Dr Steven Patterson

Publications


Journals

  • Benlahrech A; Patterson S. (Sep 2011). HIV-1 infection and induction of interferon alpha in plasmacytoid dendritic cells. Curr Opin HIV AIDS. 6:373-378. DOI.
  • Benlahrech A; Gotch F; Kelleher P; Patterson S. (2011). Loss of NK stimulatory capacity by plasmacytoid and monocyte-derived DC but not myeloid DC in HIV-1 infected patients. PLoS One. 6:e17525. DOI.
  • Duraisingham SS; Hornig J; Gotch F; Patterson S. (Oct 2010). CD34-derived human Langerhans cells stimulate a T helper type 2 response independently of extracellular-signal-regulated kinase phosphorylation. Immunology. 131:210-219. DOI.
  • Benlahrech A; Harris J; Meiser A; Papagatsias T; Hornig J; Hayes P; Lieber A; Athanasopoulos T; et alBachy V; Csomor E; Daniels R; Fisher K; Gotch F; Seymour L; Logan K; Barbagallo R; Klavinskis L; Dickson G; Patterson S. (24 Nov 2009). Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1. Proc Natl Acad Sci U S A. 106:19940-19945. DOI.
  • Duraisingham SS; Hornig J; Gotch F; Patterson S. (15 Aug 2009). TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses. J Immunol. 183:2242-2251. DOI.
  • Buisson S; Benlahrech A; Gazzard B; Gotch F; Kelleher P; Patterson S. (15 Jun 2009). Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10. J Infect Dis. 199:1862-1871. DOI.
  • Benlahrech A; Donaghy H; Rozis G; Goodier M; Klavinskis L; Gotch F; Patterson S. (2009). Human NK Cell Up-regulation of CD69, HLA-DR, Interferon  Secretion and Cytotoxic Activity by Plasmacytoid Dendritic Cells is Regulated Through Overlapping but Different Pathways. Sensors. 9:386-403.
  • Patterson S; Papagatsias T; Benlahrech A. (2009). Use of adenovirus in vaccines for HIV. Handb Exp Pharmacol. 275-293. DOI.
  • Rozis G; Benlahrech A; Duraisingham S; Gotch F; Patterson S. (Jul 2008). Human Langerhans' cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligands. Immunology. 124:329-338. DOI.
  • Papagatsias T; Rozis G; Athanasopoulos T; Gotch F; Dickson G; Patterson S. (2008). Activity of different vaccine-associated promoter elements in human dendritic cells. Immunology Letters. 115:117-125.
  • Rozis G; de Silva S; Benlahrech A; Papagatsias T; Harris J; Gotch F; Dickson G; Patterson S. (Sep 2005). Langerhans cells are more efficiently transduced than dermal dendritic cells by adenovirus vectors expressing either group C or group B fibre protein: implications for mucosal vaccines. Eur J Immunol. 35:2617-2626. DOI.
  • Kebba A; Stebbing J; Rowland S; Ingram R; Agaba J; Patterson S; Kaleebu P; Imami N; et alGotch F. (Jul 2005). Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjects. J Leukoc Biol. 78:37-42. DOI.
  • Patterson S; Donaghy H; Amjadi P; Gazzard B; Gotch F; Kelleher P. (15 Jun 2005). Human BDCA-1-positive blood dendritic cells differentiate into phenotypically distinct immature and mature populations in the absence of exogenous maturational stimuli: differentiation failure in HIV infection. J Immunol. 174:8200-8209.
  • Prakash M; Patterson S; Kapembwa MS. (Mar 2005). Hormonal upregulation of CCR5 expression on T lymphocytes as a possible mechanism for increased HIV-1 risk. J Acquir Immune Defic Syndr. 38 Suppl 1:S14-S16.
  • Prakash M; Patterson S; Gotch F; Kapembwa MS. (Dec 2004). Ex vivo analysis of HIV-1 co-receptors at the endocervical mucosa of women using oral contraceptives. BJOG. 111:1468-1470.
  • Stebbing J; Gazzard B; Patterson S; Bower M; Nelson M; Epenetos A; Ogg G; Gotch F; et alSavage P. (21 Oct 2004). Simplified one-step antibody-HLA directed expansion of HIV-specific cytotoxic T lymphocytes: a system suited for use in vivo (vol 18, pg 2099, 2004). AIDS. 18:2099-2101. Author weblink DOI.
  • Shaunak S; Thomas S; Gianasi E; Godwin A; Jones E; Teo I; Mireskandari K; Luthert P; et alDuncan R; Patterson S; Khaw P; Brocchini S. (Aug 2004). Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation. Nat Biotechnol. 22:977-984. DOI.
  • Prakash M; Kapembwa MS; Gotch F; Patterson S. (15 Jul 2004). Chemokine receptor expression on mucosal dendritic cells from the endocervix of healthy women. J Infect Dis. 190:246-250. DOI.
  • Stebbing J; Patterson S; Portsmouth S; Thomas C; Glassman R; Wildfire A; Gotch F; Bower M; et alNelson M; Gazzard B. (Jun 2004). Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients. Cell Res. 14:251-256. DOI.
  • Stebbing J; Gazzard B; Patterson S; Bower M; Perumal D; Nelson M; McMichael A; Ogg G; et alEpenetos A; Gotch F; Savage P. (1 Mar 2004). Antibody-targeted MHC complex-directed expansion of HIV-1- and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccination. Blood. 103:1791-1795. DOI.
  • Donaghy H; Stebbing J; Patterson S. (Feb 2004). Antigen presentation and the role of dendritic cells in HIV. Curr Opin Infect Dis. 17:1-6.
  • Stebbing J; Gazzard B; Newsom-Davis T; Nelson M; Patterson S; Gotch F; Mandalia S; Bower M. (20 Jan 2004). Nadir B cell counts are significantly correlated with the risk of Kaposi's sarcoma. Int J Cancer. 108:473-474. DOI.
  • Stebbing J; Savage P; Patterson S; Gazzard B. (Jan 2004). All for CD91 and CD91 for all. J Antimicrob Chemother. 53:1-3. DOI.
  • Stebbing J; Wildfire A; Portsmouth S; Powles T; Thirlwell C; Hewitt P; Nelson M; Patterson S; et alMandalia S; Gotch F; Gazzard BG; Bower M. (Nov 2003). Paclitaxel for anthracycline-resistant AIDS-related Kaposi's sarcoma: clinical and angiogenic correlations. Ann Oncol. 14:1660-1666.
  • Stebbing J; Gazzard B; Flore O; Thomas C; Benlahrech A; Mandalia S; Bower M; Gotch F; et alPatterson S. (5 Sep 2003). Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma. AIDS. 17:1998-2000. DOI.
  • Stebbing J; Gazzard B; Portsmouth S; Gotch F; Kim L; Bower M; Mandalia S; Binder R; et alSrivastava P; Patterson S. (1 Sep 2003). Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor. Blood. 102:1806-1814. DOI.
  • Donaghy H; Gazzard B; Gotch F; Patterson S. (1 Jun 2003). Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1. Blood. 101:4505-4511. DOI.
  • Stebbing J; Gazzard B; Kim L; Portsmouth S; Wildfire A; Teo I; Nelson M; Bower M; et alGotch F; Shaunak S; Srivastava P; Patterson S. (15 May 2003). The heat-shock protein receptor CD91 is up-regulated in monocytes of HIV-1-infected "true" long-term nonprogressors. Blood. 101:4000-4004. DOI.
  • Stebbing J; Patterson S; Gotch F. (Feb 2003). New insights into the immunology and evolution of HIV. Cell Res. 13:1-7. DOI.
  • Prakash M; Patterson S; Gotch F; Kapembwa MS. (Feb 2003). Recruitment of CD4 T lymphocytes and macrophages into the cervical epithelium of women after coitus. Am J Obstet Gynecol. 188:376-381.
  • Prakash M; Kapembwa MS; Gotch F; Patterson S. (Mar 2002). Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4(+) T cells in the cervical epithelium of healthy women. J Reprod Immunol. 54:117-131.
  • Prakash M; Patterson S; Kapembwa MS. (1 Dec 2001). Evaluation of the cervical cytobrush sampling technique for the preparation of CD45+ mononuclear cells from the human cervix. J Immunol Methods. 258:37-46.
  • Donaghy H; Pozniak A; Gazzard B; Qazi N; Gilmour J; Gotch F; Patterson S. (15 Oct 2001). Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood. 98:2574-2576.
  • Prakash M; Kapembwa MS; Gotch F; Patterson S. (Oct 2001). Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women. J Reprod Immunol. 52:101-111.
  • Prakash M; Patterson S; Kapembwa MS. (Oct 2001). Macrophages are increased in cervical epithelium of women with cervicitis. Sex Transm Infect. 77:366-369.
  • Jones GJ; Watera C; Patterson S; Rutebemberwa A; Kaleebu P; Whitworth JA; Gotch FM; Gilmour JW. (7 Sep 2001). Comparative loss and maturation of peripheral blood dendritic cell subpopulations in African and non-African HIV-1-infected patients. AIDS. 15:1657-1663.
  • Patterson S; Rae A; Hockey N; Gilmour J; Gotch F. (Jul 2001). Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus. J Virol. 75:6710-6713. DOI.
  • Patterson S; English NR; Longhurst H; Jain P; Balfe P; Knight SC. (20 Jan 2001). Relationship between V3 sequences of HIV type 1 from plasma, T cells, and dendritic cells suggests that plasma virus may arise from different cell sources. AIDS Res Hum Retroviruses. 17:179-184. DOI.
  • Gompels M; Patterson S; Roberts MS; Macatonia SE; Pinching AJ; Knight SC. (May 1998). Increase in dendritic cell numbers, their function and the proportion uninfected during AZT therapy. Clin Exp Immunol. 112:347-353.
  • Patterson S; English NR; Longhurst H; Balfe P; Helbert M; Pinching AJ; Knight SC. (Feb 1998). Analysis of human immunodeficiency virus type 1 (HIV-1) variants and levels of infection in dendritic and T cells from symptomatic HIV-1-infected patients. J Gen Virol. 79 ( Pt 2):247-257.
  • Knight SC; Patterson S. (1997). Bone marrow-derived dendritic cells, infection with human immunodeficiency virus, and immunopathology. Annu Rev Immunol. 15:593-615. DOI.
  • Knight SC; Patterson S. (7 Sep 1996). AIDS--beyond helper T cells. Lancet. 348:631. DOI.
  • Gabrilovich DI; Patterson S; Timofeev AV; Harvey JJ; Knight SC. (Aug 1996). Mechanism for dendritic cell dysfunction in retroviral infection of mice. Clin Immunol Immunopathol. 80:139-146.
  • Patterson S; Roberts MS; English NR; Stackpoole A; Gompels MN; Pinching AJ; Knight SC. (1995). HIV infection of blood dendritic cells in vitro and in vivo. Adv Exp Med Biol. 378:443-445.
  • Knight SC; Macatonia SE; Cruickshank K; Rudge P; Patterson S. (1993). Dendritic cells in HIV-1 and HTLV-1 infection. Adv Exp Med Biol. 329:545-549.

Books

  • Patterson S; Donaghy H; Kelleher P. Gessani S (ed); Belardelli F (ed). Loss, infection, and dysfunction of dendritic cells in HIV infection. The Biology of Dendritic cells and HIV Infection:405-446. Springer, New York (2007).

Conferences

  • Prakash M; Patterson S; Kapembwa MS. Topic II: Hormonal influences on HIV acquisition - Hormonal upregulation of CCR5 expression on T lymphocytes as a possible mechanism for increased HIV-1 risk. Conference on Fertility Regulation and Systemic Hormones in HIV-infected and At-Risk Women, 13 Jan 2003 - 15 Jan 2003. 38:S14-S16. LIPPINCOTT WILLIAMS & WILKINS (1 Mar 2005). Author weblink DOI.
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