Department of Medicine

Centre for Neuropsychopharmacology

  • Centre for Neuropsychopharmacology

The Centre for Neuropsychopharmacology conducts pioneering research into neuropsychiatric disorders merging pharmacological approaches with state-of-the-art imaging techniques – PET, MR and MEG. The particular emphasis is on brain disorders such as addiction, dementia and affective disorders. The Centre is multidisciplinary with psychiatrists, cognitive neuroscientists, methodologists and pharmacologists in addition to a range of PhD students.

There are close links with Imanova where the group conduct PET and MR imaging studies and The Cardiff University Brain Research Imaging Centre for MEG and MR. The psychiatrists also work within Central North West London NHS Foundation Trust from which we recruit for our imaging studies.

The current Centre head is Professor David Nutt.

Current areas of Research

Recent Publications

  •  Nutt DJ  Rhem J (2014) Doing it by numbers: a simple approach to reducing the harms of alcohol  Journal of Psychopharmacology  Jan;28(1):3-7. doi: 10.1177/0269881113512038 www.ncbi.nlm.nih.gov/pubmed/24399337

    Nutt DJ, Phillips LD, David BalfourD,  Curran HV, Dockrell M, FouldsJ, FagerstromK, LetlapeK, MiltonA, PolosaR, RamseyJ, SweanorD(2014) Estimating the harms of nicotine-containing products using the MCDA approach. Europ J Addiction 2014;20:218-225DOI: 10.1159/000360220 http://www.karger.com/Article/FullText/360220.

    (2013) Effects of Schedule I drug laws on neuroscience research and treatment innovation. Nat Rev Neurosci. Aug;14(8):577-85. doi: 10.1038/nrn3530. Epub 2013 Jun 12. 

    Muthukumaraswamy SD, Myers JFM, Wilson SJ, Nutt DJ, Hamandi K, Lingford-Hughes A, Singh KD (2013)  Elevating Endogenous GABA Levels with GAT-1 Blockade Modulates Evoked but Not Induced Responses in Human Visual Cortex.  Neuropsychopharmacology (2013), 1–8 http://www.nature.com/npp/journal/vaop/ncurrent/pdf/npp20139a.pdf

    Watson BJ, Taylor LG, Reid AG, Wilson SJ, Stokes PR, Brooks DJ, MyersJF, TurkheimerFE, NuttDJ, Lingford-HughesAR.  (2013) A critical test of the role of dopamine in human opioid addiction.  Addiction Biology  (in press – epub july 2013)dicdoi:10.1111/adb.12073 

    Fineberg NA, Haddad PM, Carpenter L, Gannon B, Sharpe R, Young AH, Joyce E, Rowe J, Wellsted D, Nutt DJ & Sahakian BJ. (2013)  The size, burden and cost of disorders of the brain in the UK. Journal of Psychopharmacology, 27(9), 761-770 doi 10.1177/0269881113495118                                                

    Muthukumaraswamy S, Carhart-Harris R, Moran R, Brookes M, Williams M,  Erritzoe D,  Sessa B, Papadopoulos A, Bolstridge M, Singh K, Fielding A,  Friston K, Nutt DJ (2013) Broadband cortical desynchronisation underlies the human psychedelic state The Journal of Neuroscience, September 18, 2013 • 33(38):15171–15183 • 1517 

    Jones AA, Vila-Rodriguez F, Panenka WJ, Leonova O, Strehlau V, Lang DJ,  Thornton AE, Wong H, Alasdair AM, Procyshyn RM, Smith GN, Buchanan T, Krajden M, Krausz M, Montaner JS,  MacEwan JW,  Nutt DJ ,  Honer WG  (2013) Personalized risk assessment of drug-related harm is associated with health outcomes  PLOS1 

    Carhart-Harris RL, Wall MB, Erritzoe D, Kaelen M, Ferguson B, De Meer I, Tanner M3 Bloomfield M, Williams TM, Bolstridge M,Stewart L, Morgan C, Newbould RD, Feilding A, Curran HV, Nutt DJ (2013) The effect of acutely administered MDMA on subjective and BOLD fMRI responses to favourite and worst autobiographical memories.   Int J of Neuropsychopharmacology (online= http://www.ncbi.nlm.nih.gov/pubmed/24345398

    Carhart-Harris RL, Nutt DJ [2014] Was it a vision or a waking dream? Frontiers in Psychology, section Consciousness Research http://www.frontiersin.org/Journal/FullText.aspx?

    Carhart-Harris RL, Murphy K, Leech R, Erritzoe D, Wall MB, Ferguson B, Williams LTJ, Roseman L, Brugger S, De Meer, Tanner M, Tyacke R, Wolff K, Sethi A, Bloomfield MAP, Williams TM, Bolstridge M,Stewart L, Morgan C, Newbould RD, Feilding A, Curran HV, Nutt DJ  (2014) The effects of acutely administered MDMA on spontaneous brain function in healthy volunteers measured with arterial spin labelling and BOLD resting-state functional connectivity.   Biological Psychiatry – epub

    Nutt DJ, Phillips LD, David BalfourD,  Curran HV, Dockrell M, FouldsJ, FagerstromK, LetlapeK, MiltonA, PolosaR, RamseyJ, SweanorD(2014) Estimating the harms of nicotine-containing products using the MCDA approach. Europ J Addiction 2014;20:218-225DOI: 10.1159/000360220 http://www.karger.com/Article/FullText/360220.

     Parker CA, Nabeel Nabulsi, Daniel Holden, Shu-fei Lin, Tara Cass, David Labaree, Steven Kealey, Antony D. Gee, Stephen M. Husbands, Darren Quelch, Richard E. Carson, David J. Nutt, Yiyun Huang, and Robin J. Tyacke Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain J Nucl Med 2014 jnumed.113.131854 published ahead of print April 7, 2014 http://jnm.snmjournals.org/content/early/2014/04/04/jnumed.113.131854.full.pdf+html 

  • Clark L, Stokes PR, Wu K, Michalczuk R, Benecke A, Watson BJ, Egerton A, Piccini P, Nutt DJ, Bowden-Jones H, Lingford-Hughes AR: Striatal dopamine D₂/D₃ receptor binding in pathological gambling is correlated with mood-related impulsivity. Neuroimage 2012, Oct; 63(1): 40-6
  • Myers JF, Rosso L, Watson BJ, Wilson SJ, Kalk NJ, Clementi N, Brooks DJ, Nutt DJ, Turkheimer FE, Lingford-Hughes AR: Characterisation of the contribution of the GABA-benzodiazepine α1 receptor subtype to [(11)C]Ro15-4513 PET images. Journal of Cerebral Blood Flow and Metabolism 2012, Apr; 32(4): 731-44
  • Watson BJ, Taylor LG, Reid AG, Wilson SJ, Stokes PR, Brooks DJ, Myers JF, Turkheimer FE, Nutt DJ, Lingford-Hughes AR: Investigating expectation and reward in human opioid addiction with [11 C]raclopride PET. Addiction Biology 2013, Jul
  • Stokes PR, Benecke A, Myers J, Erritzoe D, Watson BJ, Kalk N, Barros DR, Hammers A, Nutt DJ, Lingford-Hughes AR: History of cigarette smoking is associated with higher limbic GABAA receptor availability. Neuroimage 2013, Apr; 69: 70-7
  • Nutt DJ, King LA, Phillips LD: Drug harms in the UK: a multicriteria decision analysis. The Lancet 2010, November; 376(9752): 1558 – 1565
  • Carhart-Harris RL, Erritzoe D, Williams T, Stone JM, Reed LJ, Colasanti A, Tyacke RJ, Leech R, Malizia AL, Murphy K, Hobden P, Evans J, Feilding A, Wise RG, Nutt DJ: Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences of the United States of America 2012, January
  • Nash JR, Sargent PA, Rabiner EA, Hood SD, Argyropoulos SV, Potokar JP, Grasby PM, Nutt DJ: Serotonin 5-HT1A receptor binding in people with panic disorder: positron emission tomography study. British Journal of Psychiatry 2008, Sep; 193(3): 229-34
  • Daglish MR, Williams TM, Wilson SJ, Taylor LG, Eap CB, Augsburger M, Giroud C, Brooks DJ, Myles JS, Grasby P, Lingford-Hughes AR, Nutt DJ: Brain dopamine response in human opioid addiction. Brain dopamine response in human opioid addiction 2008, Jul; 193(1): 65-72
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