JM; Asquith B; Bangham C; Merien F; Moules V; Mortreux F; Wattel E; et alBurny A; Kettmann R; Kazanji M; Willems L. (17 Nov 2005). Reduced cell turnover in lymphocytic monkeys infected by human T-lymphotropic virus type 1. Oncogene. 24:7514-7523. DOI.
  • Asquith B; Mosley AJ; Barfield A; Marshall SE; Heaps A; Goon P; Hanon E; Tanaka Y; et alTaylor GP; Bangham CR. (May 2005). A functional CD8+ cell assay reveals individual variation in CD8+ cell antiviral efficacy and explains differences in human T-lymphotropic virus type 1 proviral load. J Gen Virol. 86:1515-1523. DOI.
  • Macallan DC; Wallace DL; Zhang Y; Ghattas H; Asquith B; de Lara C; Worth A; Panayiotakopoulos G; et alGriffin GE; Tough DF; Beverley PC. (1 May 2005). B-cell kinetics in humans: rapid turnover of peripheral blood memory cells. Blood. 105:3633-3640. DOI.
  • Mosley AJ; Asquith B; Bangham CR. (2005). Cell-mediated immune response to human T-lymphotropic virus type I. Viral Immunol. 18:293-305. DOI.
  • Vine AM; Heaps AG; Kaftantzi L; Mosley A; Asquith B; Witkover A; Thompson G; Saito M; et alGoon PK; Carr L; Martinez-Murillo F; Taylor GP; Bangham CR. (15 Oct 2004). The role of CTLs in persistent viral infection: cytolytic gene expression in CD8+ lymphocytes distinguishes between individuals with a high or low proviral load of human T cell lymphotropic virus type 1. J Immunol. 173:5121-5129.
  • Goon PK; Biancardi A; Fast N; Igakura T; Hanon E; Mosley AJ; Asquith B; Gould KG; et alMarshall S; Taylor GP; Bangham CR. (15 Jun 2004). Human T cell lymphotropic virus (HTLV) type-1-specific CD8+ T cells: frequency and immunodominance hierarchy. J Infect Dis. 189:2294-2298. DOI.
  • Debacq C; Asquith B; Reichert M; Burny A; Kettmann R; Willems L. (Dec 2003). Reduced cell turnover in bovine leukemia virus-infected, persistently lymphocytotic cattle. J Virol. 77:13073-13083.
  • Macallan DC; Asquith B; Irvine AJ; Wallace DL; Worth A; Ghattas H; Zhang Y; Griffin GE; et alTough DF; Beverley PC. (Oct 2003). Measurement and modeling of human T cell kinetics (vol 33, pg 2316, 2003). EUR J IMMUNOL. 33:2947-2947.
  • Macallan DC; Wallace DL; Irvine AJ; Asquith B; Worth A; Ghattas H; Zhang Y; Griffin GE; et alTough DF; Beverley PC. (Oct 2003). Rapid turnover of T cells in acute infectious mononucleosis. Eur J Immunol. 33:2655-2665. DOI.
  • Goon PK; Igakura T; Hanon E; Mosley AJ; Asquith B; Gould KG; Taylor GP; Weber JN; et alBangham CR. (Sep 2003). High circulating frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells in patients with HTLV-1-associated neurological disease. J Virol. 77:9716-9722.
  • Asquith B; Bangham CR. (22 Aug 2003). An introduction to lymphocyte and viral dynamics: the power and limitations of mathematical analysis. Proc Biol Sci. 270:1651-1657. DOI.
  • Macallan DC; Asquith B; Irvine AJ; Wallace DL; Worth A; Ghattas H; Zhang Y; Griffin GE; et alTough DF; Beverley PC. (Aug 2003). Measurement and modeling of human T cell kinetics. Eur J Immunol. 33:2316-2326. DOI.
  • Asquith B; Bangham CR. (7 May 2003). The dynamics of T-cell fratricide: application of a robust approach to mathematical modelling in immunology. J Theor Biol. 222:53-69.
  • Asquith B; Debacq C; Macallan DC; Willems L; Bangham CR. (Dec 2002). Lymphocyte kinetics: the interpretation of labelling data. Trends Immunol. 23:596-601.
  • Debacq C; Asquith B; Kerkhofs P; Portetelle D; Burny A; Kettmann R; Willems L. (23 Jul 2002). Increased cell proliferation, but not reduced cell death, induces lymphocytosis in bovine leukemia virus-infected sheep. Proc Natl Acad Sci U S A. 99:10048-10053. DOI.
  • Bangham CRM; Asquith B. (9 Feb 2001). Virus dynamics - Mathematical principles of immunology and virology. SCIENCE. 291:992-992.
  • Asquith B; Bangham CR. (7 Nov 2000). The role of cytotoxic T lymphocytes in human T-cell lymphotropic virus type 1 infection. J Theor Biol. 207:65-79. DOI.
  • Hanon E; Asquith RE; Taylor GP; Tanaka Y; Weber JN; Bangham CR. (1 Nov 2000). High frequency of viral protein expression in human T cell lymphotropic virus type 1-infected peripheral blood mononuclear cells. AIDS Res Hum Retroviruses. 16:1711-1715. DOI.
  • Hanon E; Stinchcombe JC; Saito M; Asquith BE; Taylor GP; Tanaka Y; Weber JN; Griffiths GM; et alBangham CR. (Nov 2000). Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I. Immunity. 13:657-664.
  • Asquith B; Hanon E; Taylor GP; Bangham CR. (29 Aug 2000). Is human T-cell lymphotropic virus type I really silent?. Philos Trans R Soc Lond B Biol Sci. 355:1013-1019. DOI.
  • Asquith B. (11 Jan 1996). Non-commutative geometry and the strong force. PHYS LETT B. 366:220-223.

Chapters in books

  • Asquith B; Borghans J. Modelling lymphocyte dynamics in vivo. In Current Mathematical Models in Immunology. Springer (2011).

Conferences

  • al Basatena NKS; Macnamara A; Vine AM; Thio CL; Astemborski J; Usuku K; Osame M; Kirk GD; et alDonfield SM; Goedert JJ; Bangham CRM; Carrington M; Khakoo SI; Asquith B. KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection. 131:148-148. (Dec 2010).
  • Rowan A; Macnamara A; Asquith B; Bangham C; Taylor G; Kattan T. Sensitivity and Efficiency of HTLV-1-Specific Cytotoxic T Lymphocytes. 25:1286-1287. (Nov 2009).
  • Macnamara A; Rowan A; Asquith B; Bangham C; Taylor G; Kadolsky U. HLA Class I Binding of HBZ is Associated with Reduced HTLV-I Proviral Load and HAM/TSP Prevalence. 25:1258-1259. (Nov 2009).
  • MacNamara A; Rowan A; Kadolsky U; Taylor G; Bangham C; Asquith B. HBZ Binding to HLA Class 1 Determines the Outcome of HTLV-1. 25:1201-1202. (Nov 2009).
  • Florins A; Gillet N; Asquith B; Mortreux F; Wattel E; Burny A; Kettmann R; Bangham C; et alWillems L. Cell dynamics and immune response to BLV infection: A unifying model. 13th International Conference on Human Retrovirology - HTLV and Related Viruses. 23:589-589. (Apr 2007).
  • Lezin A; Gillet N; Olindo S; Belrose G; Verlaeten O; Asquith B; Grandvaux N; Burny A; et alSmadja D; Cesaire R; Willems L. Activation of latent provirus: nEw therapy for HTLV-1-associated myelopathy/tropical spastic paraparesis? (a proof-of-concept study). 13th International Conference on Human Retrovirology - HTLV and Related Viruses. 23:643-644. (Apr 2007).
  • Gillet N; Lezin A; Mosley A; Defoiche J; Belrose G; Verlaten O; Olindo S; Smadja D; et alCesaire R; Macallan D; Asquith B; Bangham C; Burny A; Willems L. HTLV-1 can infect human lung epithelial cells and induce gene expression of cytokines, chemokines, and cell adhesion molecules. 23:618-619. (Apr 2007).
  • Defoiche J; Debacq C; Asquith B; Zhang Y; Burny A; Bron D; Lagneaux L; Macallan D; et alWillems L. Reduced rates of B cell proliferation in chronic lymphocytic leukemia. 108:798A-798A. (16 Nov 2006).
  • Florins A; Debacq C; Gillet N; Jean G; Thewis A; Schwartz-Cornil I; Bonneau M; Hay JB; et alAsquith B; Burny A; Kettmann R; Willems L. Key role of the spleen in the cell turnover of bovine leukemia virus infected B lymphocytes. 12th International Conference on Human Retrovirology - HTLV and Related Viruses. 21:512-512. (May 2005).
  • Asquith B; Mosley A; Barfield A; Marshall S; Heaps AG; Goon P; Hanon E; Tanaka Y; et alTaylor GP; Bangham CR. Determinants of HTLV-I proviral load and HAM/TSP risk. 21:482-482. (May 2005).
  • Heaps AG; Vine AM; Kaftantzi L; Russell R; Witkover A; Asquith B; Mosley A; Goon PK; et alThompson G; Saito M; Carr L; Martinez-Murillo F; Burns G; Hillyard G; Botcherby M; Taylor GP; Freeman T; Campbell D; Bangham C. Gene expression analysis of the T lymphocyte response to HTLV-1. 12th International Conference on Human Retrovirology - HTLV and Related Viruses. 21:483-483. (May 2005).
  • Debacq C; Sanchez T; Asquith B; Heraud J; Kazanji M; Merien F; Kerkhofs P; Reichert M; et alMoules V; Mortreux F; Burny A; Kettmann R; Willems L. Cell dynamics in animal models for HTLV. 19:S17-S18. (2003).
  • Asquith BE; Mosley AJ; Goon PK; Heaps AG; Biancardi A; Barfield A; Vine AM; Taylor GP; et alBangham CR. Does the CTL response determine HTLV-I equilibrium proviral load?. 19:S38-S38. (2003).
  • Saito M; Hanada K; Kodama D; Asquith B; Izumo S; Usuku K; Gojobori T; Bangham CR; et alOsame M. Naturally occurring mutations of HTLV-1 proviral genome within HAM/TSP patients and asymptomatic carriers; Relationship between proviral load, host genotype and disease state. 11th International Conference on Human Retrovirology: HTLV and Related Viruses. 19:S60-S60. (2003).
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