Dr Richard Harbottle

Publications


Journals

  • Klausner EA; Zhang Z; Wong SP; Chapman RL; Volin MV; Harbottle RP. (Feb 2012). Corneal gene delivery: chitosan oligomer as a carrier of CpG rich, CpG free or S/MAR plasmid DNA. J Gene Med. 14:100-108. DOI.
  • Argyros O; Wong S-P; Harbottle RP. (1 Sep 2011). Non-viral episomal modification of cells using S/MAR elements. EXPERT OPINION ON BIOLOGICAL THERAPY. 11:1177-1191. DOI.
  • Argyros O; Wong SP; Harbottle RP. (Sep 2011). Non-viral episomal modification of cells using S/MAR elements. Expert Opin Biol Ther. 11:1177-1191. DOI.
  • Argyros O; Wong SP; Fedonidis C; Tolmachov O; Waddington SN; Howe SJ; Niceta M; Coutelle C; et alHarbottle RP. (Feb 2011). Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver. Journal of molecular medicine (Berlin, Germany). 89(5):515-529. Publisher weblink DOI.
  • Wong SP; Argyros O; Howe SJ; Harbottle RP. (Dec 2010). Systemic gene transfer of polyethylenimine (PEI)-plasmid DNA complexes to neonatal mice. Journal of controlled release : official journal of the Controlled Release Society. Publisher weblink DOI.
  • Wong SP; Argyros O; Coutelle C; Harbottle RP. (Jan 2011). Non-viral S/MAR vectors replicate episomally in vivo when provided with a selective advantage. Gene Ther. 18:82-87. DOI.
  • Wong SP; Argyros O; Coutelle C; Harbottle RP. (Aug 2010). Non-viral S/MAR vectors replicate episomally in vivo when provided with a selective advantage. Gene Therapy. Publisher weblink DOI.
  • Viecelli HM; Wong SP; Harbottle RP; Petrus I; Chuah M; VandenDriessche T; Thony B. (1 Aug 2010). COMPARATIVE STUDY OF CHIMERIC LIVER-SPECIFIC PROMOTER EXPRESSION FROM A NON-VIRAL VECTOR FOR HEPATIC GENE THERAPY. JOURNAL OF INHERITED METABOLIC DISEASE. 33:S166-S166. Author weblink.
  • Haase R; Argyros O; Wong SP; Harbottle RP; Lipps HJ; Ogris M; Magnusson T; Vizoso Pinto MG; et alHaas J; Baiker A. (2010). pEPito: a significantly improved non-viral episomal expression vector for mammalian cells. BMC Biotechnol. 10:20. DOI.
  • Wong SP; Argyros O; Coutelle C; Harbottle RP. (Aug 2009). Strategies for the episomal modification of cells. Curr Opin Mol Ther. 11:433-441.
  • Argyros O; Wong SP; Niceta M; Waddington SN; Howe SJ; Coutelle C; Miller AD; Harbottle RP. (Dec 2008). Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector. Gene Ther. 15:1593-1605. DOI.
  • Argyros O; Wong S; Niceta M; Waddington S; Howe S; Coutelle C; Miller A; Richard P Harbottle RP. (Jul 2008). Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector. Gene Therapy. Publisher weblink DOI.
  • Hibbitt OC; Harbottle RP; Waddington SN; Bursill CA; Coutelle C; Channon KM; Wade-Martins R. (Jun 2007). Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection. J Gene Med. 9:488-497. DOI.
  • Vaysse L; Gregory LG; Harbottle RP; Perouzel E; Tolmachov O; Coutelle C. (1 Jun 2006). Nuclear-targeted minicircle to enhance gene transfer with non-viral vectors in vitro and in vivo. JOURNAL OF GENE MEDICINE. 8:754-763. Author weblink DOI.
  • Waterhouse JE; Harbottle RP; Keller M; Kostarelos K; Coutelle C; Jorgensen MR; Miller AD. (Jul 2005). Synthesis and application of integrin targeting lipopeptides in targeted gene delivery. Chembiochem. 6:1212-1223. DOI.
  • Keller M; Harbottle RP; Perouzel E; Colin M; Shah L; Rahim A; Vaysse L; Bergau A; et alMoritz S; Brahimi-Horn C; Coutelle C; Miller AD. (4 Apr 2003). Nuclear localisation sequence templated nonviral gene delivery vectors: Investigation of intracellular trafficking events, of LMD and LD vector systems. CHEMBIOCHEM. 4:286-298. Author weblink DOI.
  • Keller M; Harbottle RP; Perouzel E; Colin M; Shah I; Rahim A; Vaysse L; Bergau A; et alMoritz S; Brahimi-Horn C; Coutelle C; Miller AD. (4 Apr 2003). Nuclear localisation sequence templated nonviral gene delivery vectors: investigation of intracellular trafficking events of LMD and LD vector systems. Chembiochem. 4:286-298. DOI.
  • Gregory LG; Harbottle RP; Lawrence L; Knapton HJ; Themis M; Coutelle C. (Jan 2003). Enhancement of adenovirus-mediated gene transfer to the airways by DEAE dextran and sodium caprate in vivo. Mol Ther. 7:19-26.
  • Tagawa T; Manvell M; Brown N; Keller M; Perouzel E; Murray KD; Harbottle RP; Tecle M; et alBooy F; Brahimi-Horn MC; Coutelle C; Lemoine NR; Alton EW; Miller AD. (May 2002). Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu and plasmid DNA. Gene Ther. 9:564-576. DOI.
  • Jost PJ; Harbottle RP; Knight A; Miller AD; Coutelle C; Schneider H. (2 Feb 2001). A novel peptide, THALWHT, for the targeting of human airway epithelia. FEBS LETTERS. 489:263-269. Author weblink DOI.
  • Colin,M.; Maurice,M.; Trugnan,G.; Kornprobst,M.; Harbottle,R.P.; Knight,A.; Cooper,R.G.; Miller,A.D.; et alCapeau,J.; Coutelle,C.; BrahimiHorn,M.C.. (2000). Cell delivery, intracellular trafficking and expression of an integrin-mediated gene transfer vector in tracheal epithelial cells. Gene Therapy. 7:139-152.
  • Schneider H; Harbottle RP; Yokosaki Y; Jost P; Coutelle C. (24 Sep 1999). Targeted gene delivery into alpha9beta1-integrin-displaying cells by a synthetic peptide. FEBS Lett. 458:329-332.
  • Cooper RG; Harbottle RP; Schneider H; Coutelle C; Miller AD. (1 Jan 1999). Peptide mini-vectors for gene delivery. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 38:1949-1952. Author weblink DOI.
  • Colin M; Harbottle RP; Knight A; Kornprobst M; Cooper RG; Miller AD; Trugnan G; Capeau J; et alCoutelle C; Brahimi-Horn MC. (1 Nov 1998). Liposomes enhance delivery and expression of an RGD-oligolysine gene transfer vector in human tracheal cells. GENE THERAPY. 5:1488-1498. Author weblink DOI.
  • Villaverde A; Feliu JX; Arís A; Harbottle RP; Benito A; Coutelle C. (5 Aug 1998). A cell adhesion peptide from foot-and-mouth disease virus can direct cell targeted delivery of a functional enzyme. Biotechnol Bioeng. 59:294-301.
  • Schneider H; Harbottle RP; Yokosaki Y; Kunde J; Sheppard D; Coutelle C. (16 Jun 1998). A novel peptide, PLAEIDGIELTY, for the targeting of alpha9beta1-integrins. FEBS Lett. 429:269-273.
  • Harbottle RP; Cooper RG; Hart SL; Ladhoff A; McKay T; Knight AM; Wagner E; Miller AD; et alCoutelle C. (1 May 1998). An RGD-oligolysine peptide: A prototype construct for integrin-mediated gene delivery. HUMAN GENE THERAPY. 9:1037-1047. Author weblink DOI.
  • Hart SL; Arancibia-Carcamo CV; Wolfert MA; Mailhos C; O'Reilly NJ; Ali RR; Coutelle C; George AJT; et alHarbottle RP; Knight AM; Larkin DFP; Levinsky RJ; Seymour LW; Thrasher AJ; Kinnon C. (1 Mar 1998). Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector. HUMAN GENE THERAPY. 9:575-585. Author weblink DOI.
  • Mistry AR; Falciola L; Monaco L; Tagliabue R; Acerbis G; Knight A; Harbottle RP; Soria M; et alBianchi ME; Coutelle C; Hart SL. (Apr 1997). Recombinant HMG1 protein produced in Pichia pastoris: a nonviral gene delivery agent. Biotechniques. 22:718-729.
  • Villaverde A; Feliu JX; Harbottle RP; Benito A; Coutelle C. (21 Nov 1996). A recombinant, arginine-glycine-aspartic acid (RGD) motif from foot-and-mouth disease virus binds mammalian cells through vitronectin and, to a lower extent, fibronectin receptors. Gene. 180:101-106.
  • Hart SL; Harbottle RP; Cooper R; Miller A; Williamson R; Coutelle C. (1 Nov 1996). Gene delivery and expression mediated by an integrin-binding peptide (vol 2, pg 552, 1995). GENE THERAPY. 3:1032-1033. Author weblink.
  • Hart SL; Harbottle RP; Cooper R; Miller A; Williamson R; Coutelle C. (Oct 1995). Gene delivery and expression mediated by an integrin-binding peptide. Gene Ther. 2:552-554.
  • HART SL; HARBOTTLE RP; COOPER R; MILLER A; WILLIAMSON R; COUTELLE C. (1 Oct 1995). GENE DELIVERY AND EXPRESSION MEDIATED BY AN INTEGRIN-BINDING PEPTIDE. GENE THERAPY. 2:552-554. Author weblink.
  • Hart SL; Knight AM; Harbottle RP; Mistry A; Hunger HD; Cutler DF; Williamson R; Coutelle C. (29 Apr 1994). Cell binding and internalization by filamentous phage displaying a cyclic Arg-Gly-Asp-containing peptide. J Biol Chem. 269:12468-12474.
  • HART SL; HARBOTTLE RP; KINRADE EFV; COUTELLE C; WILLIAMSON B. (29 Mar 1993). GENE DELIVERY SYSTEMS INCORPORATING BACTERIAL INVASION PROTEINS. JOURNAL OF CELLULAR BIOCHEMISTRY. 237-237. Author weblink.

Chapters in books

  • Tolmachov O; Harbottle R; Bigger B; Coutelle C. Minimized, CpG-Depleted, and Methylated DNA Vectors: Toward Perfection in Nonviral Gene Therapy. In DNA-Pharmaceuticals: Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy. 43-54. Schleef M (ed). Wiley (2005). Publisher weblink.

Conferences

  • Viecelli HM; Chen ZY; Kay MA; Harbottle RP; Thony B. Comparison of minicircle production methods for delivering naked DNA and expressing genes in animals. 18th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy, 22 Oct 2010 - 25 Oct 2010. 21:1450-1450. MARY ANN LIEBERT INC (1 Oct 2010). Author weblink.
  • Argyros O; Wong S-P; Fedonidis C; Tolmachov O; Waddington S; Howe S; Coutelle C; Harbottle R. Development of Scaffold/Matrix Attachment Region (S/MAR) Minicircles for Enhanced and Persistent Transgene Expression in the Mouse Liver. 17th Annual Meeting of German Society for Gene Therapy (DG-GT e.V.), 7 Oct 2010 - 9 Oct 2010. 1197-1198. Mary Ann Liebert Inc Publishers (Sep 2010). Publisher weblink.
  • Wong SP; Argyros O; Coutelle C; Harbottle RP. Development of S/MAR Minicircle Vectors for Persistent Expression In Vivo. 12th Annual Meeting of the American Society of Gene Therapy, 27 May 2009 - 30 May 2009. 17:S286-S286. NATURE PUBLISHING GROUP (1 May 2009). Author weblink.
  • Argyros O; Wong SP; Nicetta M; Waddington SN; Coutelle C; Miller AD; Harbottle RP. Persistent episomal transgene expression in liver following hydrodynamic delivery of S/MAR-Containing plasmid DNA. 5th Annual Conference of the British-Society-for-Gene-Therapy, 7 Apr 2008 - 9 Apr 2008. 19:399-399. MARY ANN LIEBERT INC (1 Apr 2008). Author weblink.
  • Wong SP; Argyros O; Coutelle C; Harbottle RP. Development of an S/MAR plasmid for extrachromosomal stability in vivo. 5th Annual Conference of the British-Society-for-Gene-Therapy, 7 Apr 2008 - 9 Apr 2008. 19:406-406. MARY ANN LIEBERT INC (1 Apr 2008). Author weblink.
  • Waterhouse JE; Jorgensen MR; Harbottle RP; Kostarelos K; Miller AD. Synthesis and biological evaluation of alpha 9 beta 1 integrin targeted non-viral gene delivery system. 6th Annual Meeting of the American-Society-of-Gene-Therapy, 4 Jun 2003 - 8 Jun 2003. 7:S218-S218. ACADEMIC PRESS INC ELSEVIER SCIENCE (1 May 2003). Author weblink.
  • Hart SL; Harbottle RP; Coutelle C. Integrin-mediated gene delivery. NATO Advanced Study Institute on Targeting of Drugs - Strategies for Oligonucleotide and Gene Delivery in Therapy, 24 Jun 1995 - 5 Jul 1995. 290:101-106. PLENUM PRESS DIV PLENUM PUBLISHING CORP (1 Jan 1996). Author weblink.
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