Statistical Modelling

The overall aim of the project is to evaluate the causal pathway between air pollution concentrations and lung cancer, considering biomarkers as intermediate steps in the pathway.

The data come from Genair, a case-control study nested within the EPIC cohort. Air pollutants included in the study are NO2, SO2, O3 and PM10 and DNA adducts are used as intermediate biomarker (N>1,000). The investigation of the pathway is done by structural equation modeling (SEM) and effects are expressed in the form of odds ratios.

This project is complementary to the application of “profile modeling” to the same and other datasets on lung cancer (within the ILCCO consortium), by Michail Papathomas, John Molitor (Sylvia Richardson’s group) and Clive Hoggart.

For further information e-mail v.troncosobaltar@imperial.ac.uk