National Heart & Lung Institute (NHLI)

NHLI Scholarships

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3 Year PhD studentship in Medical Statistics

"Novel statistical methods to determine whether early life growth and nutrition predict outcomes in cystic fibrosis"

The National Heart and Lung Institute of Imperial College London is seeking applications from candidates with a Master’s degree (or equivalent) in Medical Statistics or Epidemiology or a related discipline, for a 3 year PhD studentship. The candidate will apply novel statistical methods to data from a longitudinal clinical database to assess whether early life growth and nutrition predict later health in children with cystic fibrosis.

This project will use data from cystic fibrosis registries in the UK, Canada and Denmark. Candidates will use and develop novel statistical methods for longitudinal growth curve analysis to identify differences in growth trajectories between children with cystic fibrosis, identify factors that may explain such differences and determine whether these differences influence long term prognosis.  We are particularly interested in applications from those with experience working with large and complex epidemiological datasets arising from surveys or health utilisation records and who envisage a career in medical statistics.

The studentship has been made possible by a Strategic Research Centre (SRC) grant from the Cystic Fibrosis Trust (CF-EpiNet; Harnessing Data to Improve Lives) and is a collaboration between epidemiologists, statisticians, economists and clinicians working across 6 universities. The studentship will be based within the group of Professors Deborah Jarvis and Paul Cullinan at the National Heart and Lung Institute, Imperial College London, at the Royal Brompton Campus. Work will be co-supervised by Dr Sanja Stanojevic at the University of Toronto.

 The National Heart and Lung Institute provides an exciting environment, with state of the art facilities and excellent opportunities for PhD student training including research seminars and journal clubs. Senior, post-doctoral and PhD student statisticians working in epidemiology (Bayesian modelling, longitudinal analyses, statistical genetics work) meet regularly to discuss their developments in their specialty. NHLI also provides extensive collaborative opportunities with other research groups.

Applicants should hold a first or upper second class honours degree in a relevant subject (mathematics, statistics or epidemiology) and an MSc in a relevant subject (medical statistics, epidemiology or related discipline). Excellent skills in quantitative research methodology, statistical methods, analysis of large and complex datasets, data management and the use of statistical software are all essential. All students will belong to Imperial’s Graduate School which provides a comprehensive Professional Skills Programme and has received the Times Higher Award for Outstanding Support for Early Careers Researchers in 2006 and 2008.

The studentship will be funded for 3 years with a tax free bursary of £22,278 per annum. Tuition fees at the Home/EU rate will also be paid. International students should note that those who are not UK/EU citizens will need to provide evidence that they have financial resources to pay the difference between the Home/EU and the overseas tuition fee rates.

Any enquiries relating to the project and/or suitability should be directed to Prof. Debbie Jarvis (d.jarvis@imperial.ac.uk) or Dr Sanja Stanojevic (sanja.stanojevic@sickkids.ca).

How to apply

please send a CV, a one page personal statement, and the names and addresses of at least two academic referees to Deborah Jarvis by email on d.jarvis@imperial.ac.uk.    Please note that all candidates must fulfil College admissions criteria.

 Application deadline: 5pm, 28 February 2016

Start date: At a time between 04 April and 03 October 2016 (latest)

MRC logo 

3 or 4yr PhD MRC-Industrial CASE partnership studentship commencing in Autumn 2016

"Investigation into the role of TRPV4 in chronic respiratory diseases"

Applications are invited from candidates with a Master’s degree (or equivalent) in Biological Sciences or a related discipline, for a 3 or 4 year PhD studentship to investigate the “The role of transient receptor potential channels in chronic respiratory diseases” carried out in partnership with Chiesi, an international pharmaceutical company based in Parma, Italy with a strong focus on research, development, production and the commercialisation of innovative medicines in the Respiratory, Area.

Asthma and COPD are respiratory diseases with ever-increasing global prevalence that represent a social and economic burden for industrialised and developing countries. There is a desperate need for effective, novel therapy to treat these patients. Preclinical data suggests that transient receptor potential cation channel subfamily V member 4 (TRPV4) channel blockers could represent a novel class of disease modifying compounds, in patients with chronic lung diseases such as asthma and COPD. Recent evidence suggests that TRPV4 could also play a prominent role in idiopathic pulmonary fibrosis (IPF). The central aim of this collaborative studentship is to confirm this hypothesis and to investigate the mechanisms involved. A key strength of this project based around a collaborative partnership is the early integration of human tissue studies (with Dr Maher, ICL), in which to investigate possible biomarkers, mechanisms of action, test candidate therapies and to boost translation. Chiesi's commitment to respiratory research and ability to take products right through to the market place is a clear advantage of this industrial collaborative collaboration in an area of clear unmet medical need.

The studentship will be funded for up to 4 years with a tax free bursary in excess of £18,550 per annum. Tuition fees at the Home/EU rate will also be paid.

The student will work within the group of Professor Maria Belvisi & Dr Toby Maher. The group is based within the Airway Disease section of the National Heart and Lung Institute, Imperial College London, at the South Kensington Campus, with approximately 3-6 months spent at Chiesi’s site in Parma.

The National Heart and Lung Institute provides an exciting environment, with state of the art facilities and excellent opportunities for PhD student training including research seminars and journal clubs. In addition, the institute provides extensive collaborative opportunities with other research groups.

How to Apply

Applicants must hold, or expect to obtain, a first or upper second-class undergraduate degree or UK equivalent, along with a Masters, both in an appropriate subject from a recognised academic institution. To apply please send a CV, a one page personal statement, and the names and addresses of at least two academic referees to Maria Belvisi by email on m.belvisi@imperial.ac.uk. Please note that candidates must fulfil College admissions criteria.

Application deadline: 5pm, 14 February 2016

Website: http://www.imperial.ac.uk/people/m.belvisi

3yr British Lung Foundation PhD studentship

"A bioinformatic approach to diagnosing interstitial lung disease"

    

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Applications are invited from candidates with a Master’s degree (or equivalent) in Biological Sciences, Computer Sciences, Physics or Mathematics or a related discipline, for a 3 year PhD studentship to investigate A bioinformatic approach to diagnosing interstitial lung disease.

This project will apply novel data-intensive mathematical techniques to information held in the newly developed Royal Brompton Hospital clinical data warehouse together with genomic and proteomic information generated using novel molecular research techniques. In doing so this PhD will seek to improve the diagnosis and treatment of a rare group of lung disorders collectively known as interstitial lung disease. At the same time it is hoped to identify new targets for future drug development together with measurements (biomarkers) which will help to simplify and shorten future clinical trials. 

The studentship will be funded by a grant from the British Lung Foundation and provides a 3 years tax free bursary of £17,500 per annum. Tuition fees at the Home/EU rate will also be paid.

The student will work within the Fibrosis Research Group of Dr Toby Maher.  The group is based within the Inflammation, Repair and Development section of the National Heart and Lung Institute, Imperial College London, at the South Kensington Campus.

The National Heart and Lung Institute provides an exciting environment, with state of the art facilities and excellent opportunities for PhD student training including research seminars and journal clubs. In addition, the institute provides extensive collaborative opportunities with other research groups. The PhD studentship will also provide the opportunity for time to be spent with an industrial partner so as to provide a wider research experience. 

All students will belong to Imperial’s Graduate School which provides a comprehensive Professional Skills Programme and has received the Times Higher Award for Outstanding Support for Early Careers Researchers in 2006 and 2008. 

How to Apply

Applicants must hold, or expect to obtain, a first or upper second-class undergraduate degree or UK equivalent, along with a Masters, both in an appropriate subject from a recognised academic institution.  To apply please send a CV, a one page personal statement, and the names and addresses of at least two academic referees to Toby Maher by email on t.maher@imperial.ac.uk.    Please note that candidates must fulfil College admissions criteria.

Application deadline: 7 February 2016

Website: http://www.imperial.ac.uk/people/t.maher 

National Heart and Lung Institute Foundation Studentship 

3 or 4-year MRes/PhD Studentships 2016

Lab work


Applications are invited for six 4-year MRes/PhD studentships at the National Heart and Lung Institute, funded by the National Heart and Lung Institute Foundation (Charity 1048073) to start in October 2016. The studentships will be funded for 4 years, on a bursary of £17,500 per annum and tuition fees at the Home/EU rate.  There is no provision for overseas student fees.

The NHLI Foundation’s interest is in all aspects of heart, lung and cardiovascular disease and projects offered involve a variety of disciplines including bioengineering, cell biology, chemistry, epidemiology, genetics, immunology, molecular biology, pharmacology, physics, physiology and public health.

NHLI Foundation research studentships enable graduates with excellent honours degrees to undertake a three to four year training programme that includes a research project plus training in research methods and transferable key skills.

Students would be expected to register for the MRes in Biomedical Research, Respiratory and Cardiovascular Science stream (yr 1) in the first instance.  Successful completion of the MRes degree with Merit is followed by PhD studies (yrs 2-4), on the NHLI Foundation research project of their choice.  Applicants with a relevant Masters degree may be exempt from year one of the programme.

NHLI and Imperial College London provide excellent opportunities for postgraduate research student training including research seminars, journal clubs and an exciting collaborative environment.  All students will belong to the Graduate School which provides a comprehensive Transferable Skills Programme and has received the Times Higher Award for Outstanding Support for Early Careers Researchers in 2006 and 2008.

How to Apply

Applicants must hold, or expect to obtain, a first or upper second-class honours degree or UK equivalent in an appropriate subject from a recognised academic institution.  To apply please send a CV with your grades clearly listed, a one page personal statement, and the names and addresses of at least two academic referees to NHLI’s PGR Office nhlipgr.team@imperial.ac.uk.

Application closing date is 31 January 2016 Please note that candidates must fulfil College admissions criteria.  

Further information on the NHLI Foundation 4-year MRes/PhD Scholarship 

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