Critical Care, Pulmonary Vascular and Sleep Science
These three groups focus on clinical physiological research.
The critical care team are primarily concerned with vascular disease as it affects the critically ill. Molecular and novel in vitro and in vivo models are used to facilitate the study of inflammatory pathways activated in pulmonary and systemic vascular disease, both congenital and acquired. Diseases of interest include primary and secondary pulmonary hypertension, pulmonary vascular malformation, sepsis, the systemic inflammatory response syndrome and the acute respiratory distress syndrome. Work continues to try and identify genes involved in disease process to enable the prediction of patients who will be at risk of acute respiratory failure following elective surgery.
The Respiratory and Skeletal Muscle group looks at respiratory muscles in COPD, physiological approaches to the palliation of advanced COPD and lung regeneration.
The Sleep and Ventilation group investigates at the cardiovascular and neurological consequences of sleep disturbances - particularly in vulnerable patients with pre existing heart disease and older people. The group has a special interest in treatment in non-invasive ventilation, especially in the pediatric population.