Dr Suet-Ping Wong

Suet Ping Wong is currently working as a Post-Doctoral Research Associate within the Gene Therapy group in the National Heart and Lung Institute.

Suet Ping obtained her BSc degree in Biomedical Sciences from King's College London and then went on to complete a MSc degree in Human Molecular Genetics at Imperial College. Following this, she undertook her PhD in Imperial College researching non-viral vector for gene therapy with a particular focus on the application of gene vectors harbouring a Scaffold Matrix Attachment Region (S/MAR). This research enabled the development and optimisation of gene vectors that are able to provide physiologically relevant levels of transgene expression for inherited liver disorders.

Since completion of her PhD, she has been working on applying S/MAR-based vectors to other disease models. Specifically, her current research is aimed towards providing a mutation-proof copy of the folliculin gene into renal cells of Birt-Hogg-Dubé (BHD) patients to investigate its resistance to BHD-associated renal neoplasia. She is also working on developing technologies for delivery of these gene vectors to renal cells.

Selected Publications

Wong SP; Argyros O; Howe SJ; Harbottle RP. (March 2011). Systemic gene transfer of polyethylenimine (PEI)-plasmid DNA complexes to neonatal mice. Journal of controlled release : official journal of the Controlled Release Society. Publisher weblink DOI.

Wong SP; Argyros O; Coutelle C; Harbottle RP. (Jan 2011). Non-viral S/MAR vectors replicate episomally in vivo when provided with a selective advantage. Gene Ther. 18:82-87. DOI.

Argyros O; Wong SP; Harbottle RP. (May 2011). Non-viral episomal modifcation of cells using S/MAR elements. Expert Opinion Biol Ther. May 9. Publisher weblink DOI

Wong SP; Argyros O; Harbottle RP. (Aug 2009) Strategies for episomal modification of cells. Curr Opin Mol Ther.11(4):433-41

Argyros O; Wong SP; Niceta M; Waddington SN; Howe SJ; Coutelle C; Miller AD; Harbottle RP. (Dec 2008).Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector. Gene Ther. 15:1593-1605. DOI.