Professor Timothy J Aitman

Publications


Journals

  • Simonis M; Atanur SS; Linsen SE; Guryev V; Ruzius FP; Game L; Lansu N; de Bruijn E; et alvan Heesch S; Jones SJ; Pravenec M; Aitman TJ; Cuppen E. (27 Apr 2012). Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel. Genome Biol. 13:R31. DOI.
  • Vernon KA; Goicoechea de Jorge E; Hall AE; Fremeaux-Bacchi V; Aitman TJ; Cook HT; Hangartner R; Koziell A; et alPickering MC. (12 Apr 2012). Acute Presentation and Persistent Glomerulonephritis Following Streptococcal Infection in a Patient With Heterozygous Complement Factor H-Related Protein 5 Deficiency. Am J Kidney Dis. DOI.
  • Cook HT; Tarzi R; D'Souza Z; Laurent G; Lin W-C; Aitman TJ; Mechta-Grigoriou F; Behmoaras J. (1 Jul 2011). AP-1 Transcription Factor JunD Confers Protection from Accelerated Nephrotoxic Nephritis and Control Podocyte-Specific Vegfa Expression. AMERICAN JOURNAL OF PATHOLOGY. 179:134-140. DOI.
  • Page TH; D'Souza Z; Nakanishi S; Serikawa T; Pusey CD; Aitman TJ; Cook HT; Behmoaras J. (17 Feb 2012). Role of novel rat-specific Fc receptor in macrophage activation associated with crescentic glomerulonephritis. J Biol Chem. 287:5710-5719. DOI.
  • Morrissey C; Grieve IC; Heinig M; Atanur S; Petretto E; Pravenec M; Hubner N; Aitman TJ. (7 Nov 2011). Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat. Physiol Genomics. 43:1207-1218. DOI.
  • Aitman TJ; Boone C; Churchill GA; Hengartner MO; Mackay TF; Stemple DL. (Aug 2011). The future of model organisms in human disease research. Nat Rev Genet. 12:575-582. DOI.
  • Clark SJ; Falchi M; Olsson B; Jacobson P; Cauchi S; Balkau B; Marre M; Lantieri O; et alAndersson JC; Jernås M; Aitman TJ; Richardson S; Sjöström L; Wong HY; Carlsson LM; Froguel P; Walley AJ. (Jan 2012). Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity. Obesity (Silver Spring). 20:178-185. DOI.
  • Cook HT; Tarzi R; D'Souza Z; Laurent G; Lin WC; Aitman TJ; Mechta-Grigoriou F; Behmoaras J. (Jul 2011). AP-1 transcription factor JunD confers protection from accelerated nephrotoxic nephritis and control podocyte-specific Vegfa expression. Am J Pathol. 179:134-140. DOI.
  • Molokhia M; Fanciulli M; Petretto E; Patrick AL; McKeigue P; Roberts AL; Vyse TJ; Aitman TJ. (Jul 2011). FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans. Rheumatology (Oxford). 50:1206-1210. DOI.
  • Heinig M; Petretto E; Wallace C; Bottolo L; Rotival M; Lu H; Li Y; Sarwar R; et alLangley SR; Bauerfeind A; Hummel O; Lee YA; Paskas S; Rintisch C; Saar K; Cooper J; Buchan R; Gray EE; Cyster JG; Cardiogenics Consortium; Erdmann J; Hengstenberg C; Maouche S; Ouwehand WH; Rice CM; Samani NJ; Schunkert H; Goodall AH; Schulz H; Roider HG; Vingron M; Blankenberg S; Münzel T; Zeller T; Szymczak S; Ziegler A; Tiret L; Smyth DJ; Pravenec M; Aitman TJ; Cambien F; Clayton D; Todd JA; Hubner N; Cook SA. (23 Sep 2010). A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature. 467:460-464. DOI.
  • Behmoaras J; Smith J; D'Souza Z; Bhangal G; Chawanasuntoropoj R; Tam FW; Pusey CD; Aitman TJ; et alCook HT. (Jul 2010). Genetic loci modulate macrophage activity and glomerular damage in experimental glomerulonephritis. J Am Soc Nephrol. 21:1136-1144. DOI.
  • McKinney C; Fanciulli M; Merriman ME; Phipps-Green A; Alizadeh BZ; Koeleman BP; Dalbeth N; Gow PJ; et alHarrison AA; Highton J; Jones PB; Stamp LK; Steer S; Barrera P; Coenen MJ; Franke B; van Riel PL; Vyse TJ; Aitman TJ; Radstake TR; Merriman TR. (Sep 2010). Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Ann Rheum Dis. 69:1711-1716. DOI.
  • Atanur SS; Birol I; Guryev V; Hirst M; Hummel O; Morrissey C; Behmoaras J; Fernandez-Suarez XM; et alJohnson MD; McLaren WM; Patone G; Petretto E; Plessy C; Rockland KS; Rockland C; Saar K; Zhao Y; Carninci P; Flicek P; Kurtz T; Cuppen E; Pravenec M; Hubner N; Jones SJ; Birney E; Aitman TJ. (Jun 2010). The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance. Genome Res. 20:791-803. DOI.
  • Morris DL; Roberts AL; Witherden AS; Tarzi R; Barros P; Whittaker JC; Cook TH; Aitman TJ; et alVyse TJ. (Sep 2010). Evidence for both copy number and allelic (NA1/NA2) risk at the FCGR3B locus in systemic lupus erythematosus. Eur J Hum Genet. 18:1027-1031. DOI.
  • Petretto E; Bottolo L; Langley SR; Heinig M; McDermott-Roe C; Sarwar R; Pravenec M; Hübner N; et alAitman TJ; Cook SA; Richardson S. (Apr 2010). New insights into the genetic control of gene expression using a Bayesian multi-tissue approach. PLoS Comput Biol. 6:e1000737. DOI Open Access copy.
  • Jirout ML; Friese RS; Mahapatra NR; Mahata M; Taupenot L; Mahata SK; Kren V; Zídek V; et alFischer J; Maatz H; Ziegler MG; Pravenec M; Hubner N; Aitman TJ; Schork NJ; O'Connor DT. (1 Jul 2010). Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat. Hum Mol Genet. 19:2567-2580. DOI.
  • Grieve IC; Dickens NJ; Pravenec M; Kren V; Hubner N; Cook SA; Aitman TJ; Petretto E; et alMangion J. (29 Dec 2008). Genome-Wide Co-Expression Analysis in Multiple Tissues. PLOS ONE. 3. Author weblink DOI.
  • Fanciulli M; Petretto E; Aitman TJ. (Mar 2010). Gene copy number variation and common human disease. Clin Genet. 77:201-213. DOI.
  • Aitman TJ; Petretto E; Behmoaras J. (2010). Genetic mapping and positional cloning. Methods Mol Biol. 597:13-32. DOI.
  • McBride MW; McClure JD; Gilday K; Khanin R; Maratou K; Aitman TJ; Graham D; Dominiczak AF. (1 Oct 2009). Dissecting microRNA and mRNA regulatory networks in cardiac hypertrophy. JOURNAL OF HUMAN HYPERTENSION. 23:705-705. Author weblink.
  • Johnson MD; He L; Herman D; Wakimoto H; Wallace CA; Zidek V; Mlejnek P; Musilova A; et alSimakova M; Vorlicek J; Kren V; Viklicky O; Qi NR; Wang J; Seidman CE; Seidman J; Kurtz TW; Aitman TJ; Pravenec M. (Sep 2009). Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat. Hypertension. 54:639-645. DOI.
  • Fanciulli M; Vyse TJ; Aitman TJ. (2008). Copy number variation of Fc gamma receptor genes and disease predisposition. Cytogenet Genome Res. 123:161-168. DOI.
  • Schaschl H; Aitman TJ; Vyse TJ. (Apr 2009). Copy number variation in the human genome and its implication in autoimmunity. Clin Exp Immunol. 156:12-16. DOI.
  • Pravenec M; Churchill PC; Churchill MC; Viklicky O; Kazdova L; Aitman TJ; Petretto E; Hubner N; et alWallace CA; Zimdahl H; Zidek V; Landa V; Dunbar J; Bidani A; Griffin K; Qi N; Maxova M; Kren V; Mlejnek P; Wang J; Kurtz TW. (1 Aug 2008). Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. NATURE GENETICS. 40:952-954. Author weblink DOI.
  • Behmoaras J; Bhangal G; Smith J; McDonald K; Mutch B; Lai PC; Domin J; Game L; et alSalama A; Foxwell BM; Pusey CD; Cook HT; Aitman TJ. (1 May 2008). Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. NATURE GENETICS. 40:553-559. Author weblink DOI.
  • Aitman TJ; Critser JK; Cuppen E; Dominiczak A; Fernandez-Suarez XM; Flint J; Gauguier D; Geurts AM; et alGould M; Harris PC; Holmdahl R; Hubner N; Izsvák Z; Jacob HJ; Kuramoto T; Kwitek AE; Marrone A; Mashimo T; Moreno C; Mullins J; Mullins L; Olsson T; Pravenec M; Riley L; Saar K; Serikawa T; Shull JD; Szpirer C; Twigger SN; Voigt B; Worley K. (May 2008). Progress and prospects in rat genetics: a community view. Nat Genet. 40:516-522. DOI.
  • Petretto E; Sarwar R; Grieve I; Lu H; Kumaran MK; Muckett PJ; Mangion J; Schroen B; et alBenson M; Punjabi PP; Prasad SK; Pennell DJ; Kiesewetter C; Tasheva ES; Corpuz LM; Webb MD; Conrad GW; Kurtz TW; Kren V; Fischer J; Hubner N; Pinto YM; Pravenec M; Aitman TJ; Cook SA. (May 2008). Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass. Nat Genet. 40:546-552. DOI.
  • Pravenec M; Kazdova L; Landa V; Zidek V; Mlejnek P; Simakova M; Jansa P; Forejt J; et alKren V; Krenova D; Qi N; Wang JM; Chan D; Aitman TJ; Kurtz TW. (Jan 2008). Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat. Hypertension. 51:148-153. DOI.
  • Bernichtein S; Petretto E; Jamieson S; Goel A; Aitman TJ; Mangion JM; Huhtaniemi IT. (Feb 2008). Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci. Endocrinology. 149:651-661. DOI.
  • Petretto E; Liu ET; Aitman TJ. (Nov 2007). A gene harvest revealing the archeology and complexity of human disease. Nat Genet. 39:1299-1301. DOI.
  • Martin CA; Longman E; Wooding C; Hoosdally SJ; Ali S; Aitman TJ; Gutmann DA; Freemont PS; et alByrne B; Linton KJ. (Nov 2007). Cd36, a class B scavenger receptor, functions as a monomer to bind acetylated and oxidized low-density lipoproteins. Protein Sci. 16:2531-2541. DOI.
  • Fanciulli M; Norsworthy PJ; Petretto E; Dong R; Harper L; Kamesh L; Heward JM; Gough SC; et alde Smith A; Blakemore AI; Froguel P; Owen CJ; Pearce SH; Teixeira L; Guillevin L; Graham DS; Pusey CD; Cook HT; Vyse TJ; Aitman TJ. (Jun 2007). FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet. 39:721-723. DOI.
  • Bell CG; Meyre D; Petretto E; Levy-Marchal C; Hercberg S; Charles MA; Boyle C; Weill J; et alTauber M; Mein CA; Aitman TJ; Froguel P; Walley AJ. (Mar 2007). No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases. Eur J Hum Genet. 15:320-327. DOI.
  • Petretto E; Mangion J; Dickens NJ; Cook SA; Kumaran MK; Lu H; Fischer J; Maatz H; et alKren V; Pravenec M; Hubner N; Aitman TJ. (20 Oct 2006). Heritability and tissue specificity of expression quantitative trait loci. PLoS Genet. 2:e172. DOI.
  • Petretto E; Mangion J; Cook SA; Aitman TJ; Pravenec M; Schulz H; Fischer J; Hubner N. (Aug 2006). Reply to "Normalization procedures and detection of linkage signal in genetical-genomics experiments". Nat Genet. 38:858-859. Publisher weblink DOI.
  • Petretto E; Mangion J; Pravanec M; Hubner N; Aitman TJ. (12 Jun 2006). Integrated gene expression profiling and linkage analysis in the rat. Mamm Genome. Publisher weblink DOI.
  • Petretto E; Mangion J; Pravanec M; Hubner N; Aitman TJ. (Jun 2006). Integrated gene expression profiling and linkage analysis in the rat. Mamm Genome. 17:480-489. DOI.
  • Parry S; Hadaschik D; Blancher C; Kumaran MK; Bochkina N; Morris HR; Richardson S; Aitman TJ; et alGauguier D; Siddle K; Scott J; Dell A. (Apr 2006). Glycomics investigation into insulin action. Biochim Biophys Acta. 1760:652-668. DOI.
  • Aitman TJ; Dong R; Vyse TJ; Norsworthy PJ; Johnson MD; Smith J; Mangion J; Roberton-Lowe C; et alMarshall AJ; Petretto E; Hodges MD; Bhangal G; Patel SG; Sheehan-Rooney K; Duda M; Cook PR; Evans DJ; Domin J; Flint J; Boyle JJ; Pusey CD; Cook HT. (16 Feb 2006). Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature. 439:851-855. DOI.
  • Mueller M; Goel A; Thimma M; Dickens NJ; Aitman TJ; Mangion J. (15 Feb 2006). eQTL Explorer: integrated mining of combined genetic linkage and expression experiments. Bioinformatics. 22:509-511. DOI.
  • Hubner N; Wallace CA; Zimdahl H; Petretto E; Schulz H; Maciver F; Mueller M; Hummel O; et alMonti J; Zidek V; Musilova A; Kren V; Causton H; Game L; Born G; Schmidt S; Müller A; Cook SA; Kurtz TW; Whittaker J; Pravenec M; Aitman TJ. (Mar 2005). Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet. 37:243-253. DOI.
  • Wallace CA; Aitman TJ. (May 2004). The rat comes clean. Nat Genet. 36:441-442. DOI.
  • Aitman TJ. (22 May 2003). Genetic medicine and obesity. N Engl J Med. 348:2138-2139. DOI.
  • Englyst NA; Taube JM; Aitman TJ; Baglin TP; Byrne CD. (May 2003). A novel role for CD36 in VLDL-enhanced platelet activation. Diabetes. 52:1248-1255.
  • Pravenec M; Wallace C; Aitman TJ; Kurtz TW. (Jan 2003). Gene expression profiling in hypertension research: a critical perspective. Hypertension. 41:3-8.
  • Glazier AM; Nadeau JH; Aitman TJ. (20 Dec 2002). Finding genes that underlie complex traits. Science. 298:2345-2349. DOI.
  • Curtis BR; Ali S; Glazier AM; Ebert DD; Aitman TJ; Aster RH. (Sep 2002). Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature. Transfusion. 42:1173-1179.
  • Wallace CA; Ali S; Glazier AM; Norsworthy PJ; Carlos DC; Scott J; Freeman TC; Stanton LW; et alKwitek AE; Aitman TJ. (Apr 2002). Radiation hybrid mapping of 70 rat genes from a data set of differentially expressed genes. Mamm Genome. 13:194-197. DOI.
  • Glazier AM; Scott J; Aitman TJ. (Feb 2002). Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism. Mamm Genome. 13:108-113. DOI.
  • Reynolds J; Cook PR; Ryan JJ; Norsworthy PJ; Glazier AM; Duda MA; Evans DJ; Aitman TJ; et alPusey CD. (2002). Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Col4a3 as a candidate gene. Exp Nephrol. 10:402-407.
  • Curtis BR; Ali S; Aitman TJ; Ebert DD; Lenes BA; Aster RH. (16 Nov 2001). Maternal isoimmunization against CD36 (GPIV) should be considered in unresolved cases of apparent immune neonatal thrombocytopenia. BLOOD. 98:710A-710A. Author weblink.
  • Aitman TJ. (15 Sep 2001). DNA microarrays in medical practice. BMJ. 323:611-615.
  • Aitman TJ. (15 Sep 2001). Science, medicine, and the future - DNA microarrays in medical practice. BRITISH MEDICAL JOURNAL. 323:611-615. Author weblink DOI.
  • Aitman TJ; Wallace CA; Glazier AM; Norsworthy PJ; Gray JK; Ali S; Stanton LW; Scott J. (1 Jun 2001). Combined linkage analysis and microarray-based expression profiling for identification of complex trait genes. DIABETES. 50:A77-A77. Author weblink.
  • Aitman TJ. (3 Mar 2001). CD36, insulin resistance, and coronary heart disease. Lancet. 357:651-652. DOI.
  • Pravenec M; Landa V; Zidek V; Musilova A; Kren V; Kazdova L; Aitman TJ; Glazier AM; et alIbrahimi A; Abumrad NA; Qi N; Wang JM; St Lezin EM; Kurtz TW. (Feb 2001). Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Nat Genet. 27:156-158. DOI.
  • Collison M; Glazier AM; Graham D; Morton JJ; Dominiczak MH; Aitman TJ; Connell JM; Gould GW; et alDominiczak AF. (Dec 2000). Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat. Diabetes. 49:2222-2226.
  • Aitman TJ; Cooper LD; Norsworthy PJ; Wahid FN; Gray JK; Curtis BR; McKeigue PM; Kwiatkowski D; et alGreenwood BM; Snow RW; Hill AV; Scott J. (29 Jun 2000). Malaria susceptibility and CD36 mutation. Nature. 405:1015-1016. DOI.
  • Aitman TJ; Cooper LD; Norsworthy PJ; Wahid FN; Gray JK; Curtis BR; McKeigue PM; Kwiatkowski D; et alGreenwood BM; Snow RW; Hill AV; Scott J. (29 Jun 2000). Population genetics - Malaria susceptibility and CD36 mutation. NATURE. 405:1015-1016. Author weblink DOI.
  • Collison M; Glazier AM; Graham D; Morton I; Dominiczak MH; Aitman TJ; Connell JMC; Dominiczak AF; et alGould GW. (1 May 2000). Cd36 and the molecular basis of insulin resistance in the stroke-prone spontaneously hypertensive rat. DIABETES. 49:A211-A211. Author weblink.
  • de Silva AM; Walder KR; Aitman TJ; Gotoda T; Goldstone AP; Hodge AM; de Courten MP; Zimmet PZ; et alCollier GR. (Aug 1999). Combination of polymorphisms in OB-R and the OB gene associated with insulin resistance in Nauruan males. Int J Obes Relat Metab Disord. 23:816-822.
  • Pravenec M; Zidek V; Simakova M; Kren V; Krenova D; Horky K; Jachymova M; Mikova B; et alKazdova L; Aitman TJ; Churchill PC; Webb RC; Hingarh NH; Yang Y; Wang JM; Lezin EM; Kurtz TW. (Jun 1999). Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension. J Clin Invest. 103:1651-1657. DOI.
  • al-Majali KM; Glazier AM; Norsworthy PJ; Wahid FN; Cooper LD; Wallace CA; Scott J; Lausen B; et alAitman TJ. (May 1999). A high-resolution radiation hybrid map of the proximal region of rat chromosome 4. Mamm Genome. 10:471-476.
  • Brosnan MJ; Clark JS; Jeffs B; Negrin CD; Van Vooren P; Arribas SM; Carswell H; Aitman TJ; et alSzpirer C; Macrae IM; Dominiczak AF. (Jan 1999). Genes encoding atrial and brain natriuretic peptides as candidates for sensitivity to brain ischemia in stroke-prone hypertensive rats. Hypertension. 33:290-297.
  • Aitman TJ; Glazier AM; Wallace CA; Cooper LD; Norsworthy PJ; Wahid FN; Al-Majali KM; Trembling PM; et alMann CJ; Shoulders CC; Graf D; St Lezin E; Kurtz TW; Kren V; Pravenec M; Ibrahimi A; Abumrad NA; Stanton LW; Scott J. (Jan 1999). Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet. 21:76-83. DOI.
  • Aitman TJ; Pravenec M; Kurtz TW; Scott J. (Nov 1998). The spontaneously hypertensive rat: a model to dissect cellular defects in glucose and fatty acid metabolism. Pathol Biol (Paris). 46:693-694.
  • Kooner JS; Baliga RR; Wilding J; Crook D; Packard CJ; Banks LM; Peart S; Aitman TJ; et alScott J. (Jul 1998). Abdominal obesity, impaired nonesterified fatty acid suppression, and insulin-mediated glucose disposal are early metabolic abnormalities in families with premature myocardial infarction. Arterioscler Thromb Vasc Biol. 18:1021-1026.
  • Trembling PM; Boyton RJ; Evans AL; Wallace CA; Medbak SH; Scott J; Aitman TJ. (21 Oct 1997). Identification of a quantitative trait locus for catecholamine secretion in the spontaneously hypertensive rat. CIRCULATION. 96:561-561. Author weblink.
  • Gotoda T; Scott J; Aitman TJ. (Aug 1997). Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin. Diabetologia. 40:976-979. DOI.
  • Reynolds J; Newman VO; Aitman TJ; Evans DJ; Pusey CD. (1 Jul 1997). Genetic analysis of susceptibility to EAG in Wister Kyoto rats. KIDNEY INTERNATIONAL. 52:268-268. Author weblink.
  • Gotoda T; Manning BS; Goldstone AP; Imrie H; Evans AL; Strosberg AD; McKeigue PM; Scott J; et alAitman TJ. (Jun 1997). Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum Mol Genet. 6:869-876.
  • Aitman TJ; Gotoda T; Evans AL; Imrie H; Heath KE; Trembling PM; Truman H; Wallace CA; et alRahman A; Doré C; Flint J; Kren V; Zidek V; Kurtz TW; Pravenec M; Scott J. (Jun 1997). Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Nat Genet. 16:197-201. DOI.
  • Aitman TJ; Godsland IF; Farren B; Crook D; Wong HJ; Scott J. (Apr 1997). Defects of insulin action on fatty acid and carbohydrate metabolism in familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 17:748-754.
  • Aitman TJ; Imrie H; Evans AL; Truman H; Gotoda T; Scott J. (15 Oct 1996). Genetic analysis of insulin action in spontaneously hypertensive rats. CIRCULATION. 94:3676-3676. Author weblink.
  • KOONER JS; BALIGA RR; WILDING J; PEART S; AITMAN TJ; SCOTT J. (15 Oct 1995). METABOLIC PHENOTYPES FOR GENETIC-ANALYSIS IN CORONARY HEART-DISEASE. CIRCULATION. 92:76-76. Author weblink.
  • Aitman TJ; Todd JA. (Jul 1995). Molecular genetics of diabetes mellitus. Baillieres Clin Endocrinol Metab. 9:631-656.
  • PEARCE SHS; AITMAN TJ. (21 Sep 1994). ADVANCES IN THE MOLECULAR-BASIS OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS. BRITISH JOURNAL OF HOSPITAL MEDICINE. 52:291-294. Author weblink.
  • Todd JA; Reed PW; Prins JB; Bain SC; Palmer SM; Cordell HJ; Pritchard LE; Ghosh S; et alCornall RJ; Aitman TJ. (1993). Dissection of the pathophysiology of type 1 diabetes by genetic analysis. Autoimmunity. 15 Suppl:16-17.
  • McAleer MA; Aitman TJ; Cornall RJ; Ghosh S; Hall JR; Hearne CM; Love JM; Prins JB; et alRamachandran S; Rodrigues N. (1992). Linkage analysis of 84 microsatellite markers in intra- and interspecific backcrosses. Mamm Genome. 3:457-460.
  • Cornall RJ; Aitman TJ; Hearne CM; Todd JA. (Aug 1991). The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome. Genomics. 10:874-881.
  • Todd JA; Aitman TJ; Cornall RJ; Ghosh S; Hall JR; Hearne CM; Knight AM; Love JM; et alMcAleer MA; Prins JB. (13 Jun 1991). Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature. 351:542-547. DOI.
  • Todd JA; Aitman TJ; Cornall RJ; Ghosh S; Hall J; Hearne CM; Knight A; Love J; et alMcAleer MA; Prins JB. (Jun 1991). Genetic analysis of a complex, multifactorial disease, autoimmune type 1 (insulin-dependent) diabetes. Res Immunol. 142:483.
  • Hearne CM; McAleer MA; Love JM; Aitman TJ; Cornall RJ; Ghosh S; Knight AM; Prins JB; et alTodd JA. (1991). Additional microsatellite markers for mouse genome mapping. Mamm Genome. 1:273-282.
  • Aitman TJ; Hearne CM; McAleer MA; Todd JA. (1991). Mononucleotide repeats are an abundant source of length variants in mouse genomic DNA. Mamm Genome. 1:206-210.
  • PRINS JB; AITMAN TJ; CORNALL RJ; GOSH S; HALL J; HEARNE CM; KNIGHT AM; LOVE JM; et alMCALEER MA; RODRIGUES NR; LATHROP M; PRESSEY A; DELARENTO NH; PETERSON LB; WICKER LS; TODD JA. (1 Jan 1991). THE LOCALIZATION OF 2 SUSCEPTIBILITY GENES FOR INSULIN-DEPENDENT DIABETES IN THE NONOBESE DIABETIC MOUSE. CYTOGENETICS AND CELL GENETICS. 58:2137-2138. Author weblink.
  • HEARNE CM; AITMAN TJ; PRINS JB; RODRIGUEZ N; LOVE JM; BAIN SC; TODD JA. (1 Jan 1991). TRI AND TETRANUCLEOTIDE MICROSATELLITES FOR LINKAGE ANALYSIS OF TYPE-1 DIABETES. CYTOGENETICS AND CELL GENETICS. 58:1896-1896. Author weblink.
  • Jones AJ; Aitman TJ; Edmonds CJ; Burke M; Hudson E; Tellez M. (Nov 1990). Comparison of fine needle aspiration cytology, radioisotopic and ultrasound scanning in the management of thyroid nodules. Postgrad Med J. 66:914-917.
  • Aitman TJ; Palmer RG; Loftus J; Ansell BM; Royston JP; Teale JD; Clayton RN. (Sep 1989). Serum IGF-I levels and growth failure in juvenile chronic arthritis. Clin Exp Rheumatol. 7:557-561.
  • Oliver JE; Aitman TJ; Powell JF; Wilson CA; Clayton RN. (Jun 1989). Insulin-like growth factor I gene expression in the rat ovary is confined to the granulosa cells of developing follicles. Endocrinology. 124:2671-2679.
  • Aitman TJ; Rafferty B; Coy D; Lynch SS; Clayton RN. (Jan 1989). Bioactivity of growth hormone releasing hormone (1-29) analogues after SC injection in man. Peptides. 10:1-4.
  • Baudouin SV; Aitman TJ; Johnson AJ. (May 1988). Prazosin in the treatment of chronic asthma. Thorax. 43:385-387.
  • AITMAN TJ; COY D; RAFFERTY B; LYNCH SS; CLAYTON RN. (1 Nov 1986). GROWTH-HORMONE RESPONSES TO 2 GRF1-29 PEPTIDES IN NORMAL SUBJECTS. JOURNAL OF ENDOCRINOLOGY. 111:74-74. Author weblink.
  • Scott DL; Bradby GV; Aitman TJ; Zaphiropoulos GC; Hawkins CF. (Apr 1981). Relationship of gold and penicillamine therapy to diffuse interstitial lung disease. Ann Rheum Dis. 40:136-141.
  • Aitman TJ; Hudlicka O; Tyler KR. (Oct 1979). Long-term effects of tetanic stimulation on blood flow, metabolism and performance of fast skeletal muscle [proceedings]. J Physiol. 295:36P-37P.
  • AITMAN TJ; HUDLICKA O; TYLER KR. (1 Jan 1979). LONG-TERM EFFECTS OF TETANIC STIMULATION ON BLOOD-FLOW, METABOLISM AND PERFORMANCE OF FAST SKELETAL-MUSCLES. JOURNAL OF PHYSIOLOGY-LONDON. 295:P36-P37. Author weblink.

Conferences

  • Sarwar R; Petretto E; Grieve IC; Lu H; Kumaran MK; Muckett PJ; Mangion J; Schroen B; et alBenson M; Punjabi PP; Prasad SK; Pennell DJ; Kiesewetter C; Tasheva ES; Conrad GW; Kurtz TW; Fischer J; Hubner N; Pinto YM; Kren V; Pravenec M; Aitman TJ; Cook SA. INTEGRATED GENOMICS APPROACHES IDENTIFY OSTEOGLYCIN AS A REGULATOR OF LEFT VENTRICULAR MASS. Annual Scientific Conference of the British-Cardiovascular-Society, 1 Jun 2009 - 3 Jun 2009. 95:A4-A4. B M J PUBLISHING GROUP (1 Jun 2009). Author weblink.
  • Reynolds J; Tadros S; Smith J; Cook PR; Bhangal G; Salama AD; Aitman TJ; Cook HT; et alPusey CD. Genetic susceptibility to experimental autoimmune glomerulonephritis in congenic rats. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:36-37. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2008). Author weblink.
  • Sarwar R; Petretto E; Lu H; Schroen B; Kumaran MK; Grieve IC; Fischer J; Hubner N; et alMangion J; Pinto YM; Pravenec M; Aitman TJ; Cook SA. Integrated genetic linkage analysis and expression profiling in the rat heart to identify primary drivers of cardiac hypertrophy. 80th Annual Scientific Session of the American-Heart-Association. 116:142-142. (16 Oct 2007).
  • Aitman TJ. Genomic approaches to dissecting complex phenotypes. IUBMB 50th Anniversary Symposium. 272:117-117. (Jul 2005).
  • Aitman TJ. What can genetics offer in understanding the pathogenesis of coronary heart disease?. 75th Congress of the European-Atherosclerosis-Society, 23 Apr 2005 - 26 Apr 2005. 6:38-39. ELSEVIER IRELAND LTD (1 Apr 2005). Author weblink.
  • Hubner N; Wallace CA; Zimdahl H; Maciver F; Schulz H; Hummel O; Monti J; Zidek V; et alKren V; Petretto E; Pravenec M; Aitman TJ. Integrated gene expression profiling and linkage mapping in rat recombinant inbred strains. 9th Annual Meeting of the European Council for Cardiovascular Research, 1 Oct 2004 - 3 Oct 2004. 44:544-544. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2004). Author weblink.
  • Aitman TJ. Genetics of metabolic syndrome X and implications for therapy. 13th International Symposium on Atherosclerosis, 28 Sep 2003 - 2 Oct 2003. 4:93-93. ELSEVIER SCI IRELAND LTD (1 Sep 2003). Author weblink DOI.
  • TODD JA; AITMAN TJ; CORNALL RJ; GHOSH S; HALL J; HEARNE CM; KNIGHT A; LOVE J; et alMCALEER MA; PRINS JB; LATHROP M; PETERSON L; WICKER L. GENETIC-ANALYSIS OF A COMPLEX, MULTIFACTORIAL DISEASE, AUTOIMMUNE TYPE-1 (INSULIN-DEPENDENT) DIABETES. INTERNATIONAL SYMP ON IR GENES : FROM BIOLOGY TO MEDICINE, 31 Oct 1990 - 2 Nov 1990. 142:483-483. EDITIONS SCIENTIFIQUES ELSEVIER (1 Jun 1991). Author weblink DOI.

Patents

  • Methods of Gene Mapping & Disease Diagnosis.
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