Dr Selena E Richards
Current Research
CALORIC RESTRICTION PROJECT, Nestle Research Centre, St. Louis MO (NRC-STL). The development of information rich chemometrics strategies for nutritional and preventative health diagnostics that improve the utility of currently used screening methods.
Research Interests
Integrative analysis of 'omics i.e. metabonomics, genomics, transcriptomics data to generate predictive and hypothesis generated mathematical models to better understand the physiological response to stimuli in multi-cellular systems.
Research Background
Metabonomics is concerned with characterising the metabolic response of a living system to physiological perturbations or genetic intervention either through time or between two or more states. Complex biofluids such as urine, plasma etc. are collected and analysed using state-of-the art equipment; such as high field NMR spectroscopy for the quantitative analysis of endogenous and exogenous metabolites. Multivariate statistical tools are used to decompose the measurement matrices to reveal metabolic phenotypes associated with normal and perturbed systems.
Academic Background
Graduated from the University of Hull, with a First Class Honours MChem in Chemistry with Analytical Chemistry and Toxicology (2001). Selena completed her PhD at The University of Hull in Chemometrics under the direction of Dr. Anthony Walmsley. Thesis title: Development and Application of Calibration Free Techniques for Process Monitoring and Control. Sponsored by EPSRC & CPACT (Centre for Process Analytics and Control Technology)
Publications
- Richards, S. E., et al., A Novel Approach to the Quantification of Industrial Mixtures from the Vinyl Acetate Monomer (VAM) Process using Near Infrared Spectroscopy and A Quantitative Self Modeling Curve Resolution (SMCR) Methodology, Chemometrics and Intelligent laboratory Systems, Chemometrics and Intelligent Laboratory Systems, 2008. 94(1): p.9-18.
- Richards, S. E., et al., Self-Modeling Curve Resolution: A New Approach to Recovering Temporal Metabolite Signal Modulation in NMR Spectroscopic Data: Application to a Life-Long Caloric Restriction Study in Dogs, Analytical Chemistry, 2008. 80(13): p.4876-4885
- Richards, S. E., et al., Advantages of Soft versus Hard Constraints in Self-Modeling Curve Resolution Problems. Penalty Alternating Least Squares (P-ALS) Extension to Multi-Way Problems. Applied Spectroscopy, 2008. 62(2): p. 197-206.
- Richards, S. E., et al., Quantitative Iterative Target Transformation Factor Analysis. Journal of Chemometrics, 2007. 22(1): p 63-80.
- Richards, S. E., et al., Quantitative Determination of the Catalysed Asymmetric Transfer Hydrogenation of 1-methyl-6, 7-dimethoxy-3,4-dihydroisoquinoline using in situ FTIR and Multivariate Curve resolution. Analytica Chimica Acta, 2004. 519(1): p. 1-9.
Interests & Hobbies
Selena has a number of varied interest which include classical ballet. She was the president and founder of The University of Hull Ballet Society 2001-2002. She plays the clarinet and is the British and English Tae Kwon Do (2000), Ladies Division champion. In karate, she won the silver medal at BUSA competition and has represented the UK at the Junior International Basketball Games in Poland. Selena enjoys traveling and experiencing other cultures.
