Faculty of Medicine

Research Highlights

Spotlight On: Weekend Mortality

Several studies have identified higher mortality for patients admitted as emergencies at the weekend compared with emergency admissions during the week.

Spotlight on: Hospital mortality following the junior doctor changeover in August

We have carried out a follow-up analysis re-examining the previous killing season paper (including more recent data) on the effect of the junior doctor changeover in August.

Our latest paper "Dying for the Weekend: A Retrospective Cohort Study on the Association Between Day of Hospital Presentation and the Quality and Safety of Stroke Care." featured on the front page of The Telegraph 


• Strengths and weaknesses of hospital standardised mortality ratios BMJ: British Medical Journal. 342:c7116.

• Use of administrative data or clinical databases as predictors of risk of death in hospital: comparison of models. Aylin P, Bottle A. BMJ. 334:1044-1044.

Mortality associated with delay in operation after hip fracture. Bottle A, Aylin P.BMJ 2006;332:947-951.

Comparing outcomes in laparoscopic and open elective colonic and rectal resection. Faiz O, Warusavitarne J, Bottle A, Tekkis PP, Darzi AW, Kennedy RH. Dis Colon Rectum. 52:1695-1704.

Identifying patients at high risk of emergency hospital admissions. Bottle A, Aylin P, Majeed A. JR Soc Med, Aug 2006; 99:406-414.

Assessment of paediatric cardiac surgical mortality in England after Bristol. Aylin P, Bottle B, Jarman B, Elliott P. 1991-2002. BMJ 2004;329:825.

Intelligent Information: a national system for monitoring clinical performance. Bottle A, Aylin P. Health Services Research Feb 2008;43:10-31. 

Spotlight On: Weekend Mortality


Several studies have identified higher mortality for patients admitted as emergencies at the weekend compared with emergency admissions during the week. Using routinely collected hospital administrative data, we examined in-hospital deaths for all emergency inpatient admissions to all public acute hospitals in England for 2005/2006. Odds of death were calculated for admissions at the weekend compared to admissions during the week, adjusted for age, sex, socioeconomic deprivation, comorbidity and diagnosis. Of a total of 4 317 866 emergency admissions, we found 215 054 in-hospital deaths with an overall crude mortality rate of 5.0% (5.2% for all weekend admissions and 4.9% for all weekday admissions). The overall adjusted odds of death for all emergency admissions was 10% higher (OR 1.10, 95% CI 1.08 to 1.11) in those patients admitted at the weekend compared with patients admitted during a weekday (p<0.001).

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Spotlight on: Hospital mortality following the junior doctor changeover in August


We have carried out a follow-up analysis re-examining the previous killing season paper (including more recent data) on the effect of the junior doctor changeover in August. We found the odds of death for patients admitted on the first Wednesday in August was 6% higher (OR 1.06, 95% CI 1.00 to 1.13, p=0.05) after controlling for year, gender, age, socio-economic deprivation and co-morbidity.

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Other past research

  • Investigating the use of ONS mortality data for examining long term survival rates for several conditions and procedures
  • Developed statistical methodology used within the Real Time Monitoring Tool to minimise the false alarm rate and improve the successful detection rate through the use of different statistical process control charts
  • Comparison of HES data with the UK Colorectal Cancer Database compiled by the Association of Coloproctology of Great Britain and Ireland. This compares both counts and mortality for seven procedures, and has been carried out in conjunction with the ACPGBI. A similar study comparing Hospital Episode Statistics with the Vascular Society of Great Britain and Ireland’s National Vascular Database was carried out in conjunction with the Vascular Society. Aylin P; Lees T; Baker S; Prytherch D; Ashley S. Eur J Vasc Endovasc Surg. 33:461-465 DOI
  • Development of indicators for orthopaedics
  • Population Health Monitoring Tool
  • Trends in hospital admissions for pulmonary embolism in England: 1996/7 to 2005/6. Aylin P; Bottle A; Kirkwood G; Bell D. Clin Med. 8:388-392
  • Input into Dutch RTM 
  • Developing a framework for evaluating the impact of the use of tools like the RTM on patient outcomes
  • Data processing and accommodation of SUS
  • Healthcare Related Infection research
  • Use of A&E data to examine patient flow
  • Trends in day surgery rates
  • Variation in operation rates by primary care trust
  • Length of hospital stay and subsequent emergency readmission
  • Hospital indicators of poor sexual health
  • Assessment of “HRG drift” and payment by results
  • Monitoring changes in hospital standardised mortality ratios
  • Hospital admissions for drug and alcohol use in people aged under 45
  • Variations in vaginal and abdominal hysterectomy by region and trust in England

A complete  list of our publications can be found on the publication page (last updated August 2011). The most recent publications can be found on the personal pages of the unit’s academic staff.

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