Dr Utz J Pape

Current Research

Since October 2010, I'm supporting the Dept. of Public Health and Primary Case in statistical analyses. The bottom line of the project is the assessment of an intervention in the health system. For example, the Quality Outcome Framework (QOF) has been extend in the district Hammersmith & Fulham to QOF+ by more ambitious incentives. We analyze the effect of this intervention to assess its benefits and relate it to the costs.

Other Involvements

In addition to my affiliation at Imperial College, I'm studying in the MPA International Development program of the London School of Economics (more). Before I arrived to London, I was PostDoc at Harvard University in Computational Molecular Biology and Biostatistics. Here is some more information about my research in Boston. Our latest contribution related a new DNA modification (hydroxymethylation) to cancer in humans was recently published in Nature (read here more). I also studied Philosophy and I'm interested in Theory of Science, Bioethics and Theory of Justice (read more here). 

Publications

Ko, M., Huang, Y., Jankowska, A., Pape, U.J., Tahiliani, M., Bandukwala, H., An, J., Lamperti, E., Koh, K.P., Aravind, L., Liu, X.S., Agarwal, S., Maciejewski, J., Rao, A., Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. doi:10.1038/nature09586, Nature, 2010.

Wang, H., Wang, Q., Pape, U.J., Shen, B., Huang, J., Wu, B., Li, X., Systematic investigation of global coordination among mRNA and protein in cellular society. BMC Genomics, 2010, 11: 364.

Pape, U.J., Warum Meme nicht Genen entsprechen!, Master (Magister) thesis, Free University of Berlin, 2009.

Pape, U.J., Klein, H., Vingron, M., Statistical detection of co-operative transcription factors with similarity adjustment, Bioinformatics, 2009, 25 (16), 2103-2109.

Pape, U.J., Statistics for Transcription Factor Binding Sites, PhD thesis, Free University of Berlin, 2008.

Pape, U.J., Klein, H., Vingron, M., Statistical detection of co-operative transcription factors with similarity adjustment. In Beyer, A., Schroeder, M. (eds), Lecture Notes in Informatics: Proc. of German Conference on Bioinformatics (GCB), 2008, 96-105.

Pape, U.J., Vingron, M., Statistics for Co-Occurrence of DNA Motifs. In Chiquet, J., Glaz, J., Limnios, N., Moyal, P. (eds), Proc. of International Workshop for Applied Probability (IWAP), 2008.

Pape, U.J., Rahmann, S., Sun, F., Vingron, M., Compound Poisson approximation of DNA motif counts on both strands, Journal of Computational Biology, 2008, 15 (6), 547-564.

Toenjes, M., Schueler, M., Hammer, S., Pape, U.J., Fischer, J.J., Berger, F., Vingron , M., Sperling, S., Prediction of cardiac transcription networks based on molecular data and complex clinical phenotypes, Molecular BioSystems, 2008, 4 (6), 589-598.

Pape, U.J., Rahmann, S., Vingron, M., Natural Similarity Measures between Position Frequency Matrices with an Application to Clustering, Bioinformatics, 2008, 24 (3), 350-357.

Pape, U.J., Grossmann, S., Hammer, S., Sperling, S., Vingron, M., A new statistical model to select target sequences bound by transcription factors, Genome Informatics, 2006, 17 (1), 134-140.

Schmid, M., Davison, T.S., Henz, S.R., Pape, U.J., Demar, M., Vingron, M., Schölkopf, B., Weigel, D., and Lohman, J.U., A gene expression map of Arabidopsis development, Nature Genetics, 2005, 37 (5), 501-506.

Pape, U.J., Estimation of Genetic Regulatory Networks with Aggregated Bayesian Networks, Master Thesis, Free University of Berlin, 2003.

Pape, U.J., Differentiation in the Tissues of the Zebrafish, Bachelor Thesis, Free University of Berlin, 2002.