Human Disease Immunogenetics
Research in this area:
- HLA-T cell receptor interactions.
- 'Humanised' TCR/HLA transgenic models for analysis of disease pathogenesis, particularlyl in multiple sclerosis.
- CD4 T cell responses to bacterial infection.
- HLA class II and the immune response to bacterial superantigens.
Dr Daniel Altmann
Selected publications:
- HLA class II polymorphisms determine responses to bacterial superantigens. Llewelyn M, Sriskandan S, Peakman M, Abrozak DR, Douek DC, Kwok W, Cohen J & Altmann DM. J Immunol 2004; 172:1719-1726.
- High incidence of spontaneous disease in an HLA-DR15 and T cell receptor transgenic multiple sclerosis model. Ellmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RHM, Smith PA, Amor S, Herlihy AH, Hewitt RE, Jutton M, Price DA, Hafler DA, Kuchroo VK & Altmann DM. J Immunol 2005; 174:1938-1946.
- Immune responses tolerance to the RhD blood group protein in HLA-transgenic mice. Hall AM, Cairns LS, Altmann DM, Barker RN & Urbaniak SJ. Blood 2005; 105:2175-2179.
- Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. Illes Z, Stern JN, Reddy J, Waldner H, Mycko MP, Brosnan CF, Ellmerich S, Altmann DM, Santambrogio L, Strominger JL & Kuchroo VK. Proc Natl Acad Sci USA 2004; 101(32):11749-11754.
- Spread of T lymphocyte responses to myelin epitopes with duration of multiple sclerosis. Davies S, Nicholson T, Laura M, Giovannoni G & Altmann DM. J Neuropath Exp Neurol 2005; in press.
