Immune reconstitution in HIV-1-infected individuals

The efforts of our research team are central to the reconstitution of immunity in HIV-1 infected patients, directed specifically towards the development of an effective vaccine and immunotherapeutic treatment regimens. The outcomes of this research will ultimately assist in the design of efficacious immunotherapy in areas of infectious disease, immunodeficiencies, transplantation and oncology. The work carried out integrates basic biological science and clinical science, and has application to human health. Presently our research is focused on two interrelated areas of investigation: i) assessment of protective anti-HIV-1 immune responses and further characterisation of the mechanisms involved in T-lymphocte anergy-induction, and ii) the regulation of HIV-1-specific CD4 and CD8 T-lymphocyte responses.

The second area of investigation is intended to facilitate novel immunotherapeutic and chemotherapeutic studies and trials. Additionally, we are actively involved in transfer of technology to complementary ongoing work in Uganda.

HIV-1