Professor Timothy J Williams

Publications


Journals

  • Meiser A; Mueller A; Wise EL; McDonagh EM; Petit SJ; Saran N; Clark PC; Williams TJ; et alPease JE. (15 May 2008). The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor. JOURNAL OF IMMUNOLOGY. 180:6713-6724. Author weblink.
  • Mueller A; Meiser A; McDonagh EM; Fox JM; Petit SJ; Xanthou G; Williams TJ; Pease JE. (Apr 2008). CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3. J Leukoc Biol. 83:875-882. DOI.
  • Wise EL; Duchesnes C; da Fonseca PCA; Allen RA; Williams TJ; Pease JE. (21 Sep 2007). Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation. JOURNAL OF BIOLOGICAL CHEMISTRY. 282:27935-27943. Author weblink DOI.
  • Weller,CL; Collington,SJ; Hartnell,A; Conroy,DM; Kaise,T; Barker,JE; Wilson,MS; Taylor,GW; et alJose,PJ; Williams,TJ. (10 Jul 2007). Chemotactic action of prostaglandin E2 on mouse mast cells acting via the PGE2 receptor 3. Proceedings of the National Academy of Sciences USA. 104:11712-11717.
  • Pease JE; Williams TJ. (1 Aug 2006). Chemokines and their receptors in allergic disease. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 118:305-318. Author weblink DOI.
  • Duchesnes CE; Murphy PM; Williams TJ; Pease JE. (Mar 2006). Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines. Mol Immunol. 43:1221-1231. DOI.
  • Williams TJ; Weller CL. (2006). Population of lungs by mast cells. Novartis Found Symp. 279:142-150.
  • Pease JE; Williams TJ. (1 Jan 2006). The attraction of chemokines as a target for specific anti-inflammatory therapy. BRITISH JOURNAL OF PHARMACOLOGY. 147:S212-S221. Author weblink DOI.
  • Erin EM; Leaker BR; Zacharasiewicz AS; Higgins LA; Williams TJ; Boyce MJ; de Boer P; Durham SR; et alBarnes PJ; Hansel TT. (Dec 2005). Single dose topical corticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challenge. Allergy. 60:1524-1529. DOI.
  • Erin EM; Zacharasiewicz AS; Nicholson GC; Tan AJ; Higgins LA; Williams TJ; Murdoch RD; Durham SR; et alBarnes PJ; Hansel TT. (Dec 2005). Topical corticosteroid inhibits interleukin-4, -5 and -13 in nasal secretions following allergen challenge. Clin Exp Allergy. 35:1608-1614. DOI.
  • Weller CL; Collington SJ; Brown JK; Miller HR; Al-Kashi A; Clark P; Jose PJ; Hartnell A; et alWilliams TJ. (20 Jun 2005). Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors. J Exp Med. 201:1961-1971. DOI.
  • Sabroe I; Jorritsma A; Stubbs VE; Xanthou G; Jopling LA; Ponath PD; Williams TJ; Murphy PM; et alPease JE. (Apr 2005). The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner. Eur J Immunol. 35:1301-1310. DOI.
  • Weller CL; Jose PJ; Williams TJ. (Mar 2005). Selective suppression of leukocyte recruitment in allergic inflammation. Mem Inst Oswaldo Cruz. 100 Suppl 1:153-160.
  • de Mendonça FL; da Fonseca PC; Phillips RM; Saldanha JW; Williams TJ; Pease JE. (11 Feb 2005). Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist. J Biol Chem. 280:4808-4816. DOI.
  • Hartnell A; Heinemann A; Conroy DM; Wait R; Sturm GJ; Caversaccio M; Jose PJ; Williams TJ. (15 Nov 2004). Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2. J Immunol. 173:6448-6457.
  • Medeiros AI; Malheiro A; Jose PJ; Conroy DM; Williams TJ; Faccioli LH. (Aug 2004). Differential release of MIP-1alpha and eotaxin during infection of mice by Histoplasma capsulatum or inoculation of beta-glucan. Inflamm Res. 53:351-354. DOI.
  • Williams TJ. (Feb 2004). The eosinophil enigma. J Clin Invest. 113:507-509. DOI.
  • Buckland KF; Williams TJ; Conroy DM. (Nov 2003). Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. Br J Pharmacol. 140:1117-1127. DOI.
  • Erjefalt JS; Korsgren M; Malm-Erjefalt M; Conroy DM; Williams TJ; Persson CGA. (1 Oct 2003). Acute allergic responses induce a prompt luminal entry of airway tissue eosinophils. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 29:439-448. Author weblink DOI.
  • Conroy DM; Jopling LA; Lloyd CM; Hodge MR; Andrew DP; Williams TJ; Pease JE; Sabroe I. (Oct 2003). CCR4 blockade does not inhibit allergic airways inflammation. J Leukoc Biol. 74:558-563. DOI.
  • Martin C; Burdon PC; Bridger G; Gutierrez-Ramos JC; Williams TJ; Rankin SM. (Oct 2003). Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. Immunity. 19:583-593.
  • Xanthou G; Williams TJ; Pease JE. (Oct 2003). Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation. Eur J Immunol. 33:2927-2936. DOI.
  • Xanthou G; Duchesnes CE; Williams TJ; Pease JE. (Aug 2003). CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11. Eur J Immunol. 33:2241-2250. DOI.
  • Phillips RM; Stubbs VE; Henson MR; Williams TJ; Pease JE; Sabroe I. (15 Jun 2003). Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter. J Immunol. 170:6190-6201.
  • Culley FJ; Fadlon EJ; Kirchem A; Williams TJ; Jose PJ; Pease JE. (May 2003). Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines. Eur J Immunol. 33:1302-1310. DOI.
  • Larbi KY; Dangerfield JP; Culley FJ; Marshall D; Haskard DO; Jose PJ; Williams TJ; Nourshargh S. (Jan 2003). P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses. J Leukoc Biol. 73:65-73.
  • Pease JE; Weller CL; Williams TJ. (2003). Regulation of eosinophil trafficking in asthma and allergy. E SCHERING RES FDN W. 45:85-100.
  • Falcão PL; Correa-Oliveira R; Fraga LA; Talvani A; Proudfoot AE; Wells TN; Williams TJ; Jose PJ; et alTeixeira MM. (1 Dec 2002). Plasma concentrations and role of macrophage inflammatory protein-1alpha during chronic Schistosoma mansoni infection in humans. J Infect Dis. 186:1696-1700. DOI.
  • Menzies-Gow A; Ying S; Sabroe I; Stubbs VL; Soler D; Williams TJ; Kay AB. (1 Sep 2002). Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers. J Immunol. 169:2712-2718.
  • Stubbs VE; Schratl P; Hartnell A; Williams TJ; Peskar BA; Heinemann A; Sabroe I. (19 Jul 2002). Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils. J Biol Chem. 277:26012-26020. DOI.
  • Nouri-Aria KT; Wilson D; Francis JN; Jopling LA; Jacobson MR; Hodge MR; Andrew DP; Till SJ; et alVarga EM; Williams TJ; Pease JE; Lloyd CM; Sabroe I; Durham SR. (Jul 2002). CCR4 in human allergen-induced late responses in the skin and lung. Eur J Immunol. 32:1933-1938. DOI.
  • Bryan SA; Jose PJ; Topping JR; Wilhelm R; Soderberg C; Kertesz D; Barnes PJ; Williams TJ; et alHansel TT; Sabroe I. (15 Jun 2002). Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 165:1602-1609.
  • Erin EM; Williams TJ; Barnes PJ; Hansel TT. (Jun 2002). Eotaxin receptor (CCR3) antagonism in asthma and allergic disease. Curr Drug Targets Inflamm Allergy. 1:201-214.
  • Williams TJ. (15 May 2002). Stalking the chemokine. Am J Respir Crit Care Med. 165:1350-1351.
  • Culley FJ; Brown A; Girod N; Pritchard DI; Williams TJ. (May 2002). Innate and cognate mechanisms of pulmonary eosinophilia in helminth infection. Eur J Immunol. 32:1376-1385. DOI.
  • Banwell ME; Tolley NS; Williams TJ; Mitchell TJ. (21 Mar 2002). Regulation of human eotaxin-3/CCL26 expression: modulation by cytokines and glucocorticoids. Cytokine. 17:317-323. DOI.
  • Jopling LA; Sabroe I; Andrew DP; Mitchell TJ; Li Y; Hodge MR; Williams TJ; Pease JE. (1 Mar 2002). The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody. J Biol Chem. 277:6864-6873. DOI.
  • Sabroe I; Lloyd CM; Whyte MK; Dower SK; Williams TJ; Pease JE. (Feb 2002). Chemokines, innate and adaptive immunity, and respiratory disease. Eur Respir J. 19:350-355.
  • Chadwick SL; Walker S; Muramaki K; Heinemann A; Hartnell A; Williams TJ; Durham SR; Sabroe I. (1 Dec 2001). Basophil gated fluorescence/forward scatter (bGFS) assay for the investigation of IgE mediated allergic responses and its comparison to skin prick testing. THORAX. 56:34-34. Author weblink.
  • Penido C; Castro-Faria-Neto HC; Vieira-de-Abreu A; Figueiredo RT; Pelled A; Martins MA; Jose PJ; Williams TJ; et alBozza PT. (Dec 2001). LPS induces eosinophil migration via CCR3 signaling through a mechanism independent of RANTES and Eotaxin. Am J Respir Cell Mol Biol. 25:707-716.
  • Martinelli R; Sabroe I; LaRosa G; Williams TJ; Pease JE. (16 Nov 2001). The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b. J Biol Chem. 276:42957-42964. DOI.
  • Au BT; Teixeira MM; Collins PD; Williams TJ. (3 Aug 2001). Blockade of PAF receptors controls interleukin-8 production by regulating the activation of neutrophil CD11/CD18. Eur J Pharmacol. 425:65-71.
  • Pease JE; Williams TJ. (Jun 2001). Eotaxin and asthma. Curr Opin Pharmacol. 1:248-253.
  • Sabroe I; Williams TJ; Pease JE. (Apr 2001). Roles of chemokines in the regulation of leucocyte recruitment. Clin Sci (Lond). 100:359-362.
  • Till S; Jopling L; Wachholz P; Robson R; Qin S; Andrew D; Wu L; van Neerven J; et alWilliams T; Durham S; Sabroe I. (15 Feb 2001). T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4. J Immunol. 166:2303-2310.
  • Menzies-Gow A; Sabroe I; Meng Q; Soler D; Clarke-Lewis I; Williams TJ; Ying S; Kay AB. (1 Feb 2001). Intracutaneous eotaxin and eotaxin-2 induces the local accumulation of eosinophils, basophils, macrophages and neutrophils in human atopic and non-atopic subjects. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 107:S324-S324. Author weblink.
  • Conroy DM; Williams TJ. (2001). Eotaxin and the attraction of eosinophils to the asthmatic lung. Respir Res. 2:150-156.
  • Williams TJ; Jose PJ. (2001). Neutrophils in chronic obstructive pulmonary disease. Novartis Found Symp. 234:136-141.
  • Heinemann A; Hartnell A; Stubbs VE; Murakami K; Soler D; LaRosa G; Askenase PW; Williams TJ; et alSabroe I. (15 Dec 2000). Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling. J Immunol. 165:7224-7233.
  • Culley FJ; Brown A; Conroy DM; Sabroe I; Pritchard DI; Williams TJ. (1 Dec 2000). Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo. J Immunol. 165:6447-6453.
  • Serra MF; Diaz BL; Barreto EO; Cordeiro RS; Nazaré Meirelles MN; Williams TJ; Martins MA; Silva PM. (Dec 2000). Mechanism underlying acute resident leukocyte disappearance induced by immunological and non-immunological stimuli in rats: evidence for a role for the coagulation system. Inflamm Res. 49:708-713.
  • Sabroe I; Hartnell A; Williams TJ; Heinemann A. (1 Dec 2000). Regulation of basophil chemokine responses by sequential and co-operative receptor signalling. THORAX. 55:A21-A21. Author weblink.
  • Mitchell TJ; Walley AJ; Pease JE; Venables PJW; Wiltshire S; Williams TJ; Cookson WOCM. (28 Oct 2000). Delta 32 deletion of CCR5 gene and association with asthma or atopy. LANCET. 356:1491-1492. Author weblink DOI.
  • Sabroe I; Pease JE; Williams TJ. (1 Sep 2000). Asthma and MIF: innately Th1 and Th2. CLINICAL AND EXPERIMENTAL ALLERGY. 30:1194-1196. Author weblink.
  • Sabroe I; Peck MJ; Van Keulen BJ; Jorritsma A; Simmons G; Clapham PR; Williams TJ; Pease JE. (25 Aug 2000). A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem. 275:25985-25992. DOI.
  • Rankin SM; Conroy DM; Williams TJ. (Jan 2000). Eotaxin and eosinophil recruitment: implications for human disease. Mol Med Today. 6:20-27.
  • Sanz MJ; Jose PJ; Williams TJ. (2000). Measurement of eosinophil accumulation in vivo. Methods Mol Biol. 138:275-283. DOI.
  • Williams TJ; Jose PJ. (2000). Role of eotaxin and related CC chemokines in allergy and asthma. Chem Immunol. 78:166-177.
  • Sabroe I; Hartnell A; Jopling LA; Bel S; Ponath PD; Pease JE; Collins PD; Williams TJ. (1 Mar 1999). Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways. J Immunol. 162:2946-2955.
  • Nagai K; Larkin S; Hartnell A; Larbi K; Razi Aghakhani M; Windley C; Davies D; Lobb RR; et alWilliams TJ; Nourshargh S. (Feb 1999). Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of alpha4 integrins and vascular cell adhesion molecule-1. Immunology. 96:176-183.
  • Barkans J; Meng Q; Jose PJ; Smith S; Williams TJ; Robinson DS; Kay AB; Ying S. (1 Jan 1999). Effects of cytokines on eotaxin production by human endothelial cell line and human umbilical vein endothelial cells (HUVEC). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 103:S48-S48. Author weblink.
  • Sabroe I; Conroy DM; Gerard NP; Li Y; Collins PD; Post TW; Jose PJ; Williams TJ; et alGerard CJ; Ponath PD. (1 Dec 1998). Cloning and characterization of the guinea pig eosinophil eotaxin receptor, C-C chemokine receptor-3: blockade using a monoclonal antibody in vivo. J Immunol. 161:6139-6147.
  • Palframan RT; Collins PD; Severs NJ; Rothery S; Williams TJ; Rankin SM. (2 Nov 1998). Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J Exp Med. 188:1621-1632.
  • Evans CA; Garcia HH; Hartnell A; Gilman RH; Jose PJ; Martinez M; Remick DG; Williams TJ; et alFriedland JS. (Sep 1998). Elevated concentrations of eotaxin and interleukin-5 in human neurocysticercosis. Infect Immun. 66:4522-4525.
  • Palframan RT; Collins PD; Williams TJ; Rankin SM. (1 Apr 1998). Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow. Blood. 91:2240-2248.
  • Sanz MJ; Ponath PD; Mackay CR; Newman W; Miyasaka M; Tamatani T; Flanagan BF; Lobb RR; et alWilliams TJ; Nourshargh S; Jose PJ. (1 Apr 1998). Human eotaxin induces alpha 4 and beta 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4. J Immunol. 160:3569-3576.
  • Au BT; Teixeira MM; Collins PD; Williams TJ. (Mar 1998). Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol. Br J Pharmacol. 123:1260-1266. DOI.
  • Mitchell JA; Bishop-Bailey D; Evans TW; Giembycz MA; Belvisi MG; Chivers S; Williams TJ; Pepper JR. (1 Mar 1998). Release of neutrophil activating cytokines by human arterial and venous smooth muscle cells. BRITISH JOURNAL OF PHARMACOLOGY. 123:U56-U56. Author weblink.
  • Alcamí A; Symons JA; Collins PD; Williams TJ; Smith GL. (15 Jan 1998). Blockade of chemokine activity by a soluble chemokine binding protein from vaccinia virus. J Immunol. 160:624-633.
  • Williams CMM; Newton DJ; Wilson SA; Williams TJ; Coleman JW; Flanagan BF. (1 Jan 1998). Conserved structure and tissue expression of rat eotaxin. IMMUNOGENETICS. 47:178-180. Author weblink.
  • Ying S; Robinson DS; Meng Q; Rottman J; Kennedy R; Ringler DJ; Mackay CR; Daugherty BL; et alSpringer MS; Durham SR; Williams TJ; Kay AB. (Dec 1997). Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol. 27:3507-3516. DOI.
  • Boshoff C; Endo Y; Collins PD; Takeuchi Y; Reeves JD; Schweickart VL; Siani MA; Sasaki T; et alWilliams TJ; Gray PW; Moore PS; Chang Y; Weiss RA. (10 Oct 1997). Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. SCIENCE. 278:290-294. Author weblink DOI.
  • Teixeira MM; Wells TN; Lukacs NW; Proudfoot AE; Kunkel SL; Williams TJ; Hellewell PG. (1 Oct 1997). Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin. J Clin Invest. 100:1657-1666. DOI.
  • Li D; Wang D; Griffiths-Johnson DA; Wells TN; Williams TJ; Jose PJ; Jeffery PK. (Sep 1997). Eotaxin protein and gene expression in guinea-pig lungs: constitutive expression and upregulation after allergen challenge. Eur Respir J. 10:1946-1954.
  • Humbles AA; Conroy DM; Marleau S; Rankin SM; Palframan RT; Proudfoot AE; Wells TN; Li D; et alJeffery PK; Griffiths-Johnson DA; Williams TJ; Jose PJ. (18 Aug 1997). Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo. J Exp Med. 186:601-612.
  • Mitchell JA; Williams FM; Williams TJ; Larkin SW. (Aug 1997). Role of nitric oxide in the dilator actions of capsaicin-sensitive nerves in the rabbit coronary circulation. Neuropeptides. 31:333-338.
  • Norman KE; Williams TJ; Rossi AG. (Apr 1997). Comparison of the reversed passive Arthus and local Shwartzman reactions of rabbit skin: effects of the long-acting PAF antagonist UK-74,505. Br J Pharmacol. 120:1286-1293. DOI.
  • Sabroe I; Williams TJ; Hébert CA; Collins PD. (1 Feb 1997). Chemoattractant cross-desensitization of the human neutrophil IL-8 receptor involves receptor internalization and differential receptor subtype regulation. J Immunol. 158:1361-1369.
  • Rajakulasingam K; Hamid Q; O'Brien F; Shotman E; Jose PJ; Williams TJ; Jacobson M; Barkans J; et alDurham SR. (Feb 1997). RANTES in human allergen-induced rhinitis: cellular source and relation to tissue eosinophilia. Am J Respir Crit Care Med. 155:696-703.
  • Griffiths-Johnson DA; Collins PD; Jose PJ; Williams TJ. (1997). Animal models of asthma: role of chemokines. Methods Enzymol. 288:241-266.
  • Teixeira MM; Williams TJ; Hellewell PG. (1997). Description of an in vivo model for the assessment of eosinophil chemoattractants in the mouse. Mem Inst Oswaldo Cruz. 92 Suppl 2:211-214.
  • Conroy DM; Humbles AA; Rankin SM; Palframan RT; Collins PD; Griffiths-Johnson DA; Jose PJ; Williams TJ. (1997). The role of the eosinophil-selective chemokine, eotaxin, in allergic and non-allergic airways inflammation. Mem Inst Oswaldo Cruz. 92 Suppl 2:183-191.
  • Marleau S; Griffiths-Johnson DA; Collins PD; Bakhle YS; Williams TJ; Jose PJ. (1 Nov 1996). Human RANTES acts as a receptor antagonist for guinea pig eotaxin in vitro and in vivo. J Immunol. 157:4141-4146.
  • Wakelin MW; Sanz MJ; Dewar A; Albelda SM; Larkin SW; Boughton-Smith N; Williams TJ; Nourshargh S. (1 Jul 1996). An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane. J Exp Med. 184:229-239.
  • Fallon PG; Teixeira MM; Neice CM; Williams TJ; Hellewell PG; Doenhoff MJ. (1 Jun 1996). Enhancement of Schistosoma mansoni infectivity by intradermal injections of larval extracts: A putative role for larval proteases. JOURNAL OF INFECTIOUS DISEASES. 173:1460-1466. Author weblink.
  • Teixeira MM; Williams TJ; Hellewell PG. (May 1996). Effects of dexamethasone and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig. Br J Pharmacol. 118:317-324.
  • Miotla JM; Williams TJ; Hellewell PG; Jeffery PK. (Apr 1996). A role for the beta2 integrin CD11b in mediating experimental lung injury in mice. Am J Respir Cell Mol Biol. 14:363-373.
  • Teixeira MM; Williams TJ; Hellewell PG. (Dec 1995). Mechanisms and pharmacological manipulation of eosinophil accumulation in vivo. Trends Pharmacol Sci. 16:418-423.
  • Nourshargh S; Williams TJ. (Dec 1995). Molecular and cellular interactions mediating granulocyte accumulation in vivo. Semin Cell Biol. 6:317-326.
  • Mitchell JA; Larkin S; Williams TJ. (9 Nov 1995). Cyclooxygenase-2: regulation and relevance in inflammation. Biochem Pharmacol. 50:1535-1542.
  • Collins PD; Marleau S; Griffiths-Johnson DA; Jose PJ; Williams TJ. (1 Oct 1995). Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med. 182:1169-1174.
  • Berkman N; Jose PJ; Williams TJ; Schall TJ; Barnes PJ; Chung KF. (Oct 1995). Corticosteroid inhibition of macrophage inflammatory protein-1 alpha in human monocytes and alveolar macrophages. Am J Physiol. 269:L443-L452.
  • Belvisi M; Barnes PJ; Larkin S; Yacoub M; Tadjkarimi S; Williams TJ; Mitchell JA. (5 Sep 1995). Nitric oxide synthase activity is elevated in inflammatory lung disease in humans. Eur J Pharmacol. 283:255-258.
  • Ivey CL; Williams FM; Collins PD; Jose PJ; Williams TJ. (Jun 1995). Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8. J Clin Invest. 95:2720-2728. DOI.
  • Kwon OJ; Jose PJ; Robbins RA; Schall TJ; Williams TJ; Barnes PJ. (May 1995). Glucocorticoid inhibition of RANTES expression in human lung epithelial cells. Am J Respir Cell Mol Biol. 12:488-496.
  • Nourshargh S; Larkin SW; Das A; Williams TJ. (1 May 1995). Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor. Blood. 85:2553-2558.
  • Walsh DT; Weg VB; Williams TJ; Nourshargh S. (Apr 1995). Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br J Pharmacol. 114:1343-1350.
  • Teixeira MM; Williams TJ; Hellewell PG. (16 Jan 1995). Anti-inflammatory effects of a short-acting and a long-acting beta 2-adrenoceptor agonist in guinea pig skin. Eur J Pharmacol. 272:185-193.
  • Williams TJ; Griffiths-Johnson DA; Jose PJ; Collins PD. (1995). Eosinophil chemoattractants generated in vivo. Agents Actions Suppl. 46:1-9.
  • Larkin SW; Fraser L; Showell HJ; Williams TJ; Warren JB. (Jan 1995). Prolonged microvascular vasodilation induced by leukotriene B4 in human skin is cyclooxygenase independent. J Pharmacol Exp Ther. 272:392-398.
  • Teixeira MM; Fairbairn SM; Norman KE; Williams TJ; Rossi AG; Hellewell PG. (Dec 1994). Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators. Br J Pharmacol. 113:1363-1371.
  • Jose PJ; Adcock IM; Griffiths-Johnson DA; Berkman N; Wells TN; Williams TJ; Power CA. (30 Nov 1994). Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs. Biochem Biophys Res Commun. 205:788-794.
  • Weg VB; Watson ML; Faccioli LH; Williams TJ. (Sep 1994). Investigation of the endogenous chemoattractants involved in 111In-eosinophil accumulation in passive cutaneous anaphylactic reactions in the guinea-pig. Br J Pharmacol. 113:35-42.
  • Pons F; Williams TJ; Kirk SA; McDonald F; Rossi AG. (22 Aug 1994). Pro-inflammatory and anti-inflammatory effects of the stable prostaglandin D2 analogue, ZK 118.182. Eur J Pharmacol. 261:237-247.
  • Teixeira MM; Rossi AG; Williams TJ; Hellewell PG. (May 1994). Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig. Br J Pharmacol. 112:332-340.
  • Jose PJ; Griffiths-Johnson DA; Collins PD; Walsh DT; Moqbel R; Totty NF; Truong O; Hsuan JJ; et alWilliams TJ. (1 Mar 1994). Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med. 179:881-887.
  • Teixeira MM; Reynia S; Robinson M; Shock A; Williams TJ; Williams FM; Rossi AG; Hellewell PG. (Mar 1994). Role of CD18 in the accumulation of eosinophils and neutrophils and local oedema formation in inflammatory reactions in guinea-pig skin. Br J Pharmacol. 111:811-818.
  • Griffiths-Johnson DA; Collins PD; Rossi AG; Jose PJ; Williams TJ. (30 Dec 1993). The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo. Biochem Biophys Res Commun. 197:1167-1172.
  • Teixeira MM; Williams TJ; Hellewell PG. (Dec 1993). Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea-pig skin. Br J Pharmacol. 110:1515-1521.
  • Teixeira MM; Doenhoff MJ; McNeice C; Williams TJ; Hellewell PG. (15 Nov 1993). Mechanisms of the inflammatory response induced by extracts of Schistosoma mansoni larvae in guinea pig skin. J Immunol. 151:5525-5534.
  • Teixeira MM; Williams TJ; Hellewell PG. (Sep 1993). E-type prostaglandins enhance local oedema formation and neutrophil accumulation but suppress eosinophil accumulation in guinea-pig skin. Br J Pharmacol. 110:416-422.
  • Pons F; Williams TJ; Warren JB. (3 Aug 1993). Nitric oxide, but not interleukin-1, mediates the local blood flow response to lipopolysaccharide in rabbit skin. Eur J Pharmacol. 239:23-30.
  • Larkin SW; Williams TJ. (Jul 1993). Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans. Circ Res. 73:147-154.
  • Collins PD; Weg VB; Faccioli LH; Watson ML; Moqbel R; Williams TJ. (Jun 1993). Eosinophil accumulation induced by human interleukin-8 in the guinea-pig in vivo. Immunology. 79:312-318.
  • Collins PD; Connolly DT; Williams TJ. (May 1993). Characterization of the increase in vascular permeability induced by vascular permeability factor in vivo. Br J Pharmacol. 109:195-199.
  • Pons F; Rossi AG; Norman KE; Williams TJ; Nourshargh S. (May 1993). Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505. Br J Pharmacol. 109:234-242.
  • Yarwood H; Nourshargh S; Brain S; Williams TJ. (Apr 1993). Effect of dexamethasone on neutrophil accumulation and oedema formation in rabbit skin: an investigation of site of action. Br J Pharmacol. 108:959-966.
  • Weg VB; Williams TJ; Lobb RR; Nourshargh S. (1 Feb 1993). A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. J Exp Med. 177:561-566.
  • von Uexküll C; Nourshargh S; Williams TJ. (Dec 1992). Comparative responses of human and rabbit interleukin-1 in vivo: effect of a recombinant interleukin-1 receptor antagonist. Immunology. 77:483-487.
  • Hellewell PG; Jose PJ; Williams TJ. (Dec 1992). Inflammatory mechanisms in the passive cutaneous anaphylactic reaction in the rabbit: evidence that novel mediators are involved. Br J Pharmacol. 107:1163-1172.
  • Williams TJ; Hellewell PG. (Nov 1992). Endothelial cell biology. Adhesion molecules involved in the microvascular inflammatory response. Am Rev Respir Dis. 146:S45-S50.
  • Brady AJ; Williams FM; Williams TJ. (Nov 1992). Inflammatory injury in myocardial ischaemia. Clin Sci (Lond). 83:511-518.
  • Henriques MG; Rae GA; Cordeiro RS; Williams TJ. (Jul 1992). Endothelin-1 inhibits PAF-induced paw oedema and pleurisy in the mouse. Br J Pharmacol. 106:579-582.
  • Buckley TL; Brain SD; Jose PJ; Williams TJ. (Jun 1992). The partial inhibition of inflammatory responses induced by capsaicin using the Fab fragment of a selective calcitonin gene-related peptide antiserum in rabbit skin. Neuroscience. 48:963-968.
  • Nourshargh S; Perkins JA; Showell HJ; Matsushima K; Williams TJ; Collins PD. (1 Jan 1992). A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8. J Immunol. 148:106-111.
  • Weg VB; Watson ML; Cordeiro RS; Williams TJ. (5 Nov 1991). Histamine, leukotriene D4 and platelet-activating factor in guinea pig passive cutaneous anaphylaxis. Eur J Pharmacol. 204:157-163.
  • Jose PJ; Collins PD; Perkins JA; Beaubien BC; Totty NF; Waterfield MD; Hsuan J; Williams TJ. (1 Sep 1991). Identification of a second neutrophil-chemoattractant cytokine generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to melanoma-growth-stimulatory activity. Biochem J. 278 ( Pt 2):493-497.
  • Seale JP; Nourshargh S; Hellewell PG; Williams TJ. (Sep 1991). Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung. Br J Pharmacol. 104:251-257.
  • Faccioli LH; Nourshargh S; Moqbel R; Williams FM; Sehmi R; Kay AB; Williams TJ. (Jun 1991). The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo. Immunology. 73:222-227.
  • Buckley TL; Brain SD; Rampart M; Williams TJ. (Jun 1991). Time-dependent synergistic interactions between the vasodilator neuropeptide, calcitonin gene-related peptide (CGRP) and mediators of inflammation. Br J Pharmacol. 103:1515-1519.
  • Buckley TL; Brain SD; Collins PD; Williams TJ. (15 May 1991). Inflammatory edema induced by interactions between IL-1 and the neuropeptide calcitonin gene-related peptide. J Immunol. 146:3424-3430.
  • Collins PD; Jose PJ; Williams TJ. (15 Jan 1991). The sequential generation of neutrophil chemoattractant proteins in acute inflammation in the rabbit in vivo. Relationship between C5a and proteins with the characteristics of IL-8/neutrophil-activating protein 1. J Immunol. 146:677-684.
  • Watson ML; Williams TJ. (1991). Measurement of cell accumulation. Agents Actions Suppl. 34:429-438.
  • Williams TJ; Das A; von Uexkull C; Nourshargh S. (1991). Neutrophils in asthma. Ann N Y Acad Sci. 629:73-81.
  • Beaubien BC; Collins PD; Jose PJ; Totty NF; Hsuan J; Waterfield MD; Williams TJ. (1 Nov 1990). A novel neutrophil chemoattractant generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to interleukin 8. Biochem J. 271:797-801.
  • Nourshargh S; Williams TJ. (15 Oct 1990). Evidence that a receptor-operated event on the neutrophil mediates neutrophil accumulation in vivo. Pretreatment of 111In-neutrophils with pertussis toxin in vitro inhibits their accumulation in vivo. J Immunol. 145:2633-2638.
  • Jose PJ; Moss IK; Maini RN; Williams TJ. (Oct 1990). Measurement of the chemotactic complement fragment C5a in rheumatoid synovial fluids by radioimmunoassay: role of C5a in the acute inflammatory phase. Ann Rheum Dis. 49:747-752.
  • Williams FM; Collins PD; Tannière-Zeller M; Williams TJ. (Aug 1990). The relationship between neutrophils and increased microvascular permeability in a model of myocardial ischaemia and reperfusion in the rabbit. Br J Pharmacol. 100:729-734.
  • Brain SD; Wimalawansa S; MacIntyre I; Williams TJ. (Mar 1990). The demonstration of vasodilator activity of pancreatic amylin amide in the rabbit. Am J Pathol. 136:487-490.
  • Williams TJ; Yarwood H. (Feb 1990). Effect of glucocorticosteroids on microvascular permeability. Am Rev Respir Dis. 141:S39-S43.
  • Brain SD; Williams TJ. (1990). Leukotrienes and inflammation. Pharmacol Ther. 46:57-66.
  • Buckley TL; Brain SD; Williams TJ. (Jan 1990). Ruthenium red selectively inhibits oedema formation and increased blood flow induced by capsaicin in rabbit skin. Br J Pharmacol. 99:7-8.
  • Haslett C; Jose PJ; Giclas PC; Williams TJ; Henson PM. (15 May 1989). Cessation of neutrophil influx in C5a-induced acute experimental arthritis is associated with loss of chemoattractant activity from the joint space. J Immunol. 142:3510-3517.
  • Nourshargh S; Rampart M; Hellewell PG; Jose PJ; Harlan JM; Edwards AJ; Williams TJ. (1 May 1989). Accumulation of 111In-neutrophils in rabbit skin in allergic and non-allergic inflammatory reactions in vivo. Inhibition by neutrophil pretreatment in vitro with a monoclonal antibody recognizing the CD18 antigen. J Immunol. 142:3193-3198.
  • Hellewell PG; Williams TJ. (Jan 1989). An anti-inflammatory steroid inhibits tissue sensitization by IgE in vivo. Br J Pharmacol. 96:5-7.
  • BRAIN SD; TIPPINS J; WILLIAMS TJ. (1 Dec 1988). ENDOTHELIN INDUCES POTENT MICROVASCULAR CONSTRICTION. BRITISH JOURNAL OF PHARMACOLOGY. 95:1005-1007. Author weblink.
  • Brain SD; Williams TJ. (1 Sep 1988). Substance P regulates the vasodilator activity of calcitonin gene-related peptide. Nature. 335:73-75. DOI.
  • Williams TJ; Brain SD; Hellewell PG; Jose PJ; Nourshargh S; Rampart M. (1988). Alteration in microvascular permeability induced by products released during inflammation. Prog Clin Biol Res. 263:55-69.
  • Forrest MJ; Jose PJ; Williams TJ. (Dec 1986). Kinetics of the generation and action of chemical mediators in zymosan-induced inflammation of the rabbit peritoneal cavity. Br J Pharmacol. 89:719-730.
  • Williams TJ; Hellewell PG; Jose PJ. (Oct 1986). Inflammatory mechanisms in the Arthus reaction. Agents Actions. 19:66-72.
  • BRAIN SD; TIPPINS J; MORRIS HR; MACINTYRE I; WILLIAMS TJ. (1 Oct 1986). POTENT VASODILATOR ACTIVITY OF CALCITONIN GENE-RELATED PEPTIDE IN HUMAN-SKIN. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 87:533-536. Author weblink DOI.
  • BRAIN SD; MACINTYRE I; TIPPINS J; MORRIS HR; WILLIAMS TJ. (1 Jan 1986). THE VASODILATOR ACTIVITY OF HUMAN ALPHA-CALCITONIN GENE-RELATED PEPTIDE AND RELATED STRUCTURES. ACTA PHARMACOLOGICA ET TOXICOLOGICA. 59:147-147. Author weblink.
  • Rampart M; Williams TJ. (15 Feb 1986). Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. Biochem Pharmacol. 35:581-586.
  • BRAIN SD; MACINTYRE I; MORRIS HR; TIPPINS J; WILLIAMS TJ. (1 Dec 1985). COULD THE POTENT VASODILATOR CALCITONIN GENE-RELATED PEPTIDE BE THE MEDIATOR OF THE FLARE RESPONSE IN HUMAN-SKIN. REGULATORY PEPTIDES. 13:92-92. Author weblink DOI.
  • Brain SD; Williams TJ. (Dec 1985). Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. Br J Pharmacol. 86:855-860.
  • Jose PJ; Forrest MJ; Williams TJ. (Mar 1985). Generation of C5a and prostacyclin (PGI2) in an inflammatory response to zymosan and a reversed passive Arthus-type reaction in the peritoneal cavity of the rabbit. Agents Actions. 16:39-40.
  • BRAIN SD; WILLIAMS TJ; TIPPINS J; MORRIS HR; MACINTYRE I. (1 Jan 1985). CALCITONIN GENE-RELATED PEPTIDE IS A POTENT VASODILATOR. NATURE. 313:54-56. Author weblink DOI.
  • Williams TJ; Jose PJ; Forrest MJ; Wedmore CV; Clough GF. (1984). Interactions between neutrophils and microvascular endothelial cells leading to cell emigration and plasma protein leakage. Kroc Found Ser. 16:195-208.
  • Jose PJ; Forrest MJ; Williams TJ. (1 Dec 1983). Detection of the complement fragment C5a in inflammatory exudates from the rabbit peritoneal cavity using radioimmunoassay. J Exp Med. 158:2177-2182.
  • Williams TJ. (Jul 1983). Interactions between prostaglandins, leukotrienes and other mediators of inflammation. Br Med Bull. 39:239-242.
  • Williams TJ; Jose PJ; Wedmore CV; Peck MJ; Forrest MJ. (1983). Mechanisms underlying inflammatory edema: the importance of synergism between prostaglandins, leukotrienes, and complement-derived peptides. Adv Prostaglandin Thromboxane Leukot Res. 11:33-37.
  • Williams TJ; Jose PJ; Wedmore CV; Forrest MJ. (1982). Blood flow, vascular permeability and the role of neutrophils. Agents Actions Suppl. 11:39-49.
  • Jose PJ; Page DA; Wolstenholme BE; Williams TJ; Dumonde DC. (Dec 1981). Bradykinin-stimulated prostaglandin E2 production by endothelial cells and its modulation by antiinflammatory compounds. Inflammation. 5:363-378.
  • Williams TJ; Westwick J; Williamson EM; Evans FJ. (Mar 1981). Vascular changes in rabbit skin induced by proinflammatory phorbol and 12-deoxyphorbol esters. Inflammation. 5:29-36.
  • Wedmore CV; Williams TJ. (19 Feb 1981). Control of vascular permeability by polymorphonuclear leukocytes in inflammation. Nature. 289:646-650.
  • Williams TJ. (Mar 1979). Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation. Br J Pharmacol. 65:517-524.
  • Williams TJ. (May 1978). The role of prostaglandins in inflammation. Ann R Coll Surg Engl. 60:198-201.
  • Williams TJ; Peck MJ. (8 Dec 1977). Role of prostaglandin-mediated vasodilatation in inflammation. Nature. 270:530-532.
  • Williams TJ. (Nov 1977). Oedema and vasodilatation in inflammation: the relevance of prostaglandins. Postgrad Med J. 53:660-662.
  • Williams TJ. (1977). The relationship between inflammatory exudation and vasodilatation, with special reference to prostaglandins. Bibl Anat. 469-471.
  • Williams TJ; Morley J. (Feb 1974). Measurement of rate of extravasation of plasma protein in inflammatory responses in guinea-pig skin using a continuous recording method. Br J Exp Pathol. 55:1-12.
  • Williams TJ; Morley J. (23 Nov 1973). Prostaglandins as potentiators of increased vascular permeability in inflammation. Nature. 246:215-217.
  • MORLEY J; WILLIAMS TJ. (1 Jan 1973). PHARMACOLOGICAL PROPERTIES OF A PROPOSED MEDIATOR OF DELAYED-HYPERSENSITIVITY REACTIONS. INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY. 45:326-329. Author weblink.
  • Morley J; Williams TJ; Slater AJ; Cubitt D; Dumonde DC. (Aug 1972). Simultaneous measurements of the accumulation of isotope-labelled protein and erythrocytes in skin reactions of allergic inflammation in the guinea-pig. Immunology. 23:113-135.

Conferences

  • Buckland KF; Williams TJ; Conroy DM. Histamine induces shape change and actin polymerisation in human eosinophils via the novel H-4 receptor. Meeting of the British-Pharmacological-Society-Clinical-Pharmacology-Section, 7 Jan 2003 - 10 Jan 2003. 138:U22-U22. NATURE PUBLISHING GROUP (1 Apr 2003). Author weblink.
  • Caversaccio M; Hartnell A; Calnan D; Jose P; Mackay IS; Uguccioni M; Baggiolini M; Williams TJ; et alConroy DM. The role of chemokines in nasal polyps. Spring Meeting of the Schweizerischen-Gesellschaft-fur-Otorhinolaryngologie-Hals-und-Gesichtschirurgie. 130:92S-95S. (9 Dec 2000).
  • Mitchell TJ; Williams TJ. The role of eotaxin and related CC-chemokines in asthma and allergy. 9th International Conference of the Inflammation Association. 1-12. (2000).
  • Scheerens J; Folkerts G; Van der Linde H; Sterk PJ; Conroy DM; Williams TJ; Nijkamp FP. Eotaxin levels and eosinophils in guinea pig broncho-alveolar lavage fluid are increased at the onset of a viral respiratory infection. Symposium on the Link Between Asthma and COPD, 1998. 29:74-77. BLACKWELL SCIENCE LTD (1 Jun 1999). Author weblink.
  • Williams TJ. Role of eotaxin in allergic inflammation. Euroconference of Institut Pasteur on Chemokines and Their Receptors - From Basic Research to Therapeutic Intervention. 10:275-276. (Jun 1999).

Patents

  • Chemotactic Cytokine. Williams TJ; Jose PJ; Griffiths-Johnson DA; Hsuann JJ. Published: 29 Feb 2000.
  • Chemotactic Cytokine. Williams TJ; Jose PJ; Griffiths-Johnson DA; Hsuann JJ. Published: 30 Nov 1999.
  • Chemotactic Cytokine. Williams TJ; Jose PJ; Griffiths-Johnson DA; Hsuann JJ. Published: 2 Jul 1998.
  • Chemotactic Cytokine. Williams TJ; Jose PJ; Griffiths-Johnson DA; Hsuann JJ. Published: 15 Apr 1998.
  • Chemotactic Cytokine. Patent number: PCT/GB 94/02006 (UK). Williams TJ; Jose PJ; Griffiths-Johnson DA; Hsuann JJ. Published: 1994.
Share this on Delicious
Tweet this
Digg this
Stumble this
Share this on Facebook