Professor Sian E Harding

Publications


Journals

  • Johnson WB; Katugampola S; Able S; Napier C; Harding SE. (10 Jan 2012). Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: Comparison with rat and guinea pig. Life Sci. DOI.
  • Harding SE. (Dec 2011). Human stem cell-derived cardiomyocytes for pharmacological and toxicological modeling. Ann N Y Acad Sci. 1245:48-49. DOI.
  • Reed DM; Foldes G; Badiger RV; Ali NN; Wheeler-Jones CP; Paul-Clark MJ; Harding SE; Mitchell JA. (Oct 2011). TLR3 AND INTERFERON FUNCTION IN HUMAN EMBRYONIC STEM CELL-DERIVED ENDOTHELIAL CELLS (HESC-EC): RELEVANCE TO VIRAL IMMUNITY. HEART. 97:12-12. DOI.
  • Foldes G; Mioulane M; Chahine MN; Schneider MD; Harding SE. (Oct 2011). HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES SERVE AS IN VITRO MODEL OF CARDIAC HYPERTROPHY. HEART. 97:11-11. DOI.
  • Chahine MN; Mioulane M; Foldes G; Lyon A; Ali NN; Schneider MD; Harding SE. (Oct 2011). NUCLEAR PROTEIN IMPORT MEDIATES PHENYLEPHRINE-INDUCED HYPERTROPHY IN ADULT AND HUMAN EMBRYONIC STEM CELL-DERIVED CARDIOMYOCYTES. HEART. 97:10-10. DOI.
  • Foldes G; Ali NN; Randi A; Starke R; Paschalaki K; Gatheral T; Harding SE; Mitchell JA. (2011). PATHOGEN SENSING PATHWAYS IN HUMAN STEM CELL-DERIVED ENDOTHELIAL CELLS. SHOCK. 36:4-4.
  • Jawad H; Boccaccini AR; Ali NN; Harding SE. (Sep 2011). Assessment of cellular toxicity of TiO2 nanoparticles for cardiac tissue engineering applications. NANOTOXICOLOGY. 5:372-380. DOI.
  • Quinn TA; Granite S; Allessie MA; Antzelevitch C; Bollensdorff C; Bub G; Burton RA; Cerbai E; et alChen PS; Delmar M; Difrancesco D; Earm YE; Efimov IR; Egger M; Entcheva E; Fink M; Fischmeister R; Franz MR; Garny A; Giles WR; Hannes T; Harding SE; Hunter PJ; Iribe G; Jalife J; Johnson CR; Kass RS; Kodama I; Koren G; Lord P; Markhasin VS; Matsuoka S; McCulloch AD; Mirams GR; Morley GE; Nattel S; Noble D; Olesen SP; Panfilov AV; Trayanova NA; Ravens U; Richard S; Rosenbaum DS; Rudy Y; Sachs F; Sachse FB; Saint DA; Schotten U; Solovyova O; Taggart P; Tung L; Varró A; Volders PG; Wang K; Weiss JN; Wettwer E; White E; Wilders R; Winslow RL; Kohl P. (Oct 2011). Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol. 107:4-10. DOI.
  • Song W; Dyer E; Stuckey D; Leung MC; Memo M; Mansfield C; Ferenczi M; Liu K; et alRedwood C; Nowak K; Harding S; Clarke K; Wells D; Marston S. (Sep 2010). Investigation of a transgenic mouse model of familial dilated cardiomyopathy. J Mol Cell Cardiol. 49:380-389. DOI.
  • Song W; Dyer E; Stuckey DJ; Copeland O; Leung MC; Bayliss C; Messer A; Wilkinson R; et alTremoleda JL; Schneider MD; Harding SE; Redwood CS; Clarke K; Nowak K; Monserrat L; Wells D; Marston SB. (5 Aug 2011). Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse. J Biol Chem. 286:27582-27593. DOI.
  • Pathan N; Franklin JL; Eleftherohorinou H; Wright VJ; Hemingway CA; Waddell SJ; Griffiths M; Dennis JL; et alRelman DA; Harding SE; Levin M. (Jul 2011). Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase. Crit Care Med. 39:1692-1711. DOI.
  • Lyon AR; Bannister ML; Collins T; Pearce E; Sepehripour AH; Dubb SS; Garcia E; O'Gara P; et alLiang L; Kohlbrenner E; Hajjar RJ; Peters NS; Poole-Wilson PA; Macleod KT; Harding SE. (Jun 2011). SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circ Arrhythm Electrophysiol. 4:362-372. DOI.
  • Miragoli M; Moshkov A; Novak P; Shevchuk A; Nikolaev VO; El-Hamamsy I; Potter CM; Wright P; et alKadir SH; Lyon AR; Mitchell JA; Chester AH; Klenerman D; Lab MJ; Korchev YE; Harding SE; Gorelik J. (6 Jul 2011). Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells. J R Soc Interface. 8:913-925. DOI.
  • Michel MC; Harding SE; Bond RA. (Feb 2011). Are there functional β₃-adrenoceptors in the human heart?. Br J Pharmacol. 162:817-822. DOI.
  • Harding SE. (Nov 2010). Frontiers in Cardiovascular Biology: a new federation of European scientists. Future Cardiol. 6:765-767. DOI.
  • Stuckey DJ; Ishii H; Chen QZ; Boccaccini AR; Hansen U; Carr CA; Roether JA; Jawad H; et alTyler DJ; Ali NN; Clarke K; Harding SE. (Nov 2010). Magnetic resonance imaging evaluation of remodeling by cardiac elastomeric tissue scaffold biomaterials in a rat model of myocardial infarction. Tissue Eng Part A. 16:3395-3402. DOI.
  • Földes G; Mioulane M; Wright JS; Liu AQ; Novak P; Merkely B; Gorelik J; Schneider MD; et alAli NN; Harding SE. (Feb 2011). Modulation of human embryonic stem cell-derived cardiomyocyte growth: a testbed for studying human cardiac hypertrophy?. J Mol Cell Cardiol. 50:367-376. DOI.
  • Jawad H; Boccaccini AR; Ali NN; Harding SE. (Sep 2011). Assessment of cellular toxicity of TiO2 nanoparticles for cardiac tissue engineering applications. Nanotoxicology. 5:372-380. DOI.
  • Lyon AR; Harding SE; Peters NS. (Sep 2008). Cardiac stem cell therapy and arrhythmogenicity: prometheus and the arrows of Apollo and Artemis. J Cardiovasc Transl Res. 1:207-216. DOI.
  • Földes G; Liu A; Badiger R; Paul-Clark M; Moreno L; Lendvai Z; Wright JS; Ali NN; et alHarding SE; Mitchell JA. (2010). Innate immunity in human embryonic stem cells: comparison with adult human endothelial cells. PLoS One. 5:e10501. DOI.
  • Chen QZ; Ishii H; Thouas GA; Lyon AR; Wright JS; Blaker JJ; Chrzanowski W; Boccaccini AR; et alAli NN; Knowles JC; Harding SE. (May 2010). An elastomeric patch derived from poly(glycerol sebacate) for delivery of embryonic stem cells to the heart. BIOMATERIALS. 31:3885-3893. DOI.
  • Nikolaev VO; Moshkov A; Lyon AR; Miragoli M; Novak P; Paur H; Lohse MJ; Korchev YE; et alHarding SE; Gorelik J. (26 Mar 2010). Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science. 327:1653-1657. DOI.
  • Lompré AM; Hajjar RJ; Harding SE; Kranias EG; Lohse MJ; Marks AR. (16 Feb 2010). Ca2+ cycling and new therapeutic approaches for heart failure. Circulation. 121:822-830. DOI.
  • Sato M; Carr CA; Stuckey DJ; Ishii H; Kanda GK; Terracciano CM; Siedlecka U; Tatton L; et alWatt SM; Martin-Rendon E; Clarke K; Harding SE. (Jul 2010). Functional and morphological maturation of implanted neonatal cardiomyocytes as a comparator for cell therapy. Stem Cells Dev. 19:1025-1034. DOI.
  • Abdul Kadir SH; Ali NN; Mioulane M; Brito-Martins M; Abu-Hayyeh S; Foldes G; Moshkov AV; Williamson C; et alHarding SE; Gorelik J. (Sep 2009). Embryonic stem cell-derived cardiomyocytes as a model to study fetal arrhythmia related to maternal disease. J Cell Mol Med. 13:3730-3741. DOI.
  • Sato M; Kerton A; Harding SE. (Mar 2009). Refinement of in vivo surgical procedures for cardiac gene and cell transfer in rats. LAB ANIMAL. 38:94-101. DOI.
  • Lyon AR; MacLeod KT; Zhang Y; Garcia E; Kanda GK; Lab MJ; Korchev YE; Harding SE; et alGorelik J. (21 Apr 2009). Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc Natl Acad Sci U S A. 106:6854-6859. DOI.
  • Gorelik J; Ali NN; Kadir SHSA; Lab M; Stojkovic P; Armstrong L; Sviderskaya EV; Negulyaev YA; et alKlenerman D; Bennett DC; Lako M; Harding SE; Stojkovic M; Korchev YE. (Dec 2008). Non-invasive Imaging of Stem Cells by Scanning Ion Conductance Microscopy: Future Perspective. TISSUE ENG PT C-METH. 14:311-318. DOI.
  • Siedlecka U; Arora M; Kolettis T; Soppa GKR; Lee J; Stagg MA; Harding SE; Yacoub MH; et alTerracciano CMN. (Nov 2008). Effects of clenbuterol on contractility and Ca2+ homeostasis of isolated rat ventricular myocytes. AM J PHYSIOL-HEART C. 295:H1917-H1926. DOI.
  • Jawad H; Lyon AR; Harding SE; Ali NN; Boccaccini AR. (Sep 2008). Myocardial tissue engineering. BRIT MED BULL. 87:31-47. DOI.
  • Földes G; Harding SE; Ali NN. (Oct 2008). Cardiomyocytes from embryonic stem cells: towards human therapy. Expert Opin Biol Ther. 8:1473-1483. DOI.
  • Carr CA; Stuckey DJ; Tatton L; Tyler DJ; Hale SJM; Sweeney D; Schneider JE; Martin-Rendon E; et alRadda GK; Harding SE; Watt SM; Clarke K. (Aug 2008). Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study. AM J PHYSIOL-HEART C. 295:H533-H542. DOI.
  • Jacques AM; Briceno N; Messer AE; Gallon CE; Jalilzadeh S; Garcia E; Kikonda-Kanda G; Goddard J; et alHarding SE; Watkins H; Esteban MT; Tsang VT; McKenna WJ; Marston SB. (1 Aug 2008). The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy. Cardiovasc Res. 79:481-491. DOI.
  • Lyon AR; Rees PS; Prasad S; Poole-Wilson PA; Harding SE. (Jun 2008). Authors' response to "Stress (Takotsubo) cardiomyopathy-a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning". Nat Clin Pract Cardiovasc Med. 5:E2-E2. Publisher weblink DOI.
  • Chen QZ; Harding SE; Ali NN; Lyon AR; Boccaccini AR. (29 Feb 2008). Biomaterials in cardiac tissue engineering: Ten years of research survey. MAT SCI ENG R. 59:1-37. DOI.
  • Brito-Martins M; Harding SE; Ali NN. (Feb 2008). beta(1)- and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart. Br J Pharmacol. 153:751-759. DOI.
  • Chen QZ; Bismarck A; Hansen U; Junaid S; Tran MQ; Harding SE; Ali NN; Boccaccini AR. (Jan 2008). Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue. Biomaterials. 29:47-57. DOI.
  • Lyon AR; Sato M; Hajjar RJ; Samulski RJ; Harding SE. (Jan 2008). Gene therapy: targeting the myocardium. Heart. 94:89-99. DOI.
  • Lyon AR; Rees PSC; Prasad S; Poole-Wilson PA; Harding SE. (Jan 2008). Stress (Takotsubo) cardiomyopathy - a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. NAT CLIN PRACT CARD. 5:22-29. DOI.
  • Patel TA; Belcher E; Warner TD; Harding SE; Mitchell JA. (Oct 2007). Identification and characterization of a dysfunctional cardiac myocyte phenotype: Role of bacteria, toll-like receptors, and endothelin. SHOCK. 28:434-440. DOI.
  • Jawad H; Ali NN; Lyon AR; Chen QZ; Harding SE; Boccaccini AR. (Sep 2007). Myocardial tissue engineering: a review. J Tissue Eng Regen Med. 1:327-342. DOI.
  • Harding SE; Ali NN; Brito-Martins M; Gorelik J. (Feb 2007). The human embryonic stem cell-derived cardiomyocyte as a pharmacological model. Pharmacol Ther. 113:341-353. DOI.
  • Gorelik J; Yang LQ; Zhang Y; Lab M; Korchev Y; Harding SE. (1 Dec 2006). A novel Z-groove index characterizing myocardial surface structure. Cardiovasc Res. 72:422-429. DOI.
  • Stuckey DJ; Carr CA; Martin-Rendon E; Tylera DJ; Willmott C; Cassidy PJ; Hale SJM; Schneider JE; et alTatton L; Harding SE; Radda GK; Watt S; Clarke K. (Aug 2006). Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heart. STEM CELLS. 24:1968-1975. DOI.
  • Gorelik J; Ali NN; Shevchuk AI; Lab M; Williamson C; Harding SE; Korchev YE. (Apr 2006). Functional characterization of embryonic stem cell-derived cardiomyocytes using scanning ion conductance microscopy. Tissue Eng. 12:657-664. DOI.
  • Harding SE. (Sep 2005). Modelling GPCR effects in the cardiomyocyte: A bridge from reconstituted systems to human heart. J MOL CELL CARDIOL. 39:411-413. DOI.
  • Sato M; Fuller SJ; Hajjar RJ; Harding SE. (Jul 2005). Targeting genes and cells in the progression to heart failure. Heart Fail Clin. 1:287-301. DOI.
  • Harding SE. (Jul 2005). The failing cardiomyocyte. Heart Fail Clin. 1:171-181. DOI.
  • Sato M; O'Gara P; Harding SE; Fuller SJ. (Jun 2005). Enhancement of adenoviral gene transfer to adult rat cardiomyocytes in vivo by immobilization and ultrasound treatment of the heart. Gene Ther. 12:936-941. DOI.
  • Harding SE; del Monte F; Hajjar RJ. (2005). Antisense strategies for treatment of heart failure. Methods Mol Med. 106:69-82.
  • Ali NN; Xu X; Brito-Martins M; Poole-Wilson PA; Harding SE; Fuller SJ. (Nov 2004). Beta-adrenoceptor subtype dependence of chronotropy in mouse embryonic stem cell-derived cardiomyocytes. Basic Res Cardiol. 99:382-391. DOI.
  • Stark JCC; Haydock SF; Foo R; Brown MJ; Harding SE. (Oct 2004). Effect of overexpressed adenylyl cyclase VI on beta(1)- and beta(2)-adrenoceptor responses in adult rat ventricular myocytes. BRIT J PHARMACOL. 143:465-476. DOI.
  • Harding SE; Gong H. (Jul 2004). beta-adrenoceptor blockers as agonists: coupling of beta2-adrenoceptors to multiple G-proteins in the failing human heart. Congest Heart Fail. 10:181-185.
  • Sato M; Harding SE; Poole-Wilson PA. (Apr 2004). beta-blockers, myocardial ischaemia and collateral circulation. EUR HEART J. 25:537-539. DOI.
  • Lewis CJ; Gong HB; Brown MJ; Harding SE. (Mar 2004). Overexpression of beta(1)-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta(4)-adrenoceptor pharmacology. BRITISH JOURNAL OF PHARMACOLOGY. 141:813-824. DOI.
  • Chaudhri BB; del Monte F; Harding SE; Hajjar RJ. (Feb 2004). Gene transfer in cardiac myocytes. Surg Clin North Am. 84:141-x. DOI.
  • Pathan N; Hemingway CA; Alizadeh AA; Stephens AC; Boldrick JC; Oragui EE; McCabe C; Welch SB; et alWhitney A; O'Gara P; Nadel S; Relman DA; Harding SE; Levin M. (17 Jan 2004). Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet. 363:203-209. DOI.
  • Sato M; Gong H; Terracciano CM; Ranu H; Harding SE. (Jan 2004). Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger. J Mol Cell Cardiol. 36:43-48.
  • Chaudhri B; del Monte F; Hajjar RJ; Harding SE. (Sep 2003). Contractile effects of adenovirally-mediated increases in SERCA2a activity: a comparison between adult rat and rabbit ventricular myocytes. Mol Cell Biochem. 251:103-109.
  • Terracciano CM; Harding SE; Adamson D; Koban M; Tansley P; Birks EJ; Barton PJ; Yacoub MH. (Jul 2003). Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy. Eur Heart J. 24:1329-1339.
  • Heubach JF; Blaschke M; Harding SE; Ravens U; Kaumann AJ. (Apr 2003). Cardiostimulant and cardiodepressant effects through overexpressed human beta(2)-adrenoceptors in murine heart: regional differences and functional role of beta(1)-adrenoceptors. N-S ARCH PHARMACOL. 367:380-390. DOI.
  • El-Armouche A; Rau T; Zolk O; Ditz D; Pamminger T; Zimmermann WH; Jackel E; Harding SE; et alBoknik P; Neumann J; Eschenhagen T. (Jan 2003). Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes. FASEB J. 17:437-+. DOI.
  • Harding SE; Del Monte F. (Dec 2002). Dissociation of hypertrophic growth from changes in myocyte contractile function. J Card Fail. 8:S415-S420. DOI.
  • Chaudhri B; Del Monte F; Hajjar RJ; Harding SE. (Dec 2002). Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes. Am J Physiol Heart Circ Physiol. 283:H2450-H2457. DOI.
  • Gorelik J; Gu Y; Spohr HA; Shevchuk AI; Lab MJ; Harding SE; Edwards CR; Whitaker M; et alMoss GW; Benton DC; Sánchez D; Darszon A; Vodyanoy I; Klenerman D; Korchev YE. (Dec 2002). Ion channels in small cells and subcellular structures can be studied with a smart patch-clamp system. Biophys J. 83:3296-3303. DOI.
  • Pathan N; Sandiford C; Harding SE; Levin M. (Oct 2002). Characterization of a myocardial depressant factor in meningococcal septicemia. Crit Care Med. 30:2191-2198. DOI.
  • Gorelik J; Harding SE; Shevchuk AI; Koralage D; Lab M; de Swiet M; Korchev Y; Williamson C. (Aug 2002). Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics. Clin Sci (Lond). 103:191-200.
  • Terracciano CM; Hajjar RJ; Harding SE. (Jun 2002). Overexpression of SERCA2a accelerates repolarisation in rabbit ventricular myocytes. Cell Calcium. 31:299-305.
  • Gong H; Sun H; Koch WJ; Rau T; Eschenhagen T; Ravens U; Heubach JF; Adamson DL; et alHarding SE. (28 May 2002). Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. Circulation. 105:2497-2503.
  • Ranu HK; Terracciano CM; Davia K; Bernobich E; Chaudhri B; Robinson SE; Bin Kang Z; Hajjar RJ; et alMacLeod KT; Harding SE. (Apr 2002). Effects of Na(+)/Ca(2+)-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes. J Mol Cell Cardiol. 34:389-400. DOI.
  • Gu YC; Gorelik J; Spohr HA; Shevchuk A; Lab MJ; Harding SE; Vodyanoy I; Klenerman D; et alKorchev YE. (Mar 2002). High-resolution scanning patch-clamp: new insights into cell function. FASEB J. 16:748-+. DOI.
  • del Monte F; Harding SE; Dec GW; Gwathmey JK; Hajjar RJ. (26 Feb 2002). Targeting phospholamban by gene transfer in human heart failure. Circulation. 105:904-907.
  • Song GJ; Harding SE; Duchen MR; Tunwell R; O'Gara P; Hawkins TE; Moss SE. (Feb 2002). Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice. FASEB J. 16:622-+. DOI.
  • Sarkar D; Vallance P; Harding SE. (Oct 2001). Nitric oxide: not just a negative inotrope. Eur J Heart Fail. 3:527-534.
  • Watt DJ; Goldring K; Harding SE; Fuller S; Sun H; Naunton-Morgan N. (Sep 2001). A preliminary study on the effect of galectin-1 on cardiomyocytes. NEUROMUSCULAR DISORD. 11:651-651.
  • Shevchuk AI; Gorelik J; Harding SE; Lab MJ; Klenerman D; Korchev YE. (Sep 2001). Simultaneous measurement of Ca2+ and cellular dynamics: combined scanning ion conductance and optical microscopy to study contracting cardiac myocytes. Biophys J. 81:1759-1764. DOI.
  • del Monte F; Hajjar RJ; Harding SE. (8 Jun 2001). Overwhelming evidence of the beneficial effects of SERCA gene transfer in heart failure. CIRC RES. 88:E66-E66.
  • Heubach JF; Graf EM; Molenaar P; Jäger A; Schröder F; Herzig S; Harding SE; Ravens U. (May 2001). Murine ventricular L-type Ca(2+) current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptor. Br J Pharmacol. 133:73-82. DOI.
  • Davia K; Bernobich E; Ranu HK; del Monte F; Terracciano CM; MacLeod KT; Adamson DL; Chaudhri B; et alHajjar RJ; Harding SE. (May 2001). SERCA2A overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytes. J Mol Cell Cardiol. 33:1005-1015. DOI.
  • Sarkar D; Vallance P; Amirmansour C; Harding SE. (Dec 2000). Positive inotropic effects of NO donors in isolated guinea-pig and human cardiomyocytes independent of NO species and cyclic nucleotides. Cardiovasc Res. 48:430-439.
  • Gong H; Adamson DL; Ranu HK; Koch WJ; Heubach JF; Ravens U; Zolk O; Harding SE. (Oct 2000). The effect of Gi-protein inactivation on basal, and beta(1)- and beta(2)AR-stimulated contraction of myocytes from transgenic mice overexpressing the beta(2)-adrenoceptor. Br J Pharmacol. 131:594-600. DOI.
  • Yokoyama H; Gunasegaram S; Harding SE; Avkiran M. (Aug 2000). Sarcolemmal Na+/H+ exchanger activity and expression in human ventricular myocardium. J AM COLL CARDIOL. 36:534-+.
  • Adamson DL; Money-Kyrle AR; Harding SE. (Jul 2000). Functional evidence for a cyclic-AMP related mechanism of action of the beta(2)-adrenoceptor in human ventricular myocytes. J Mol Cell Cardiol. 32:1353-1360. DOI.
  • Ranu HK; Mak JC; Barnes PJ; Harding SE. (Jun 2000). G(i)-dependent suppression of beta(1)-adrenoceptor effects in ventricular myocytes from NE-treated guinea pigs. Am J Physiol Heart Circ Physiol. 278:H1807-H1814.
  • Adamson DL; Harding SE. (Apr 2000). Rp-cAMPS has no effect on adenosine A1 receptors in guinea-pig cardiomyocytes. Basic Res Cardiol. 95:114-118.
  • Tweedie D; Harding SE; MacLeod KT. (Feb 2000). Sarcoplasmic reticulum Ca content, sarcolemmal Ca influx and the genesis of arrhythmias in isolated guinea-pig cardiomyocytes. J Mol Cell Cardiol. 32:261-272. DOI.
  • Bernobich E; Davia K; Ranu HK; Terracciano CMN; MacLeod KT; Hajjar RJ; Harding SE. (Jan 2000). Adenovirus-mediated Na/Ca exchanger overexpression depresses contractile function in adult rabbit cardiomyocytes. BIOPHYS J. 78:373A-373A.
  • Terracciano CMN; Bernobich E; Davia K; Ranu HK; MacLeod KT; Hajjar RJ; Harding SE. (Jan 2000). Adenovirus-mediated Na/Ca exchanger overexpression reduces sarcoplasmic reticulum (SR) Ca content in adult rabbit cardiomyocytes. BIOPHYS J. 78:373A-373A.
  • del Monte F; Harding SE; Schmidt U; Matsui T; Kang ZB; Dec W; Gwathmey JK; Rosenzweig A; et alHajjar RJ. (7 Dec 1999). Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. CIRCULATION. 100:2308-2311.
  • Song GJ; Harding SE; Duchen M; O'Gara P; Hawkins T; Moss SE. (2 Nov 1999). Altered cardiomyocyte dynamics in annexin VI knockout mice. CIRCULATION. 100:762-763.
  • Adamson DL; Davies CH; Moat N; Harding SE. (2 Nov 1999). Isolated ventricular myocytes from patients with chronic mitral regurgitation have significant abnormalities of relaxation. CIRCULATION. 100:94-95.
  • Adamson DL; O'Brookes CI; Kemp M; Hooper J; Harding SE. (2 Nov 1999). Neurohormonal activation correlates with cellular and clinical markers of left ventricular dysfunction in patients with chronic mitral regurgitation. CIRCULATION. 100:461-461.
  • Davia K; Hajjar RJ; Terracciano CM; Kent NS; Ranu HK; O'Gara P; Rosenzweig A; Harding SE. (31 Aug 1999). Functional alterations in adult rat myocytes after overexpression of phospholamban with use of adenovirus. Physiol Genomics. 1:41-50.
  • Owen VJ; Burton PB; Michel MC; Zolk O; Böhm M; Pepper JR; Barton PJ; Yacoub MH; et alHarding SE. (18 May 1999). Myocardial dysfunction in donor hearts. A possible etiology. Circulation. 99:2565-2570.
  • Heubach JF; Trebess I; Wettwer E; Himmel HM; Michel MC; Kaumann AJ; Koch WJ; Harding SE; et alRavens U. (Apr 1999). L-type calcium current and contractility in ventricular myocytes from mice overexpressing the cardiac beta(2)-adrenoceptor. CARDIOVASC RES. 42:173-182.
  • Kent NS; Davia K; Harding SE. (Feb 1999). Characterisation of the function of adult guinea-pig ventricular myocytes following co-culture with neonatal rat myocytes. Basic Res Cardiol. 94:9-14.
  • Terracciano CMN; Davia K; Kent NS; Ranu HK; O'Gara P; Rosenzweig A; Hajjar RJ; Harding SE. (Jan 1999). Overexpression of phospholamban affects sarcoplasmic reticulum (SR) Ca uptake in rat ventricular myocytes. BIOPHYS J. 76:A306-A306.
  • Harding SE; Davies CH; Money-Kyrle AM; Poole-Wilson PA. (Dec 1998). An inhibitor of nitric oxide synthase does not increase contraction or beta-adrenoceptor sensitivity of ventricular myocytes from failing human heart. Cardiovasc Res. 40:523-529.
  • Harding SE; Davia K; Davies CH; del Monte F; Money-Kyrle AR; Poole-Wilson PA. (Aug 1998). From overload to failure: what happens inside the myocyte. ANNALS OF MEDICINE. 30:14-23.
  • Money-Kyrle AR; Davies CH; Ranu HK; O'Gara P; Kent NS; Poole-Wilson PA; Harding SE. (Feb 1998). The role of cAMP in the frequency-dependent changes in contraction of guinea-pig cardiomyocytes. Cardiovasc Res. 37:532-540.
  • Davia K; Harding SE. (1998). Post-rest contraction amplitude in myocytes from failing human ventricle. Basic Res Cardiol. 93 Suppl 1:33-37.
  • Heubach JF; Harding SE; Schroeder F; Herzig S; Ravens U. (21 Oct 1997). Delayed inactivation kinetic of L-type I-Ca in myocytes from mice overexpressing the beta(2)-adrenoceptor. CIRCULATION. 96:2774-2774.
  • Harding SE. (21 Oct 1997). Lack of evidence for beta 3-adrenoceptor modulation of contractile function in human ventricular myocytes. CIRCULATION. 96:284-284.
  • MoneyKyrle ARW; OGara P; Davies CH; PooleWilson PA; Harding SE. (21 Oct 1997). The force-frequency relationship in myocytes from failing human ventricle is not altered by either blocking or stimulating protein kinase A with membrane permeant cAMP analogues. CIRCULATION. 96:3414-3414.
  • Tweedie D; O'Gara P; Harding SE; MacLeod KT. (May 1997). The effect of alterations to action potential duration on beta-adrenoceptor-mediated aftercontractions in human and guinea-pig ventricular myocytes. J Mol Cell Cardiol. 29:1457-1467.
  • Wright AR; Rees SA; Harding SE; Powell T. (Feb 1997). Sodium-calcium exchange in guinea-pig, marmoset and human cardiac cells. BIOPHYS J. 72:MP234-MP234.
  • Ferrara N; Böhm M; Zolk O; O'Gara P; Harding SE. (Feb 1997). The role of Gi-proteins and beta-adrenoceptors in the age-related decline of contraction in guinea-pig ventricular myocytes. J Mol Cell Cardiol. 29:439-448.
  • Ravens U; Trebess I; Himmel HM; Wettwer E; Michel MC; Harding SE. (1997). Contractile function and L-type Ca2+ currents (I-Ca) in myocardium from mice overexpressing the beta 2-adrenoceptor. N-S ARCH PHARMACOL. 355:76-76.
  • Davia K; Davies CH; Harding SE. (Jan 1997). Effects of inhibition of sarcoplasmic reticulum calcium uptake on contraction in myocytes isolated from failing human ventricle. Cardiovasc Res. 33:88-97.
  • Harding SE. (15 Oct 1996). Depressed contraction and poor frequency response of myocytes from failing human ventricle is not related to nitric oxide synthesis. CIRCULATION. 94:3044-3044.
  • Harding SE; Trebess I; OGara P; Ravens U. (15 Oct 1996). Inhomogeneous desensitisation in ventricular myocytes from mice overexpressing the B2-adrenoceptor. CIRCULATION. 94:2743-2743.
  • Ravens U; Davia K; Davies CH; OGara P; DrakeHolland AJ; Hynd JW; Noble MIM; Harding SE. (Sep 1996). Tachycardia-induced failure alters contractile properties of canine ventricular myocytes. CARDIOVASC RES. 32:613-621.
  • Wynne DG; Del Monte F; Harding SE. (29 Aug 1996). Cyclic AMP levels in ventricular myocytes from noradrenaline-treated guinea-pigs. Eur J Pharmacol. 310:235-242.
  • Davies CH; Harding SE; Poole-Wilson PA. (Feb 1996). Cellular mechanisms of contractile dysfunction in human heart failure. Eur Heart J. 17:189-198.
  • Davies CH; Ferrara N; Harding SE. (Jan 1996). Beta-adrenoceptor function changes with age of subject in myocytes from non-failing human ventricle. Cardiovasc Res. 31:152-156.
  • Davies CH; Davia K; Bennett JG; Pepper JR; Poole-Wilson PA; Harding SE. (1 Nov 1995). Reduced contraction and altered frequency response of isolated ventricular myocytes from patients with heart failure. Circulation. 92:2540-2549.
  • Harding SE; MacLeod KT; Davies CH; Wynne DG; Poole-Wilson PA. (Aug 1995). Abnormalities of the myocytes in ischaemic cardiomyopathy. Eur Heart J. 16 Suppl I:74-81.
  • del Monte F; O'Gara P; Poole-Wilson PA; Yacoub M; Harding SE. (Aug 1995). Cell geometry and contractile abnormalities of myocytes from failing human left ventricle. Cardiovasc Res. 30:281-290.
  • Ferrara N; O'Gara P; Wynne DG; Brown LA; del Monte F; Poole-Wilson PA; Harding SE. (May 1995). Decreased contractile responses to isoproterenol in isolated cardiac myocytes from aging guinea-pigs. J Mol Cell Cardiol. 27:1141-1150.
  • Harding SE; Davies CH; Wynne DG; Poole-Wilson PA. (Dec 1994). Contractile function and response to agonists in myocytes from failing human heart. Eur Heart J. 15 Suppl D:35-36.
  • Harding SE; Brown LA; Wynne DG; Davies CH; Poole-Wilson PA. (Oct 1994). Mechanisms of beta adrenoceptor desensitisation in the failing human heart. Cardiovasc Res. 28:1451-1460.
  • Jiang C; Mochizuki S; Poole-Wilson PA; Harding SE; MacLeod KT. (Jun 1994). Effect of lemakalim on action potentials, intracellular calcium, and contraction in guinea pig and human cardiac myocytes. Cardiovasc Res. 28:851-857.
  • Naqvi RU; del Monte F; O'Gara P; Harding SE; MacLeod KT. (May 1994). Characteristics of myocytes isolated from hearts of renovascular hypertensive guinea pigs. Am J Physiol. 266:H1886-H1895.
  • NISHIKAWA M; MAK JCW; SHIRASAKI H; HARDING SE; BARNES PJ. (Jan 1994). LONG-TERM EXPOSURE TO NOREPINEPHRINE RESULTS IN DOWN-REGULATION AND REDUCED MESSENGER-RNA EXPRESSION OF PULMONARY BETA-ADRENERGIC RECEPTORS IN GUINEA-PIGS. AM J RESP CELL MOL. 10:91-99.
  • del Monte F; Kaumann AJ; Poole-Wilson PA; Wynne DG; Pepper J; Harding SE. (Sep 1993). Coexistence of functioning beta 1- and beta 2-adrenoceptors in single myocytes from human ventricle. Circulation. 88:854-863.
  • Wynne DG; Poole-Wilson PA; Harding SE. (Aug 1993). Incomplete reversal of beta-adrenoceptor desensitization in human and guinea-pig cardiomyocytes by cyclic nucleotide phosphodiesterase inhibitors. Br J Pharmacol. 109:1071-1078.
  • Brady AJ; Warren JB; Poole-Wilson PA; Williams TJ; Harding SE. (Jul 1993). Nitric oxide attenuates cardiac myocyte contraction. Am J Physiol. 265:H176-H182.
  • Brady AJ; Poole-Wilson PA; Harding SE; Warren JB. (Dec 1992). Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia. Am J Physiol. 263:H1963-H1966.
  • Harding SE; Jones SM; Vescovo G; Del Monte F; Poole-Wilson PA. (13 Nov 1992). Reduced contractile responses to forskolin and a cyclic AMP analogue in myocytes from failing human ventricle. Eur J Pharmacol. 223:39-48.
  • Amrani M; O'Shea J; Allen NJ; Harding SE; Jayakumar J; Pepper JR; Moncada S; Yacoub MH. (Oct 1992). Role of basal release of nitric oxide on coronary flow and mechanical performance of the isolated rat heart. J Physiol. 456:681-687.
  • Harding SE; Jones SM; O'Gara P; del Monte F; Vescovo G; Poole-Wilson PA. (May 1992). Isolated ventricular myocytes from failing and non-failing human heart; the relation of age and clinical status of patients to isoproterenol response. J Mol Cell Cardiol. 24:549-564.
  • MacLeod KT; Harding SE. (Dec 1991). Effects of phorbol ester on contraction, intracellular pH and intracellular Ca2+ in isolated mammalian ventricular myocytes. J Physiol. 444:481-498.
  • Harding SE; MacLeod KT; Jones SM; Vescovo G; Poole-Wilson PA. (Aug 1991). Contractile responses of myocytes isolated from patients with cardiomyopathy. Eur Heart J. 12 Suppl D:44-48.
  • Harding SE; Gurden JM; Poole-Wilson PA. (Jun 1991). A comparison of contractile function between papillary muscles and isolated myocytes from the same human hearts. Cardioscience. 2:141-146.
  • del Monte F; Harding SE; Puddu PE; Poole-Wilson PA. (Apr 1991). [Isolated cardiac myocytes: preparation and use in experimental cardiology]. Cardiologia. 36:319-329.
  • Jones SM; Hunt NA; Del Monte F; Harding SE. (27 Nov 1990). Contraction of cardiac myocytes from noradrenaline-treated rats in response to isoprenaline, forskolin and dibutyryl cAMP. Eur J Pharmacol. 191:129-140.
  • Jones SM; Kirby MS; Harding SE; Vescova G; Wanless RB; Dalla Libera LD; Poole-Wilson PA. (Oct 1990). Adriamycin cardiomyopathy in the rabbit: alterations in contractile proteins and myocyte function. Cardiovasc Res. 24:834-842.
  • Harding SE; Jones SM; O'Gara P; Vescovo G; Poole-Wilson PA. (Oct 1990). Reduced beta-agonist sensitivity in single atrial cells from failing human hearts. Am J Physiol. 259:H1009-H1014.
  • Moody CJ; Dashwood MR; Sykes RM; Chester M; Jones SM; Yacoub MH; Harding SE. (Sep 1990). Functional and autoradiographic evidence for endothelin 1 receptors on human and rat cardiac myocytes. Comparison with single smooth muscle cells. Circ Res. 67:764-769.
  • Gailis L; Nayler WG; Harding SE. (Aug 1990). Reversible elimination of myofibrillar Ca2+ sensitivity by diamide and other sulfhydryl reagents: comparison with reversible contracture produced in intact cells. Can J Physiol Pharmacol. 68:1170-1175.
  • Harding SE; O'Gara P; Jones SM; Brown LA; Vescovo G; Poole-Wilson PA. (Mar 1990). Species dependence of contraction velocity in single isolated cardiac myocytes. Cardioscience. 1:49-53.
  • Vescovo G; Harding SE; Jones M; Dalla Libera L; Pessina AC; Poole-Wilson PA. (Dec 1989). Contractile abnormalities of single right ventricular myocytes isolated from rats with right ventricular hypertrophy. J Mol Cell Cardiol. 21 Suppl 5:103-111.
  • Harding SE; Vescovo G; Jones SM; Bennett G; Yacoub M; Poole-Wilson PA. (Nov 1989). Morphological and functional characteristics of myocytes isolated from human left ventricular aneurysms. J Pathol. 159:191-196. DOI.
  • Vescovo G; Jones SM; Harding SE; Poole-Wilson PA. (Oct 1989). Isoproterenol sensitivity of isolated cardiac myocytes from rats with monocrotaline-induced right-sided hypertrophy and heart failure. J Mol Cell Cardiol. 21:1047-1061.
  • Vescovo G; Harding SE; Jones SM; Dalla Libera L; Pessina AC; Poole-Wilson PA. (Sep 1989). Comparison between isomyosin pattern and contractility of right ventricular myocytes isolated from rats with right cardiac hypertrophy. Basic Res Cardiol. 84:536-543.

Conferences

  • Rees PSC; Davidson SM; Harding SE; Elliott PM; Hausenloy DJ; Yellon DM. The Mitochondrial Permeability Transition Pore is a Target for Pharmacological Cardioprotection in Human Hypertrophic Cardiomyopathy. 58:B119-B119. (8 Nov 2011).
  • Reed DM; Foldes G; Gatheral T; Badiger RV; Wheeler-Jones CP; Ali NN; Harding SE; Mitchell JA. ENDOTHELIN-1 RELEASE FROM HUMAN EMBRYONIC STEM CELL DERIVED-ENDOTHELIAL CELLS (HESC-EC): COMPARISONS WITH HUMAN ENDOTHELIAL CELLS. 60:224-224. (Jun 2011).
  • Rees PSC; Davidson SM; Harding SE; Elliott PM; Yellon DM; Hausenloy DJ. The mitochondrial permeability transition pore is a functional target for cardioprotection in human hypertrophic cardiomyopathy. 31:925-925. (Sep 2010).
  • Jawad H; El Fray M; Boccaccini AR; Harding SE; Wright JS; Chen QZ; Piegat A; Ali NN. Nanocomposite Elastomeric Biomaterials for Myocardial Tissue Engineering Using Embryonic Stem Cell-derived Cardiomyocytes. 12:B664-B674. (Dec 2010). DOI.
  • Mioulane M; Foldes G; Ali NN; Harding SE. Cardiomyocytes derived from human embryonic stem cells as an alternative model for cardiotoxicity and contractility studies. 87:S110-S110. (Jul 2010).
  • Foldes G; Mioulane M; Iqbal A; Schneider MD; Ali NN; Harding SE. Growth and proliferative activity of human embryonic stem cell-derived cardiomyocytes is modulated in a calcineurin-NFAT-dependent manner. 87:S111-S111. (Jul 2010).
  • Paur HE; Nikolaev V; Lyon A; Harding SE. Stress cardiomyopathy: a role for stimulus trafficking at the beta-2 adrenoceptor in cardiac depression?. 87:S127-S127. (Jul 2010).
  • Lyon AR; Bannister ML; Coward E; Dubb SS; Garcia E; Kohlbrenner E; Hajjar RJ; Harding SE; et alMacleod KM. STABILISATION OF SR LEAK IN HEART FAILURE AFTER SERCA2A GENE THERAPY. 96:A10-A10. (Jun 2010). DOI.
  • Lyon AR; Bannister ML; Kohlbrenner E; Hajjar RJ; Harding SE; Macleod KT. Stabilisation of SR Leak in Heart Failure After SERCA2a Gene Therapy. 21:503-503. (Apr 2010).
  • Song W; Stuckey DJ; Dyer E; Wells D; Harding SE; Carr CA; Clarke K; Marston SB. PHENOTYPE OF THE ACTC E99K TRANSGENIC MOUSE REPRODUCES HYPERTROPHIC CARDIOMYOPATHY IN PATIENTS. 96. (Feb 2010). DOI.
  • Lyon AR; Coward E; Dubb S; Garcia E; Liang LF; Kohlbrenner E; Hajjar RJ; Peters NS; et alHarding SE; Macleod KT. Stabilisation of SR Leak in Heart Failure After SERCA2a Gene Therapy. 120:S688-S689. (3 Nov 2009).
  • Lyon AR; Macleod KT; Dubb S; Sepehripour A; Poole-Wilson PA; Peters NS; Harding SE. Opposing Influences Of Serca2a Gene Transfer Upon Catecholamine-induced Ventricular Arrhythmias In Normal And Failing Hearts. 118:S527-S527. (28 Oct 2008).
  • Song WH; Dyer E; Wells D; Harding SE; Stuckey DJ; Carr CA; Clarke K; Marston SB. Mouse Model of Familial Hypertrophic Cardiomyopathy with E99K ACTC Mutation Recapitulates Many Features of Hypertrophic Cardiomyopathy in Patients. 118:S521-S521. (28 Oct 2008).
  • Park JES; Lyon AR; Harding SE; Griffiths MJD. MECHANICAL STIMULATION OF HUMAN LUNG MICROVASCULAR ENDOTHELIAL CELLS CAUSES REMODELLING OF THE ALVEOLAR-CAPILLARY MEMBRANE AND DYSPNOEA IN CHRONIC HEART FAILURE. 63:A27-A28. (Dec 2008).
  • Lyon AR; Sepehripour AH; Dubb S; Macleod K; Poole-Wilson PA; Peters NS; Harding SE. Heterogeneous SERCA2a transfection reduces spontaneous and inducible ventricular arrhythmias in the rat model of heart failure. Annual Scientific Conference of the British-Cardiovascular-Society. 94:A7-A7. (Jul 2008).
  • Jawad H; Harding SE; Piegat A; El Fray M; Boccaccini AR; Ali NN. Myocardial tissue engineering using ES cell-derived cardiomyocytes and elastomeric polymers. Annual Tissue-Engineering-and-Regenerative-Medicine-International-Society-European-Chapter Meeting. 14:759-759. (May 2008).
  • Sato M; O'Gara P; Fuller SJ; Harding SE. Protective effects of limited in vivo gene transfer of phospholamban antisense in a catecholamine induced hypertrophic rat heart model. 10:473-474. (Apr 2008).
  • Lyon AR; Sepehripour AH; Poole-Wilson PA; Peters NS; Harding SE. Heterogeneous SERCA2a transfection reduces spontaneous and inducible ventricular arrhythmias in the post-myocardial infarction rat heart. Autumn Meeting of the British-Society-for-Cardiovascular-Research. 94:U175-U175. (Feb 2008).
  • Terracciano CMN; Payne J; Harding SE; Ali NN. Human embryonic stem cell-derived cardiomyocytes as a model for assessing HERG channel blockade. 94. (Feb 2008).
  • Chena QZ; Wright JS; Harding SE; Junaid S; Hansen U; Jawad H; Boccaccini AR; Ali NN. Heart tissue engineering using a novel elastomer and ES-derived cardiac cells. Conference of the Tissue-Engineering-and-Regenerative-Medicine-International-Society (TERMIS-EU). 13:1703-1703. (Jul 2007).
  • Gorelik J; Yang L; Zhang Y; Lab M; Korcbev YE; del Monte F; Harding SE. A novel Z-groove index characterizing myocardial surface structure and its modification in failing human heart. 42:S153-S153. (Jun 2007). DOI.
  • Siedlecka U; Arora M; Soppa GKR; Lee J; Stagg MA; Harding SE; Yacoub MH; Terracciano CMN. Clenbuterol affects rat ventricular myocyie contractility via an inhibitory G protein-mediated pathway. 19th World Congress of the ISHR. 42:S49-S49. (Jun 2007).
  • Lyon AR; Poole-Wilson PA; Peters NS; Harding SE. Differential effects of SERCA2a transfection on ventricular arrhythmia susceptibility in the normal rat heart. 42:S20-S20. (Jun 2007). DOI.
  • Carr CA; Stuckey DJ; Tatton L; Tyler DJ; Harding SE; Clarke K. MRI tracking of systemically administered bone marrow stem cells. 19th World Congress of the ISHR. 42:S88-S89. (Jun 2007).
  • Johnson WB; Katugampola S; Napier C; Harding SE. Phosphodiesterase activity in isolated cardiomyocytes from rat, guinea pig and human heart. 19th World Congress of the ISHR. 42:S116-S116. (Jun 2007).
  • Wright J; Ahmet S; Harding SE; Ali NN. Responses to endothelin in human embryonic stem cell-derived cardiomyocytes. 42:S88-S88. (Jun 2007). DOI.
  • Zheng ZL; O'Gara P; Petrou M; Harding SE. Different effects of carvedilol, propranolol and ICI 118 551 on activation of p38 MAP kinase through the beta(2)-adrenoceptor in human myocardium. 28th Annual International-Society-for-Heart-Research North American Section Meeting. 40:952-953. (Jun 2006).
  • Johnson WB; Katugampola S; Napier C; Harding SE. Effects of phosphodiesterase inhibitors on the contraction of myocytes from rat, guinea pig and human ventricle. 28th Annual International-Society-for-Heart-Research North American Section Meeting. 40:954-954. (Jun 2006).
  • Patel TA; Mitchell JA; Warner TD; Harding SE. Gram positive bacteria reduce viability and contraction of isolated cardiomyocytes: Role of endothelin-1. 28th Annual International-Society-for-Heart-Research North American Section Meeting. 40:1007-1007. (Jun 2006).
  • Yang LQ; Gorelik J; Korchev Y; Harding SE. Increase in beta(1)AR-Gi coupling after detubulation in rat ventricular myocytes. 40:923-924. (Jun 2006). DOI.
  • Sato M; O'Gara P; Fuller SJ; Harding SE. Interaction between in vivo gene transfer of phospholamban antisense and catecholamine infusion in rat heart. 38:1064-1064. (Jun 2005).
  • Zheng Z; O'Gara P; Lee J; Terracciano CMN; Harding SE. Interaction of Na+/Ca2+ exchanger with B2Ar/Gi pathway in rat ventricular myocytes. 25th Annual Scientific Session of the European Section of the International-Society-Heart-Research. 38:1084-1085. (Jun 2005).
  • Franklin JL; Pathan N; Levin M; Harding SE. Myocardial depression by IL-6 is reversed by P38 MAP kinase inhibition. 25th Annual Scientific Session of the European Section of the International-Society-Heart-Research. 38:1021-1021. (Jun 2005).
  • Duclohier HPM; Gorelik J; Yang LQ; Harding SE; Korchev YE. Distribution of sodium channels in ventricular heart cells. 88:378A-378A. (Jan 2005).
  • Malik AH; Khan SG; Harding SE; Terracciano CMN. Overexpression of Na/K ATPase alpha-1 and 2 subunits differentially affects calcium regulation in rat ventricular myocytes. 49th Annual Meeting of the Biopysical-Society. 88:297A-297A. (Jan 2005).
  • Scoote M; MacLeod KT; Harding SE; Kingsbury MP; Turner MA; Sheridan DJ; Williams AJ. Sarcolemmal L-type calcium channel : Intracellular calcium release channel (ryanodine receptor) stoichiometry is reduced in pressure overload heart failure but not in chronic catecholaminergic exposure. 49th Annual Meeting of the Biopysical-Society. 88:487A-488A. (Jan 2005).
  • Zheng ZL; Gong HB; Yang LQ; Petrou M; Harding SE. p38-MAPK signaling pathway plays an important role in the acute negative inotropic effect of beta-blockers in human ventricular myocytes. 110:91-92. (26 Oct 2004).
  • Zheng Z; Gong H; Petrou M; Yang LQ; Harding SE. Acute negative inotropic effect of beta(2)AR-blockers through p38-MAPK signaling pathway in human ventricular myocytes. 8th Annual Scientific Sessions of the Latin American Section of the International-Society-for-Heart-Research. 37:297-298. (Jul 2004).
  • Harding SE. Does beta-blocker-mediated stimulation of gi contribute to recovery mechanisms?. 37:324-325. (Jul 2004).
  • Scoote M; Harding SE; MacLeod KT; Kingsbury MP; Sheridan DJ; Williams AJ. Altered cardiac ryanodine receptor: dihydropyridine receptor stoichiometry in an experimental model of heart failure. 24th Annual Scientific Sessions of the European-Section of the International-Society-for-Heart-Research. 36:732-732. (May 2004).
  • Ali NN; Xu X; Martins M; Poole-Wilson PA; Harding SE; Fuller SJ. Characterisation of beta-adrenoceptor responses in mouse embryonic stem cell-derived cardiomyocytes. 24th Annual Scientific Sessions of the European-Section of the International-Society-for-Heart-Research. 36:731-732. (May 2004).
  • Scoote M; Harding SE; MacLeod KT; Kingsbury MP; Sheridan DJ; Williams AJ. Functional characteristics of the cardiac ryanodine receptor in an experimental model of heart failure. 24th Annual Scientific Sessions of the European-Section of the International-Society-for-Heart-Research. 36:757-758. (May 2004).
  • Harding SE. Modulation of contractility by gene therapy. 24th Annual Scientific Sessions of the European-Section of the International-Society-for-Heart-Research. 36:731-731. (May 2004).
  • Harding SE. beta-blockers as activators of Gi-coupled pathways in the failing human heart. Fetzer-Institiute Conference on Religiosity and Substance Use. 35:A43-A43. (Nov 2003).
  • Harding SE. Interaction between NCX, SERCA2a and beta AR changes in heart failure investigated by adenoviral gene transfer. Fetzer-Institiute Conference on Religiosity and Substance Use. 35:A13-A13. (Nov 2003).
  • Sato M; Terracciano CM; Ranu HK; Harding SE. Beta2-adrenoceptor coupling to the Na/Ca exchanger depresses contraction in adult rat ventricular myocytes. 108:179-180. (28 Oct 2003).
  • Terracciano CM; Birks E; Hardy J; Harding SE; Tansley P; Barton PJ; Yacoub MH. Clinical recovery with successful LVAD explantation correlates with increased sarcoplasmic reticulum (SR) Ca content but not with regression of cellular hypertrophy. 108:430-430. (28 Oct 2003).
  • Lewis CJ; Koch WJ; Brown MJ; Harding SE. Adenovirally-overexpressed beta 1- and beta 2-adrenoceptors enhances the contractile response to CGP 12177A in adult rat cardiomyocytes. Meeting of the British-Pharmacological-Society-Clinical-Pharmacology-Section. 138:U9-U9. (Apr 2003).
  • Gong HB; Lewis CJ; Terracciano CMN; Koch WJ; O'Gara P; Brown MJ; Harding SE. Adenovirally-overexpressed beta(1)ARs activate contraction by a non-cyclic AMP-dependent pathway in adult rat myocytes. 84:397A-397A. (Feb 2003).
  • Lewis CJ; Gong H; Koch WJ; Brown MJ; Harding SE. Adenovirally-overexpressed beta 2-adrenoceptors enhance the contractile response to CGP 12177A in adult rat cardiomyocytes. Meeting of the British-Pharmacological-Society. 137:U4-U4. (Dec 2002).
  • Chaudhri B; Hajjar RJ; Harding SE; Terracciano CMN. Effects of over-expression of SERCA2a on action potential duration, Ca2+ entry and sarcoplasmic reticulum Ca2+ content in rabbit ventricular myocytes. 536:74P-74P. (Nov 2001).
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