Professor Wendy Barclay

Publications


Journals

  • Fouchier RA; García-Sastre A; Kawaoka Y; Barclay WS; Bouvier NM; Brown IH; Capua I; Chen H; et alCompans RW; Couch RB; Cox NJ; Doherty PC; Donis RO; Feldmann H; Guan Y; Katz J; Klenk HD; Kobinger G; Liu J; Liu X; Lowen A; Mettenleiter TC; Osterhaus AD; Palese P; Peiris JS; Perez DR; Richt JA; Schultz-Cherry S; Steel J; Subbarao K; Swayne DE; Takimoto T; Tashiro M; Taubenberger JK; Thomas PG; Tripp RA; Tumpey TM; Webby RJ; Webster RG. (27 Jan 2012). Pause on avian flu transmission research. Science. 335:400-401. DOI.
  • Fouchier RA; García-Sastre A; Kawaoka Y; Barclay WS; Bouvier NM; Brown IH; Capua I; Chen H; et alCompans RW; Couch RB; Cox NJ; Doherty PC; Donis RO; Feldmann H; Guan Y; Katz J; Klenk HD; Kobinger G; Liu J; Liu X; Lowen A; Mettenleiter TC; Osterhaus AD; Palese P; Peiris JS; Perez DR; Richt JA; Schultz-Cherry S; Steel J; Subbarao K; Swayne DE; Takimoto T; Tashiro M; Taubenberger JK; Thomas PG; Tripp RA; Tumpey TM; Webby RJ; Webster RG. (20 Jan 2012). Pause on Avian Flu Transmission Research. Science. DOI.
  • Elderfield R; Barclay W. (2011). Influenza pandemics. Adv Exp Med Biol. 719:81-103. DOI.
  • van Doremalen N; Shelton H; Roberts KL; Jones IM; Pickles RJ; Thompson CI; Barclay WS. (2011). A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets. PLoS One. 6:e25755. DOI Open Access copy.
  • Roberts KL; Shelton H; Scull M; Pickles R; Barclay WS. (Aug 2011). Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo. J GEN VIROL. 92:1822-1831. DOI.
  • Roberts KL; Shelton H; Scull M; Pickles R; Barclay WS. (Aug 2011). Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo. J Gen Virol. 92:1822-1831. DOI.
  • Foeglein Á; Loucaides EM; Mura M; Wise HM; Barclay WS; Digard P. (Jul 2011). Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase. J Gen Virol. 92:1650-1661. DOI.
  • Loureiro S; Ren J; Phapugrangkul P; Colaco CA; Bailey CR; Shelton H; Molesti E; Temperton NJ; et alBarclay WS; Jones IM. (Mar 2011). Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines. J Virol. 85:3010-3014. DOI.
  • Brookes DW; Miah S; Lackenby A; Hartgroves L; Barclay WS. (Mar 2011). Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness. J Antimicrob Chemother. 66:466-470. DOI.
  • Shelton H; Ayora-Talavera G; Ren J; Loureiro S; Pickles RJ; Barclay WS; Jones IM. (Feb 2011). Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential. J Virol. 85:1875-1880. DOI.
  • Jackson D; Elderfield RA; Barclay WS. (Jan 2011). Molecular studies of influenza B virus in the reverse genetics era. J Gen Virol. 92:1-17. DOI.
  • Moncorgé O; Mura M; Barclay WS. (Oct 2010). Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase. J Virol. 84:9978-9986. DOI.
  • Hartgroves LC; Koudstaal W; McLeod C; Moncorgé O; Thompson CI; Ellis J; Bull C; Havenga MJ; et alGoudsmit J; Barclay WS. (9 Apr 2010). Rapid generation of a well-matched vaccine seed from a modern influenza A virus primary isolate without recourse to eggs. Vaccine. 28:2973-2979. DOI.
  • Rehwinkel J; Tan CP; Goubau D; Schulz O; Pichlmair A; Bier K; Robb N; Vreede F; et alBarclay W; Fodor E; Reis e Sousa C. (5 Feb 2010). RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell. 140:397-408. DOI.
  • Ayora-Talavera G; Shelton H; Scull MA; Ren JY; Jones IM; Pickles RJ; Barclay WS. (18 Nov 2009). Mutations in H5N1 Influenza Virus Hemagglutinin that Confer Binding to Human Tracheal Airway Epithelium. PLOS ONE. 4. DOI.
  • Johnson BF; Wilson LE; Ellis J; Elliot AJ; Barclay WS; Pebody RG; McMenamin J; Fleming DM; et alZambon MC. (30 Oct 2009). Fatal Cases of Influenza A in Childhood. PLOS ONE. 4. DOI.
  • Tsang J; Chain BM; Miller RF; Webb BL; Barclay W; Towers GJ; Katz DR; Noursadeghi M. (13 Nov 2009). HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation. AIDS. 23:2255-2263. DOI.
  • Scull MA; Gillim-Ross L; Santos C; Roberts KL; Bordonali E; Subbarao K; Barclay WS; Pickles RJ. (May 2009). Avian Influenza Virus Glycoproteins Restrict Virus Replication and Spread through Human Airway Epithelium at Temperatures of the Proximal Airways. PLOS PATHOG. 5. DOI.
  • Wise HM; Foeglein A; Sun J; Dalton RM; Patel S; Howard W; Anderson EC; Barclay WS; et alDigard P. (Aug 2009). A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA. J Virol. 83:8021-8031. DOI.
  • Koudstaal W; Hartgroves L; Havenga M; Legastelois I; Ophorst C; Sieuwerts M; Zuijdgeest D; Vogels R; et alCusters J; de Boer-Luijtze E; de Leeuw O; Cornelissen L; Goudsmit J; Barclay W. (28 Apr 2009). Suitability of PER.C6 (R) cells to generate epidemic and pandemic influenza vaccine strains by reverse genetics. VACCINE. 27:2588-2593. DOI.
  • Whiteley A; Major D; Legastelois I; Campitelli L; Donatelli I; Thompson CI; Zambon MC; Wood JM; et alBarclay WS. (Jul 2007). Generation of candidate human influenza vaccine strains in cell culture - rehearsing the European response to an H7N1 pandemic threat. Influenza Other Respi Viruses. 1:157-166. DOI.
  • Cox RJ; Madhun AS; Hauge S; Sjursen H; Major D; Kuhne M; Höschler K; Saville M; et alVogel FR; Barclay W; Donatelli I; Zambon M; Wood J; Haaheim LR. (18 Mar 2009). A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine. Vaccine. 27:1889-1897. DOI.
  • Barclay W. (11 Oct 2008). Bird flu is out there just biding its time (vol 199, pg 8, 2008). NEW SCI. 200:21-21.
  • Hale BG; Barclay WS; Randall RE; Russell RJ. (15 Aug 2008). Structure of an avian influenza A virus NS1 protein effector domain. VIROLOGY. 378:1-5. DOI.
  • Owen RE; Yamada E; Thompson CI; Phillipson LJ; Thompson C; Taylor E; Zambon M; Osborn HMI; et alBarclay WS; Borrow P. (Oct 2007). Alterations in receptor binding properties of recent human influenza H3N2 viruses are associated with reduced natural killer cell lysis of infected cells. J VIROL. 81:11170-11178. DOI.
  • Barclay WS; Jones IM; Osborn HMI; Phillipson L; Ren JY; Talevera GA; Thompson CI. (15 Jun 2007). Probing the receptor interactions ofan H5 avian influenza virus using a baculovirus expression system and functionalised poly(acrylic acid) ligands. BIOORGAN MED CHEM. 15:4038-4047. DOI.
  • Zambon M; Barclay W. (7 Dec 2002). Unravelling the mysteries of influenza. Lancet. 360:1801-1802. DOI.
  • Powell R; Ren J; Lewith G; Barclay W; Holgate S; Almond J. (Oct 2003). Identification of novel expressed sequences, up-regulated in the leucocytes of chronic fatigue syndrome patients. Clin Exp Allergy. 33:1450-1456.
  • Jackson D; Zürcher T; Barclay W. (1 May 2004). Reduced incorporation of the influenza B virus BM2 protein in virus particles decreases infectivity. Virology. 322:276-285. DOI.
  • Jackson D; Barclay W; Zürcher T. (Feb 2005). Characterization of recombinant influenza B viruses with key neuraminidase inhibitor resistance mutations. J Antimicrob Chemother. 55:162-169. DOI.
  • Hayman A; Comely S; Lackenby A; Murphy S; McCauley J; Goodbourn S; Barclay W. (30 Mar 2006). Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway. Virology. 347:52-64. DOI.
  • Howard W; Hayman A; Lackenby A; Whiteley A; Londt B; Banks J; McCauley J; Barclay W. (Mar 2007). Development of a reverse genetics system enabling the rescue of recombinant avian influenza virus A/Turkey/England/50-92/91 (H5N1). Avian Dis. 51:393-395.
  • Barclay WS; Zambon M. (31 Jan 2004). Pandemic risks from bird flu - The risk to humans is small, but we need to be better prepared. BRIT MED J. 328:238-239.
  • Yao Y; Mingay LJ; McCauley JW; Barclay WS. (Jun 2001). Sequences in influenza A virus PB2 protein that determine productive infection for an avian influenza virus in mouse and human cell lines. J Virol. 75:5410-5415. DOI.
  • Jackson D; Cadman A; Zurcher T; Barclay WS. (Nov 2002). A reverse genetics approach for recovery of recombinant influenza B viruses entirely from cDNA. J Virol. 76:11744-11747.
  • Harvey R; Martin AC; Zambon M; Barclay WS. (Jan 2004). Restrictions to the adaptation of influenza a virus h5 hemagglutinin to the human host. J Virol. 78:502-507.
  • Barclay WS; Zambon M. (31 Jan 2004). Pandemic risks from bird flu. BMJ. 328:238-239. DOI.
  • Griffin SD; Harvey R; Clarke DS; Barclay WS; Harris M; Rowlands DJ. (Feb 2004). A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria. J Gen Virol. 85:451-461.
  • Thompson CI; Barclay WS; Zambon MC. (May 2004). Changes in in vitro susceptibility of influenza A H3N2 viruses to a neuraminidase inhibitor drug during evolution in the human host. J Antimicrob Chemother. 53:759-765. DOI.
  • Elleman CJ; Barclay WS. (30 Mar 2004). The M1 matrix protein controls the filamentous phenotype of influenza A virus. Virology. 321:144-153. DOI.
  • Heydarnejad J; Barclay WS; Izadpanah K; Hunter FR; Gooding MJ. (Feb 2006). Molecular characterization of Iranian wheat stripe virus shows its taxonomic position as a distinct species in the genus Tenuivirus. Arch Virol. 151:217-227. DOI.
  • Thompson CI; Barclay WS; Zambon MC; Pickles RJ. (Aug 2006). Infection of human airway epithelium by human and avian strains of influenza a virus. J Virol. 80:8060-8068. DOI.
  • Hayman A; Comely S; Lackenby A; Hartgroves LC; Goodbourn S; McCauley JW; Barclay WS. (Mar 2007). NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response. J Virol. 81:2318-2327. DOI.

Conferences

  • Sridhar S; Begom S; Bermingham A; Roberts K; Barclay W; Openshaw P; Lalvani A. Predominance of heterosubtypic IFN-gamma-only-secreting effector memory T cells in pandemic H1N1 naive adults. 135:65-65. (Dec 2011).
  • Whiteley A; Trikic MZ; Barclay WS. Attenuating mutations in the influenza virus genome which may increase the safety of vaccine production. 1263:687-690. (2004). DOI.
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