Dr Vincenzo Libri

Publications


Journals

  • Devanand DP; Mikhno A; Pelton GH; Cuasay K; Pradhaban G; Dileep Kumar JS; Upton N; Lai R; et alGunn RN; Libri V; Liu X; Van Heertum R; Mann JJ; Parsey RV. (2010). Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment and healthy controls. Journal of Geriatric Psychiatry and Neurology. 23:185-198.
  • Thompson PW, Ye L, Morgenstern JL, Sue L, Beach TG, Judd DJ, Shipley NJ, Libri V, Lockhart A. (2009). Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer’s disease pathologies. Journal of Neurochemistry. 109:623-630.
  • Ye L, Velasco A, Fraser G, Beach G, Sue L, Osredkar T, Libri V, Spillantini MG, Goedert M, Lockhart A. (2008). In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in post-mortem human brain. Journal of Neurochemistry. 105:1428-1437.
  • Mikhno A, Devanand DP, Parsey R, Pelton GH, Cuasay K, Kumar JSD, Upton N, Lai R, Pradhaban G, Libri V, Gunn RN, Mann JJ. (2008). The use of voxel-based analysis of [11C]PIB scans for the diagnosis of Alzheimer’s disease. Journal of Nuclear Medicine. 49:1262-1269.
  • Jones N, Messenger MJ, O’Neill MJ, Oldershaw A, Gilmour G, Simmons RMA, Iyengar S, Libri V, Tricklebank M, Williams SCR. (2008). AMPA receptor potentiation can prevent ethanol-induced intoxication. Neuropsychopharmacology. 33:1713.
  • Lockhart A, Lamb JR, Osredkar T, Sue LI, Newell A, Poston M, Joyce JN, Ye L, Libri V, Leppert D, Beach TG. (2007). Senile plaque type and ApoE genotype affect PIB retention in Alzheimer’s disease. Brain. 130:2607-2615.
  • Jones N, O’Neill MJ, Tricklebank M, Libri V, Williams SCR. (2005). Examining the neural targets of the AMPA receptor potentiator LY404187 in the rat brain using pharmacological magnetic resonance imaging. Psychopharmacol. 180:743-751.
  • Skljarevski V, Nitu A, Libri V, Ramadan N.M., Kaube H. (2004). Blink reflex - a review article. J Clin Neurophysiol. 36:244-251.
  • Giffin NJ, Kowacs F, Libri V, Williams P, Goadsby PJ, Kaube H. (2002). Effects of Adenosine A1 receptor agonist GR79236 on trigeminal nociception with blink reflex recordings in healthy human subjects. Cephalalgia. 21:267-272.
  • McCarthy LC, Hosford D, et al., Libri V, Humphrey P, Roses A, Purvis J, et al.. (2001). Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine. Genomics. 78:135-149.
  • Postlethwaite M, Constanti M, Libri V. (2000). Investigation of the role of intracellular Ca2+ stores in generation of the muscarinic agonist-induced slow afterdepolarization (sADP) in guinea-pig olfactory cortical neurones, in vitro. Br J Pharmacol. 129:1447-1457.
  • Postlethwaite M, Constanti A, Libri V. (1999). Caffeine blocks the post-stimulus afterdepolarizing tail current (IADP) induced by muscrinic receptor activation in olfactory cortical neurones in vitro. Br. J. Pharmacol. 126:292P.
  • Postlethwaite M, Constanti A, Libri V. (1999). Epileptiform potentials induced by muscarinic but not metabotropic-glutamate receptor activation in immature rat olfactory cortex, in vitro. Br. J. Pharmacol. 122:84P.
  • Chimirri A, De Sarro GB, De Sarro A, Gitto R, Quartarone S, Zappalà M, Constanti A, Libri V. (1998). 3,5-dihydro-4H-2,3-benzodiazepin-4-thiones: A new class of AMPA receptor antagonists. J. Medic. Chem. 41:3409-3416.
  • Libri V, Constanti A, Postlethwaite M, Bowery NG. (1998). Increased muscarinic agonist-induced epileptiform activity after blockade of GABAB receptors in immature rat olfactory cortical neurones, in vitro. NS Arch. Pharmacol. 358:168-174.
  • Postlethwaite M, Constanti A, Libri V. (1998). Muscarinic-induced burst firing in immature rat olfactory cortex: an in vitro electrophysiological study. J. Neurophysiol. 79:2003-2012.
  • Chimirri A., De Sarro GB., De Sarro A, Gitto A, Grasso A, Quartarone S, Zappalà M, Giusti P, Libri V, Constanti A, Chapman AG. (1997). 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: new AMPA receptor antagonists. J. Medic. Chem. 40:1258-1269.
  • De Sarro GB, Libri V, Ascioti C, Testa R, Nisticò G. (1997). Anticonvulsant effect of denzimol in DBA/2 mice. Neuropharmacol. 26:1425-1429.
  • Libri V, Santarelli MR, Nisticò S, Azzena GB. (1997). Inhibition of nitric oxide synthase prevents magnesium-free-induced epileptiform activity in guinea-pig olfactory cortex neurones in vitro. NS Arch. Pharmacol. 355:452-456.
  • Libri V, Santarelli MR, Nisticò S, Azzena GB. (1997). Involvement of L-arginine-NO pathway in Mg2+-free-induced burst firing in guinea-pig olfactory cortex neurones in vitro. Pharmacologist. 39:84.
  • Libri V, Constanti A, Zibetti M, Postlethwaite M. (1997). Metabotropic glutamate receptor subtypes mediating slow inward tail current (IADP) induction and inhibition of synaptic transmission in cortical neurones. Br. J. Pharmacol. 120:1083-1095.
  • Libri V, Constanti A, Zibetti M, Postlethwaite M. (1997). Pre- and post-synaptic metabotropic glutamate receptor pharmacology in guinea-pig olfactory cortical neurones in vitro. Br. J. Pharmacol. 120:-345P.
  • Libri V, Constanti A, Zibetti M, Nisticò S. (1996). Effects of felbamate on muscarinic/metabotropic agonist-mediated responses and magnesium free or 4-aminopyridine induced epileptiform activity in guinea-pig olfactory cortex neurones in vitro. J. Pharmacol. Exp. Ther. 277:1759-1769.
  • Libri V, Constanti A, Nisticò S, Bowery NG. (1996). Involvement of GABA-B receptor down-regulation in cortical epileptogenesis. Fundam. Clin. Pharm. 10:199.
  • Libri V, Constanti A, Bowery NG. (1996). Role of GABAB receptor down-regulation in the generation of epileptiform activity in disinhibited rat olfactory cortical neurones. Pharmacol. Comm. 8:185-190.
  • Libri V, Constanti A. (1995). Antagonism by felbamate of muscarinic and metabotropic receptor mediated responses in guinea-pig olfactory cortex neurones in vitro. Br. J. Pharmacol. 114:333P.
  • Malcangio M, Libri V, Constanti A, Bowery NG. (1995). Chronic (-)baclofen or CGP 36742 elicits sub- or supersensitivity of the GABAB receptor in rat brain and spinal cord. Neuroreport. 6:399-403.
  • Libri V, Constanti A, Bowery NG. (1995). GABAB receptor down-regulation facilitates muscarinic or metabotropic agonist-dependent burst firing in rat olfactory cortical neurones, in vitro. Br. J. Pharmacol. 116:332P.
  • Bowery NG, Constanti A, Fowler L, Libri V, Lemos T, Malcangio M, Richard D, Teoh H, Wheaten P. (1995). GABAB receptor plasticity. J. Neurochem. 65.
  • Libri V, Constanti A, Calaminici M, Nisticò G. (1994). A comparison of the muscarinic response and morphological properties of identified cells in the guinea-pig olfactory cortex in vitro. Neurosci. 59:331-345.
  • Harris NC, Libri V, Constanti A. (1994). Selective blockade of the hyperpolarization-activated cationic current (Ih) in rat substantial nigra pars compacta neurones by a novel bradycardic agent, Zeneca ZM 227189. Neurosci. Lett. 176:221-225.
  • Libri V, Giglio A, Nisticò G. (1993). Evidence that nitric oxide modulates learning processes and memory in mice. Pharmacol. Comm. 3:81-88.
  • Libri V, Scorsa AM, Dawe G, Nisticò G. (1993). Long-term potentiation of synaptic transmission in rodents: effects of pramiracetam sulphate. Pharmacol. Comm. 4:125-135.
  • Constanti A, Bagetta G, Libri V. (1993). Persistent muscarinic excitation in guinea-pig olfactory cortex neurones: involvement of a slow post-stimulus afterdepolarizing current. Neurosci. 56:887-904.
  • Carletti R, Libri V, Bowery NG. (1993). The GABAB antagonist, CGP 36742, enhances spatial learning performance and antagonizes baclofen-induced amnesia in mice. Br. J. Pharmacol. 109:74P.
  • Das B, Libri V, Constanti A. (1992). Carbachol-evoked suppression of excitatory neurotransmission in guinea-pig olfactory cortex slices is unlikely to involve an M4 muscarinic receptor subtype. Funct. Neurol. 7:135-140.
  • Libri V, Das B, Constanti A. (1992). Ganglionic nicotinic receptor agonists exhibit anti-muscarinic effects in guinea-pig olfactory cortical brain slices. Eur. J. Pharmacol. 212:253-258.
  • Libri V, Constanti A, Bagetta G, Nisticò G. (1992). Metabotropic (glutamate) receptor agonists induce a post-stimulus afterdepolarization in guinea-pig olfactory cortex neurones in vitro. Pharmacol. Res. 26:251-252.
  • Das B, Libri V, Constanti A. (1992). Muscarinic suppression of excitatory neurotransmission in guinea-pig olfactory cortex slices is unlikely to involve an M4 muscarinic receptor subtype. Br. J. Pharmacol. 106:141P.
  • Constanti A, Libri V. (1992). Trans-ACPD induces a slow post-stimulus inward tail current in guinea -pig olfactory cortex neurones in vitro. Eur. J. Pharmacol. 214:105-106.
  • Libri V, Das B, Constanti A. (1991). Anti-muscarinic effects of some ganglionic nicotinic receptor agonists in guinea-pig olfactory cortex slices. Br. J. Pharmacol. 104:459P.
  • Libri V, Del Gobbo V, Agosto R, Villani N, Caliò R, Nisticò G. (1991). Microinfusion of Ethyl-ß-carboline-3-carboxylate into the locus coeruleus reduces both interleukin-2 production and natural killer cell activity. Prog. Neuroendocr. Immunol. 4:79-85.
  • Libri V, Priolo E, Lopilato R, David E, Nappi G, Nisticò G. (1991). Panic-like attack induced by microinfusion into the locus coeruleus of antagonists and inverse agonists at GABAA receptors in rodents. Funct.Neurol. 6:393-403.
  • Libri V, Del Gobbo V, Villani N, Caliò R, Nisticò G. (1990). Influence of pineal gland lesion on interleukin-2 production and natural killer activity in C57BL/6 mice. Pharmacol. Res. 22:52-53.
  • De Sarro GB, Ascioti C, Audino MG, Libri V, De Sarro A, Nisticò G. (1989). Behavioural and electrocortical effects of two ornithine decarboxylase inhibitors into several areas of the brain in the rat. Neuropharmacol. 28:1245-1251.
  • Libri V, Ammassari-Teule M, Castellano C. (1989). Blocking of morphine-induced locomotor hyperactivity by amygdaloid lesions in C57BL/6 mice. Brain Res. 479:1-5.
  • De Sarro GB, Bagetta G, Ascioti C, Libri V, Nisticò G. (1989). Effects of pertussis toxin on the behavioural and ECoG spectrum changes induced by clonidine and yohimbine after their microinfusion into the locus coeruleus. Br. J. Pharmacol. 96:59-64.
  • Del Gobbo V, Libri V, Villani N, Caliò R, Nisticò G. (1989). Pinealectomy inhibits interleukin-2 production and natural killer activity in mice. Intern. J. Immunopharmacol. 567-573.
  • De Sarro A, De Sarro GB, Ascioti C, Libri V, Nisticò G. (1988). Comparative epileptogenic activity of various ß-lactam derivatives in rats. Pharmacological. Res. Comm. 20:129-130.
  • Sansone M, Libri V, Pavone F, Ammassari M. (1988). Effect of oxiracetam-scopolamine combinations on shuttle-box avoidance acquisition in mice. Arch. Int. Pharmacod. Therap. 291:208-216.
  • Libri V, Ammassari-Teule M, Castellano C. (1988). Effects of amygdaloid lesions on morphine-induced hyperactivity in C57BL/6 mice. Pharmacol. Res. Comm. 20:251-252.
  • Castellano C, Ammassari-Teule M, Libri V, Pavone F. (1988). Effects of k-opioid receptor agonists on locomotor activity and memory processes in mice. J. Pharmacol. 40:507-513.
  • De Sarro GB, Bagetta G, Ascioti C, Libri V, Nisticò G. (1988). Microinfusion of clonidine and yohimbine into the locus coeruleus alters EEG power spectrum: effects of ageing and reversal by phosphatidylserine. Br. J. Pharmacol. 95:1278-1286.
  • Castellano C, Libri V, Ammassari-Teule M. (1988). The amygdala mediates the impairing effect of the selective k-opioid receptor agonist U-50,488 on memory in CD1 mice. Behav. Brain Res. 30:259-263.
  • Sansone M, Castellano C, Libri V. (1988). Tripelennamine enhances buprenorphine-, but not pentazocine-induced hyperactivity in mice. Psychopharmacol. 95:176-179.
  • De Sarro GB, Ascioti C, Froio F, Libri V, Nisticò G. (1987). Evidence that locus coeruleus is the site were clonidine and drugs acting at á1 and á2 adrenoceptors affect sleep and arousal mechanisms. Br. J. Pharmacol. 90:675-685.
  • De Sarro GB, Ascioti C, Fersini G, Libri V, Marmo E, Nisticò G. (1986). Behavioural and electrocortical effects of tolonidine in rats. Res.Comm.Chem.Path.Pharmacol. 54:299-312.
  • Ascioti C, De Sarro GB, Froio F, Libri V, Nisticò G. (1985). Locus Coeruleus: site of sedation and sleep induced by clonidine. Br. J. Pharmacol. 86:676P.

Chapters in books

  • Libri V. Experimental medicine endpoints in early-phase clinical trials for CNS indications. In Forty Years of Advances in Pharmacology. 152-165. Nistico G (ed); Rotiroti D (ed); De Sarro GB (ed). (2010).
  • Libri V, Nisticò G. Experimental Models of Pharmacology: effects of new acetam-derivatives. In Modelli di ricerca neurologica applicata. 7-19. ASK (1994).
  • Libri V, Schindler U, Nisticò G. Inhibitors of nitric oxide synthase impair passive and active avoidance learning in rodents. In Nitric oxide: brain and immune system. Portland Press Proceedings:181-189. Moncada S (ed); Nisticò G (ed); Higgs EA (ed). (1993).
  • Libri V, Del Gobbo V, Villani N, Caliò R, Nisticò G. Role of the pineal gland in the control of interleukin-2 production and natural killer activity in mice. In Interactions among CNS, Neuroendocrine and Immune system. 81-91. Pythagora Press (1989).
  • Sarro GB, Ascioti C, Bagetta G, Libri V, Nisticò G. Behavioural and electrocortical changes of the polyamines after their microinfusion in several areas of the rat brain. In Neurotransmitters, seizures and epilepsy III. 423-438. Raven Press, New York (1986).

Conferences

  • Pan M; Chuah LYM; Chen A; Chong D; Rekshan W; Tan JC; Lay RYK; Libri V; et alChee MWL. The neurocognitive effects of donepezil on visual short-term memory capacity following 24 Hours of sleep deprivation. 4:T507-T508. (2008).
  • Pan M; Chuah LYM; Chong D; Tan JC; Rekshan W; Chen A; Lai RYK; Libri V; et alChee MWL. The neurocognitive benefits of donepezil on episodic memory in young, healthy individuals following 24 Hours of sleep deprivation. 4:T506-T507. (2008).
  • Lai RY; Gregory S; Hall D; Kenny G; Caceres A; Libri V; Williams SCR; Zelaya FO; et alMehta MA. A novel potent histamine H3 receptor antagonist produces discrete changes in brain activity during learning and episodic memory: Implications for cognitive enhancement. 4:T503-T504. (2008).
  • Devanand DP; Mikhno A; Pelton GH; Cuasay K; Kumar JSD; Upton N; Lai R; Gunn R; et alLibri V; Mann JJ; Parsey RV. Comparison of Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18F-FDG) PET in patients with Alzheimer's disease, mild cognitive impairment, and healthy controls. 5:T194. (2009).
  • Devanand DP; Mikhno A; Pelton GH; Cuasay K; Kumar JSD; Tabert MH; Pradhaban G; Upton N; et alLai R; Libri V; Gunn RN; Mann JJ; Parsey RV. PET amyloid imaging with Pittsburgh Compound B in Alzheimer's disease. 4:T282. (2008).
  • Mikhno A; Devanand DP; Pelton GH; Cuasay K; Gunn RN; Upton N; Libri V; Mann JJ; et alParsey RV. Voxel-based analysis of C11 Pittsburgh compound B for diagnosing Alzheimer's disease. 4:T294. (2008).
Share this on Delicious
Tweet this
Digg this
Stumble this
Share this on Facebook