Publications

Journals

• Choi O; Heathcote DA; Ho KK; Müller PJ; Ghani H; Lam EW; Ashton-Rickardt PG; Rutschmann S. (15 Apr 2012). A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival. J Immunol. 188:3920-3927. DOI.
• Popkin DL; Teijaro JR; Sullivan BM; Urata S; Rutschmann S; de la Torre JC; Kunz S; Beutler B; et alOldstone M. (17 Mar 2011). Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner. Cell Host Microbe. 9:212-222. DOI.
• Blasius AL; Arnold CN; Georgel P; Rutschmann S; Xia Y; Lin P; Ross C; Li X; et alSmart NG; Beutler B. (16 Nov 2010). Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 107:19973-19978. DOI.
• Brandl K; Rutschmann S; Li X; Du X; Xiao N; Schnabl B; Brenner DA; Beutler B. (3 Mar 2009). Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A. 106:3300-3305. DOI.
• Croker BA; Lawson BR; Rutschmann S; Berger M; Eidenschenk C; Blasius AL; Moresco EM; Sovath S; et alCengia L; Shultz LD; Theofilopoulos AN; Pettersson S; Beutler BA. (30 Sep 2008). Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A. 105:15028-15033. DOI.
• Rutschmann S; Hoebe K. (Apr 2008). Dissecting innate immunity by germline mutagenesis. Immunology. 123:459-468. DOI.
• Rutschmann S; Jung AC; Hetru C; Reichhart JM; Hoffmann JA; Ferrandon D. (May 2000). The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila. Immunity. 12:569-580.
• Rutschmann S; Jung AC; Zhou R; Silverman N; Hoffmann JA; Ferrandon D. (Oct 2000). Role of Drosophila IKK gamma in a toll-independent antibacterial immune response. Nat Immunol. 1:342-347. DOI.
• Jung AC; Criqui MC; Rutschmann S; Hoffmann JA; Ferrandon D. (Mar 2001). Microfluorometer assay to measure the expression of beta-galactosidase and green fluorescent protein reporter genes in single Drosophila flies. Biotechniques. 30:594-601.
• Rutschmann S; Kilinc A; Ferrandon D. (15 Feb 2002). Cutting edge: the toll pathway is required for resistance to gram-positive bacterial infections in Drosophila. J Immunol. 168:1542-1546.
• Gobert V; Gottar M; Matskevich AA; Rutschmann S; Royet J; Belvin M; Hoffmann JA; Ferrandon D. (19 Dec 2003). Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Science. 302:2126-2130. DOI.
• Beutler B; Georgel P; Rutschmann S; Jiang Z; Croker B; Crozat K. (Nov 2005). Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Brief Funct Genomic Proteomic. 4:203-213.
• Georgel P; Crozat K; Lauth X; Makrantonaki E; Seltmann H; Sovath S; Hoebe K; Du X; et alRutschmann S; Jiang Z; Bigby T; Nizet V; Zouboulis CC; Beutler B. (Aug 2005). A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun. 73:4512-4521. DOI.
• Hoebe K; Georgel P; Rutschmann S; Du X; Mudd S; Crozat K; Sovath S; Shamel L; et alHartung T; Zähringer U; Beutler B. (3 Feb 2005). CD36 is a sensor of diacylglycerides. Nature. 433:523-527. DOI.
• Beutler B; Jiang Z; Georgel P; Crozat K; Croker B; Rutschmann S; Du X; Hoebe K. (2006). Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol. 24:353-389. DOI.
• Rutschmann S; Hoebe K; Zalevsky J; Du X; Mann N; Dahiyat BI; Steed P; Beutler B. (15 Jun 2006). PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development. J Immunol. 176:7525-7532.
• Janssen E; Tabeta K; Barnes MJ; Rutschmann S; McBride S; Bahjat KS; Schoenberger SP; Theofilopoulos AN; et alBeutler B; Hoebe K. (Jun 2006). Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway. Immunity. 24:787-799. DOI.
• Crozat K; Georgel P; Rutschmann S; Mann N; Du X; Hoebe K; Beutler B. (May 2006). Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome. 17:398-406. DOI.
• Jiang Z; Georgel P; Li C; Choe J; Crozat K; Rutschmann S; Du X; Bigby T; et alMudd S; Sovath S; Wilson IA; Olson A; Beutler B. (18 Jul 2006). Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci U S A. 103:10961-10966. DOI.
• Crozat K; Hoebe K; Ugolini S; Hong NA; Janssen E; Rutschmann S; Mudd S; Sovath S; et alVivier E; Beutler B. (16 Apr 2007). Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med. 204:853-863. DOI.
• Munafó DB; Johnson JL; Ellis BA; Rutschmann S; Beutler B; Catz SD. (1 Mar 2007). Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochem J. 402:229-239. DOI.