Dr S. John Wort

Publications


Journals

  • Diller GP; Alonso-Gonzalez R; Kempny A; Dimopoulos K; Inuzuka R; Giannakoulas G; Castle L; Lammers AE; et alHooper J; Uebing A; Swan L; Gatzoulis M; Wort SJ. (May 2012). B-type natriuretic peptide concentrations in contemporary Eisenmenger syndrome patients: predictive value and response to disease targeting therapy. Heart. 98:736-742. DOI.
  • Diller GP; Alonso-Gonzalez R; Dimopoulos K; Alvarez-Barredo M; Koo C; Kempny A; Harries C; Parfitt L; et alUebing AS; Swan L; Marino PS; Wort SJ; Gatzoulis MA. (3 Mar 2012). Disease targeting therapies in patients with Eisenmenger syndrome: Response to treatment and long-term efficiency. Int J Cardiol. DOI.
  • Park JE; Shao D; Upton PD; Desouza P; Adcock IM; Davies RJ; Morrell NW; Griffiths MJ; et alWort SJ. (2012). BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production. PLoS One. 7:e30075. DOI.
  • Price LC; McAuley DF; Marino PS; Finney SJ; Griffiths MJ; Wort SJ. (13 Jan 2012). Pathophysiology of pulmonary hypertension in acute lung injury. Am J Physiol Lung Cell Mol Physiol. DOI.
  • Price LC; McAuley DF; Marino PS; Finney SJ; Griffiths MJ; Wort SJ. (May 2012). Pathophysiology of pulmonary hypertension in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 302:L803-L815. DOI.
  • Price LC; Wort SJ; Perros F; Dorfmüller P; Huertas A; Montani D; Cohen-Kaminsky S; Humbert M. (Jan 2012). Inflammation in pulmonary arterial hypertension. Chest. 141:210-221. DOI.
  • Corte TJ; Wort SJ; Macdonald PS; Edey A; Hansell DM; Renzoni E; Maher TM; Nicholson AG; et alBandula S; Bresser P; Wells AU. (May 2012). Pulmonary function vascular index predicts prognosis in idiopathic interstitial pneumonia. Respirology. 17:674-680. DOI.
  • Corte TJ; McDonagh TA; Wort SJ. (3 May 2012). Pulmonary hypertension in left heart disease: A review. Int J Cardiol. 156:253-258. DOI.
  • Condliffe R; Kiely DG; Coghlan JG; Gibbs JS; Wort SJ; Corris PA; Peacock AJ; Pepke-Zaba J; et alAdult Pulmonary Hypertension Service of the United Kingdom. (Jun 2011). Survival in pulmonary hypertension registries: the importance of incident cases. Chest. 139:1547-1548. DOI.
  • Shao D; Park JE; Wort SJ. (Jun 2011). The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension. Pharmacol Res. 63:504-511. DOI.
  • Corte TJ; Gatzoulis MA; Parfitt L; Harries C; Wells AU; Wort SJ. (Nov 2010). The use of sildenafil to treat pulmonary hypertension associated with interstitial lung disease. Respirology. 15:1226-1232. DOI.
  • Corte TJ; Wells AU; Nicholson AG; Hansell DM; Wort SJ. (Jan 2011). Pulmonary hypertension in sarcoidosis: a review. Respirology. 16:69-77. DOI.
  • Price LC; Wort SJ; Finney SJ; Marino PS; Brett SJ. (2010). Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review. Crit Care. 14:R169. DOI.
  • Price LC; Montani D; Tcherakian C; Dorfmüller P; Souza R; Gambaryan N; Chaumais MC; Shao DM; et alSimonneau G; Howard LS; Adcock IM; Wort SJ; Humbert M; Perros F. (Apr 2011). Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats. Eur Respir J. 37:813-822. DOI.
  • Corte TJ; Wells AU; Gatzoulis MA; Cramer D; Ward S; Macdonald PS; Dimopoulos K; Wort SJ. (Apr 2010). Non-invasive assessment of pulmonary blood flow using an inert gas rebreathing device in fibrotic lung disease. Thorax. 65:341-345. DOI.
  • Tay EL; Papaphylactou M; Diller GP; Alonso-Gonzalez R; Inuzuka R; Giannakoulas G; Harries C; Wort SJ; et alSwan L; Dimopoulos K; Gatzoulis MA. (16 Jun 2011). Quality of life and functional capacity can be improved in patients with Eisenmenger syndrome with oral sildenafil therapy. Int J Cardiol. 149:372-376. DOI.
  • Corte TJ; Wort SJ; Gatzoulis MA; Engel R; Giannakoulas G; Macdonald PM; Wells AU. (Oct 2010). Elevated brain natriuretic peptide predicts mortality in interstitial lung disease. Eur Respir J. 36:819-825. DOI.
  • Harrington LS; Moreno L; Reed A; Wort SJ; Desvergne B; Garland C; Zhao L; Mitchell JA. (2010). The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension. PLoS One. 5:e9526. DOI.
  • Devaraj A; Wells AU; Meister MG; Corte TJ; Wort SJ; Hansell DM. (Feb 2010). Detection of pulmonary hypertension with multidetector CT and echocardiography alone and in combination. Radiology. 254:609-616. DOI.
  • Dimopoulos K; Inuzuka R; Goletto S; Giannakoulas G; Swan L; Wort SJ; Gatzoulis MA. (5 Jan 2010). Improved survival among patients with Eisenmenger syndrome receiving advanced therapy for pulmonary arterial hypertension. Circulation. 121:20-25. DOI.
  • Corte TJ; Wort SJ; Wells AU. (Jul 2009). Pulmonary hypertension in idiopathic pulmonary fibrosis: a review. Sarcoidosis Vasc Diffuse Lung Dis. 26:7-19.
  • Corte TJ; Wort SJ; Gatzoulis MA; Macdonald P; Hansell DM; Wells U. (1 Oct 2009). Pulmonary vascular resistance predicts early mortality in patients with diffuse fibrotic lung disease and suspected pulmonary hypertension. THORAX. 64:883-888. Author weblink DOI.
  • Corte TJ; Wort SJ; Wells AU. (1 Jul 2009). PULMONARY HYPERTENSION IN IDIOPATHIC PULMONARY FIBROSIS: A REVIEW. SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 26:7-19.
  • Wort SJ; Ito M; Chou P-C; Mc Master SK; Badiger R; Jazrawi E; de Souza P; Evans TW; et alMitchell JA; Pinhu L; Ito K; Adcock IM. (4 Sep 2009). Synergistic Induction of Endothelin-1 by Tumor Necrosis Factor alpha and Interferon gamma Is due to Enhanced NF-kappa B Binding and Histone Acetylation at Specific kappa B Sites. JOURNAL OF BIOLOGICAL CHEMISTRY. 284:24297-24305. Author weblink DOI.
  • Stirling SL; Cordingley JJ; Hunter DN; Griffiths MJ; Wort SJ; Evans TW; Finney SJ. (Aug 2009). Extracorporeal carbon dioxide removal to "protect" the lung. Thorax. 64:726-727. DOI.
  • Diller G-P; Bedard E; Wort SJ; Gatzoulis MA; van Eijl S; Ali O; Wilkins MR; Wharton J; et alOkonko DO; Howard LS; Thum T; Bauersachs J; Gibbs JSR; Hobbs AJ. (10 Mar 2009). Response to Letter Regarding Article, "Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension". CIRCULATION. 119:E231-E231. Author weblink DOI.
  • Corte TJ; Wort SJ. (Mar 2009). Role of pravastatin in pulmonary hypertension in chronic obstructive pulmonary disease. Clin Sci (Lond). 116:493-495. DOI.
  • Dimopoulos K; Giannakoulas G; Wort SJ; Gatzoulis MA. (1 Nov 2008). Pulmonary arterial hypertension in adults with congenital heart disease: distinct differences from other causes of pulmonary arterial hypertension and management implications. CURRENT OPINION IN CARDIOLOGY. 23:545-554. Author weblink DOI.
  • Diller G-P; van Eijl S; Okonko DO; Howard LS; Ali O; Thum T; Wort SJ; Bedard E; et alGibbs JSR; Bauersachs J; Hobbs AJ; Wilkins MR; Gatzoulis MA; Wharton J. (10 Jun 2008). Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. CIRCULATION. 117:3020-3030. Author weblink DOI.
  • Diller GP; Okonko D; van Eijl S; Ali O; Howard LS; Wort SJ; Thum T; Gibbs SR; et alBauersachs J; Wilkins MR; Wharton J; Gatzoulis MA. (16 Oct 2007). Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. CIRCULATION. 116:661-662. Author weblink.
  • Wort SJ. (3 Sep 2007). Sildenafil in Eisenmenger syndrome: Safety first. INTERNATIONAL JOURNAL OF CARDIOLOGY. 120:314-316. Author weblink DOI.
  • Rhodes A; Wort SJ; Thomas H; Collinson P; Bennett ED. (1 Jan 2006). Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. CRITICAL CARE. 10. Author weblink DOI.
  • GALLETLY NP; WORT SJ; ROGERS TR; IMPALLOMENI M. (1 Sep 1995). OUTBREAK OF CLOSTRIDIUM-DIFFICILE DIAARHOEA IN A GERIATRIC UNIT ASSOCIATED WITH CEFOTAXIME USAGE. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 43:SA14-SA14.
  • WORT SJ; HEMANACKAH C; DAVIES A. (1 Nov 1995). ACUTE URINARY RETENTION IN THE YOUNG FEMALE. BRITISH JOURNAL OF UROLOGY. 76:667-667. Author weblink DOI.
  • Wort SJ; Puleston JM; Hill PD; Holdstock GE. (12 Apr 1997). Primary tuberculosis of the oesophagus. LANCET. 349:1072-1072. Author weblink DOI.
  • Wort SJ; Rogers TR. (6 Jun 1998). Community acquired pneumonia in elderly people. BRITISH MEDICAL JOURNAL. 316:1690-1690. Author weblink.
  • Rogers T; Wort SJ. (28 Nov 1998). This pneumonia is only a small fraction of all hospital cases of chest infection and pneumonia - Reply. BRITISH MEDICAL JOURNAL. 317:1525-1525. Author weblink.
  • Wort SJ; Evans TW; Woods M; Warner TD; Mitchell JA. (1 Dec 1999). Cicaprost, a stable prostacyclin analogue, inhibits endogenous endothelin-1 release in human pulmonary artery smooth muscle cells. THORAX. 54:A41-A41. Author weblink.
  • Wort SJ; Evans TW; Warner TD; Mitchell JA. (1 Dec 1999). Cyclooxygenase-2 induction represents an endogenous 'brake' on ET-1 production by human pulmonary artery smooth muscle. THORAX. 54:A41-A41. Author weblink.
  • Wort SJ; Evans TW; Woods M; Warner TD; Mitchell JA. (1 May 2001). Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation. BRITISH JOURNAL OF PHARMACOLOGY. 133:U35-U35. Author weblink.
  • Wort SJ; Evans TW; Mitchell JA. (1 Dec 2001). The effect of growth factors on proliferation of human pulmonary artery smooth muscle cells. THORAX. 56:35-36. Author weblink.
  • Wort SJ; Heman-Ackah C; Davies A. (Nov 1995). Acute urinary retention in the young female. Br J Urol. 76:667.
  • Impallomeni M; Galletly NP; Wort SJ; Starr JM; Rogers TR. (18 Nov 1995). Increased risk of diarrhoea caused by Clostridium difficile in elderly patients receiving cefotaxime. BMJ. 311:1345-1346.
  • Wort SJ; Rogers TR. (6 Jun 1998). Community acquired pneumonia in elderly people. Current British guidelines need revision. BMJ. 316:1690.
  • Singh S; Wort SJ; Evans TW. (Nov 1999). Inducible nitric oxide and pulmonary infection. Thorax. 54:959-960.
  • Wort SJ; Evans TW. (1999). The role of the endothelium in modulating vascular control in sepsis and related conditions. Br Med Bull. 55:30-48.
  • Wort SJ; Mitchell JA; Woods M; Evans TW; Warner TD. (Nov 2000). The prostacyclin-mimetic cicaprost inhibits endogenous endothelin-1 release from human pulmonary artery smooth muscle cells. J Cardiovasc Pharmacol. 36:S410-S413.
  • Wort SJ; Mitchell JA; Evans TW. (Mar 2001). Inducible nitric oxide synthase: a tissue-specific affair?. Am J Physiol Lung Cell Mol Physiol. 280:L387-L389.
  • Wort SJ; Woods M; Warner TD; Evans TW; Mitchell JA. (Jul 2001). Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: relevance to pathogenesis of pulmonary hypertension and vascular remodeling. Am J Respir Cell Mol Biol. 25:104-110.
  • Woods M; Wood EG; Bardswell SC; Bishop-Bailey D; Barker S; Wort SJ; Mitchell JA; Warner TD. (Oct 2003). Role for nuclear factor-kappaB and signal transducer and activator of transcription 1/interferon regulatory factor-1 in cytokine-induced endothelin-1 release in human vascular smooth muscle cells. Mol Pharmacol. 64:923-931. DOI.
  • Wort SJ; Woods M; Warner TD; Evans TW; Mitchell JA. (Nov 2002). Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension. Mol Pharmacol. 62:1147-1153.

Conferences

  • Keir GJ; Wells AU; Wort SJ. THE USE OF SILDENAFIL TO TREAT PULMONARY HYPERTENSION ASSOCIATED WITH SARCOIDOSIS. Winter Meeting of the British-Thoracic-Society, 7 Dec 2011 - 9 Dec 2011. 66:A68-A68. B M J PUBLISHING GROUP (1 Dec 2011). DOI.
  • Price LC; Caramori G; Dorfmuller P; Perros F; Zhu J; Shao D; Humbert M; Adcock I; et alWort SJ. ENDOTHELIAL CELL NF-KB ACTIVATION IS INCREASED IN HUMAN IDIOPATHIC PAH. British-Thoracic-Society-Winter-Meeting 2010, 1 Dec 2010 - 3 Dec 2010. 65:A88-A89. B M J PUBLISHING GROUP (1 Dec 2010). Author weblink DOI.
  • Price LC; Wort SJ; Montani D; Tcherakian C; Dorfmuller P; Souza R; Shao D; Simonneau G; et alHoward LS; Adcock I; Humbert M; Perros F. DEXAMETHASONE REVERSES ESTABLISHED MONOCROTALINE-INDUCED PULMONARY HYPERTENSION IN RATS AND INCREASES PULMONARY BMPR2 EXPRESSION. British-Thoracic-Society-Winter-Meeting 2010, 1 Dec 2010 - 3 Dec 2010. 65:A68-A69. B M J PUBLISHING GROUP (1 Dec 2010). Author weblink DOI.
  • Park JES; Upton PD; de Souza PM; Davies RJ; Morrell NW; Griffiths MJD; Wort SJ. BONE MORPHOGENETIC PROTEIN 9 INCREASES ENDOTHELIN-1 RELEASE BY HUMAN PULMONARY ARTERY ENDOTHELIAL CELLS VIA A MAPK-DEPENDENT PATHWAY. Winter Meeting of the British-Thoracic-Society, 2 Dec 2009 - 4 Dec 2009. 64:A56-A57. B M J PUBLISHING GROUP (1 Dec 2009). Author weblink DOI.
  • Dimopoulos K; Inuzuka R; Goletto S; Giannakoulas G; Swan L; Wort SJ; Gatzoulis MA. Improved Survival Amongst Patients With Eisenmenger Syndrome Receiving Advanced Therapy for Pulmonary Arterial Hypertension. 82nd Scientific Session of the American-Heart-Association, 14 Nov 2009 - 18 Nov 2009. 120:S556-S556. LIPPINCOTT WILLIAMS & WILKINS (3 Nov 2009). Author weblink.
  • Corte TJ; Talbot S; Wort SJ; Wells AU. ELEVATED NOCTURNAL OXYGEN DESATURATION INDEX PREDICTS HIGHER SHORT-TERM MORTALITY IN INTERSTITIAL LUNG DISEASE. Winter Meeting of the British-Thoracic-Society, 2 Dec 2009 - 4 Dec 2009. 64:A5-A5. B M J PUBLISHING GROUP (1 Dec 2009). Author weblink DOI.
  • Upton PD; Park JES; Davies RJ; Griffiths M; Wort SJ; De Souza PM; Morrell NW. BMP9 SUPPRESSES MCP-1 PRODUCTION BY HUMAN PULMONARY ARTERY ENDOTHELIAL CELLS. Winter Meeting of the British-Thoracic-Society, 2 Dec 2009 - 4 Dec 2009. 64:A57-A58. B M J PUBLISHING GROUP (1 Dec 2009). DOI.
  • de Souza PM; Morrell NW; Upton PD; Park JES; Wort SJ. REGULATION OF ENDOTHELIN-1 PRODUCTION BY THE TRANSFORMING GROWTH FACTOR/BONE MORPHOGENETIC PROTEIN PATHWAY IN HUMAN PULMONARY ARTERY SMOOTH MUSCLE CELLS. Winter Meeting of the British-Thoracic-Society, 2 Dec 2009 - 4 Dec 2009. 64:A7-A8. B M J PUBLISHING GROUP (1 Dec 2009). DOI.
  • Corte TJ; Wort SJ; Ward S; Cramer D; Devaraj A; Wells AU. NON-INVASIVE ASSESSMENT OF CARDIAC OUTPUT USING AN INERT GAS REBREATHING DEVICE IN PATIENTS WITH FIBROTIC LUNG DISEASE. Winter Meeting of the British-Thoracic-Society, 3 Dec 2008 - 5 Dec 2008. 63:A134-A134. B M J PUBLISHING GROUP (1 Dec 2008). Author weblink.
  • Corte TJ; Wort SJ; Talbot S; Wells AU. NOCTURNAL DESATURATION IS ASSOCIATED WITH PULMONARY HYPERTENSION IN PATIENTS WITH MILD-TO-MODERATE INTERSTITIAL LUNG DISEASE. Winter Meeting of the British-Thoracic-Society, 3 Dec 2008 - 5 Dec 2008. 63:A132-A133. B M J PUBLISHING GROUP (1 Dec 2008). Author weblink.
  • Corte TJ; Wort SJ; Talbot S; Wells AU. NOCTURNAL OXYGEN DESATURATION IS COMMON IN INTERSTITIAL LUNG DISEASE AND OCCURS IN PATIENTS WITHOUT RESTING OR EXERCISE-INDUCED HYPOXIA. Winter Meeting of the British-Thoracic-Society, 3 Dec 2008 - 5 Dec 2008. 63:A132-A132. B M J PUBLISHING GROUP (1 Dec 2008). Author weblink.
  • Corte TJ; Wort SJ; Ward S; Cramer D; Wells AU. NON-INVASIVE ASSESSMENT OF CARDIAC OUTPUT USING AN INERT GAS REBREATHING DEVICE: REPEATABILITY AND REPRODUCIBILITY IN NORMAL CONTROLS. Winter Meeting of the British-Thoracic-Society, 3 Dec 2008 - 5 Dec 2008. 63:A127-A127. B M J PUBLISHING GROUP (1 Dec 2008). Author weblink.
  • Wort SJ; Davidson S; Corte TJ; Park J; Harries C; Gatzoulis M. THE EFFECT OF THE ENDOTHELIN-1 DUAL RECEPTOR ANTAGONIST, BOSENTAN, ON PLATELET FUNCTION. Winter Meeting of the British-Thoracic-Society, 3 Dec 2008 - 5 Dec 2008. 63:A54-A54. B M J PUBLISHING GROUP (1 Dec 2008). Author weblink.
  • Diller GP; Okonko D; van Eijl S; Ali O; Howard LS; Wort SJ; Thum T; Gibbs SR; et alBauersachs J; Wilkins MR; Wharton J; Gatzoulis MA. Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. 80th Annual Scientific Session of the American-Heart-Association. 116:661-662. (16 Oct 2007).
  • Corte TJ; Wort SJ; Nogrady S; Ip D; Ellis R; Wells AU. Six minute walk desaturation and maximal exercise test parameters: Relation in patients with fibrosing lung disease. Winter Meeting of the British-Thoracic-Society. 62:A44-A44. (Dec 2007).
  • Corte TJ; Wort SJ; Engel R; Giannakoulas G; Wells AU. Brain-natriuretic peptide correlates to echocardiographic indices of right ventricular function in patients with fibrotic lung disease. Winter Meeting of the British-Thoracic-Society. 62:A17-A18. (Dec 2007).
  • Corte TJ; Gatzoulis M; Wort SJ; Wells AU. Relationship between right heart catheterisation and non-invasive measures of pulmonary hypertension in patients with fibrosing lung disease. Winter Meeting of the British-Thoracic-Society, 5 Dec 2007 - 7 Dec 2007. 62:A123-A123. B M J PUBLISHING GROUP (1 Dec 2007). Author weblink.
  • Corte TJ; Harries C; Cramer D; Ward S; Gatzoulis M; Wort SJ. Mass spectrometry: A non-invasive measure of pulmonary blood flow in patients with pulmonary hypertension. Winter Meeting of the British-Thoracic-Society, 5 Dec 2007 - 7 Dec 2007. 62:A87-A87. B M J PUBLISHING GROUP (1 Dec 2007). Author weblink.
  • Wort SJ; Rhodes A; Thomas H; Pearse R; Collinson P; Bennett ED. The role of plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. Winter Meeting of the British-Thoracic-Society. 60:II116-II116. (1 Dec 2005).
  • Wort SJ; McMaster S; Mitchell JA; Evans TW; Ito M; Ito K; Adcock IM. Acetylation of histone H4 at NF-Kappa B sites on pre-pro ET-1 promoter is involved in synergistic synthesis of ET-1 in human pulmonary artery smooth muscle cells treated with TNF-alpha and IFN-gamma. Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), 6 Dec 2006 - 8 Dec 2006. 61:II19-II19. B M J PUBLISHING GROUP (1 Dec 2006). Author weblink.
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