Monitoring trends in malaria transmission using serological markers of malaria exposure
Project Information
People:
Funders: The Wellcome Trust, Medical Research Council
Diseases: P.falciparum and P.vivax malaria
Countries involved: Burkina Faso, Cambodia, The Gambia, Ghana, Kenya, Tanzania, Vanuatu
Collaborators:
Malaria transmission intensity has traditionally been quantified through direct measurement of the entomological inoculation rate (EIR). However, such methods are intensive to undertake and also tend to focus on areas in which mosquito density is greatest. We are investigating how transmission intensity can be inferred from cross-sectional and longitudinal serological studies using a variety of antigenic markers and how these estimates compare to EIR measures and measures of parasite prevalence.
Recent Publications
Wipasa J, Suphavilai C, Okell LC, Cook J, Corran PH, Thaikla K, Liewsaree W, Riley EM, Hafalla JC (2010). Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax. PLoS Pathogens, 6(2):e1000770. Publisher's Link.
Stewart L, Gosling R, Griffin J, Gesase S, Campo J, Hashim R, Masika P, Mosha J, Bousema T, Shekelaghe S, Cook J, Corran P, Ghani AC, Riley E, Drakeley CJ (2009). Rapid assessment of malaria transmission using age-specific sero-conversion rates. PLoS One, 4(6) e6083. Publisher's Link.
Corran PH, Cook J, Lynch C, Leendertse H, Manjurano A, Griffin J, Cox J, Abeku T, Bousema T, Ghani AC, Drakeley C, Riley E (2008) Dried blood spots as a source of anti-malarial antibodies for epidemiological studies. Malaria Journal, 7: 195. Publisher's Link.
