Professor Shiranee Sriskandan

Publications


Journals

  • Chong DL; Ingram RJ; Lowther DE; Muir R; Sriskandan S; Altmann DM. (2 Mar 2012). The nature of innate and adaptive IL-17A responses in sham or bacterial inoculation. Immunology. DOI.
  • Sriskandan S. (Dec 2011). Severe peripartum sepsis. J R Coll Physicians Edinb. 41:339-346. DOI.
  • Steer JA; Lamagni T; Healy B; Morgan M; Dryden M; Rao B; Sriskandan S; George R; et alEfstratiou A; Baker F; Baker A; Marsden D; Murphy E; Fry C; Irvine N; Hughes R; Wade P; Cordery R; Cummins A; Oliver I; Jokinen M; McMenamin J; Kearney J. (Jan 2012). Guidelines for prevention and control of group A streptococcal infection in acute healthcare and maternity settings in the UK. J Infect. 64:1-18. DOI.
  • Lynskey NN; Lawrenson RA; Sriskandan S. (Jun 2011). New understandings in Streptococcus pyogenes. Curr Opin Infect Dis. 24:196-202. DOI.
  • Chong DL; Sriskandan S. (2011). Pro-inflammatory mechanisms in sepsis. Contrib Microbiol. 17:86-107. DOI.
  • Garland P; de Lavallade H; Sekine T; Hoschler K; Sriskandan S; Patel P; Brett S; Stringaris K; et alLoucaides E; Howe K; Marin D; Kanfer E; Cooper N; Macdonald D; Rahemtulla A; Atkins M; Danga A; Milojkovic D; Gabriel I; Khoder A; Alsuliman A; Apperley J; Rezvani K. (May 2011). Humoral and cellular immunity to primary H1N1 infection in patients with hematologic malignancies following stem cell transplantation. Biol Blood Marrow Transplant. 17:632-639. DOI.
  • Musson JA; Ingram R; Durand G; Ascough S; Waters EL; Hartley MG; Robson T; Maillere B; et alWilliamson ED; Sriskandan S; Altmann D; Robinson JH. (Oct 2010). Repertoire of HLA-DR1-restricted CD4 T-cell responses to capsular Caf1 antigen of Yersinia pestis in human leukocyte antigen transgenic mice. Infect Immun. 78:4356-4362. DOI.
  • Ingram RJ; Chu KK; Metan G; Maillere B; Doganay M; Ozkul Y; Dyson H; Williamson ED; et alBaillie L; Kim LU; Ascough S; Sriskandan S; Altmann DM. (May 2010). An epitope of Bacillus anthracis protective antigen that is cryptic in rabbits may be immunodominant in humans. Infect Immun. 78:2353. DOI.
  • Yuste J; Sen A; Truedsson L; Jönsson G; Hyams C; Cohen JM; Camberlein E; Sriskandan S; et alBrown JS. (Aug 2010). Impaired opsonization with complement and phagocytosis of Streptococcus pyogenes in sera from subjects with inherited C2 deficiency. Microbes Infect. 12:626-634. DOI.
  • Ingram RJ; Metan G; Maillere B; Doganay M; Ozkul Y; Kim LU; Baillie L; Dyson H; et alWilliamson ED; Chu KK; Ascough S; Moore S; Huwar TB; Robinson JH; Sriskandan S; Altmann DM. (1 Apr 2010). Natural exposure to cutaneous anthrax gives long-lasting T cell immunity encompassing infection-specific epitopes. J Immunol. 184:3814-3821. DOI.
  • Kurupati P; Turner CE; Tziona I; Lawrenson RA; Alam FM; Nohadani M; Stamp GW; Zinkernagel AS; et alNizet V; Edwards RJ; Sriskandan S. (Jun 2010). Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract. Mol Microbiol. 76:1387-1397. DOI Open Access copy.
  • Goldblatt J; Begum J; Brannigan E; Holmes A; Sriskandan S. (1 Dec 2009). FEVER IN A RETURNED TRAVELLER. JOURNAL OF INFECTION. 59:S438-S439.
  • Turner CE; Kurupati P; Jones MD; Edwards RJ; Sriskandan S. (15 Aug 2009). Emerging role of the interleukin-8 cleaving enzyme SpyCEP in clinical Streptococcus pyogenes infection. J Infect Dis. 200:555-563. DOI.
  • Turner CE; Kurupati P; Wiles S; Edwards RJ; Sriskandan S. (6 Aug 2009). Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi. Vaccine. 27:4923-4929. DOI.
  • Russell HH; Zhou L; Sriskandan S. (Jul 2009). Rapid screen for epithelial internalization of Tn917-mutagenized Streptococcus pyogenes. J Microbiol Methods. 78:34-39. DOI.
  • Paul-Clark MJ; McMaster SK; Sorrentino R; Sriskandan S; Bailey LK; Moreno L; Ryffel B; Quesniaux VF; et alMitchell JA. (15 Feb 2009). Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Am J Respir Crit Care Med. 179:299-306. DOI.
  • Davies F; Faulkner L; Kearns A; Ellington M; Sriskandan S. (1 Nov 2008). NON-MENSTRUAL TOXIC SHOCK AND THE IN VIVO ROLES OF SEB AND IVIG. JOURNAL OF INFECTION. 57:426-426. DOI.
  • Zinkernagel AS; Timmer AM; Pence MA; Locke JB; Buchanan JT; Turner CE; Mishalian I; Sriskandan S; et alHanski E; Nizet V. (14 Aug 2008). The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing. Cell Host Microbe. 4:170-178. DOI.
  • Russell HH; Sriskandan S. (1 Jun 2008). Superantigens SPEA and SMEZ do not affect secretome expression in Streptococcus pyogenes. MICROBIAL PATHOGENESIS. 44:537-543. Author weblink DOI.
  • Sorrentino R; de Souza PM; Sriskandan S; Duffin C; Paul-Clark MJ; Mitchell JA. (Jun 2008). Pattern recognition receptors and interleukin-8 mediate effects of Gram-positive and Gram-negative bacteria on lung epithelial cell function. Br J Pharmacol. 154:864-871. DOI.
  • Paul-Clark MJ; Sorrentino R; Bailey LK; Sriskandan S; Mitchell JA. (May 2008). Gram-positive and Gram-negative bacteria synergize with oxidants to release CXCL8 from innate immune cells. Mol Med. 14:238-246. DOI.
  • Hopkins PA; Pridmore AC; Ellmerich S; Fraser JD; Russell HH; Read RC; Sriskandan S. (1 Apr 2008). Increased surface toll-like receptor 2 expression in superantigen shock. CRITICAL CARE MEDICINE. 36:1267-1276. Author weblink DOI.
  • Issa R; Sorrentino R; Sukkar MB; Sriskandan S; Chung KF; Mitchell JA. (1 Apr 2008). Differential regulation of CCL-II/eotaxin-I and CXCL-8/IL-8 by Gram-positive and Gram-negative bacteria in human airway smooth muscle cells. RESPIRATORY RESEARCH. 9. Author weblink DOI.
  • McMaster SK; Paul-Clark MJ; Walters M; Fleet M; Anandarajah J; Sriskandan S; Mitchell JA. (Feb 2008). Cigarette smoke inhibits macrophage sensing of Gram-negative bacteria and lipopolysaccharide: relative roles of nicotine and oxidant stress. Br J Pharmacol. 153:536-543. DOI.
  • Sriskandan S; Altmann DM. (1 Jan 2008). The immunology of sepsis. JOURNAL OF PATHOLOGY. 214:211-223. Author weblink DOI.
  • Faulkner L; Altmann DM; Ellmerich S; Huhtaniemi I; Stamp G; Sriskandan S. (1 Sep 2007). Sexual dimorphism in superantigen shock involves elevated TNF-alpha and TNF-alpha-induced hepatic apoptosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 176:473-482. Author weblink DOI.
  • Turner C; Sriskandan S. (1 Aug 2007). Streptococcus pyogenes under pressure. NATURE MEDICINE. 13:909-910. Author weblink DOI.
  • Edwards RJ; Wrigley A; Bai Z; Bateman M; Russell H; Murray S; Lu H; Taylor GW; et alBoobis AR; Sriskandan S. (May 2007). C-terminal antibodies (CTAbs): a simple and broadly applicable approach for the rapid generation of protein-specific antibodies with predefined specificity. Proteomics. 7:1364-1372. DOI.
  • Curtis SJ; Tanna A; Russell HH; Efstratiou A; Paul J; Cubbon M; Sriskandan S. (May 2007). Invasive group A streptococcal infection in injecting drug users and non-drug users in a single UK city. J Infect. 54:422-426. DOI.
  • Sriskandan S; Faulkner L; Hopkins P. (2007). Streptococcus pyogenes: Insight into the function of the streptococcal superantigens. Int J Biochem Cell Biol. 39:12-19. DOI.
  • Sriskandan S. (Jan 2007). Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation--author's response. J Antimicrob Chemother. 59:159-160. Publisher weblink DOI.
  • Cartwright N; McMaster SK; Sorrentino R; Paul-Clark M; Sriskandan S; Ryffel B; Quesniaux VF; Evans TW; et alMitchell JA. (Jan 2007). Elucidation of toll-like receptor and adapter protein signaling in vascular dysfunction induced by gram-positive Staphylococcus aureus or gram-negative Escherichia coli. Shock. 27:40-47. DOI.
  • Llewelyn M; Sriskandan S; Terrazzini N; Cohen J; Altmann DM. (Oct 2006). The TCR Vbeta signature of bacterial superantigens spreads with stimulus strength. Int Immunol. 18:1433-1441. DOI.
  • Paul-Clark MJ; McMaster SK; Belcher E; Sorrentino R; Anandarajah J; Fleet M; Sriskandan S; Mitchell JA. (Aug 2006). Differential effects of Gram-positive versus Gram-negative bacteria on NOSII and TNFalpha in macrophages: role of TLRs in synergy between the two. Br J Pharmacol. 148:1067-1075. DOI.
  • Sriskandan S; Ferguson M; Elliot V; Faulkner L; Cohen J. (Jul 2006). Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation. J Antimicrob Chemother. 58:117-124. DOI.
  • Yuste J; Ali S; Sriskandan S; Hyams C; Botto M; Brown JS. (15 May 2006). Roles of the alternative complement pathway and C1q during innate immunity to Streptococcus pyogenes. JOURNAL OF IMMUNOLOGY. 176:6112-6120. Author weblink.
  • Sriskandan S; Slater JD. (May 2006). Invasive disease and toxic shock due to zoonotic Streptococcus suis: an emerging infection in the East?. PLoS Med. 3:e187. DOI.
  • Faulkner L; Cooper A; Fantino C; Altmann DM; Sriskandan S. (15 Nov 2005). The mechanism of superantigen-mediated toxic shock: not a simple Th1 cytokine storm. J Immunol. 175:6870-6877.
  • Edwards RJ; Taylor GW; Ferguson M; Murray S; Rendell N; Wrigley A; Bai Z; Boyle J; et alFinney SJ; Jones A; Russell HH; Turner C; Cohen J; Faulkner L; Sriskandan S. (1 Sep 2005). Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes. J Infect Dis. 192:783-790. DOI.
  • Hopkins PA; Sriskandan S. (Jun 2005). Mammalian Toll-like receptors: to immunity and beyond. Clin Exp Immunol. 140:395-407. DOI.
  • Hopkins PA; Fraser JD; Pridmore AC; Russell HH; Read RC; Sriskandan S. (1 May 2005). Superantigen recognition by HLA class II on monocytes up-regulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin. Blood. 105:3655-3662. DOI.
  • Jimenez R; Belcher E; Sriskandan S; Lucas R; McMaster S; Vojnovic I; Warner TD; Mitchell JA. (22 Mar 2005). Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle. Proc Natl Acad Sci U S A. 102:4637-4642. DOI.
  • Llewelyn M; Sriskandan S; Peakman M; Ambrozak DR; Douek DC; Kwok WW; Cohen J; Altmann DM. (1 Feb 2004). HLA class II polymorphisms determine responses to bacterial superantigens. J Immunol. 172:1719-1726.
  • Proft T; Sriskandan S; Yang L; Fraser JD. (Oct 2003). Superantigens and streptococcal toxic shock syndrome. Emerg Infect Dis. 9:1211-1218.
  • Fenwick P; Ryan C; Sriskandan S; Cohen J. (Jan 2003). Application of a rat model of streptococcal shock to evaluate on-line hemoperfusion and removal of circulating superantigens. Crit Care Med. 31:171-178. DOI.
  • Unnikrishnan M; Altmann DM; Proft T; Wahid F; Cohen J; Fraser JD; Sriskandan S. (1 Sep 2002). The bacterial superantigen streptococcal mitogenic exotoxin Z is the major immunoactive agent of Streptococcus pyogenes. J Immunol. 169:2561-2569.
  • Unnikrishnan M; Cohen J; Sriskandan S. (Sep 2001). Complementation of a speA negative Streptococcus pyogenes with speA: effects on virulence and production of streptococcal pyrogenic exotoxin A. Microb Pathog. 31:109-114. DOI.
  • Sriskandan S; Unnikrishnan M; Krausz T; Dewchand H; Van Noorden S; Cohen J; Altmann DM. (15 Jul 2001). Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice. J Infect Dis. 184:166-173. DOI.
  • Sriskandan S; Kemball-Cook G; Moyes D; Canvin J; Tuddenham E; Cohen J. (Nov 2000). Contact activation in shock caused by invasive group A Streptococcus pyogenes. Crit Care Med. 28:3684-3691.
  • Sriskandan S; Unnikrishnan M; Krausz T; Cohen J. (Nov 2000). Mitogenic factor (MF) is the major DNase of serotype M89 Streptococcus pyogenes. Microbiology. 146 ( Pt 11):2785-2792.
  • Sriskandan S; Cohen J. (Jun 2000). Kallikrein-kinin system activation in streptococcal toxic shock syndrome. Clin Infect Dis. 30:961-962. DOI.
  • Sriskandan S. (2000). Assay for superantigens. Methods Mol Med. 36:67-79. DOI.
  • Unnikrishnan M; Cohen J; Sriskandan S. (Oct 1999). Growth-phase-dependent expression of virulence factors in an M1T1 clinical isolate of Streptococcus pyogenes. Infect Immun. 67:5495-5499.
  • Sriskandan S; Unnikrishnan M; Krausz T; Cohen J. (Aug 1999). Molecular analysis of the role of streptococcal pyrogenic Exotoxin A (SPEA) in invasive soft-tissue infection resulting from Streptococcus pyogenes. Mol Microbiol. 33:778-790.
  • Sriskandan S; Cohen J. (Jun 1999). Gram-positive sepsis. Mechanisms and differences from gram-negative sepsis. Infect Dis Clin North Am. 13:397-412.
  • Sriskandan S; Kemball-Cook G; Moyes D; Canvin J; Tuddenham E; Cohen J. (1 Jan 1999). Coagulation abnormalities in severe streptococcal shock syndrome. SHOCK. 12:21-22. Author weblink.
  • Sriskandan S; McKee A; Hall L; Cohen J. (Aug 1997). Comparative effects of clindamycin and ampicillin on superantigenic activity of Streptococcus pyogenes. J Antimicrob Chemother. 40:275-277.
  • Curtis N; Jacobs M; Sriskandan S. (31 May 1997). Musculoskeletal side-effects of varicella. LANCET. 349:1623-1624. Author weblink DOI.
  • Sriskandan S; Moyes D; Buttery LK; Wilkinson J; Evans TJ; Polak J; Cohen J. (May 1997). The role of nitric oxide in experimental murine sepsis due to pyrogenic exotoxin A-producing Streptococcus pyogenes. Infect Immun. 65:1767-1772.
  • Jones HA; Sriskandan S; Peters AM; Pride NB; Krausz T; Boobis AR; Haslett C. (Apr 1997). Dissociation of neutrophil emigration and metabolic activity in lobar pneumonia and bronchiectasis. Eur Respir J. 10:795-803.
  • Feng Q; Rahman SU; Rhodes CG; Hayes MJ; Sriskandan S; Ind PW; Jones T; Hughes JMB. (1 Mar 1997). Pulmonary and cardiac beta-adrenoceptor density in vivo in asthmatic subjects. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 155:1130-1134. Author weblink.
  • Sriskandan S; Moyes D; Lemm G; Cohen J. (Dec 1996). Lymphotoxin-alpha (TNF-beta) during sepsis. Cytokine. 8:933-937. DOI.
  • Sriskandan S; Moyes D; Cohen J. (9 Nov 1996). Detection of circulating bacterial superantigen and lymphotoxin-alpha in patients with streptococcal toxic-shock syndrome. Lancet. 348:1315-1316.
  • Hayes MJ; Qing F; Rhodes CG; Rahman SU; Ind PW; Sriskandan S; Jones T; Hughes JM. (Nov 1996). In vivo quantification of human pulmonary beta-adrenoceptors: effect of beta-agonist therapy. Am J Respir Crit Care Med. 154:1277-1283.
  • Sriskandan S; Moyes D; Buttery LK; Krausz T; Evans TJ; Polak J; Cohen J. (Jun 1996). Streptococcal pyrogenic exotoxin A release, distribution, and role in a murine model of fasciitis and multiorgan failure due to Streptococcus pyogenes. J Infect Dis. 173:1399-1407.
  • Sriskandan S; Evans TJ; Cohen J. (1 Apr 1996). Bacterial superantigen-induced human lymphocyte responses are nitric oxide dependent and mediated by IL-12 and IFN-gamma. J Immunol. 156:2430-2435.
  • Sriskandan S; Labrecque LG; Schofield J. (Mar 1996). Diffuse pneumonia associated with infectious mononucleosis: detection of Epstein-Barr virus in lung tissue by in situ hybridization. Clin Infect Dis. 22:578-579.
  • Sriskandan S; Soto A; Evans TJ; Cohen J. (Jun 1995). Viridans streptococcal bacteraemia: a clinical survey. QJM. 88:415-420.
  • Sriskandan S; Cohen J. (May 1995). The pathogenesis of septic shock. J Infect. 30:201-206.
  • SRISKANDAN S; OBRIEN MER; SMITH IE; COLLINS P; GORE ME. (1 Oct 1994). AGGRESSIVE MANAGEMENT OF DOXORUBICIN-INDUCED CARDIOMYOPATHY ASSOCIATED WITH LOW-DOSES OF DOXORUBICIN. POSTGRADUATE MEDICAL JOURNAL. 70:759-761. Author weblink.
  • Sriskandan S; Shaunak S. (Dec 1993). Respiratory syncytial virus infection in an adult with AIDS. Clin Infect Dis. 17:1065.
  • SRISKANDAN S; SHAUNAK S. (1 Dec 1993). RESPIRATORY SYNCYTIAL VIRUS-INFECTION IN AN ADULT WITH AIDS. CLINICAL INFECTIOUS DISEASES. 17:1065-1065. Author weblink.
  • SRISKANDAN S; LACEY S; FISCHER L. (1 Aug 1993). ISOLATION OF VANCOMYCIN-RESISTANT LACTOBACILLI FROM 3 NEUTROPENIC PATIENTS WITH PNEUMONIA. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. 12:649-650. Author weblink DOI.

Conferences

  • Ingram RJ; Chu K; Metan G; Ascough S; Doganay M; Sriskandan S; Altmann DM. T cell epitope mapping anthrax: the detection of CD4 epitopes in lethal factor. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:144-144. WILEY-BLACKWELL (1 Dec 2008). Author weblink.
  • Ingram RJ; Chong DLW; Turner CE; Sriskandan S; Altmann DM. The role of T cells in acute Streptococcus pyogenes infection. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:62-62. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2008). Author weblink.
  • Llewelyn M; Sriskandan S; Terrazzini N; Cohen J; Altmann DM. The V beta specific response to bacterial superantigens is determined by concentration and HLA class II. Annual Congress of the British-Society-of-Immunology, 20 Feb 2007 - 23 Feb 2007. 120:77-77. BLACKWELL PUBLISHING (1 Mar 2007). Author weblink.
  • Lundberg K; Kinloch A; Allison H; Sriskandan S; Moyes D; Venables P. Mapping of citrullinated alpha-enolase antibodies to an immunodominant epitope with high sequence similarity to bacterial enolase. 27th European Workshop for Rheumatology Research, 22 Feb 2007 - 24 Feb 2007. 66:A18-A19. B M J PUBLISHING GROUP (1 Mar 2007). Author weblink.
  • Hopkins P; Pridmore A; Reid R; Fraser JD; Sriskandan S. Pattern-recognition of superantigens by MHC class II receptors on human monocytes facilitates pro-inflammatory synergy with endotoxin and parallel up-regulation of toll-like receptor 4. Spring Meeting of the Intensive-Care-Society. 93:314P-314P. (Aug 2004).
  • Fleet MR; Anandarajah J; Walters MJ; Belcher PE; Sriskandan S; Mitchell JA. Cigarette smoke inhibits the induction of NOSII activity in murine macrophages stimulated with Gram negative bacteria. Meeting of the British-Pharmacological-Society. 140:U7-U7. (Sep 2003).
  • Anandarajah J; Fleet MR; Walters MJ; Belcher PE; Sriskandan S; Mitchell JA. Gram positive and Gram negative bacteria synergise to cause nitric oxide synthase induction in murine macrophages. Meeting of the British-Pharmacological-Society. 140:U8-U8. (Sep 2003).
  • Belcher E; Evans TW; Sriskandan S; Mitchell JA. Staphylococcus aureus induces nitric oxide release in cardiovascular tissue via a toll like receptor 2-independent pathway. Meeting of the British-Pharmacological-Society-Clinical-Pharmacology-Section, 7 Jan 2003 - 10 Jan 2003. 138:U16-U16. NATURE PUBLISHING GROUP (1 Apr 2003). Author weblink.
  • Belcher E; Evans TW; Sriskandan S; Mitchell JA. Gram-positive Staphylococcus aureus contrasts with Gram-negative Escherichia coli in the induction of tumour necrosis factor-alpha and nitric oxide from macrophages in urine. Meeting of the Intensive-Care-Society. 90:540P-541P. (Apr 2003).
  • Hopkins P; Sriskandan S. The synergistic up-regulation of the proinflammatory innate response by Gram-positive superantigens and endotoxin. Meeting of the Intensive-Care-Society, 12 Dec 2002 - 13 Dec 2002. 90:555P-555P. OXFORD UNIV PRESS (1 Apr 2003). Author weblink.
  • Belcher E; Evans TW; Sriskandan S; Mitchell JA. Escherichia coli induces nitric oxide release in cardiovascular tissue via a toll like receptor 4-independent pathway. Meeting of the British-Pharmacological-Society-Clinical-Pharmacology-Section. 138:U16-U16. (Apr 2003).
  • Belcher E; Evans TW; Sriskandan S; Mitchell JA. The main site of iNOS activity induced by Gram postive Staphylococcus aureus may be blood vessels and not macrophages: Comparisons with Gram negative Escherichia coli. Winter Meeting of the British-Thoracic-Society. 57:U28-U28. (Dec 2002).
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