National Heart & Lung Institute (NHLI)

HACVD image

The Hypertension Associated Cardiovascular Disease (HACVD) study: a substudy of the Anglo Scandinavian Cardiac Outcome Trial (ASCOT) which collected extensive cardiac and vascular measurements on approximately 1000 patients with parallel biomarker and genetic samples. 


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UMPIRE imageUse of a Multidrug Pill In Reducing  cardiovascular Events (UMPIRE): People with established cardiovascular disease need secondary prevention that addresses multiple risk factors. This trial will evaluate a low-cost, fixed-dose, once-daily combination ‘Polypill’, the Red Heart Pill, in high-risk patients in Europe and India in a collaboration with colleagues in Australia, India, Ireland and the Netherlands. The results will be used to develop recommendations for equitable access. 

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SABRE imageSouthall And Brent REvisited (SABRE): A follow up study of the largest tri-ethnic cohort in the UK investigating the relationship between metabolic disturbance and cardiovascular disease.SABRE image

 

 

 

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ELBA imageEarly Life determinants of Blood pressure patterns in young Adults (ELBA): a study to investigate the determinants of blood pressure in youth in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort in collaboration with Professor G Davey-Smith and Professor D Lawlor and colleagues in Bristol, UK.

 

 

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DIRECT image

The DIabetic REtinopathy Candesartan Trial (DIRECT):  an intervention trial evaluating the inhibition of angiotensin AT1 receptors on the development or progression of diabetic eye disease (retinopathy). The trial involved 320 centres in 27 countries and recruited a total of 5300 patients.

 

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Hypertension imageHypertension related damage to the microcirculation in South Asians – emergence, predictive power and reversibility: A study conducted in Pakistan in collaboration with Professor Tazeen Jafar and colleagues (AKU, Karachi, Pakistan) showing that offspring of hypertensive parents have evidence of endothelial dysfunction in the microcirculation.

 

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British  Randomized trial of Atrio-Ventricular Optimization (BRAVO): A new study funded by the British Heart Foundation and the UK Biomedical Research Centre to investigate a novel technique for optimization of biventricular pacemaker settings. BRAVO image

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Using a novel dynamic therapeutic strategy in cardiorespiratory regulation: The team has invented a new pacing algorithm to dynamically (‘actively’) stabilise respiratory control. A prototype implantable cardiac pacing device is being designed for clinical trials in collaboration with industrial partners. Patents have been filed for two new methods for treating periodic breathing ("sleep apnoea") and methods for automatically controlling the delivery of those treatments. Therapeutic strategy image

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