Vaccine Epidemiology

We are interested in the impact of vaccines and treatment on infectious diseases. Specifically we aim to better understand the response to these interventions at the individual and population level in order to improve their effectiveness.

In collaboration with researchers in Asia and Africa we are carrying out epidemiological studies and clinical trials to characterize the immune response to oral vaccines, particularly against poliovirus. We are also investigating the epidemiology of trachoma in Africa and the response of populations to different strategies for mass treatment with antibiotics. Our approach is characterized by a recognition of the benefits of integrating theoretical models with results from experiments and epidemiological data using statistical and mathematical models. 

Vaccines

Our research on vaccines focuses on the systemic and mucosal immune response of individuals and the impact of vaccination on the dynamics of infection in the population. We are especially interested in explaining the poor immunogenicity and effectiveness of oral vaccines in lower-income countries. Read more...

Polio

Our work on poliovirus epidemiology aims to better understand the factors determining poliovirus transmission and the impact of vaccination with oral and inactivated poliovirus vaccines. We are especially interested in identifying optimal vaccination strategies to achieve eradication of wild-type polioviruses and to minimise risks of re-emergence of wild-type or vaccine-derived polioviruses post-eradication. Read more...

Trachoma

Trachoma is a major cause of blindness in some of the world's poorest communities. Our research aims to identify the most effective and cost-effective strategies for trachoma control. We are especially interested in the importance of transmission of Chlamydia trachomatis within households and the potential for targetted treatment with antibiotics. Read more...

Theory

Underpinning our research in infectious disease epidemiology are mathematical and statistical methods appropriate to the data collected and the research question under consideration. We are interested in developing methods for analysing infectious disease data including immunological measurements, case reports, genetic sequences and outcomes from clinical trials and other intervention studies. Read more...