Dr Aylin C Hanyaloglu

Dr. Aylin Hanyaloglu joined the Institute of Reproductive Biology and Development (IRDB), Imperial College London, as a Lecturer in August 2007. Her research interests are in understanding fundamental cell biological mechanisms regulating G protein-coupled receptor (GPCR) signal transduction.

Dr. Hanyaloglu has a long-standing interest in GPCR signalling stemming from her PhD studies at the MRC Human Reproductive Sciences unit, University of Edinburgh studying the molecular mechanisms regulating signal activation of two pituitary GPCRs that are key regulators of the reproductive and thyroid axis (the GnRH and TRH receptors respectively). In 1999 she relocated with her PhD supervisor A/Prof Eidne to the Western Australian Institute for Medical Research and graduated with Distinction from the University of Western Australia in 2002. The published research from her PhD has recived awards from the Australian Women in Endocrinology, US Women in Endocrinology and a Raine Medical Research Foundation Certificate of Distinction. In 2002, Dr. Hanyaloglu joined the laboratory of A/Prof Mark von Zastrow at the University of California, San Francisco (UCSF) as a postdoctoal fellow. Her research has uncovered a novel system for reprogramming GPCR activity, providing important clues to both how these receptors function in diverse physiological systems and in the cellular action of clinically relevant drugs to these GPCRs. During this period Dr. Hanyaloglu was awarded a Postdoctoral Fellowship from the American Heart Association.

Dr. Hanyaloglu's research is currently funded by Institute of Obsetetrics and Gynaecolgical Trust and The Wellcome Trust to study the post-endocytic trafficking mechanisms of the gonadotrophin hormone receptors, in colloboration with Professor Ilpo Huhtaniemi. An award from The Royal Society Research has provided funding to study GPCR/protein interactions in real time via Bioluminescence resonance energy transfer (BRET). Further details on her research can be found at:

http://www1.imperial.ac.uk/medicine/about/divisions/olddivisions/sora/reproductivebiology/irdb/cellsigngenexp/ahanyaloglu/