Selected recent studies
- The Hypertension Associated Cardiovascular Disease (HACVD) study:
- Use of a Multidrug Pill In Reducing cardiovascular Events (UMPIRE):
- Southall And Brent REvisited (SABRE):
- Early Life determinants of Blood pressure patterns in young Adults (ELBA):
- The DIabetic REtinopathy Candesartan Trial (DIRECT):
- Hypertension related damage to the microcirculation in South Asians – emergence, predictive power and reversibility:
- British Randomized trial of Atrio-Ventricular Optimization (BRAVO):
- Using a novel dynamic therapeutic strategy in cardiorespiratory regulation:
Use of a Multidrug Pill In Reducing cardiovascular Events (UMPIRE): People with established cardiovascular disease need secondary prevention that addresses multiple risk factors. This trial will evaluate a low-cost, fixed-dose, once-daily combination ‘Polypill’, the Red Heart Pill, in high-risk patients in Europe and India in a collaboration with colleagues in Australia, India, Ireland and the Netherlands. The results will be used to develop recommendations for equitable access.
Southall And Brent REvisited (SABRE): A follow up study of the largest tri-ethnic cohort in the UK investigating the relationship between metabolic disturbance and cardiovascular disease.
Early Life determinants of Blood pressure patterns in young Adults (ELBA): a study to investigate the determinants of blood pressure in youth in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort in collaboration with Professor G Davey-Smith and Professor D Lawlor and colleagues in Bristol, UK.
The DIabetic REtinopathy Candesartan Trial (DIRECT): an intervention trial evaluating the inhibition of angiotensin AT1 receptors on the development or progression of diabetic eye disease (retinopathy). The trial involved 320 centres in 27 countries and recruited a total of 5300 patients.
Hypertension related damage to the microcirculation in South Asians – emergence, predictive power and reversibility: A study conducted in Pakistan in collaboration with Professor Tazeen Jafar and colleagues (AKU, Karachi, Pakistan) showing that offspring of hypertensive parents have evidence of endothelial dysfunction in the microcirculation.
Using a novel dynamic therapeutic strategy in cardiorespiratory regulation: The team has invented a new pacing algorithm to dynamically (‘actively’) stabilise respiratory control. A prototype implantable cardiac pacing device is being designed for clinical trials in collaboration with industrial partners. Patents have been filed for two new methods for treating periodic breathing ("sleep apnoea") and methods for automatically controlling the delivery of those treatments.
