Imperial Clinical Trials Unit

AARDVARK - Aortic Aneurysmal Regression of Dilation Value of Ace-inhibition on RisK

Current Study Information:


An Abdominal Aortic Aneurysm is a balloon-like swelling of the main blood vessel of the body (the aorta) as it runs through the abdomen. The normal diameter of the abdominal aorta is approximately 1.8cm or about three quarters of an inch in diameter. Small aneurysms grow slowly and do not appear to cause problems until the diameter exceeds 2-3 times the diameter of the normal aorta (about 5.5cm or more than 2 inches in size).

When the aneurysm is small it is safer to monitor using regular ultrasound scanning - an ultrasound scan is a painless test that uses sound waves to create images of organs and structures inside your body. If the aneurysm reaches a large size (usually over 5.5cm), repair with an operation is recommended to avoid the serious problem of bursting, causing significant internal bleeding (aneurysm rupture).

It is important to find treatments that help prevent an aneurysm enlarging.

This trial will assess whether an Angiotensin Converting Enzyme (ACE) inhibitor drug called perindopril will reduce the growth rate of small AAA's. It will also assess whether a small reduction in blood pressure levels could reduce the growth rate of these aneurysms.

One trial in the past has shown that ACE inhibitors, which are usually used to treat high blood pressure, may reduce the risk of bursting (rupture) of  large aneurysms.   Therefore it has been suggested that ACE inhibitors also might slow the growth of small aneurysms. It is not clear whether these drugs, ACE inhibitors, would have their effect by reducing blood pressure or by acting directly on the aneurysm or both. 


ICTU AARDVARK Management Team:

Chief Investigator:     Professor Neil Poulter

Trial Manager:          Ms Miriam Adesokan/ Ms Gaia Mahalingam (on maternity leave)

Medical Advisor:       Dr Andrew Whitehouse

Trial Monitor:            Ms Annette Wilson

Clinical Trial Administrator:  Ms Sharon Spence


Participating Study Sites:


Study Team:

Open to recruitment since:

St Marys Hospital

Mr Colin Bicknell

Dr Alex Rolls/ Ms Louise Allen

September 2011

Charing Cross Hospital

Prof Janet Powell

Ms Angie Williams

October 2011

Coventry & Warwickshire

Prof Christopher Imray

Ms Alison Kite

November 2011

Royal Free Hospital

Ms Meryl Davis

December 2011


Guys and St Thomas’

Mr Matt Waltham

Ms Susan Clark

January 2012

Colchester Hospital

Mr Sohail Choksy

Ms Marianne Morgan / Ms Nyasha Nago

July 2012


Hull & East Yorkshire

Mr Ian Chetter 

Ms Emma Clarke / Ms Anna Firth                                  

July 2012


Royal Bournemouth                       

Mr Dynesh Rittoo

Ms Sara Baker

August 2012


 Norfolk and Norwich

Ms Felicity Meyer

Ms Mandy Burrows  

November 2012


Mr Tim Lees

Ms Lesley Wilson / Ms Vera Wealleans

 November 2012


Mr Andrew Thompson

Mr Andy Gibson / Ms Zoe Coleman / Mr Tom Smith

 December 2012


Mr Shah Nawaz

Ms Rebecca Warren

 December 2012


Mr Vince Smyth

Dr Andrew Schirro / Ellie Ridyard

March 2013


Mr Andrew Brown

Ms Florrie Mowatt/ Ms Ruth Chipp/ Ms Dorothy Stewart

March 2013


AARDVARK Total Recruitment (19/04/2013):

Final AARDVARK Recruitment Chart by month PDF Acrobat Document

AARDVARK Recruitment By Site (19/04/2013):

Final AARDVARK Recruitment Chart by site PDF Acrobat Document


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