Modelling the impact of malaria vaccines
Project Information
People:
Funders: Medical Research Council
Disease: P.falciparum malaria
Countries involved: Africa
Collaborators:
Malaria vaccines are likely to be a key element in an arsenal of interventions aimed at malaria eradication. In order for vaccines to be integrated into wider control efforts, it will be necessary to develop models to understand the population effects of different vaccines, and how they will interact with existing control measures.
In this project we are developing a suite of models to consider the potential impact and roll-out of the current RTS,S vaccine, and more generally the properties that a pre-erythrocytic vaccine might need to have to be useful to eradication programs. We will subsequently consider other potential lifecycle targets and the profiles they would need to have to enhance elimination programs in different transmission settings.
This project is linked to the Vaccine Modelling Initiative.
Recent Publications
White MT, Griffin JT, Riley EM, Drakeley CJ, Moorman AM, Odada Sumba P, Kazura JW, Ghani AC, John CC (2010). Efficacy model for antibody-mediated pre-erthrocytic malaria vaccines. Proc. Roy. Soc. B. Publisher's Link.
White M, Griffin JT, Drakeley CJ, Ghani AC (2010). Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials. Malaria Journal, 9 82. Publisher's Link.
