Professor Robert J Wilkinson

Publications


Journals

  • Wilkinson RJ. (15 Feb 2012). Human Genetic Susceptibility to Tuberculosis: Time for a Bottom-Up Approach?. JOURNAL OF INFECTIOUS DISEASES. 205:525-527. Author weblink DOI.
  • Rangaka MX; Gideon HP; Wilkinson KA; Pai M; Mwansa-Kambafwile J; Maartens G; Glynn JR; Boulle A; et alFielding K; Goliath R; Titus R; Mathee S; Wilkinson RJ. (1 Jan 2012). Interferon release does not add discriminatory value to smear-negative HIV-tuberculosis algorithms. EUROPEAN RESPIRATORY JOURNAL. 39:163-171. DOI.
  • Matthews K; Ntsekhe M; Syed F; Scriba T; Russell J; Tibazarwa K; Deffur A; Hanekom W; et alMayosi BM; Wilkinson RJ; Wilkinson KA. (1 Jan 2012). HIV-1 infection alters CD4+memory T-cell phenotype at the site of disease in extrapulmonary tuberculosis. EUROPEAN JOURNAL OF IMMUNOLOGY. 42:147-157. DOI.
  • Walker NF; Clark SO; Oni T; Andreu N; Tezera L; Singh S; Saraiva L; Pedersen B; et alKelly DL; Tree JA; D'Armiento JM; Meintjes G; Mauri FA; Williams A; Wilkinson RJ; Friedland JS; Elkington PT. (1 May 2012). Doxycycline and HIV Infection Suppress Tuberculosis-induced Matrix Metalloproteinases. Am J Respir Crit Care Med. 185:989-997. DOI.
  • Rangaka MX; Wilkinson KA; Glynn JR; Ling D; Menzies D; Mwansa-Kambafwile J; Fielding K; Wilkinson RJ; et alPai M. (1 Jan 2012). Predictive value of interferon-gamma release assays for incident active tuberculosis: a systematic review and meta-analysis. LANCET INFECTIOUS DISEASES. 12:45-55. Author weblink DOI.
  • Bond E; Liang F; Sandgren KJ; Smed-Sorensen A; Bergman P; Brighenti S; Adams WC; Betemariam SA; et alRangaka MX; Lange C; Wilkinson RJ; Andersson J; Lore K. (1 Jan 2012). Plasmacytoid Dendritic Cells Infiltrate the Skin in Positive Tuberculin Skin Test Indurations. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 132:114-123. DOI.
  • Esmail H; Barry CE; Wilkinson RJ. (May 2012). Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies. Drug Discov Today. 17:514-521. DOI.
  • Martineaua AR; Nhamoyebonde S; Onic T; Rangaka MX; Marais S; Bangani N; Tsekela R; Bashe L; et alde Azevedo V; Caldwell J; Venton TR; Timms PM; Wilkinson KA; Wilkinson RJ. (22 Nov 2011). Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108:19013-19017. Author weblink DOI.
  • Matthews K; Wilkinson KA; Kalsdorf B; Roberts T; Diacon A; Walzl G; Wolske J; Ntsekhe M; et alSyed F; Russell J; Mayosi BM; Dawson R; Dheda K; Wilkinson RJ; Hanekom WA; Scriba TJ. (1 Nov 2011). Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis. TUBERCULOSIS. 91:587-593. Author weblink DOI.
  • Lowe DM; Redford PS; Wilkinson RJ; O'Garra A; Martineau AR. (Jan 2012). Neutrophils in tuberculosis: friend or foe?. Trends Immunol. 33:14-25. DOI.
  • Oni T; Burke R; Tsekela R; Bangani N; Seldon R; Gideon HP; Wood K; Wilkinson KA; et alOttenhoff THM; Wilkinson RJ. (1 Aug 2011). High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB screening. THORAX. 66:669-673. DOI.
  • McNab FW; Berry MP; Graham CM; Bloch SA; Oni T; Wilkinson KA; Wilkinson RJ; Kon OM; et alBanchereau J; Chaussabel D; O'Garra A. (Jul 2011). Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis. Eur J Immunol. 41:1941-1947. DOI.
  • Jones GJ; Pirson C; Gideon HP; Wilkinson KA; Sherman DR; Wilkinson RJ; Hewinson RG; Vordermeier HM. (21 Jun 2011). Immune Responses to the Enduring Hypoxic Response Antigen Rv0188 Are Preferentially Detected in Mycobacterium bovis Infected Cattle with Low Pathology. PLOS ONE. 6. Author weblink DOI.
  • Pepper DJ; Marais S; Wilkinson RJ; Bhaijee F; De Azevedo V; Meintjes G. (12 May 2011). Barriers to Initiation of Antiretrovirals during Antituberculosis Therapy in Africa. PLOS ONE. 6. DOI.
  • Marais S; Pepper DJ; Schutz C; Wilkinson RJ; Meintjes G. (19 May 2011). Presentation and Outcome of Tuberculous Meningitis in a High HIV Prevalence Setting. PLOS ONE. 6. DOI.
  • Dodd LE; Wilkinson RJ. (7 May 2011). Isoniazid preventive therapy in HIV infection. LANCET. 377:1548-1550. DOI.
  • Tadokera R; Meintjes G; Skolimowska KH; Wilkinson KA; Matthews K; Seldon R; Chegou NN; Maartens G; et alRangaka MX; Rebe K; Walzl G; Wilkinson RJ. (May 2011). Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome. Eur Respir J. 37:1248-1259. DOI.
  • Pepper DJ; Rebe K; Morroni C; Wilkinson RJ; Meintjes G. (20 Feb 2009). Clinical Deterioration during Antitubercular Treatment at a District Hospital in South Africa: The Importance of Drug Resistance and AIDS Defining Illnesses. PLOS ONE. 4. DOI.
  • Gideon HP; Wilkinson KA; Rustad TR; Oni T; Guio H; Kozak RA; Sherman DR; Meintjes G; et alBehr MA; Vordermeier HM; Young DB; Wilkinson RJ. (1 Dec 2010). Hypoxia Induces an Immunodominant Target of Tuberculosis Specific T Cells Absent from Common BCG Vaccines. PLOS PATHOGENS. 6. DOI Open Access copy.
  • Schutz C; Meintjes G; Almajid F; Wilkinson RJ; Pozniak A. (1 Dec 2010). Clinical management of tuberculosis and HIV-1 co-infection. EUROPEAN RESPIRATORY JOURNAL. 36:1460-1481. DOI.
  • Marais S; Thwaites G; Schoeman JF; Török ME; Misra UK; Prasad K; Donald PR; Wilkinson RJ; et alMarais BJ. (Nov 2010). Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis. 10:803-812. DOI.
  • Lawn SD; Wood R; Wilkinson RJ. (1 Jan 2011). Changing Concepts of "Latent Tuberculosis Infection" in Patients Living with HIV Infection. CLINICAL & DEVELOPMENTAL IMMUNOLOGY. . DOI.
  • Asselman V; Thienemann F; Pepper DJ; Boulle A; Wilkinson RJ; Meintjes G; Marais S. (27 Nov 2010). Central nervous system disorders after starting antiretroviral therapy in South Africa. AIDS. 24:2871-2876. DOI.
  • Wilkinson KA; Wilkinson RJ. (1 Aug 2010). Polyfunctional T cells in human tuberculosis. EUROPEAN JOURNAL OF IMMUNOLOGY. 40:2139-2142. DOI.
  • Meintjes G; Wilkinson RJ; Morroni C; Pepper DJ; Rebe K; Rangaka MX; Oni T; Maartens G. (24 Sep 2010). Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome. AIDS. 24:2381-2390. DOI.
  • Lawn SD; Wilkinson RJ. (1 Jul 2010). Primate model to study reactivation of TB associated with retroviral infection. FUTURE VIROLOGY. 5:391-395. DOI.
  • Berry MP; Graham CM; McNab FW; Xu Z; Bloch SA; Oni T; Wilkinson KA; Banchereau R; et alSkinner J; Wilkinson RJ; Quinn C; Blankenship D; Dhawan R; Cush JJ; Mejias A; Ramilo O; Kon OM; Pascual V; Banchereau J; Chaussabel D; O'Garra A. (19 Aug 2010). An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature. 466:973-977. DOI.
  • Chatterjee A; D'Souza D; Vira T; Bamne A; Ambe GT; Nicol MP; Wilkinson RJ; Mistry N. (Oct 2010). Strains of Mycobacterium tuberculosis from western Maharashtra, India, exhibit a high degree of diversity and strain-specific associations with drug resistance, cavitary disease, and treatment failure. J Clin Microbiol. 48:3593-3599. DOI.
  • Meintjes G; Wilkinson RJ. (1 Oct 2010). Undiagnosed active tuberculosis in HIV-infected patients commencing antiretroviral therapy. Clin Infect Dis. 51:830-832. DOI.
  • Bhaijee F; Wainwright H; Meintjes G; Wilkinson RJ; Todd G; de Vries E; Pepper DJ. (1 Jun 2010). Warfarin-induced skin necrosis in HIV-1-infected patients with tuberculosis and venous thrombosis. SAMJ SOUTH AFRICAN MEDICAL JOURNAL. 100:372-377.
  • Connell TG; Davies M-A; Johannisen C; Wood K; Pienaar S; Wilkinson KA; Wilkinson RJ; Zar HJ; et alBeatty D; Nicol MP; Curtis N; Eley B. (27 May 2010). Reversion and conversion of Mycobacterium tuberculosis IFN-gamma ELISpot results during anti-tuberculous treatment in HIV-infected children. BMC INFECTIOUS DISEASES. 10. Author weblink DOI.
  • Meintjes G; Rabie H; Wilkinson RJ; Cotton MF. (1 Dec 2009). Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome and Unmasking of Tuberculosis by Antiretroviral Therapy. CLINICS IN CHEST MEDICINE. 30:797-+. Author weblink DOI.
  • Meintjes G; Wilkinson RJ. (1 Jun 2010). Optimum Timing of Antiretroviral Therapy for HIV-Infected Patients with Concurrent Serious Opportunistic Infections. CLINICAL INFECTIOUS DISEASES. 50:1539-1541. Author weblink DOI.
  • Dash S; Langenberg C; Fawcett KA; Semple RK; Romeo S; Sharp S; Sano H; Lienhard GE; et alRochford JJ; Howlett T; Massoud AF; Hindmarsh P; Howell SJ; Wilkinson RJ; Lyssenko V; Groop L; Baroni MG; Barroso I; Wareham NJ; O' Rahilly S; Savage DB. (1 Jun 2010). Analysis of TBC1D4 in patients with severe insulin resistance. DIABETOLOGIA. 53:1239-1242. Author weblink DOI.
  • Pepper DJ; Marais S; Wilkinson RJ; Bhaijee F; Maartens G; McIlleron H; De Azevedo V; Cox H; et alMcDermid C; Sokhela S; Patel J; Meintjes G. (30 Mar 2010). Clinical deterioration during antituberculosis treatment in Africa: Incidence, causes and risk factors. BMC INFECTIOUS DISEASES. 10. Author weblink DOI.
  • Chun RF; Lauridsen AL; Suon L; Zella LA; Pike JW; Modlin RL; Martineau AR; Wilkinson RJ; et alAdams J; Hewison M. (Jul 2010). Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D. J Clin Endocrinol Metab. 95:3368-3376. DOI.
  • Wood R; Liang H; Wu H; Middelkoop K; Oni T; Rangaka MX; Wilkinson RJ; Bekker L-G; et alLawn SD. (1 Apr 2010). Changing prevalence of tuberculosis infection with increasing age in high-burden townships in South Africa. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. 14:406-412. Author weblink.
  • Tena-Coki NG; Scriba TJ; Peteni N; Eley B; Wilkinson RJ; Andersen P; Hanekom WA; Kampmann B. (1 Jul 2010). CD4 and CD8 T-cell responses to mycobacterial antigens in African children. Am J Respir Crit Care Med. 182:120-129. DOI.
  • Barry CE; Boshoff HI; Dartois V; Dick T; Ehrt S; Flynn J; Schnappinger D; Wilkinson RJ; et alYoung D. (1 Mar 2010). Spectrum of latent tuberculosis - existing tests cannot resolve the underlying phenotypes Reply. NATURE REVIEWS MICROBIOLOGY. 8. DOI.
  • Marais S; Scholtz P; Pepper DJ; Meintjes G; Wilkinson RJ; Candy S. (1 Feb 2010). Neuroradiological features of the tuberculosis-associated immune reconstitution inflammatory syndrome. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. 14:188-196.
  • Oni T; Patel J; Gideon HP; Seldon R; Wood K; Hlombe Y; Wilkinson KA; Rangaka MX; et alMendelson M; Wilkinson RJ. (Sep 2010). Enhanced diagnosis of HIV-1-associated tuberculosis by relating T-SPOT.TB and CD4 counts. Eur Respir J. 36:594-600. DOI.
  • Lange C; Wilkinson RJ. (1 Jan 2010). Vitamin D and Active Tuberculosis: A Futile Quest?. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 181:95-95. Author weblink.
  • Kalsdorf B; Scriba TJ; Wood K; Day CL; Dheda K; Dawson R; Hanekom WA; Lange C; et alWilkinson RJ. (15 Dec 2009). HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria. Am J Respir Crit Care Med. 180:1262-1270. DOI.
  • Barry CE; Boshoff HI; Dartois V; Dick T; Ehrt S; Flynn J; Schnappinger D; Wilkinson RJ; et alYoung D. (1 Dec 2009). The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. NATURE REVIEWS MICROBIOLOGY. 7:845-855. Author weblink DOI.
  • Wilkinson KA; Seldon R; Meintjes G; Rangaka MX; Hanekom WA; Maartens G; Wilkinson RJ. (1 Oct 2009). Dissection of Regenerating T-Cell Responses against Tuberculosis in HIV-infected Adults Sensitized by Mycobacterium tuberculosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 180:674-683. Author weblink DOI.
  • Martineau AR; Leandro AC; Anderson ST; Newton SM; Wilkinson KA; Nicol MP; Pienaar SM; Skolimowska KH; et alRocha MA; Rolla VC; Levin M; Davidson RN; Bremner SA; Griffiths CJ; Eley BS; Bonecini-Almeida MG; Wilkinson RJ. (May 2010). Association between Gc genotype and susceptibility to TB is dependent on vitamin D status. Eur Respir J. 35:1106-1112. DOI.
  • D'souza DTB; Mistry NF; Vira TS; Dholakia Y; Hoffner S; Pasvol G; Nicol M; Wilkinson RJ. (29 Jun 2009). High levels of multidrug resistant tuberculosis in new and treatment-failure patients from the Revised National Tuberculosis Control Programme in an urban metropolis (Mumbai) in Western India. BMC PUBLIC HEALTH. 9. Author weblink DOI.
  • Schaefer G; Jacobs M; Wilkinson RJ; Brown GD. (1 Jan 2009). Non-Opsonic Recognition of Mycobacterium tuberculosis by Phagocytes. JOURNAL OF INNATE IMMUNITY. 1:231-243. Author weblink DOI.
  • Coussens AK; Timms PM; Boucher BJ; Venton TR; Ashcroft AT; Skolimowska KH; Newton SM; Wilkinson KA; et alDavidson RN; Griffiths CJ; Wilkinson RJ; Martineau AR. (1 Aug 2009). 1 alpha,25-dihydroxyvitamin D-3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection. IMMUNOLOGY. 127:539-548. Author weblink DOI.
  • Wilkinson KA; Newton SM; Stewart GR; Martineau AR; Patel J; Sullivan SM; Herrmann J-L; Neyrolles O; et alYoung DB; Wilkinson RJ. (14 May 2009). Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis. BMC MICROBIOLOGY. 9. Author weblink DOI.
  • Young DB; Gideon HP; Wilkinson RJ. (1 May 2009). Eliminating latent tuberculosis. TRENDS IN MICROBIOLOGY. 17:183-188. Author weblink DOI.
  • Davies M-A; Connell T; Johannisen C; Wood K; Pienaar S; Wilkinson KA; Wilkinson RJ; Zar HJ; et alEley B; Beatty D; Curtis N; Nicol MP. (15 May 2009). Detection of tuberculosis in HIV-infected children using an enzyme-linked immunospot assay. AIDS. 23:961-969. Author weblink DOI.
  • Pepper DJ; Marais S; Maartens G; Rebe K; Morroni C; Rangaka MX; Oni T; Wilkinson RJ; et alMeintjes G. (1 Jun 2009). Neurologic Manifestations of Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome: A Case Series. CLINICAL INFECTIOUS DISEASES. 48:E96-E107. Author weblink DOI.
  • Wilkinson RJ; Lange C. (1 May 2009). Vitamin D and Tuberculosis New Light on a Potent Biologic Therapy?. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 179:740-742. Author weblink DOI.
  • Sarrazin H; Wilkinson KA; Andersson J; Rangaka MX; Radler L; van Veen K; Lange C; Wilkinson RJ. (1 Mar 2009). Association between tuberculin skin test reactivity, the memory CD4 cell subset, and circulating FoxP3-expressing cells in HIV-infected persons. J Infect Dis. 199:702-710. DOI.
  • Nicol MP; Davies M-A; Wood K; Hatherill M; Workman L; Hawkridge A; Eley B; Wilkinson KA; et alWilkinson RJ; Hanekom WA; Beatty D; Hussey G. (1 Jan 2009). Comparison of T-SPOT.TB Assay and Tuberculin Skin Test for the Evaluation of Young Children at High Risk for Tuberculosis in a Community Setting. PEDIATRICS. 123:38-43. Author weblink DOI.
  • Martineau AR; Nanzer AM; Satkunam KR; Packe GE; Rainbow SJ; Maunsell ZJ; Timms PM; Venton TR; et alEldridge SM; Davidson RN; Wilkinson RJ; Griffiths CJ. (Jan 2009). Influence of a single oral dose of vitamin D(2) on serum 25-hydroxyvitamin D concentrations in tuberculosis patients. Int J Tuberc Lung Dis. 13:119-125.
  • Cowley D; Govender D; February B; Wolfe M; Steyn L; Evans J; Wilkinson RJ; Nicol MP. (15 Nov 2008). Recent and Rapid Emergence of W-Beijing Strains of Mycobacterium tuberculosis in Cape Town, South Africa. CLINICAL INFECTIOUS DISEASES. 47:1252-1259. Author weblink DOI.
  • Nicol MP; Wilkinson RJ. (1 Oct 2008). The clinical consequences of strain diversity in Mycobacterium tuberculosis. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE. 102:955-965. Author weblink DOI.
  • Meintjes G; Wilkinson KA; Rangaka MX; Skolimowska K; van Veen K; Abrahams M; Seldon R; Pepper DJ; et alRebe K; Mouton P; van Cutsem G; Nicol MP; Maartens G; Wilkinson RJ. (15 Nov 2008). Type 1 helper T cells and FoxP3-positive T cells in HIV-tuberculosis-associated immune reconstitution inflammatory syndrome. Am J Respir Crit Care Med. 178:1083-1089. DOI.
  • O'Riordan P; Schwab U; Logan S; Cooke G; Wilkinson RJ; Davidson RN; Bassett P; Wall R; et alPasvol G; Flanagan KL. (2008). Rapid molecular detection of rifampicin resistance facilitates early diagnosis and treatment of multi-drug resistant tuberculosis: case control study. PLoS One. 3:e3173. DOI.
  • Newton SM; Mackie SL; Martineau AR; Wilkinson KA; Kampmann B; Fisher C; Dutta S; Levin M; et alWilkinson RJ; Pasvol G. (1 Mar 2008). Reduction of chemokine secretion in response to mycobacteria in infliximab-treated patients. CLINICAL AND VACCINE IMMUNOLOGY. 15:506-512. Author weblink DOI.
  • Meintjes G; Lawn SD; Scono F; Moartens G; French MA; Worodria W; Elliott JH; Murdoch D; et alWilkinson RJ; Seyler C; John L; van der Loeff MS; Reiss P; Lynen L; Janoff EN; Gilks C; Colebunders R. (1 Aug 2008). Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. LANCET INFECTIOUS DISEASES. 8:516-523. Author weblink DOI.
  • Lawn SD; Wilkinson RJ; Lipman MCI; Wood R. (1 Apr 2008). Immune reconstitution and "Unmasking" of tuberculosis during antiretroviral therapy. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 177:680-685. Author weblink DOI.
  • Chege GK; Warren RM; van Pittius NCG; Burgers WA; Wilkinson RJ; Shephard EG; Williamson A-L. (7 Feb 2008). Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10IFN-gamma ELISPOT tests following a tuberculosis outbreak. BMC MICROBIOLOGY. 8. Author weblink DOI.
  • Dhasmana DJ; Dheda K; Ravn P; Wilkinson RJ; Meintjes G. (1 Jan 2008). Immune reconstitution inflammatory syndrome in HIV-Infected patients receiving Antiretroviral therapy - Pathogenesis, clinical manifestations and management. DRUGS. 68:191-208. Author weblink DOI.
  • Scriba TJ; Kalsdorf B; Abrahams D-A; Isaacs F; Hofmeister J; Black G; Hassan HY; Wilkinson RJ; et alWalzl G; Gelderbloem SJ; Mahomed H; Hussey GD; Hanekom WA. (1 Feb 2008). Distinct, specific IL-17- and IL-22-producing CD4(+) T cell subsets contribute to the human anti-mycobacterial immune response. JOURNAL OF IMMUNOLOGY. 180:1962-1970. Author weblink.
  • Pepper DJ; Meintjes GA; Mcllleron H; Wilkinson RJ. (1 Nov 2007). Combined therapy for tuberclosis and HIV-1: the challenge for drug discovery. DRUG DISCOVERY TODAY. 12:980-989. Author weblink DOI.
  • Maartens G; Wilkinson RJ. (15 Dec 2007). Tuberculosis. LANCET. 370:2030-2043. Author weblink DOI.
  • McIlleron H; Watkins ML; Folb PI; Ress SR; Wilkinson RJ. (1 Nov 2007). Rifampin levels, interferon-gamma release and outcome in complicated pulmonary tuberculosis. TUBERCULOSIS. 87:557-564. Author weblink DOI.
  • Lawn SD; Bangani N; Vogt M; Bekker L-G; Badri M; Ntobongwana M; Dockrell HM; Wilkinson RJ; et alWood R. (28 Aug 2007). Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa. BMC INFECTIOUS DISEASES. 7. Author weblink DOI.
  • Henao-Tamayo M; Junqueira-Kipnis AP; Ordway D; Gonzales-Juaffero M; Stewart GR; Young DB; Wilkinson RJ; Basaraba RJ; et alOrme IM. (10 Oct 2007). A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties. VACCINE. 25:7153-7159. Author weblink DOI.
  • Wilkinson RJ; Milledge JS. (1993). Microalbuminuria in chronic obstructive lung disease. BMJ. 307:239.
  • Rangaka MX; Diwakar L; Seldon R; van Cutsem G; Meintjes GA; Morroni C; Mouton P; Shey MS; et alMaartens G; Wilkinson KA; Wilkinson RJ. (15 Jun 2007). Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans. CLINICAL INFECTIOUS DISEASES. 44:1639-1646. Author weblink DOI.
  • Martineau AR; Newton SM; Wilkinson KA; Kampmann B; Hall BM; Nawroly N; Packe GE; Davidson RN; et alGriffiths CJ; Wilkinson RJ. (Jul 2007). Neutrophil-mediated innate immune resistance to mycobacteria. J Clin Invest. 117:1988-1994. DOI.
  • Martineau AR; Wilkinson KA; Newton SM; Floto RA; Norman AW; Skolimowska K; Davidson RN; Sørensen OE; et alKampmann B; Griffiths CJ; Wilkinson RJ. (1 Jun 2007). IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J Immunol. 178:7190-7198.
  • Connell TG; Shey MS; Seldon R; Rangaka MX; van Cutsem G; Simsova M; Marcekova Z; Sebo P; et alCurtis N; Diwakar L; Meintjes GA; Leclerc C; Wilkinson RJ; Wilkinson KA. (Jul 2007). Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector. Clin Vaccine Immunol. 14:847-854. DOI.
  • Martineau AR; Wilkinson RJ; Wilkinson KA; Newton SM; Kampmann B; Hall BM; Packe GE; Davidson RN; et alEldridge SM; Maunsell ZJ; Rainbow SJ; Berry JL; Griffiths CJ. (15 Jul 2007). A single dose of vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med. 176:208-213. DOI.
  • Nicol MP; Wilkinson RJ. (15 Apr 2007). Evidence guiding the treatment of children with mycobacterial diseases - Editorial commentary. CLINICAL INFECTIOUS DISEASES. 44:1065-1066. Author weblink DOI.
  • Martineau AR; Honecker FU; Wilkinson RJ; Griffiths CJ. (Mar 2007). Vitamin D in the treatment of pulmonary tuberculosis. J Steroid Biochem Mol Biol. 103:793-798. DOI.
  • Rangaka MX; Wilkinson KA; Seldon R; Van Cutsem G; Meintjes GA; Morroni C; Mouton P; Diwakar L; et alConnell TG; Maartens G; Wilkinson RJ. (1 Mar 2007). Effect of HIV-1 infection on T-Cell-based and skin test detection of tuberculosis infection. Am J Respir Crit Care Med. 175:514-520. DOI.
  • Lawn SD; Wilkinson RJ. (1 Nov 2006). Immune reconstitution disease associated with parasitic infections following antiretroviral treatment. PARASITE IMMUNOLOGY. 28:625-633. Author weblink DOI.
  • Newton SM; Smith RJ; Wilkinson KA; Nicol MP; Garton NJ; Staples KJ; Stewart GR; Wain JR; et alMartineau AR; Fandrich S; Smallie T; Foxwell B; Al-Obaidi A; Shafi J; Rajakumar K; Kampmann B; Andrew PW; Ziegler-Heitbrock L; Barer MR; Wilkinson RJ. (17 Oct 2006). A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion. Proc Natl Acad Sci U S A. 103:15594-15598. DOI.
  • Connell TG; Rangaka MX; Curtis N; Wilkinson RJ. (1 Sep 2006). QuantiFERON-TB Gold: state of the art for the diagnosis of tuberculosis infection?. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. 6:663-677. Author weblink DOI.
  • Anderson ST; Williams AJ; Brown JR; Newton SM; Simsova M; Nicol MP; Sebo P; Levin M; et alWilkinson RJ; Wilkinson KA. (1 May 2006). Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing. Am J Respir Crit Care Med. 173:1038-1042. DOI.
  • Wilkinson KA; Kon OM; Newton SM; Meintjes G; Davidson RN; Pasvol G; Wilkinson RJ. (1 Feb 2006). Effect of treatment of latent tuberculosis infection on the T cell response to Mycobacterium tuberculosis antigens. J Infect Dis. 193:354-359. DOI.
  • Nicol MP; Sola C; February B; Rastogi N; Steyn L; Wilkinson RJ. (1 Nov 2005). Distribution of strain families of Mycobacterium tuberculosis causing pulmonary and extrapulmonary disease in hospitalized children in Cape Town, South Africa. JOURNAL OF CLINICAL MICROBIOLOGY. 43:5779-5781. DOI.
  • Stewart GR; Wilkinson KA; Newton SM; Sullivan SM; Neyrolles O; Wain JR; Patel J; Pool KL; et alYoung DB; Wilkinson RJ. (Oct 2005). Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosis. Infect Immun. 73:6831-6837. DOI.
  • Wilkinson RJ; Hawkey CR; Davidson RN. (15 Sep 2005). Reply to garcia vidal and garau. Clin Infect Dis. 41:916-917. Publisher weblink DOI.
  • Kampmann B; Hemingway C; Stephens A; Davidson R; Goodsall A; Anderson S; Nicol M; Schölvinck E; et alRelman D; Waddell S; Langford P; Sheehan B; Semple L; Wilkinson KA; Wilkinson RJ; Ress S; Hibberd M; Levin M. (Sep 2005). Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma. J Clin Invest. 115:2480-2488. DOI.
  • Kaushik N; Fear D; Richards SC; McDermott CR; Nuwaysir EF; Kellam P; Harrison TJ; Wilkinson RJ; et alTyrrell DA; Holgate ST; Kerr JR. (Aug 2005). Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome. J Clin Pathol. 58:826-832. DOI.
  • Ustianowski A; Shaffer R; Collin S; Wilkinson RJ; Davidson RN. (Jun 2005). Prevalence and associations of vitamin D deficiency in foreign-born persons with tuberculosis in London. J Infect. 50:432-437. DOI.
  • Hawkey CR; Yap T; Pereira J; Moore DA; Davidson RN; Pasvol G; Kon OM; Wall RA; et alWilkinson RJ. (1 May 2005). Characterization and management of paradoxical upgrading reactions in HIV-uninfected patients with lymph node tuberculosis. Clin Infect Dis. 40:1368-1371. DOI.
  • Wilkinson KA; Simsova M; Schölvinck E; Sebo P; Leclerc C; Vordermeier HM; Dickson SJ; Brown JR; et alDavidson RN; Pasvol G; Levin M; Wilkinson RJ. (May 2005). Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids. Infect Immun. 73:2991-2998. DOI.
  • Nicol MP; Pienaar D; Wood K; Eley B; Wilkinson RJ; Henderson H; Smith L; Samodien S; et alBeatty D. (1 May 2005). Enzyme-linked immunospot assay responses to early secretory antigenic target 6, culture filtrate protein 10, and purified protein derivative among children with tuberculosis: Implications for diagnosis and monitoring of therapy. CLINICAL INFECTIOUS DISEASES. 40:1301-1308. Author weblink DOI.
  • Wilkinson RJ; Lockwood DN. (Apr 2005). Antigenic trigger for type 1 reaction in leprosy. J Infect. 50:242-243. DOI.
  • Wilkinson KA; Stewart GR; Newton SM; Vordermeier HM; Wain JR; Murphy HN; Horner K; Young DB; et alWilkinson RJ. (1 Apr 2005). Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2. J Immunol. 174:4237-4243.
  • Stewart GR; Newton SM; Wilkinson KA; Humphreys IR; Murphy HN; Robertson BD; Wilkinson RJ; Young DB. (Feb 2005). The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Mol Microbiol. 55:1127-1137. DOI.
  • Wilkinson KA; Wilkinson RJ; Pathan A; Ewer K; Prakash M; Klenerman P; Maskell N; Davies R; et alPasvol G; Lalvani A. (1 Jan 2005). Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. CLINICAL INFECTIOUS DISEASES. 40:184-187. Author weblink DOI.
  • Vordermeier HM; Simsova M; Wilkinson KA; Wilkinson RJ; Hewinson RG; Sebo P; Leclerc C. (1 Nov 2004). Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis. INFECTION AND IMMUNITY. 72:6255-6261. Author weblink DOI.
  • Wilkinson RJ; DesJardin LE; Islam N; Gibson BM; Kanost RA; Wilkinson KA. (1 Aug 2004). An increase in expression of a Mycobacterium tuberculosis mycolyl transferase gene (fbpB) occurs early after infection of human monocytes (vol 39, pg 813, 2001). MOLECULAR MICROBIOLOGY. 53:1001-1001. Author weblink DOI.
  • Islam N; Kanost AR; Teixeira L; Johnson J; Hejal R; Aung H; Wilkinson RJ; Hirsch CS; et alToossi Z. (15 Jul 2004). Role of cellular activation and tumor necrosis factor-alpha alpha in the early expression of Mycobacterium tuberculosis 85B mRNA in human alveolar macrophages. JOURNAL OF INFECTIOUS DISEASES. 190:341-351. Author weblink DOI.
  • Schölvinck E; Wilkinson KA; Whelan AO; Martineau AR; Levin M; Wilkinson RJ. (Feb 2004). Gamma interferon-based immunodiagnosis of tuberculosis: comparison between whole-blood and enzyme-linked immunospot methods. J Clin Microbiol. 42:829-831.
  • Chua-Intra B; Wilkinson RJ; Ivanyi J. (Mar 2002). Selective T-cell recognition of the N-terminal peptide of GroES in tuberculosis. Infect Immun. 70:1645-1647.
  • Canaday DH; Wilkinson RJ; Li Q; Harding CV; Silver RF; Boom WH. (1 Sep 2001). CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism. J Immunol. 167:2734-2742.
  • Lalvani A; Pathan AA; McShane H; Wilkinson RJ; Latif M; Conlon CP; Pasvol G; Hill AV. (Mar 2001). Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells. Am J Respir Crit Care Med. 163:824-828.
  • Wilkinson RJ; DesJardin LE; Islam N; Gibson BM; Kanost RA; Wilkinson KA; Poelman D; Eisenach KD; et alToossi Z. (Feb 2001). An increase in expression of a Mycobacterium tuberculosis mycolyl transferase gene (fbpB) occurs early after infection of human monocytes. Mol Microbiol. 39:813-821.
  • Pathan AA; Wilkinson KA; Wilkinson RJ; Latif M; McShane H; Pasvol G; Hill AVS; Lalvani A. (1 Sep 2000). High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M-tuberculosis-infected subjects without disease. EUROPEAN JOURNAL OF IMMUNOLOGY. 30:2713-2721. Author weblink DOI.
  • Wilkinson RJ; Davidson RN. (1 Jul 2000). Vitamin D deficiency and tuberculosis - Reply. LANCET. 356:74-75. Author weblink DOI.
  • Wilkinson RJ; Llewelyn M; Toossi Z; Patel P; Pasvol G; Lalvani A; Wright D; Latif M; et alDavidson RN. (19 Feb 2000). Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. LANCET. 355:618-621. Author weblink DOI.
  • Llewelyn M; Cropley I; Wilkinson RJ; Davidson RN. (Feb 2000). Tuberculosis diagnosed during pregnancy: a prospective study from London. Thorax. 55:129-132.
  • Wilkinson KA; Hudecz F; Vordermeier HM; Ivanyi J; Wilkinson RJ. (Sep 1999). Enhancement of the T cell response to a mycobacterial peptide by conjugation to synthetic branched polypeptide. Eur J Immunol. 29:2788-2796. DOI.
  • Wilkinson RJ; Patel P; Llewelyn M; Hirsch CS; Pasvol G; Snounou G; Davidson RN; Toossi Z. (21 Jun 1999). Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1 beta on tuberculosis. JOURNAL OF EXPERIMENTAL MEDICINE. 189:1863-1873. Author weblink DOI.
  • Agrewala JN; Wilkinson RJ. (Jun 1999). Influence of HLA-DR on the phenotype of CD4+ T lymphocytes specific for an epitope of the 16-kDa alpha-crystallin antigen of Mycobacterium tuberculosis. Eur J Immunol. 29:1753-1761. DOI.
  • Wilkinson KA; Katoch K; Sengupta U; Singh M; Sarin KK; Ivanyi J; Wilkinson RJ. (Apr 1999). Immune responses to recombinant proteins of Mycobacterium leprae. J Infect Dis. 179:1034-1037. DOI.
  • Wilkinson RJ; Wilkinson KA; Jurcevic S; Hills A; Sinha S; Sengupta U; Lockwood DN; Katoch K; et alAltman D; Ivanyi J. (Mar 1999). Specificity and function of immunogenic peptides from the 35-kilodalton protein of Mycobacterium leprae. Infect Immun. 67:1501-1504.
  • Wilkinson RJ; Zhu X; Wilkinson KA; Lalvani A; Ivanyi J; Pasvol G; Vordermeier HM. (Dec 1998). 38 000 MW antigen-specific major histocompatibility complex class I restricted interferon-gamma-secreting CD8+ T cells in healthy contacts of tuberculosis. Immunology. 95:585-590.
  • Agrewala JN; Wilkinson RJ. (Dec 1998). Differential regulation of Th1 and Th2 cells by p91-110 and p21-40 peptides of the 16-kD alpha-crystallin antigen of Mycobacterium tuberculosis. Clin Exp Immunol. 114:392-397.
  • Wilkinson RJ; Wilkinson KA; De Smet KA; Haslov K; Pasvol G; Singh M; Svarcova I; Ivanyi J. (Oct 1998). Human T- and B-cell reactivity to the 16kDa alpha-crystallin protein of Mycobacterium tuberculosis. Scand J Immunol. 48:403-409.
  • Wilkinson RJ; Vordermeier HM; Wilkinson KA; Sjölund A; Moreno C; Pasvol G; Ivanyi J. (Sep 1998). Peptide-specific T cell response to Mycobacterium tuberculosis: clinical spectrum, compartmentalization, and effect of chemotherapy. J Infect Dis. 178:760-768.
  • Wilkinson KA; Vordermeier H; Wilkinson RJ; Ivanyi J; Hudecz F. (1 Sep 1998). Synthesis and in vitro T-cell immunogenicity of conjugates with dual specificity: Attachment of epitope peptides of 16 and 38 kDa proteins from Mycobacterium tuberculosis to branched polypeptide. BIOCONJUGATE CHEMISTRY. 9:539-547. Author weblink DOI.
  • Lalvani T; Brookes R; Wilkinson RJ; Malin AS; Pathan AA; Andersen P; Dockrell H; Pasvol G; et alHill AVS. (6 Jan 1998). Human cytolytic and interferon gamma-secreting CD8(+) T lymphocytes specific for Mycobacterium tuberculosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 95:270-275. Author weblink.
  • Marshall BG; Wilkinson RJ; Davidson RN. (Jan 1998). Pathogenesis of tropical pulmonary eosinophilia: parasitic alveolitis and parallels with asthma. Respir Med. 92:1-3.
  • Wilkinson RJ; Pasvol G. (Jun 1997). Host resistance to malaria runs into swampy water. Trends Microbiol. 5:213-215. DOI.
  • Wilkinson RJ; Hasløv K; Rappuoli R; Giovannoni F; Narayanan PR; Desai CR; Vordermeier HM; Paulsen J; et alPasvol G; Ivanyi J; Singh M. (Mar 1997). Evaluation of the recombinant 38-kilodalton antigen of Mycobacterium tuberculosis as a potential immunodiagnostic reagent. J Clin Microbiol. 35:553-557.
  • Jurcevic S; Wilkinson RJ; Hills A; Pasvol G; Davidson RN; Ivanyi J. (1 Nov 1996). T cell responses to a mixture of M-tuberculosis peptides with complementary HLA-DR binding profiles. IMMUNOLOGY. 89:FF368-FF368. Author weblink.
  • SanchezGarcia J; Atkins C; Pasvol G; Wilkinson RJ; Colston MJ. (1 Oct 1996). Antigen-driven shedding of L-selectin from human gamma delta T cells. IMMUNOLOGY. 89:213-219. Author weblink DOI.
  • Jurcevic S; Hills A; Pasvol G; Davidson RN; Ivanyi J; Wilkinson RJ. (Sep 1996). T cell responses to a mixture of Mycobacterium tuberculosis peptides with complementary HLA-DR binding profiles. Clin Exp Immunol. 105:416-421.
  • Davidson RN; di Martino L; Gradoni L; Giacchino R; Gaeta GB; Pempinello R; Scotti S; Cascio A; et alCastagnola E; Maisto A; Gramiccia M; di Caprio D; Wilkinson RJ; Bryceson AD. (Jun 1996). Short-course treatment of visceral leishmaniasis with liposomal amphotericin B (AmBisome). Clin Infect Dis. 22:938-943.
  • WILKINSON RJ; PASVOL G. (1 Mar 1995). TUBERCULOSIS, HIV, HORMONES AND CHILDREN. JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF LONDON. 29:86-88. Author weblink.
  • Wilkinson RJ; Brown JL; Pasvol G; Chiodini PL; Davidson RN. (Sep 1994). Severe falciparum malaria: predicting the effect of exchange transfusion. QJM. 87:553-557.

Books

  • Eddleston M; Davidson RN; Wilkinson RJ; Pierini S. Oxford handbook of tropical medicine. 2:1-712. Oxford University Press (2004).

Chapters in books

  • Cooke GS; Levin M; Wilkinson RJ; Pasvol G. Host Genetics and Susceptibility to Infection. In Tropcial Infectious Diseases: Principles, Pathogens and Practice. Third. Guerrant RL (ed); Walker DH (ed); Weller PF (ed). Elsevier (2011).
  • Wilkinson RJ. Novel Vaccines Against Tuberculosis. In New Generation Vaccines. 3:519-535. Levine MM (ed); Kaper JB (ed); Rappuoli R (ed); Liu M (ed); Good MF (ed). Marcel Dekker, New York (2004).
  • Wilkinson RJ; Levin M. Host Genetics and Susceptibility to infection. In Tropical Infectious Diseases: Principles, pathogens and practice. 2, 1:53-67. Guerrant RL (ed); Walker (ed); D H (ed); Weller (ed); P F (ed). Churchill Livingstone, Philadelphia (2006).

Conferences

  • Martineau AR; Hall BM; Newton SM; Wilkinson KA; Kampmann B; Packe GE; Davidson RN; Maunsell Z; et alRainbow S; Norman AW; Eldridge S; Wilkinson RJ; Griffiths CJ. Vitamin D enhances antimycobacterial immunity in vivo and in vitro. Winter Meeting of the British-Thoracic-Society, 2005. 60:II43-II44. B M J PUBLISHING GROUP (1 Dec 2005). Author weblink.
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