Dr Robert J Edwards

Publications


Journals

  • Hasan N; McColgan P; Bentley P; Edwards RJ; Sharma P. (9 Feb 2012). Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review. Br J Clin Pharmacol. DOI.
  • Zabron AA; Horneffer-van der Sluis VM; Wadsworth CA; Laird F; Gierula M; Thillainayagam AV; Vlavianos P; Westaby D; et alTaylor-Robinson SD; Edwards RJ; Khan SA. (1 Sep 2011). Elevated Levels of Neutrophil Gelatinase-Associated Lipocalin in Bile From Patients With Malignant Pancreatobiliary Disease. AMERICAN JOURNAL OF GASTROENTEROLOGY. 106:1711-1717. Author weblink DOI.
  • Rodriguez-Antona C; Donato MT; Boobis A; Edwards RJ; Watts PS; Castell JV; Gomez-Lechon MJ. (2002). Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells. 32:505-520.
  • Salonen JS; Nyman L; Boobis AR; Edwards RJ; Watts P; Lake BG; Price RJ; Renwick AB; et alGomez-Lechon MJ; Castell JV; Ingelman-Sundberg M; Hidestrand M; Guillouzo A; Corcos L; Goldfarb PS; Lewis DF; Taavitsainen P; Pelkonen O. (2003). Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. 31:1093-1102.
  • Edwards RJ; Adams DA; Watts PS; Davies DS; Boobis AR. (1998). Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans. 56:377-387.
  • Andersson TB; Sjoberg H; Hoffmann KJ; Boobis AR; Watts P; Edwards RJ; Lake BG; Price RJ; et alRenwick AB; Gomez-Lechon MJ; Castell JV; Ingelman-Sundberg M; Hidestrand M; Goldfarb PS; Lewis DF; Corcos L; Guillouzo A; Taavitsainen P; Pelkonen O. (2001). An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant. 29:712-720.
  • Edwards RJ; Price RJ; Watts PS; Renwick AB; Tredger JM; Boobis AR; Lake BG. (2003). Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices. 31:282-288.
  • Zabron AA; Horneffer-van der Sluis VM; Wadsworth CA; Laird F; Gierula M; Thillainayagam AV; Vlavianos P; Westaby D; et alTaylor-Robinson SD; Edwards RJ; Khan SA. (Sep 2011). Elevated levels of neutrophil gelatinase-associated lipocalin in bile from patients with malignant pancreatobiliary disease. Am J Gastroenterol. 106:1711-1717. DOI.
  • Abdul-Salam VB; Wharton J; Cupitt J; Berryman M; Edwards RJ; Wilkins MR. (16 Nov 2010). Proteomic analysis of lung tissues from patients with pulmonary arterial hypertension. Circulation. 122:2058-2067. DOI.
  • Godsland IF; Pavitt D; Okoturo O; Edwards RJ; Rubens MB; Feher MD; Flather MD; Elkeles RS; et alPREDICT Study Group. (Dec 2010). Can protein biomarkers provide an index of coronary artery calcification in patients with Type 2 diabetes?. Atherosclerosis. 213:570-572. DOI.
  • d'Esposito F; Nebot N; Edwards RJ; Murray M. (1 Sep 2010). Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 70:400-408. DOI.
  • Edwards RJ; Boobis AR; Davies DS. (Dec 2003). A strategy for investigating the CYP superfamily using targeted antibodies is a paradigm for functional genomic studies. Drug Metab Dispos. 31:1476-1480. DOI.
  • Fabrizi L; Taylor GW; Cañas B; Boobis AR; Edwards RJ. (Mar 2003). Adduction of the chloroform metabolite phosgene to lysine residues of human histone H2B. Chem Res Toxicol. 16:266-275. DOI.
  • Fabrizi L; Taylor GW; Edwards RJ; Boobis AR. (2001). Adducts of the chloroform metabolite phosgene. Adv Exp Med Biol. 500:129-132.
  • Schulz-Utermoehl T; Edwards RJ; Boobis AR. (May 2000). Affinity and potency of proinhibitory antipeptide antibodies against CYP2D6 is enhanced using cyclic peptides as immunogens. Drug Metab Dispos. 28:544-551.
  • Wernicke D; Thiel C; Duja-Isac CM; Essin KV; Spindler M; Nunez DJR; Plehm R; Wessel N; et alHammes A; Edwards RJ; Lippoldt A; Zacharias U; Stromer H; Neubauer S; Davies MJ; Morano I; Thierfelder L. (1 Sep 2004). alpha-tropomyosin mutations Asp(175)Asn and Glu(180)Gly affect cardiac function in transgenic rats in different ways. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 287:R685-R695. Author weblink DOI.
  • EDWARDS RJ; MCKENZIE JE; ROBERTS GW; ROYSTON MC. (1 Nov 1993). ALZHEIMERS-DISEASE AND LEWY BODY DEMENTIA. BRITISH JOURNAL OF PSYCHIATRY. 163:692-692. Author weblink DOI.
  • Andersson TB; Sjoberg H; Hoffmann KJ; Boobis AR; Watts P; Edwards RJ; Lake BG; Price RJ; et alRenwick AB; Gomez-Lechon MJ; Castell JV; Ingelman-Sundberg M; Hidestrand M; Goldfarb PS; Lewis DFV; Corcos L; Guillouzo A; Taavitsainen P; Pelkonen O. (1 May 2001). An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant. DRUG METABOLISM AND DISPOSITION. 29:712-720. Author weblink.
  • Schulz TG; Thiel R; Neubert D; Brassil PJ; Schulz-Utermoehl T; Boobis AR; Edwards RJ. (9 Mar 2001). Assessment of P450 induction in the marmoset monkey using targeted anti-peptide antibodies. Biochim Biophys Acta. 1546:143-155.
  • Baker JR; Satarug S; Urbenjapol S; Edwards RJ; Williams DJ; Moore MR; Reilly PE. (15 Feb 2002). Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein. Biochem Pharmacol. 63:693-696.
  • Baker JR; Satarug S; Reilly PEB; Edwards RJ; Williams DJ; Moore MR. (8 Jul 2001). Characterisation of cytochrome P450 expression in human liver and kidney. TOXICOLOGY. 164:140-140. Author weblink.
  • Moilanen A-M; Hakkola J; Vaarala MH; Kauppila S; Hirvikoski P; Vuoristo JT; Edwards RJ; Paavonen TK. (1 May 2007). Characterization of androgen-regulated expression of CYP3A5 in human prostate. CARCINOGENESIS. 28:916-921. Author weblink DOI.
  • Kurupati P; Turner CE; Tziona I; Lawrenson RA; Alam FM; Nohadani M; Stamp GW; Zinkernagel AS; et alNizet V; Edwards RJ; Sriskandan S. (Jun 2010). Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract. Mol Microbiol. 76:1387-1397. DOI Open Access copy.
  • Watts PM; Riedl AG; Douek DC; Edwards RJ; Boobis AR; Jenner P; Marsden CD. (1 Sep 1998). Co-localization of P450 enzymes in the rat substantia nigra with tyrosine hydroxylase. NEUROSCIENCE. 86:511-519. DOI.
  • HARRIES GC; BOOBIS AR; SESARDIC D; EDWARDS RJ; DAVIES DS. (1 Jun 1986). COMPARATIVE ACTIVATION OF AROMATIC-AMINES TO MUTAGENIC METABOLITES BY HUMAN AND RAT-LIVER. FOOD AND CHEMICAL TOXICOLOGY. 24:757-757. Author weblink DOI.
  • Westlind-Johnsson A; Malmebo S; Johansson A; Otter C; Andersson TB; Johansson I; Edwards RJ; Boobis AR; et alIngelman-Sundberg M. (1 Jun 2003). Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. DRUG METABOLISM AND DISPOSITION. 31:755-761. Author weblink DOI.
  • Salonen JS; Nyman L; Boobis AR; Edwards RJ; Watts P; Lake BG; Price RJ; Renwick AB; et alGomez-Lechon MJ; Castell JV; Ingelman-Sundberg M; Hidestrand M; Guillouzo A; Corcos L; Goldfarb PS; Lewis DFV; Taavitsainen A; Pelkonen O. (1 Sep 2003). Comparative studies on the cytochrome P450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. DRUG METABOLISM AND DISPOSITION. 31:1093-1102. Author weblink DOI.
  • Edwards RJ; Wrigley A; Bai Z; Bateman M; Russell H; Murray S; Lu H; Taylor GW; et alBoobis AR; Sriskandan S. (May 2007). C-terminal antibodies (CTAbs): a simple and broadly applicable approach for the rapid generation of protein-specific antibodies with predefined specificity. Proteomics. 7:1364-1372. DOI.
  • Sim SC; Edwards RJ; Boobis AR; Ingelman-Sundberg M. (1 Sep 2005). CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele. PHARMACOGENETICS AND GENOMICS. 15:625-631. Author weblink DOI.
  • Zangar RC; Kimzey AL; Okita JR; Wunschel DS; Edwards RJ; Kim H; Okita RT. (Apr 2002). Cytochrome P450 3A conjugation to ubiquitin in a process distinct from classical ubiquitination pathway. Mol Pharmacol. 61:892-904.
  • Hakkola J; Raunio H; Purkunen R; Saarikoski S; Vahakangas K; Pelkonen O; Edwards RJ; Boobis AR; et alPasanen M. (1 Jan 2001). Cytochrome P450 3A expression in the human fetal liver: Evidence that CYP3A5 is expressed in only a limited number of fetal livers. BIOLOGY OF THE NEONATE. 80:193-201. Author weblink DOI.
  • Rodríguez-Antona C; Donato MT; Boobis A; Edwards RJ; Watts PS; Castell JV; Gómez-Lechón MJ. (Jun 2002). Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells. Xenobiotica. 32:505-520. DOI.
  • Wu SWL; Jean WC; Peng FC; Edwards RJ. (14 Mar 2003). Cytochrome P-4503A1 catalyzes the formation of MA(1) from territrem A in liver microsomes of 7-week-old female Wistar rats. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A. 66:453-467. Author weblink DOI.
  • Hakooz N; Ito K; Rawden H; Gill H; Lemmers L; Boobis AR; Edwards RJ; Carlile DJ; et alLake BG; Houston JB. (1 Mar 2006). Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance. PHARMACEUTICAL RESEARCH. 23:533-539. Author weblink DOI.
  • Edwards RJ; Adams DA; Watts PS; Davies DS; Boobis AR. (1 Aug 1998). Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans. Biochem Pharmacol. 56:377-387.
  • Kappers WA; Edwards RJ; Murray S; Boobis AR. (15 Nov 2001). Diazinon is activated by CYP2C19 in human liver. Toxicol Appl Pharmacol. 177:68-76. DOI.
  • Gilbert EA; Edwards RJ; Boobis AR; Rose S; Jenner P. (1 Oct 2003). Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon. JOURNAL OF NEURAL TRANSMISSION. 110:1091-1101. Author weblink DOI.
  • Kim H; Putt DA; Zangar RC; Wolf CR; Guengerich FP; Edwards RJ; Hollenberg PF; Novak RF. (1 Mar 2001). Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment. DRUG METABOLISM AND DISPOSITION. 29:353-360. Author weblink.
  • Renwick AB; Watts PS; Edwards RJ; Barton PT; Guyonnet I; Price RJ; Tredger JM; Pelkonen O; et alBoobis AR; Lake BG. (1 Oct 2000). Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices. DRUG METABOLISM AND DISPOSITION. 28:1202-1209. Author weblink.
  • Zangar RC; Okita JR; Kim H; Thomas PE; Anderson A; Edwards RJ; Springer DL; Okita RT. (1 Sep 1999). Effect of calcium channel antagonists nifedipine and nicardipine on rat cytochrome P-4502B and 3A forms. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 290:1436-1441. Author weblink.
  • Satarug S; Baker JR; Reilly PEB; Edwards RJ; Williams DJ; Moore MR. (8 Jul 2001). Effects of environmental cadmium on zinc homeostasis and cytochrome P4502B6 and 4A11 in human liver and kidney. TOXICOLOGY. 164:61-61.
  • Turner CE; Kurupati P; Jones MD; Edwards RJ; Sriskandan S. (15 Aug 2009). Emerging role of the interleukin-8 cleaving enzyme SpyCEP in clinical Streptococcus pyogenes infection. J Infect Dis. 200:555-563. DOI.
  • Riedl AG; Watts PM; Douek DC; Edwards RJ; Boobis AR; Rose S; Jenner P. (15 Dec 2000). Expression and distribution of CYP2C enzymes in rat basal ganglia. SYNAPSE. 38:392-402. Author weblink DOI.
  • Riedl AG; Watts PM; Edwards RJ; Schulz-Utermoehl T; Boobis AR; Jenner P; Marsden CD. (20 Mar 1999). Expression and localisation of CYP2D enzymes in rat basal ganglia. BRAIN RESEARCH. 822:175-191. Author weblink DOI.
  • Piipari R; Savela K; Nurminen T; Hukkanen J; Raunio H; Hakkola J; Mantyla T; Beaune P; et alEdwards RJ; Boobis AR; Anttila S. (1 Jun 2000). Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers. INTERNATIONAL JOURNAL OF CANCER. 86:610-616. Author weblink DOI.
  • Kapucuoglu N; Coban T; Raunio H; Pelkonen O; Edwards RJ; Boobis AR; Iscan M. (8 Dec 2003). Expression of CYP3A4 in human breast tumour and non-tumour tissues. CANCER LETTERS. 202:17-23. Author weblink DOI.
  • Canaparo R; Nordmark A; Finnstrom N; Lundgren S; Seidegard J; Jeppsson B; Edwards RJ; Boobis AR; et alRane A. (1 Apr 2007). Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 100:240-248. Author weblink DOI.
  • Zhu Z; Hotchkiss SA; Boobis AR; Edwards RJ. (13 Sep 2002). Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes. Biochem Biophys Res Commun. 297:65-70.
  • O'Leary KA; Edwards RJ; Town MM; Boobis AR. (Jan 2005). Genetic and other sources of variation in the activity of serum paraoxonase/diazoxonase in humans: consequences for risk from exposure to diazinon. Pharmacogenet Genomics. 15:51-60.
  • Cheung C; Yu AM; Chen CS; Krausz KW; Byrd LG; Feigenbaum L; Edwards RJ; Waxman DJ; et alGonzalez FJ. (1 Mar 2006). Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 316:1328-1334. Author weblink DOI.
  • ALISON MR; GOLDING MCHM; SARRAF CE; EDWARDS RJ; LALANI EN. (1 Oct 1995). HEPATOCYTE DIFFERENTIATION EN-MASSE FROM DUCTULAR OVAL CELLS IN THE DAMAGED RAT-LIVER. HEPATOLOGY. 22:1125-1125. Author weblink.
  • Watson K; Edwards RJ. (15 Nov 1999). HIV-1 trans-activating (tat) protein. BIOCHEMICAL PHARMACOLOGY. 58:1521-1528. Author weblink DOI.
  • Watson K; Edwards RJ. (15 Nov 1999). HIV-1-trans-activating (Tat) protein: both a target and a tool in therapeutic approaches. Biochem Pharmacol. 58:1521-1528.
  • Abdul-Salam VB; Ramrakha P; Krishnan U; Owen DR; Shalhoub J; Davies AH; Tang TY; Gillard JH; et alBoyle JJ; Wilkins MR; Edwards RJ. (May 2010). Identification and assessment of plasma lysozyme as a putative biomarker of atherosclerosis. Arterioscler Thromb Vasc Biol. 30:1027-1033. DOI.
  • Schulz TG; Thiel R; Davies DS; Edwards RJ. (17 Feb 1998). Identification of CYP2E1 in marmoset monkey. Biochim Biophys Acta. 1382:287-294.
  • Zhu Z; Boobis AR; Edwards RJ. (May 2008). Identification of estrogen-responsive proteins in MCF-7 human breast cancer cells using label-free quantitative proteomics. Proteomics. 8:1987-2005. DOI.
  • Abdul-Salam VB; Paul GA; Ali JO; Gibbs SR; Rahman D; Taylor GW; Wilkins MR; Edwards RJ. (Apr 2006). Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension. Proteomics. 6:2286-2294. DOI.
  • Schulz TG; Wiebel FA; Thier R; Neubert D; Davies DS; Edwards RJ. (May 2000). Identification of theta-class glutathione S-transferase in liver cytosol of the marmoset monkey. Arch Toxicol. 74:133-138.
  • Kapucuoglu N; Coban T; Raunio H; Pelkonen O; Edwards RJ; Boobis AR; Iscan M. (10 Jul 2003). Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues. CANCER LETTERS. 196:153-159. Author weblink DOI.
  • Sivolapenko GB; Kanariou M; Edwards RJ; Epenetos AA; Ritter MA. (Oct 1989). Immunosuppression by immunoglobulin deaggregation is not effective in reducing the anti-xenogeneic immunoglobulin response: experimental and clinical studies. Br J Cancer. 60:511-516.
  • Turner CE; Kurupati P; Wiles S; Edwards RJ; Sriskandan S. (6 Aug 2009). Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi. Vaccine. 27:4923-4929. DOI.
  • Chetty M; d'Esposito F; Zhang WV; Glen J; Dore G; Stankovic Z; Edwards RJ; Ramzan I; et alMurray M. (1 Oct 2009). In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 68:574-579. Author weblink DOI.
  • Zhu Z; Edwards RJ; Boobis AR. (1 Jun 2009). Increased Expression of Histone Proteins during Estrogen-Mediated Cell Proliferation. ENVIRONMENTAL HEALTH PERSPECTIVES. 117:928-934. Author weblink DOI.
  • Zangar RC; Okita JR; Kim HS; Edwards RJ; Okita RT. (11 May 2000). Induction of a microsomal ubiquitin ligase by in vivo nicardipine treatment. FASEB JOURNAL. 14:A1333-A1333. Author weblink.
  • Edwards RJ; Price RJ; Watts PS; Renwick AB; Tredger JM; Boobis AR; Lake BG. (Mar 2003). Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices. Drug Metab Dispos. 31:282-288.
  • SIVOLAPENKO GB; EDWARDS RJ; KANARIOU M; COURTENAYLUCK NS; EPENETOS AA; RITTER MA. (1 Feb 1989). INDUCTION OF TOLERANCE TO XENOGENEIC IMMUNOGLOBULINS. BRITISH JOURNAL OF CANCER. 59:323-323. Author weblink.
  • Murray S; Odupitan AO; Murray BP; Boobis AR; Edwards RJ. (Mar 2001). Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. Xenobiotica. 31:135-151. DOI.
  • Watson K; Gooderham NJ; Davies DS; Edwards RJ. (1 Apr 1999). Interaction of the transactivating protein HIV-1 tat with sulphated polysaccharides. Biochem Pharmacol. 57:775-783.
  • Zhang WV; D'Esposito F; Edwards RJ; Ramzan I; Murray M. (1 Dec 2008). Interindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic Microsomes. DRUG METABOLISM AND DISPOSITION. 36:2547-2555. DOI.
  • Satarug S; Nishijo M; Lasker JM; Edwards RJ; Moore MR. (1 Mar 2006). Kidney dysfunction and hypertension: Role for cadmium, P450 and heme oxygenases?. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE. 208:179-202. Author weblink DOI.
  • Riedl AG; Brown CT; Rose S; Schulz-Utermoehl T; Edwards RJ; Boobis AR; Jenner P. (1 Mar 1998). Localisation of CYP2D enzymes in naive rat basal ganglia. BRITISH JOURNAL OF PHARMACOLOGY. 123:U132-U132. Author weblink.
  • Peng FC; Chen PC; Jeng YJ; Edwards RJ. (27 Feb 2005). Metabolism of territrem B and C in liver microsomes from 14-wk-old Wistar rats is catalyzed by cytochrome P-450 3A. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 68:299-314. Author weblink DOI.
  • Watson K; Gooderham NJ; Davies DS; Edwards RJ. (30 Jul 1999). Nucleosomes bind to cell surface proteoglycans. J Biol Chem. 274:21707-21713.
  • Schulz-Utermoehl T; Bennett AJ; Ellis SW; Tucker GT; Boobis AR; Edwards RJ. (Jun 1999). Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression. Pharmacogenetics. 9:357-366.
  • Peng FC; Jian WC; Edwards RJ. (12 Nov 2005). Profile of territrem metabolism and cytochrome P-450 3A expression in liver microsomes from Wistar rats of both genders as a function of age. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 68:1871-1888. Author weblink DOI.
  • Zhu Z; Edwards RJ; Boobis AR. (26 Sep 2008). Proteomic analysis of human breast cell lines using SELDI-TOF MS shows that mixtures of estrogenic compounds exhibit simple similar action (concentration additivity). Toxicol Lett. 181:93-103. DOI.
  • Brassil PJ; Debri K; Nakura H; Kobayashi S; Davies DS; Edwards RJ. (15 Jul 1998). Reduced hepatic expression of CYP7A1 and CYP2C13 in rats with spontaneous hyperlipidaemia. Biochem Pharmacol. 56:253-257.
  • Fan LQ; You L; Brown-Borg H; Brown S; Edwards RJ; Corton JC. (15 Nov 2004). Regulation of phase I and phase II steroid metabolism enzymes by PPAR alpha activators. TOXICOLOGY. 204:109-121. Author weblink DOI.
  • Baker JR; Satarug S; Reilly PEB; Edwards RJ; Ariyoshi N; Kamataki T; Moore MR; Williams DJ. (15 Sep 2001). Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples. BIOCHEMICAL PHARMACOLOGY. 62:713-721. Author weblink DOI.
  • Baker JR; Edwards RJ; Lasker JM; Moore MR; Satarug S. (15 Nov 2005). Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1. TOXICOLOGY LETTERS. 159:182-191. Author weblink DOI.
  • McCloskey P; Edwards RJ; Tootle R; Selden C; Roberts E; Hodgson HJ. (Nov 1999). Resistance of three immortalized human hepatocyte cell lines to acetaminophen and N-acetyl-p-benzoquinoneimine toxicity. J Hepatol. 31:841-851.
  • Sarraf CE; Horgan M; Edwards RJ; Alison MR. (Feb 1997). Reversal of phenobarbital-induced hyperplasia and hypertrophy in the livers of lpr mice. Int J Exp Pathol. 78:49-56.
  • Barter ZE; Bayliss MK; Beaune PH; Boobis AR; Carlile DJ; Edwards RJ; Houston JB; Lake BG; et alLipscomb JC; Pelkonen OR; Tucker GT; Rostami-Hodjegan A. (1 Jan 2007). Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver. CURRENT DRUG METABOLISM. 8:33-45. Author weblink DOI.
  • Fang M; Boobis AR; Edwards RJ. (Nov 2007). Searching for novel biomarkers of centrally and peripehrally-acting neurotoxicants, using surface-enhanced laser desorption/ionisation-time-of-flight mass spectrometry (SELDI-TOF MS). Food Chem Toxicol. 45:2126-2137. DOI.
  • Edwards RJ; Taylor GW; Ferguson M; Murray S; Rendell N; Wrigley A; Bai Z; Boyle J; et alFinney SJ; Jones A; Russell HH; Turner C; Cohen J; Faulkner L; Sriskandan S. (1 Sep 2005). Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes. J Infect Dis. 192:783-790. DOI.
  • Edwards RJ. (1 Mar 1998). Structural features of P450 and its antigenic determinants revealed by designer antibody studies. BRITISH JOURNAL OF PHARMACOLOGY. 123:U199-U199. Author weblink.
  • Edwards RJ. (2006). Targeting antipeptide antibodies toward cytochrome P450 enzymes. Methods Mol Biol. 320:173-182. DOI.
  • Edwards RJ. (1998). Targeting antipeptide antibodies towards cytochrome P450 enzymes. Methods Mol Biol. 107:239-249. DOI.
  • Peng FC; Chang CC; Yang CY; Edwards RJ; Doehmer J. (1 Feb 2006). Territrems B and C metabolism in human liver microsomes: Major role of CYP3A4 and CYP3A5. TOXICOLOGY. 218:172-185. Author weblink DOI.
  • Brooks RA; Gooderham NJ; Edwards RJ; Boobis AR; Winton DJ. (1 Jan 1999). The mutagenicity of benzo[a]pyrene in mouse small intestine. CARCINOGENESIS. 20:109-114. Author weblink DOI.
  • Thatcher NJ; Edwards RJ; Lemoine NR; Doehmer J; Davies DS. (Apr 2000). The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy. Cancer Gene Ther. 7:521-525. DOI.
  • Vig P; Russo FP; Edwards RJ; Tadrous PJ; Wright NA; Thomas HC; Alison MR; Forbes SJ. (Feb 2006). The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice. Hepatology. 43:316-324. DOI.
  • STORCH J; EDWARDS RJ; MACDERMOT J. (1 Sep 1990). THROMBOXANE RELEASE BY LYMPHOKINE-DIFFERENTIATED U937 HUMAN MONOCYTIC CELLS - RESPONSE TO PLATELET-ACTIVATING FACTOR (PAF) AND CHEMOTACTIC PEPTIDE (FMLP) BUT NOT TO LOW AFFINITY IGE-RECEPTOR (FC-EPSILON-RII-CD23) OCCUPATION. JOURNAL OF LEUKOCYTE BIOLOGY. 48:266-273. Author weblink.
  • McCloskey P; Edwards RJ; Tootle R; Selden C; Roberts E; Hodgson HJF. (1 Oct 1998). Tolerance of three human hepatocyte cell lines to acetaminophen reflects resistance to toxic effects of NABQI and maintenance of intracellular glutathione. HEPATOLOGY. 28:636A-636A. Author weblink.
  • Fang M; Edwards RJ; Bartlet-Jones M; Taylor GW; Murray S; Boobis AR. (Jun 2004). Urinary N2-(2'-deoxyguanosin-8-yl)PhIP as a biomarker for PhIP exposure. Carcinogenesis. 25:1053-1062. DOI.
  • Mosley K; Tam FW; Edwards RJ; Crozier J; Pusey CD; Lightstone L. (Dec 2006). Urinary proteomic profiles distinguish between active and inactive lupus nephritis. Rheumatology (Oxford). 45:1497-1504. DOI.
  • Zhu Z; Boobis AR; Edwards RJ. (20 Sep 2006). Use of protein profiles to characterise concentration-effect curves of mixtures of estrogenic compounds in human breast cell lines. TOXICOLOGY LETTERS. 164:S165-S166. Author weblink DOI.

Conferences

  • Abdul-Salam VB; Wharton J; Wilkins MR; Edwards RJ. APPLICATION OF PROTEOMICS TO EXPLORE THE PATHOBIOLOGY OF PULMONARY ARTERIAL HYPERTENSION. British-Thoracic-Society-Winter-Meeting 2010, 1 Dec 2010 - 3 Dec 2010. 65:A44-A44. B M J PUBLISHING GROUP (1 Dec 2010). Author weblink DOI.
  • Konstantinou DK; Marek CJ; Edwards RJ; Hawksworth GM; Goodwin B; Wright MC. Disabled pregnane X receptor function potentiates constitutive androstane receptor-mediated CYP3A induction. 26th Spring Annual Congress of the British-Toxicology-Society, 19 Mar 2005 - 23 Mar 2005. 213:227-228. ELSEVIER IRELAND LTD (1 Oct 2005). Author weblink.
  • Turner CE; Kurupati P; Jones MD; Edwards RJ; Sriskandan S. Emerging Role of the Interleukin-8 Cleaving Enzyme SpyCEP in Clinical Streptococcus pyogenes Infection. 17th Lancefield International Symposium on Streptococci and Streptococcal Diseases, 22 Jun 2008 - 26 Jun 2008. 200:555-563. UNIV CHICAGO PRESS (15 Aug 2009). Author weblink DOI.
  • Coban T; Kapucuoglu N; Raunio H; Pelkonen O; Edwards RJ; Boobis AR; Iscan M. Expression of CYP3A4 in human breast tumors. 7th European ISSX Meeting. 36:92-92. (Aug 2004).
  • Brassil PJ; Davis CD; Edwards RJ; Alberts J; Bidwell V; Zadjura L; Daumerie G; Hansel S; et alSantone KS; Greene DS. Hepatic and gut CYP3A12 expression in male beagle dogs. 11th North-American-International-Society-for-the-Study-of-Xenobiotics Meeting. 34:101-101. (Jan 2002).
  • Wilson ZE; Ellis SW; Edwards RJ; Tucker GT; Rostami-Hodjegan A. Implications of the disparity in relative holo : apo-protein contents of different standards used for immuno-quantification of hepatic cytochrome P450 3A4 (CYP3A4). 9th European ISSX Meeting, 12 Jun 2005 - 17 Jun 2005. 37:77-77. TAYLOR & FRANCIS INC (1 Jan 2005). Author weblink.
  • Goetz C; Ruwiedel K; Pfeiffer R; Huebenthal U; Edwards RJ; Carmichael P; Aeby P; Goebel C; et alPease CK; Fritsche E. Metabolic capacities of in vitro alternatives for chemical testing in skin: insights from the COLIPA skin metabolism project. 51st Annual Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und-Toxikologie, 23 Mar 2010 - 25 Mar 2010. 381:80-80. SPRINGER (1 Mar 2010).
  • Parviz N; Edwards RJ; Wasan HS; Taylor-Robinson SD; Toledano MB; Cox J; Khan S. PLASMA PROTEOMIC PROFILING OF PATIENTS WITH CHOLANGIOCARCINOMA. 59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, 31 Oct 2008 - 4 Nov 2008. 48:984A-985A. JOHN WILEY & SONS INC (1 Oct 2008). Author weblink.
  • Nassim P; Edwards RJ; Wasan H; Cox I; Toledano MB; Taylor-Robinson SD; Khan SA. PLASMA PROTEOMIC PROFILING OF PATIENTS WITH CHOLANGIOCARCINOMA. Annual Meeting of the British-Society-of-Gastroenterology, 23 Mar 2009 - 26 Mar 2009. 58:A17-A17. B M J PUBLISHING GROUP (1 Apr 2009).
  • O'Leary KA; Edwards RJ; Town M; Boobis AR. Polymorphic variation in PON1 affects the detoxitication of diazoxon in serum. BTS 2004 Annual Congress. 202:89-90. (30 Sep 2004).
  • Baker JR; Satarug S; Edwards RJ; Moore MR; Williams DJ; Reilly PEB. Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity. 9th International Congress of Toxicology (ICT IX). 137:85-93. (31 Jan 2003).
  • Zabron AA; Horneffer-Van der Sluis VM; Geirula M; Wadsworth CA; Laird F; Thillainayagam AV; Vlavianos P; Westaby D; et alTaylor-Robinson SD; Edwards RJ; Khan SA. PROTEOMIC ANALYSIS OF BILE IN BENIGN AND MALIGNANT PANCREATOBILIARY DISEASE. Annual General Meeting of the British-Society-of-Gastroenterology, 22 Mar 2010 - 25 Mar 2010. 59:A82-A83. B M J PUBLISHING GROUP (1 Apr 2010). DOI.
  • Zhu Z; Boobis AR; Edwards RJ. Proteomic analysis of the differential effects of estrogens on human breast cancer cells. Annual Congress of the British-Toxicological-Society, 15 Apr 2007 - 18 Apr 2007. 240:167-168. ELSEVIER IRELAND LTD (6 Nov 2007). Author weblink DOI.
  • Ruwiedel K; Edwards RJ; Carmichael P; Aeby P; Goebel C; Pease CK; Fritsche E. The COLIPA Skin Metabolism Project - towards the inclusion of appropriate metabolism in in vitro alternatives for skin sensitisation and genotoxicity. 49th Annual Meeting German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology, 11 Mar 2008 - 13 Mar 2008. 377:89-89. SPRINGER (1 Mar 2008). Author weblink.
  • Fang M; Boobis AR; Edwards RJ. The search for novel protein biomarkers of neurotoxicity using SELDI-TOF mass spectrometry. 10th International Congress of Toxicology, 11 Jul 2004 - 15 Jul 2004. 197:318-318. ACADEMIC PRESS INC ELSEVIER SCIENCE (15 Jun 2004). Author weblink.
  • Perrett HF; Barter ZE; Edwards RJ; Lennard MS; Rostami-Hodjegan A; Tucker GT. The use of recombinantly expressed CYP3A5 as a standard for immuno-quantification of hepatic CYP3A5 can result in underestimation of its abundance. 9th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX). 38:109-109. (Jan 2006).

Other publications

  • Abdul-Salam VB. Wilkins MW (ed); Edwards RJ (ed). (21 Feb 2007). Application of protein profiling to biomarker discovery in idiopathic pulmonary arterial hypertension.
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