School of Public Health

Neuroepidemiology and Ageing (NEA) Research Unit



With a rapidly ageing population, age-related neurodegenerative diseases such as these are fast becoming a major issue of public health worldwide.

The common aim of projects within the department is to better understand risk and protective factors for these diseases on a population level, and in turn inform methods for early prediction and prevention.

About the NEA Unit

The department, headed by Professor Lefkos Middleton and Professor Robert Perneczky, is part of the School of Public Health at Imperial College, based at the Charing Cross Hospital campus.

The department also collaborates with a number of organisations across the NHS Trust:

  • WLMHT - West London Mental Health Trust
  • CLRN - Clinical Research Network

Areas of Research

  • Gene-environment interactions in age-related neurodegenerative diseases
  • Early detection and prediction
  • Targeted interventions for the prevention of dementia and Parkinson’s disease
  • Setting up and managing patient and healthy volunteer registers for research participation
  • Natural history studies of age- related neurodegenerative diseases

Major Projects

  • CHARIOT – Cognitive Health in Ageing Register for Investigations, Observations & Trials in Dementia Research
  • EPIC4PD – Working with the European Prospective Investigation into Cancer and Nutrition (EPIC) to look at gene-environment interactions in Parkinson’s Disease
  • Dementias related to PD: working with the Parkinson’s UK Brain Bank and replication sample
  • Read More
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