Hypertension & Circulation
Professor Nish Chaturvedi, Principal Investigator
Dr Darrel Francis, Principal Investigator
Professor Alun Hughes, Principal Investigator
Professor Jamil Mayet, Principal Investigator
Professor Simon Thom, Principal Investigator
The Hypertension & Circulation group undertakes a wide range of studies that explores the origins and consequences of cardiovascular disease related to hypertension, atherosclerosis, diabetes, ethnicity and the lifecourse. All the Principal Investigators are members of the International Centre for Circulatory Health collaboration and the British Heart Foundation Centre of Research Excellence; Professor Chaturvedi is also the Associate Director of the UK Diabetes Research Network and Professor Thom is the clinical lead of the North West London Diabetes Research Network. The group also has a major interest in the application of biomedical engineering, fluid dynamics and computational techniques to the diagnosis and treatment of cardiovascular disease.
Selected Publications
Baruah R, Manisty CH, Giannoni A, Willson K, Mebrate Y, Baksi AJ, Unsworth B, Hadjiloizou N, Sutton R, Mayet J, Francis DP. Novel use of cardiac pacemakers in heart failure to dynamically manipulate the respiratory system through algorithmic changes in cardiac output. Circ Heart Fail. 2009 May;2(3):166-74.
Chaturvedi N, Porta M, Klein R, Orchard T, Fuller J, Parving HH, Bilous R, Sjølie AK; DIRECT Programme Study Group. Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials. Lancet. 2008 Oct 18;372(9647):1394-402.
Davies JE, Whinnett ZI, Francis DP, Manisty CH, Aguado-Sierra J, Willson K, Foale RA, Malik IS, Hughes AD, Parker KH, Mayet J. Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy. Circulation. 2006 Apr 11;113(14):1768-78.
Manisty CH, Zambanini A, Parker KH, Davies JE, Francis DP, Mayet J, McG Thom SA, Hughes AD; Anglo-Scandinavian Cardiac Outcome Trial Investigators. Differences in the magnitude of wave reflection account for differential effects of amlodipine- versus atenolol-based regimens on central blood pressure: an Anglo-Scandinavian Cardiac Outcome Trial substudy. Hypertension. 2009 Oct;54(4):724-30.
Thom S, Stettler C, Stanton A, Witt N, Tapp R, Chaturvedi N, Allemann S, Mayet J, Sever P, Poulter N, O'Brien E, Hughes A. Differential effects of antihypertensive treatment on the retinal microcirculation: an Anglo-Scandinavian Cardiac Outcomes Trial substudy. Hypertension. 2009 Aug;54(2):405-8.
