Professor Frances M Gotch

Publications


Journals

  • Herasimtschuk A; Thaventhiran T; Nelson M; Moyle G; Gazzard B; Gotch F; Imami N. (1 Apr 2012). Distinct HIV-1 Gag-and Nef- specific responses correlate with immunophenotype in treated chronic HIV-1 infection. HIV MEDICINE. 13:32-32. Author weblink.
  • Robey RC; Mletzko S; Gotch FM. (2010). The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus. Adv Virol. 2010:340356. DOI.
  • Guergnon J; Dalmasso C; Broet P; Meyer L; Westrop SJ; Imami N; Vicenzi E; Morsica G; et alTinelli M; Zanone Poma B; Goujard C; Potard V; Gotch FM; Casoli C; Cossarizza A; Macciardi F; Debré P; Delfraissy JF; Galli M; Autran B; Costagliola D; Poli G; Theodorou I; Riva A; GISHEAL Consortium. (Mar 2012). Single-nucleotide polymorphism-defined class I and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection. J Infect Dis. 205:718-724. DOI.
  • Serwanga J; Mugaba S; Pimego E; Nanteza B; Lyagoba F; Nakubulwa S; Heath L; Nsubuga RN; et alNdembi N; Gotch F; Kaleebu P. (Apr 2012). Profile of T cell recognition of HIV type 1 consensus group M Gag and Nef peptides in a clade A1- and D-infected Ugandan population. AIDS Res Hum Retroviruses. 28:384-392. DOI.
  • Gudmundsdotter L; Wahren B; Haller BK; Boberg A; Edback U; Bernasconi D; Butto S; Gaines H; et alImami N; Gotch F; Lori F; Lisziewicz J; Sandstrom E; Hejdeman B. (26 Jul 2011). Amplified antigen-specific immune responses in HIV-1 infected individuals in a double blind DNA immunization and therapy interruption trial. VACCINE. 29:5558-5566. DOI.
  • Kaltsidis H; Cheeseman H; Kopycinski J; Ashraf A; Cox MC; Clark L; Anjarwalla I; Dally L; et alBergin P; Spentzou A; Higgs C; Gotch F; Gazzard B; Gomez R; Hayes P; Kelleher P; Gill DK; Gilmour J. (29 Jul 2011). Measuring human T cell responses in blood and gut samples using qualified methods suitable for evaluation of HIV vaccine candidates in clinical trials. JOURNAL OF IMMUNOLOGICAL METHODS. 370:43-54. DOI.
  • Downey JS; Attaf M; Moyle G; Gazzard B; Gotch F; Imami N. (23 Oct 2011). T-cell signalling in antiretroviral-treated, aviraemic HIV-1-positive individuals is present in a raised state of basal activation that contributes to T-cell hyporesponsiveness. AIDS. 25:1981-1986. DOI.
  • Clark S; Page E; Ford T; Metcalf R; Pozniak A; Nelson M; Henderson DC; Asboe D; et alGotch F; Gazzard BG; Kelleher P. (Oct 2011). Reduced T(H)1/T(H)17 CD4 T-cell numbers are associated with impaired purified protein derivative-specific cytokine responses in patients with HIV-1 infection. J Allergy Clin Immunol. 128:838-846.e5. DOI.
  • Edmonds E; Barton G; Buisson S; Francis N; Gotch F; Game L; Haddad M; Dinneen M; et alBunker C. (Oct 2011). Gene expression profiling in male genital lichen sclerosus. Int J Exp Pathol. 92:320-325. DOI.
  • Kaltsidis H; Cheeseman H; Kopycinski J; Ashraf A; Cox MC; Clark L; Anjarwalla I; Dally L; et alBergin P; Spentzou A; Higgs C; Gotch F; Gazzard B; Gomez R; Hayes P; Kelleher P; Gill DK; Gilmour J. (29 Jul 2011). Measuring human T cell responses in blood and gut samples using qualified methods suitable for evaluation of HIV vaccine candidates in clinical trials. J Immunol Methods. 370:43-54. DOI.
  • Robey RC; Mletzko S; Bower M; Meys R; Boffito M; Nelson M; Bunker CB; Gotch FM. (Jun 2011). Ex-vivo recognition of late-lytic CD8 epitopes specific for Kaposi's sarcoma-associated herpesvirus (KSHV) by HIV/KSHV-coinfected individuals. Viral Immunol. 24:211-220. DOI.
  • Guimaraes-Walker A; Mackie N; McCormack S; Hanke T; Schmidt C; Gilmour J; Barin B; McMichael A; et alWeber J; Legg K; Babiker A; Hayes P; Gotch F; Smith C; Dally L; Dorrell L; Cebere I; Kay R; Winstone N; Moore S; Goonetilleke N; Fast P. (18 Apr 2011). Lessons from IAVI-006, a Phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers (vol 26, pg 6671, 2008). VACCINE. 29:3511-3511. DOI.
  • Mletzko S; Kyriakou A; Robey R; Bower M; Nelson M; Merchant S; Gazzard B; Boshoff C; et alGotch F. (1 Apr 2011). Impaired dendritic cell (DC) function in Kaposi's sarcoma-associated herpesvirus (KSHV) infections. HIV MEDICINE. 12:28-29. Author weblink.
  • Herasimtschuk A; Downey J; Nelson M; Higgs C; Sikut R; Stanescu I; Gazzard B; Gotch F; et alImami N. (1 Apr 2011). Impact of IL-2/GM-CSF, rhGH and therapeutic immunization in treated HIV-1 infection: a randomized, open-label, Phase I immunotherapeutic study. HIV MEDICINE. 12:27-27. Author weblink.
  • Robey R; Mletzko S; Bower M; Meys R; Boffito M; Nelson M; Merchant S; Gazzard B; et alBoshoff C; Gotch F. (1 Apr 2011). Ex-vivo recognition of late-lytic CD8 epitopes specific for Kaposi's sarcoma-associated herpesvirus (KSHV) by HIV/KSHV-coinfected individuals. HIV MEDICINE. 12:23-23. Author weblink.
  • Serwanga J; Mugaba S; Betty A; Pimego E; Walker S; Munderi P; Gilks C; Gotch F; et alGrosskurth H; Kaleebu P. (2011). CD8 T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4 T Cells <200 Cell/μL: The DART Trial STI Substudy. AIDS Res Treat. 2011:875028. DOI.
  • Brinckmann S; da Costa K; van Gils MJ; Hallengärd D; Klein K; Madeira L; Mainetti L; Palma P; et alRaue K; Reinhart D; Reudelsterz M; Ruffin N; Seifried J; Schäfer K; Sheik-Khalil E; Sköld A; Uchtenhagen H; Vabret N; Ziglio S; Scarlatti G; Shattock R; Wahren B; Gotch F. (2011). Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010. J Transl Med. 9:40. DOI.
  • Matthews NC; Goodier MR; Robey RC; Bower M; Gotch FM. (Jul 2011). Killing of Kaposi's sarcoma-associated herpesvirus-infected fibroblasts during latent infection by activated natural killer cells. Eur J Immunol. 41:1958-1968. DOI.
  • Benlahrech A; Gotch F; Kelleher P; Patterson S. (2011). Loss of NK stimulatory capacity by plasmacytoid and monocyte-derived DC but not myeloid DC in HIV-1 infected patients. PLoS One. 6:e17525. DOI.
  • Gudmundsdotter L; Wahren B; Haller BK; Boberg A; Edbäck U; Bernasconi D; Buttò S; Gaines H; et alImami N; Gotch F; Lori F; Lisziewicz J; Sandström E; Hejdeman B. (26 Jul 2011). Amplified antigen-specific immune responses in HIV-1 infected individuals in a double blind DNA immunization and therapy interruption trial. Vaccine. 29:5558-5566. DOI.
  • Meys R; Macedo C; Jones R; Day S; Weir J; Gotch FM; Bunker CB. (Feb 2011). Cutaneous human papillomavirus-related immune reconstitution-associated disease in human immunodeficiency virus: an under-recognized phenomenon. Br J Dermatol. 164:458-459. DOI.
  • Duraisingham SS; Hornig J; Gotch F; Patterson S. (Oct 2010). CD34-derived human Langerhans cells stimulate a T helper type 2 response independently of extracellular-signal-regulated kinase phosphorylation. Immunology. 131:210-219. DOI.
  • Lagos D; Pollara G; Henderson S; Gratrix F; Fabani M; Milne RS; Gotch F; Boshoff C. (May 2010). miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator. Nat Cell Biol. 12:513-519. DOI.
  • Spentzou A; Bergin P; Gill D; Cheeseman H; Ashraf A; Kaltsidis H; Cashin-Cox M; Anjarwalla I; et alSteel A; Higgs C; Pozniak A; Piechocka-Trocha A; Wong J; Anzala O; Karita E; Dally L; Gotch F; Walker B; Gilmour J; Hayes P. (Mar 2010). Viral inhibition assay: a CD8 T cell neutralization assay for use in clinical trials of HIV-1 vaccine candidates. J Infect Dis. 201:720-729. DOI.
  • Spentzou A; Bergin P; Gill D; Cheeseman H; Ashraf A; Kaltsidis H; Cashin-Cox M; Anjarwalla I; et alSteel A; Higgs C; Pozniak A; Piechocka-Trocha A; Wong J; Anzala O; Karita E; Dally L; Gotch F; Walker B; Gilmour J; Hayes P. (1 Mar 2010). Viral Inhibition Assay: A CD8 T Cell Neutralization Assay for Use in Clinical Trials of HIV-1 Vaccine Candidates. JOURNAL OF INFECTIOUS DISEASES. 201:720-729. Author weblink DOI.
  • Meys R; Gotch FM; Bunker CB. (1 Jan 2010). Human papillomavirus in the era of highly active antiretroviral therapy for human immunodeficiency virus: an immune reconstitution-associated disease?. BRITISH JOURNAL OF DERMATOLOGY. 162:6-11. Author weblink DOI.
  • Kyosiimire-Lugemwa J; Pala P; Miiro G; Todd J; Kaleebu P; Imami N; Gotch F. (1 Jan 2009). Gag and Nef specific T-cell responses in HIV-1 infected long-term non-progressors in Uganda. RETROVIROLOGY. 6. Author weblink.
  • Benlahrech A; Harris J; Meiser A; Papagatsias T; Hornig J; Hayes P; Lieber A; Athanasopoulos T; et alBachy V; Daniels R; Fisher K; Gotch F; Klavinskis L; Seymour L; Logan K; Barbagallo R; Dickson G; Patterson S. (1 Jan 2009). Adenovirus vectors induce expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1 infection. RETROVIROLOGY. 6. Author weblink.
  • Benlahrech A; Harris J; Meiser A; Papagatsias T; Hornig J; Hayes P; Lieber A; Athanasopoulos T; et alBachy V; Csomor E; Daniels R; Fisher K; Gotch F; Seymour L; Logan K; Barbagallo R; Klavinskis L; Dickson G; Patterson S. (24 Nov 2009). Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1. Proc Natl Acad Sci U S A. 106:19940-19945. DOI.
  • Meys R; Mantovani C; Asboe D; Hawkins DA; Gotch FM; Terenghi G; Bunker CB. (1 Sep 2009). The neurocutaneous environment of warts in HIV infection. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 129:S103-S103. Author weblink.
  • Duraisingham SS; Hornig J; Gotch F; Patterson S. (15 Aug 2009). TLR-Stimulated CD34 Stem Cell-Derived Human Skin-Like and Monocyte-Derived Dendritic Cells Fail to Induce Th17 Polarization of Naive T Cells but Do Stimulate Th1 and Th17 Memory Responses. JOURNAL OF IMMUNOLOGY. 183:2242-2251. Author weblink DOI.
  • Rosignoli G; Lim CH; Bower M; Gotch F; Imami N. (1 Jul 2009). Programmed death (PD)-1 molecule and its ligand PD-L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus-1-infected individuals. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 157:90-97. Author weblink DOI.
  • Buisson S; Benlahrech A; Gazzard B; Gotch F; Kelleher P; Patterson S. (15 Jun 2009). Monocyte-derived dendritic cells from HIV type 1-infected individuals show reduced ability to stimulate T cells and have altered production of interleukin (IL)-12 and IL-10. J Infect Dis. 199:1862-1871. DOI.
  • Abbadessa G; Accolla R; Aiuti F; Albini A; Aldovini A; Alfano M; Antonelli G; Bartholomew C; et alBentwich Z; Bertazzoni U; Berzofsky JA; Biberfeld P; Boeri E; Buonaguro L; Buonaguro FM; Bukrinsky M; Burny A; Caruso A; Cassol S; Chandra P; Ceccherini-Nelli L; Chieco-Bianchi L; Clerici M; Colombini-Hatch S; de Giuli Morghen C; de Maria A; de Rossi A; Dierich M; Della-Favera R; Dolei A; Douek D; Erfle V; Felber B; Fiorentini S; Franchini G; Gershoni JM; Gotch F; Green P; Greene WC; Hall W; Haseltine W; Jacobson S; Kallings LO; Kalyanaraman VS; Katinger H; Khalili K; Klein G; Klein E; Klotman M; Klotman P; Kotler M; Kurth R; Lafeuillade A; La Placa M; Lewis J; Lillo F; Lisziewicz J; Lomonico A; Lopalco L; Lori F; Lusso P; Macchi B; Malim M; Margolis L; Markham PD; McClure M; Miller N; Mingari MC; Moretta L; Noonan D; O'Brien S; Okamoto T; Pal R; Palese P; Panet A; Pantaleo G; Pavlakis G; Pistello M; Plotkin S; Poli G; Pomerantz R; Radaelli A; Robertguroff M; Roederer M; Sarngadharan MG; Schols D; Secchiero P; Shearer G; Siccardi A; Stevenson M; Svoboda J; Tartaglia J; Torelli G; Tornesello ML; Tschachler E; Vaccarezza M; Vallbracht A; van Lunzen J; Varnier O; Vicenzi E; von Melchner H; Witz I; Zagury D; Zagury JF; Zauli G; Zipeto D. (9 Jan 2009). Unsung hero Robert C. Gallo. Science. 323:206-207. DOI.
  • Gregson JNS; Steel A; Bower M; Gazzard BG; Gotch FM; Goodier MR. (2 Jan 2009). Elevated plasma lipopolysaccharide is not sufficient to drive natural killer cell activation in HIV-1-infected individuals. AIDS. 23:29-34. Author weblink DOI.
  • Serwanga J; Shafer LA; Pimego E; Auma B; Watera C; Rowland S; Yirrell D; Pala P; et alGrosskurth H; Whitworth J; Gotch F; Kaleebu P. (2009). Host HLA B*allele-associated multi-clade Gag T-cell recognition correlates with slow HIV-1 disease progression in antiretroviral therapy-naïve Ugandans. PLoS One. 4:e4188. DOI.
  • Benlahrech A; Donaghy H; Rozis G; Goodier M; Klavinskis L; Gotch F; Patterson S. (1 Jan 2009). Human NK Cell Up-regulation of CD69, HLA-DR, Interferon gamma Secretion and Cytotoxic Activity by Plasmacytoid Dendritic Cells is Regulated through Overlapping but Different Pathways. SENSORS. 9:386-403. Author weblink DOI.
  • Robey RC; Lagos D; Gratrix F; Henderson S; Matthews NC; Vart RJ; Bower M; Boshoff C; et alGotch FM. (2009). The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens. PLoS One. 4:e5890. DOI.
  • Westrop SJ; Qazi NA; Pido-Lopez J; Nelson MR; Gazzard B; Gotch FM; Imami N. (2009). Transient nature of long-term nonprogression and broad virus-specific proliferative T-cell responses with sustained thymic output in HIV-1 controllers. PLoS One. 4:e5474. DOI.
  • Guimarães-Walker A; Mackie N; McCormack S; Hanke T; Schmidt C; Gilmour J; Barin B; McMichael A; et alWeber J; Legg K; Babiker A; Hayes P; Gotch F; Smith C; Dally L; Dorrell L; Cebere I; Kay R; Winstone N; Moore S; Goonetilleke N; Fast P; IAVI-006 Study Group. (2 Dec 2008). Lessons from IAVI-006, a phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers. Vaccine. 26:6671-6677. DOI.
  • Lagos D; Vart RJ; Gratrix F; Westrop SJ; Emuss V; Wong P-P; Robey R; Imami N; et alBower M; Gotch F; Boshoff C. (13 Nov 2008). Toll-like Receptor 4 Mediates Innate Immunity to Kaposi Sarcoma Herpesvirus. CELL HOST & MICROBE. 4:470-483. Author weblink DOI.
  • Gudmundsdotter L; Bostrom A-C; Burton C; Rosignoli G; Sandstrom E; Hejdeman B; Wahren B; Imami N; et alGotch F. (19 Sep 2008). Long-term increase of CD4(+) central memory cells in HIV-1-infected individuals by therapeutic HIV-1 rgp160 immunization. VACCINE. 26:5107-5110. Author weblink DOI.
  • Rozis G; Benlahrech A; Duraisingham S; Gotch F; Patterson S. (1 Jul 2008). Human Langerhans' cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligands. IMMUNOLOGY. 124:329-338. Author weblink DOI.
  • Burton CT; Goodall RL; Samri A; Autran B; Kelleher AD; Poli G; Pantaleo G; Gotch FM; et alImami N. (1 May 2008). Restoration of anti-tetanus toxoid responses in patients initiating highly active antiretroviral therapy with or without a boost immunization: an INITIO substudy. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 152:252-257. Author weblink DOI.
  • Steel A; Clark S-A; Hart M; Henderson D; Gotch F; Gazzard B; Kelleher P. (1 Apr 2008). Loss of memory B cell subsets in uncomplicated adult coeliac disease. GASTROENTEROLOGY. 134:A521-A521. Author weblink.
  • Steel A; John L; Shamji MH; Henderson DC; Gotch FM; Gazzard BG; Kelleher P. (1 Feb 2008). CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy. HIV MEDICINE. 9:118-125. Author weblink DOI.
  • Papagatsias T; Rozis G; Athanasopoulos T; Gotch F; Dickson G; Patterson S. (29 Jan 2008). Activity of different vaccine-associated promoter elements in human dendritic cells. IMMUNOLOGY LETTERS. 115:117-125. Author weblink DOI.
  • Gotch F. (1 Jan 2008). Calcium and phosphorus kinetics in hemodialysis therapy. HEMODIALYSIS: FROM BASIC RESEARCH TO CLINICAL TRIALS. 161:210-214. Author weblink.
  • Lacson E; Lazarus JM; Panlitio R; Gotch F. (1 Jan 2008). Comparison of hemodialysis blood access flow rates using online measurement of conductivity dialysance and ultrasound dilution. AMERICAN JOURNAL OF KIDNEY DISEASES. 51:99-106. Author weblink DOI.
  • Gotch F. (1 Jan 2008). What is important in dialysis? Efficiency: Blood flow, KoA and Kt/V?. HEMODIALYSIS: FROM BASIC RESEARCH TO CLINICAL TRIALS. 161:168-177. Author weblink.
  • Gotch F; Gilmour J. (1 Dec 2007). Science, medicine and research in the developing world: a perspective. NATURE IMMUNOLOGY. 8:1273-1276. Author weblink DOI.
  • Cronin-Fine D; Gotch F; Levin NW; Kotanko P; Lysaght M. (1 Nov 2007). A mathematical model comparing solute kinetics in low- and high-BMI hemodialysis patients. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. 30:1000-1007. Author weblink.
  • Mela CM; Steel A; Lindsay J; Gazzard BG; Gotch FM; Goodier MR. (18 Oct 2007). Depletion of natural killer cells in the colonic lamina propria of viraemic HIV-1-infected individuals. AIDS. 21:2177-2182. Author weblink.
  • Rosignoli G; Cranage A; Burton C; Nelson M; Steel A; Gazzard B; Gotch F; Imami N. (19 Jun 2007). Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients. AIDS. 21:1379-1381. Author weblink DOI.
  • Hart M; Steel A; Clark SA; Moyle G; Nelson M; Henderson DC; Wilson R; Gotch F; et alGazzard B; Kelleher P. (15 Jun 2007). Loss of discrete memory B cell subsets is associated with impaired immunization responses in HIV-1 infection and may be a risk factor for invasive pneumococcal disease. J Immunol. 178:8212-8220.
  • Gotch F. (9 Jun 2007). Kenneth Anthony ("Tony") Kalanyi Kebba - Obituary. BRITISH MEDICAL JOURNAL. 334:1227-1227.
  • Kebba A; Imami N; Bugembe-Lule D; Senkaali D; Kaleebu P; Grosskurth H; Gotch F. (Apr 2007). Recent HIV-1 infection in a high-risk Ugandan cohort: implications for Phase IIB test-of-concept HIV vaccine trials. Pharmacogenomics. 8:409-414. DOI.
  • Lagos D; Trotter MW; Vart RJ; Wang HW; Matthews NC; Hansen A; Flore O; Gotch F; et alBoshoff C. (15 Feb 2007). Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells. Blood. 109:1550-1558. DOI.
  • Page M; Ojugo A; Imami N; Hardy G; Gotch F; Almond N. (30 Jan 2007). Specificity of anti-human leukocyte antigen antibody responses after immunization with Remune, an inactivated HIV-1 vaccine. AIDS. 21:375-377. DOI.
  • Hardy GA; Imami N; Nelson MR; Sullivan AK; Moss R; Aasa-Chapman MM; Gazzard B; Gotch FM. (2007). A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapy. J Immune Based Ther Vaccines. 5:6. DOI.
  • Steel A; Cox AE; Shamji MH; John L; Nelson M; Henderson DC; Gotch FM; Gazzard BG; et alKelleher P. (1 Jan 2007). HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8(+) T-cell activation. ANTIVIRAL THERAPY. 12:971-975. Author weblink.
  • Goodier MR; Mela CM; Steel A; Gazzard B; Bower M; Gotch F. (Jan 2007). NKG2C+ NK cells are enriched in AIDS patients with advanced-stage Kaposi's sarcoma. J Virol. 81:430-433. DOI.
  • Samri A; Goodall R; Burton C; Imami N; Pantaleo G; Kelleher A; Poli G; Gotch F; et alAutran B. (2007). Three-year immune reconstitution in PI-sparing and PI-containing antiretroviral regimens in advanced HIV-1 disease. Antivir Ther. 12:553-558.
  • Imami N; Kebba A; Gotch F. (Sep 2006). An anniversary without celebration?. Nat Immunol. 7:893. DOI.
  • Townsend AR; Rothbard J; Gotch FM; Bahadur G; Wraith D; McMichael AJ. (1 May 2006). The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. 1986. J Immunol. 176:5141-5150.
  • Townsend ARM; Rothbard J; Gotch FM; Bahadur G; Wraith D; McMichael AJ. (1 May 2006). The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides (reprinted from Cell, vol. 44, pg. 959-968, yr. 1986). JOURNAL OF IMMUNOLOGY. 176:5141-5150. Author weblink.
  • Burton CT; Gotch F; Imami N. (20 Jan 2006). Rapid qualitative and quantitative analysis of T-cell responses in HIV-1-infected individuals receiving successful HAART and HIV-1 sero-negative controls: concomitant assessment of perforin, IFN-gamma and IL-4 secretion. J Immunol Methods. 308:216-230. DOI.
  • Burton CT; Mela CM; Rosignoli G; Westrop SJ; Gotch FM; Imami N. (1 Jan 2006). Immune modulation and reconstitution of HIV-1-specific responses: Novel approaches and strategies. CURRENT MEDICINAL CHEMISTRY. 13:3203-3211. Author weblink.
  • Steel AW; Cox AE; Shamji MH; Henderson DC; Gotch FM; Gazzard BG; Kelleher P. (1 Dec 2005). CD38 expression on CD8+T cells is a marker of residual viral replication in HIV-1 infected patients on successful anti-retroviral therapy. IMMUNOLOGY. 116:94-94. Author weblink.
  • Lehner T; Hoelscher M; Clerici M; Gotch F; Pedneault L; Tartaglia J; Gray C; Mestecky J; et alSattentau Q; van de Wijgert J; Toure C; Osmanov S; Schmidt RE; Debre P; Romaris M; Hoeveler A; Di Fabio S. (1 Dec 2005). European Union and EDCTP strategy in the global context: recommendations for preventive HIV/AIDS vaccines research. Vaccine. 23:5551-5556. DOI.
  • Hart M; Clark L; Steel A; Henderson DC; Gazzard B; Wilson R; Gotch F; Kelleher P. (1 Dec 2005). Marginal zone B cells are selectively depleted in HIV-1 infection and are not restored by anti-retroviral therapy. IMMUNOLOGY. 116:102-102. Author weblink.
  • Mela CM; Burton CT; Imami N; Nelson M; Steel A; Gazzard BG; Gotch FM; Goodier MR. (4 Nov 2005). Switch from inhibitory to activating NKG2 receptor expression in HIV-1 infection: lack of reversion with highly active antiretroviral therapy. AIDS. 19:1761-1769.
  • Burton CT; Nelson MR; Hay P; Gazzard BG; Gotch FM; Imami N. (Nov 2005). Immunological and virological consequences of patient-directed antiretroviral therapy interruption during chronic HIV-1 infection. Clin Exp Immunol. 142:354-361. DOI.
  • Gotch F; Holmes H; Imami N. (Nov 2005). The importance of standardisation of laboratory evaluations in HIV vaccine trials. Microbes Infect. 7:1424-1432. DOI.
  • Pires A; Nelson M; Pozniak AL; Fisher M; Gazzard B; Gotch F; Imami N. (25 Sep 2005). Mycobacterial immune reconstitution inflammatory syndrome in HIV-1 infection after antiretroviral therapy is associated with deregulated specific T-cell responses: beneficial effect of IL-2 and GM-CSF immunotherapy. J Immune Based Ther Vaccines. 3:7. DOI.
  • Rozis G; de Silva S; Benlahrech A; Papagatsias T; Harris J; Gotch F; Dickson G; Patterson S. (Sep 2005). Langerhans cells are more efficiently transduced than dermal dendritic cells by adenovirus vectors expressing either group C or group B fibre protein: implications for mucosal vaccines. Eur J Immunol. 35:2617-2626. DOI.
  • Gotch F. (Sep 2005). Therapeutic vaccines and immunotherapy revisited. J HIV Ther. 10:48-50.
  • Kebba A; Stebbing J; Rowland S; Ingram R; Agaba J; Patterson S; Kaleebu P; Imami N; et alGotch F. (Jul 2005). Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjects. J Leukoc Biol. 78:37-42. DOI.
  • Patterson S; Donaghy H; Amjadi P; Gazzard B; Gotch F; Kelleher P. (15 Jun 2005). Human BDCA-1-positive blood dendritic cells differentiate into phenotypically distinct immature and mature populations in the absence of exogenous maturational stimuli: differentiation failure in HIV infection. J Immunol. 174:8200-8209.
  • Burton CT; Gotch FM; Imami N. (May 2005). CCR2/64I mutation detection in a HIV-1-positive patient with slow CD4 T-cell decline and delay in disease progression. Int J STD AIDS. 16:392-394. DOI.
  • Gotch F. (Apr 2005). HIV/AIDS cohorts in Uganda. An interview with Frances Gotch. IAVI Rep. 9:14-17.
  • Kandil H; Bachy V; Williams DJ; Helmi R; Gotch FM; Ibrahim MA. (Apr 2005). Regulation of dendritic cell interleukin-12 secretion by tumour cell necrosis. Clin Exp Immunol. 140:54-64. DOI.
  • Prakash M; Patterson S; Gotch F; Kapembwa MS. (Dec 2004). Ex vivo analysis of HIV-1 co-receptors at the endocervical mucosa of women using oral contraceptives. BJOG. 111:1468-1470.
  • Hardy GA; Imami N; Sullivan AK; Nelson MR; Gazzard B; Gotch FM. (5 Nov 2004). Tetanus vaccination with IL-2 during highly active antiretroviral therapy induces sustained and pronounced specific CD4 T-cell responses. AIDS. 18:2199-2202.
  • Stebbing J; Gazzard B; Patterson S; Bower M; Nelson M; Epenetos A; Ogg G; Gotch F; et alSavage P. (21 Oct 2004). Simplified one-step antibody-HLA directed expansion of HIV-specific cytotoxic T lymphocytes: a system suited for use in vivo (vol 18, pg 2099, 2004). AIDS. 18:2099-2101. Author weblink DOI.
  • Greenspan G; Geiger D; Gotch F; Bower M; Patterson S; Nelson M; Gazzard B; Stebbing J. (1 Aug 2004). Model-based inference of recombination hotspots in a highly variable oncogene (vol 58, pg 239, 2004). JOURNAL OF MOLECULAR EVOLUTION. 59:283-283. Author weblink DOI.
  • Prakash M; Kapembwa MS; Gotch F; Patterson S. (15 Jul 2004). Chemokine receptor expression on mucosal dendritic cells from the endocervix of healthy women. J Infect Dis. 190:246-250. DOI.
  • Belshe R; Franchini G; Girard MP; Gotch F; Kaleebu P; Marthas ML; McChesney MB; McCullough R; et alMhalu F; Salmon-Ceron D; Sekaly RP; Van Rompay K; Verrier B; Wahren B. (9 Jul 2004). Support for the RV144 HIV vaccine trial. SCIENCE. 305:177-177. Author weblink.
  • Rutebemberwa A; Auma B; Gilmour J; Jones G; Yirrell D; Rowland S; Imami N; Watera C; et alKaleebu P; Whitworth J; Gotch F. (Jul 2004). HIV type 1-specific inter- and intrasubtype cellular immune responses in HIV type 1-infected Ugandans. AIDS Res Hum Retroviruses. 20:763-771. DOI.
  • Pires A; Hardy G; Gazzard B; Gotch F; Imami N. (1 Jul 2004). Initiation of antiretroviral therapy during recent HIV-1 infection results in lower residual viral reservoirs. J Acquir Immune Defic Syndr. 36:783-790.
  • Stebbing J; Patterson S; Portsmouth S; Thomas C; Glassman R; Wildfire A; Gotch F; Bower M; et alNelson M; Gazzard B. (Jun 2004). Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients. Cell Res. 14:251-256. DOI.
  • Kebba A; Kaleebu P; Rowland S; Ingram R; Whitworth J; Imami N; Gotch F. (1 May 2004). Distinct patterns of peripheral HIV-1-specific interferon- gamma responses in exposed HIV-1-seronegative individuals. J Infect Dis. 189:1705-1713. DOI.
  • Stebbing J; Gazzard B; Patterson S; Bower M; Perumal D; Nelson M; McMichael A; Ogg G; et alEpenetos A; Gotch F; Savage P. (1 Mar 2004). Antibody-targeted MHC complex-directed expansion of HIV-1- and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccination. Blood. 103:1791-1795. DOI.
  • Hardy G; Worrell S; Hayes P; Barnett CM; Glass D; Pido-Lopez J; Imami N; Aspinall R; et alDutton J; Gazzard B; Peters AM; Gotch FM. (Mar 2004). Evidence of thymic reconstitution after highly active antiretroviral therapy in HIV-1 infection. HIV Med. 5:67-73.
  • Greenspan G; Geiger D; Gotch F; Bower M; Patterson S; Nelson M; Gazzard B; Stebbing J. (Mar 2004). Model-based inference of recombination hotspots in a highly variable oncogene [corrected]. J Mol Evol. 58:239-251. DOI.
  • Greenspan G; Geiger D; Gotch F; Bower M; Patterdson S; Nelson M; Gazzard B; Stebbing J. (Mar 2004). Recombination does not occur in newly identified diverged oceanic picornaviruses. J Mol Evol. 58:359-360. DOI.
  • Pires A; Pido-Lopez J; Moyle G; Gazzard B; Gotch F; Imami N. (Feb 2004). Enhanced T-cell maturation, differentiation and function in HIV-1-infected individuals after growth hormone and highly active antiretroviral therapy. Antivir Ther. 9:67-75.
  • Goodier MR; Imami N; Moyle G; Gazzard B; Gotch F. (1 Feb 2004). Loss of the CD56(hi) CD16(-) NK cell subset and NK cell interferon-gamma production during antiretroviral therapy for HIV-1: partial recovery by human growth hormone (vol 134, pg 470, 2003). CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 135:344-344. Author weblink DOI.
  • Stebbing J; Gazzard B; Newsom-Davis T; Nelson M; Patterson S; Gotch F; Mandalia S; Bower M. (20 Jan 2004). Nadir B cell counts are significantly correlated with the risk of Kaposi's sarcoma. Int J Cancer. 108:473-474. DOI.
  • Kebba A; Kaleebu P; Serwanga J; Rowland S; Yirrell D; Downing R; Gilmour J; Imami N; et alGotch F; Whitworth J. (Jan 2004). HIV type 1 antigen-responsive CD4+ T-lymphocytes in exposed yet HIV Type 1 seronegative Ugandans. AIDS Res Hum Retroviruses. 20:67-75. DOI.
  • Portsmouth S; Imami N; Pires A; Stebbing J; Hand J; Nelson M; Gotch F; Gazzard BG. (Jan 2004). Treatment of primary HIV-1 infection with nonnucleoside reverse transcriptase inhibitor-based therapy is effective and well tolerated. HIV Med. 5:26-29.
  • Chadwick D; Pido-Lopez J; Pires A; Imami N; Gotch F; Villacian JS; Ravindran S; Paton NI. (Dec 2003). A pilot study of the safety and efficacy of thymosin alpha 1 in augmenting immune reconstitution in HIV-infected patients with low CD4 counts taking highly active antiretroviral therapy. Clin Exp Immunol. 134:477-481.
  • Goodier MR; Imami N; Moyle G; Gazzard B; Gotch F. (Dec 2003). Loss of the CD56hiCD16- NK cell subset and NK cell interferon-gamma production during antiretroviral therapy for HIV-1: partial recovery by human growth hormone. Clin Exp Immunol. 134:470-476.
  • Stebbing J; Wildfire A; Portsmouth S; Powles T; Thirlwell C; Hewitt P; Nelson M; Patterson S; et alMandalia S; Gotch F; Gazzard BG; Bower M. (Nov 2003). Paclitaxel for anthracycline-resistant AIDS-related Kaposi's sarcoma: clinical and angiogenic correlations. Ann Oncol. 14:1660-1666.
  • Hardy GA; Imami N; Sullivan AK; Pires A; Burton CT; Nelson MR; Gazzard BG; Gotch FM. (Oct 2003). Reconstitution of CD4+ T cell responses in HIV-1 infected individuals initiating highly active antiretroviral therapy (HAART) is associated with renewed interleukin-2 production and responsiveness. Clin Exp Immunol. 134:98-106.
  • Stebbing J; Gazzard B; Flore O; Thomas C; Benlahrech A; Mandalia S; Bower M; Gotch F; et alPatterson S. (5 Sep 2003). Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma. AIDS. 17:1998-2000. DOI.
  • Stebbing J; Gazzard B; Portsmouth S; Gotch F; Kim L; Bower M; Mandalia S; Binder R; et alSrivastava P; Patterson S. (1 Sep 2003). Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor. Blood. 102:1806-1814. DOI.
  • Donaghy H; Gazzard B; Gotch F; Patterson S. (1 Jun 2003). Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1. Blood. 101:4505-4511. DOI.
  • Sullivan AK; Burton CT; Nelson MR; Moyle G; Mandalia S; Gotch FM; Gazzard BG; Imami N. (Jun 2003). Restoration of human immunodeficiency virus-1-specific responses in patients changing from protease to non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy. Scand J Immunol. 57:600-607.
  • Imami N; Gotch F. (Jun 2003). Twenty years of HIV-1 research: what the future holds. Nat Immunol. 4:501. DOI.
  • Stebbing J; Gazzard B; Kim L; Portsmouth S; Wildfire A; Teo I; Nelson M; Bower M; et alGotch F; Shaunak S; Srivastava P; Patterson S. (15 May 2003). The heat-shock protein receptor CD91 is up-regulated in monocytes of HIV-1-infected "true" long-term nonprogressors. Blood. 101:4000-4004. DOI.
  • Stebbing J; Portsmouth S; Gotch F; Gazzard B. (Apr 2003). Kaposi's sarcoma--an update. Int J STD AIDS. 14:225-227. DOI.
  • Stebbing J; Bourboulia D; Johnson M; Henderson S; Williams I; Wilder N; Tyrer M; Youle M; et alImami N; Kobu T; Kuon W; Sieper J; Gotch F; Boshoff C. (Apr 2003). Kaposi's sarcoma-associated herpesvirus cytotoxic T lymphocytes recognize and target Darwinian positively selected autologous K1 epitopes. J Virol. 77:4306-4314.
  • Sullivan AK; Hardy GA; Nelson MR; Gotch F; Gazzard BG; Imami N. (7 Mar 2003). Interleukin-2-associated viral breakthroughs induce HIV-1-specific CD4 T cell responses in patients on fully suppressive highly active antiretroviral therapy. AIDS. 17:628-629. DOI.
  • Stebbing J; Patterson S; Gotch F. (Feb 2003). New insights into the immunology and evolution of HIV. Cell Res. 13:1-7. DOI.
  • Prakash M; Patterson S; Gotch F; Kapembwa MS. (Feb 2003). Recruitment of CD4 T lymphocytes and macrophages into the cervical epithelium of women after coitus. Am J Obstet Gynecol. 188:376-381.
  • Pido-Lopez J; Burton C; Hardy G; Pires A; Sullivan A; Gazzard B; Aspinall R; Gotch F; et alImami N. (Feb 2003). Thymic output during initial highly active antiretroviral therapy (HAART) and during HAART supplementation with interleukin 2 and/or with HIV type 1 immunogen (Remune). AIDS Res Hum Retroviruses. 19:103-109. DOI.
  • Gill J; Bourboulia D; Wilkinson J; Hayes P; Cope A; Marcelin AG; Calvez V; Gotch F; et alBoshoff C; Gazzard B. (1 Dec 2002). Prospective study of the effects of antiretroviral therapy on Kaposi sarcoma--associated herpesvirus infection in patients with and without Kaposi sarcoma. J Acquir Immune Defic Syndr. 31:384-390.
  • Burton CT; Hardy GA; Sullivan AK; Nelson MR; Gazzard B; Gotch FM; Imami N. (Nov 2002). Impact of NNRTI compared to PI-based highly active antiretroviral therapy on CCR5 receptor expression, beta-chemokines and IL-16 secretion in HIV-1 infection. Clin Exp Immunol. 130:286-292.
  • Imami N; Pires A; Hardy G; Wilson J; Gazzard B; Gotch F. (Sep 2002). A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection. J Virol. 76:9011-9023.
  • Imami N; Hardy G; Pires A; Burton C; Pido-Lopez J; Mela C; Gotch F. (Aug 2002). Immune reconstitution in HIV-1-infected patients. Curr Opin Investig Drugs. 3:1138-1145.
  • Hardy GA; Imami N; Gotch FM. (May 2002). Improving HIV-specific immune responses in HIV-infected patients. J HIV Ther. 7:40-45.
  • Imami N; Gotch F. (May 2002). Mechanisms of loss of HIV-1-specific T-cell responses. J HIV Ther. 7:30-34.
  • Miao YM; Hayes PJ; Gotch FM; Barrett MC; Francis ND; Gazzard BG. (15 Apr 2002). Elevated mucosal addressin cell adhesion molecule-1 expression in acquired immunodeficiency syndrome is maintained during antiretroviral therapy by intestinal pathogens and coincides with increased duodenal CD4 T cell densities. J Infect Dis. 185:1043-1050. DOI.
  • Wilkinson J; Cope A; Gill J; Bourboulia D; Hayes P; Imami N; Kubo T; Marcelin A; et alCalvez V; Weiss R; Gazzard B; Boshoff C; Gotch F. (Mar 2002). Identification of Kaposi's sarcoma-associated herpesvirus (KSHV)-specific cytotoxic T-lymphocyte epitopes and evaluation of reconstitution of KSHV-specific responses in human immunodeficiency virus type 1-Infected patients receiving highly active antiretroviral therapy. J Virol. 76:2634-2640.
  • Prakash M; Kapembwa MS; Gotch F; Patterson S. (Mar 2002). Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4(+) T cells in the cervical epithelium of healthy women. J Reprod Immunol. 54:117-131.
  • Imami N; Gotch F. (Mar 2002). Prospects for immune reconstitution in HIV-1 infection. Clin Exp Immunol. 127:402-411.
  • Tchilian EZ; Dawes R; Ramaley PA; Whitworth JA; Yuldasheva N; Wells RS; Watera C; French N; et alGilks CF; Kunachiwa W; Ruzibakiev R; Leetrakool N; Carrington CV; Ramdath DD; Gotch F; Stephens HA; Hill AV; Beverley PC. (Feb 2002). A CD45 polymorphism associated with abnormal splicing is absent in African populations. Immunogenetics. 53:980-983. DOI.
  • Pido-Lopez J; Pires A; Nelson M; O'Moore E; Fisher M; Gazzard B; Aspinall R; Gotch F; et alImami N. (Jan 2002). Thymic activity in late-stage HIV-1 infected individuals receiving highly active antiretroviral therapy: potential effect of steroid therapy. HIV Med. 3:56-61.
  • Tchilian EZ; Wallace DL; Dawes R; Imami N; Burton C; Gotch F; Beverly PCL. (9 Nov 2001). A point mutation in CD45 may be associated with an increased risk of HIV-1 infection (vol 15, pg 1892, 2001). AIDS. 15:2210-2210. Author weblink.
  • Gotch F. (1 Nov 2001). Dedicated to the memory of Janis V. Giorgi (1947-2000). IMMUNOLOGY LETTERS. 79:VII-VII. Author weblink DOI.
  • Imami N; Hardy G; Burton C; Pires A; Pido-Lopez J; Moss R; Gazzard B; Gotch F. (1 Nov 2001). Immune responses and reconstitution in HIV-1 infected individuals: impact of anti-retroviral therapy, cytokines and therapeutic vaccination. Immunol Lett. 79:63-76.
  • Imami N; Sullivan AK; Gotch FM. (Nov 2001). Immunomodulation in HIV-1 infection in the HAART era. J HIV Ther. 6:77-84.
  • Gotch F; Heeney J; Manca F. (1 Nov 2001). Special issue: The third international summit meeting on: "Immunological correlates of protection from HIV infection and disease", Sestri Levante, Italy, 30 November-3 December 2000. IMMUNOLOGY LETTERS. 79:1-2. DOI.
  • Donaghy H; Pozniak A; Gazzard B; Qazi N; Gilmour J; Gotch F; Patterson S. (15 Oct 2001). Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood. 98:2574-2576.
  • Gotch F. (Oct 2001). AIDS vaccine 2001. IDrugs. 4:1141-1143.
  • Gotch FM; Imami N; Hardy G. (Oct 2001). Candidate vaccines for immunotherapy in HIV. HIV Med. 2:260-265.
  • Prakash M; Kapembwa MS; Gotch F; Patterson S. (Oct 2001). Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women. J Reprod Immunol. 52:101-111.
  • Tchilian EZ; Wallace DL; Dawes R; Imami N; Burton C; Gotch F; Beverley PC. (28 Sep 2001). A point mutation in CD45 may be associated with an increased risk of HIV-1 infection. AIDS. 15:1892-1894.
  • Jones GJ; Watera C; Patterson S; Rutebemberwa A; Kaleebu P; Whitworth JA; Gotch FM; Gilmour JW. (7 Sep 2001). Comparative loss and maturation of peripheral blood dendritic cell subpopulations in African and non-African HIV-1-infected patients. AIDS. 15:1657-1663.
  • Imami N; Hardy G; Gotch F. (Sep 2001). Development of immunotherapeutic strategies for HIV-1. Expert Opin Biol Ther. 1:803-816. DOI.
  • King DJ; Gotch FM; Larsson-Sciard EL; Paediatric European Network for Treatment of AIDS (PENTA). (Sep 2001). T-cell re-population in HIV-infected children on highly active anti-retroviral therapy (HAART). Clin Exp Immunol. 125:447-454.
  • Imami N; Hardy G; Pires A; Burton C; Sullivan A; Gotch F. (Jul 2001). Detection and quantification of HIV-1 specific CD4 helper and CD8 cytotoxic cells: their role in HIV-1-infected individuals and vaccine recipients. HIV Med. 2:146-153.
  • Patterson S; Rae A; Hockey N; Gilmour J; Gotch F. (Jul 2001). Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus. J Virol. 75:6710-6713. DOI.
  • Tchilian EZ; Wallace DL; Imami N; Liao HX; Burton C; Gotch F; Martinson J; Haynes BF; et alBeverley PC. (15 May 2001). The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans. J Immunol. 166:6144-6148.
  • Gotch FM; Imami N. (2 May 2001). Outcomes of a trial of HIV-1 immunogen in patients with HIV infection. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 285:2191-2192. Author weblink.
  • Gilmour JW; Gilling-Smith C; Gotch F. (16 Feb 2001). Reduction of HIV transmission in HIV-discordant couples wishing to conceive. AIDS. 15:429-430.
  • Morgan D; Kaleebu P; Whitworth J; Yirrell D; Rutebemberwa A; Shier R; Sebabi B; Gilmour J; et alEotu H; Omoding N; Gotch F. (Feb 2001). The stability between two HIV-1 RNA measurements one year apart and the relationship with HIV subtype in rural Uganda. Int J STD AIDS. 12:116-121.
  • Wilkinson J; Gotch F. (2001). Immune interventions. Br Med Bull. 58:187-203.
  • Worrell S; Deayton J; Hayes P; Emery VC; Gotch F; Gazzard B; Larsson-Sciard EL. (Jan 2001). Molecular correlates in AIDS patients following antiretroviral therapy: diversified T-cell receptor repertoires and in vivo control of cytomegalovirus replication. HIV Med. 2:11-19.
  • Gotch F; Burton C; Donaghy H; Hardy G; Imani N; Pido-Lopez J; Pires A; Sullivan A. (2001). Novel approaches to the treatment of HIV. HIV & AIDS Current Trends. 7:7.
  • Mallon E; Bunce M; Savoie H; Rowe A; Newson R; Gotch F; Bunker CB. (1 Dec 2000). HLA-C and guttate psoriasis. BRITISH JOURNAL OF DERMATOLOGY. 143:1177-1182. Author weblink DOI.
  • Sullivan AK; Imami N; Hardy GAD; Pires A; O'Donavan B; Gotch FM; Gazzard BG. (1 Oct 2000). Acute viral load blips in response to subcutaneous interleukin-2 therapy in HIV-1 infected individuals on highly active antiretroviral therapy. AIDS. 14:S73-S74. Author weblink.
  • Sullivan AK; Pires A; Hardy GAD; Gotch FM; Gazzard BG; Imami N. (1 Oct 2000). Phenotypic T cell changes in HIV-1 infected individuals receiving highly active antiretroviral therapy. AIDS. 14:S75-S75. Author weblink.
  • Wilson JD; Imami N; Watkins A; Gill J; Hay P; Gazzard B; Westby M; Gotch FM. (Sep 2000). Loss of CD4+ T cell proliferative ability but not loss of human immunodeficiency virus type 1 specificity equates with progression to disease. J Infect Dis. 182:792-798. DOI.
  • Ibrahim MA; Gotch FM. (Jul 2000). Making smarter immunotherapies. Nat Immunol. 1:3. DOI.

Conferences

  • Page EE; Clarke SA; Hart MS; Louise G; Metcalf R; Anderson M; Gotch F; Nelson M; et alGazzard B; Kelleher WP. LIVER FIBROSIS IN HIV/HCV CO-INFECTION: THE ROLE OF TH17 AND TH22 CELLS. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), 4 Nov 2011 - 8 Nov 2011. 54:1323A-1323A. WILEY-BLACKWELL (1 Oct 2011). Author weblink.
  • Westrop S; Lagos D; Bower M; Gotch F; Gazzard B; Boshoff C; Imami N. Increased incidence of multicentric Castleman's disease in KSHV+ HIV-1(+) individuals of Black African ethnicity may result from the higher frequency of the TLR4 single nucleotide polymorphism A299G. 12:6-7. WILEY-BLACKWELL (1 Apr 2011). Author weblink.
  • Meys R; Bunker C; Gotch FM; Weir J. Cutaneous HPV-related immune reconstitution associated disease (IRAD) in HIV: An underrecognized phenomenon. 69th Annual Meeting of the American-Academy-of-Dermatology, 4 Feb 2011 - 8 Feb 2011. 64:AB107-AB107. MOSBY-ELSEVIER (1 Feb 2011).
  • Page EE; Clark S-A; Hart M; Metcalf R; Anderson M; Steel A; Gazzard B; Gotch F; et alNelson M; Kelleher P. Loss of Th22 cells, rather than a shift from a Th17 to Th1 phenotype, is associated with increased immune activation in HIV-1 infection. Annual Congress of the British-Society-for-Immunology, 6 Dec 2010 - 10 Dec 2010. 131:123-123. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2010). Author weblink.
  • Grover V; Singh S; Henderson D; Pantelidis P; Soni N; Kelleher P; Gotch F. Use of an inflammatory biomarker panel in the diagnosis of Ventilator-Associated Pneumonia. Annual Congress of the British-Society-for-Immunology, 6 Dec 2010 - 10 Dec 2010. 131:122-122. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2010). Author weblink.
  • Ford T; Clark SA; Pantelidis P; Loebinger M; Wilson R; Manson A; Seneviratne S; Henderson D; et alGotch F; Kelleher P. IL18R upregulation used in a clinical laboratory approach to identify IFN-gamma/IL12 defects in Mendalian Susceptibility to Mycobacterial Disease (MSDM). Annual Congress of the British-Society-for-Immunology, 6 Dec 2010 - 10 Dec 2010. 131:137-137. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2010). Author weblink.
  • Gotch F; Downey J; Herasimtschuk A; Randell P; Nelson M; Sikut R; Reijonen K; Stanescu I; et alImami N. Can novel rational immunotherapy lead to long term non-progressor status in chronically infected HIV plus persons receiving antiretroviral therapy (ART)?. AIDS Vaccine 2010, 28 Sep 2010 - 1 Oct 2010. 26:A89-A89. MARY ANN LIEBERT INC (1 Oct 2010). Author weblink.
  • Meys R; Purdie KJ; de Koning MN; Krishna SK; Kamp M; Nelson M; Asboe D; Hawkins DA; et alQuint WG; Gotch FM; Harwood C; Bunker CB. The HPV profile of genital warts in HIV infected patients. Annual Meeting of the Society-for-Investigative-Dermatology, 5 May 2010 - 8 May 2010. 130:S125-S125. NATURE PUBLISHING GROUP (1 Apr 2010).
  • Meys R; Purdie KJ; de Koning MN; Krishna SK; Kamp M; Nelson M; Asboe D; Hawkins DA; et alQuint WG; Gotch FM; Harwood C; Bunker CB. The HPV profile of cutaneous warts in HIV infected patients. Annual Meeting of the Society-for-Investigative-Dermatology, 5 May 2010 - 8 May 2010. 130:S125-S125. NATURE PUBLISHING GROUP (1 Apr 2010).
  • Krishna SK; Meys R; Purdie KJ; de Koning MN; Bardhan A; Gotch FM; Quint WG; Harwood C; et alBunker CB. Carcinoma in-situ of the penis and beta-HPV types. Annual Meeting of the Society-for-Investigative-Dermatology, 5 May 2010 - 8 May 2010. 130:S27-S27. NATURE PUBLISHING GROUP (1 Apr 2010).
  • Buisson S; Benlahrech A; Gazzard B; Gotch F; Kelleher P; Patterson S. Monocyte-Derived Dendritic Cells from HIV Type 1-Infected Individuals Show Reduced Ability to Stimulate T Cells and Have Altered Production of Interleukin (IL)-12 and IL-10. 4th International AIDS Symposium, Jul 2007. 199:1862-1871. UNIV CHICAGO PRESS (15 Jun 2009). Author weblink DOI.
  • Meys R; Purdie KJ; de Koning MN; Wim QG; Alison C; Atkins M; Gotch FM; Harwood CA; et alBunker CB. Beta human papillomvirus (beta-HPV) types are common in persistent warts in HAART treated HIV positive individuals. 69th Annual Meeting of the Society-of-Investigative-Dermatology, 6 May 2009 - 9 May 2009. 129:S30-S30. NATURE PUBLISHING GROUP (1 Apr 2009). Author weblink.
  • Meys R; Fowles F; Little A; Marsh SG; Asboe D; Hawkins DA; Gotch FM; bunker CB. Immunogenetics of HIV associated HPV disease after HAART. 69th Annual Meeting of the Society-of-Investigative-Dermatology, 6 May 2009 - 9 May 2009. 129:S82-S82. NATURE PUBLISHING GROUP (1 Apr 2009). Author weblink.
  • Duraisingham SS; Gotch F; Patterson S. Human CD34-derived Langerhans cells preferentially induce IL-17-producing T-helper cells compared to dermal-type DCs and monocyte-derived DCs. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:99-99. WILEY-BLACKWELL PUBLISHING, INC (1 Dec 2008). Author weblink.
  • Clark SA; Ford T; Henderson DC; Nelson M; Hawkins D; Gotch F; Gazzard B; Kelleher P. Impairment of CD4 T Cell cytokine responses to PPD in HIV infection. Annual Congress of the British-Society-of-Immunology, 17 Nov 2008 - 21 Nov 2008. 125:143-144. WILEY-BLACKWELL (1 Dec 2008). Author weblink.
  • Meys R; Asboe D; Gotch FM; Bunker CB. HPV associated mucocutaneous disease post HAART/IRD - patient immunophenotype. International Investigative Dermatology Meeting, 14 May 2008 - 17 May 2008. 128:S190-S190. NATURE PUBLISHING GROUP (1 Apr 2008). Author weblink.
  • Steel A; Clark SA; Hart M; Henderson D; Gotch F; Gazzard B; Kelleher P. Loss of memory B cell subsets in uncomplicated adult coeliac disease. Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association. 134:A521-A521. (Apr 2008).
  • Gotch F; Hayes P; Bergin P. Current strategies to test HIV vaccines. 7th Euroconference on Clinical Cell Analysis. 74B:56-56. (Jan 2008).
  • Gilmour J; Stevens G; Gill D; Tarragona T; Seamons L; Birungi J; Kato PK; Semaganda A; et alAnzala O; Farah B; Ogola S; Indangasi J; Mhlanga P; Ndzamela N; Thakar M; Pujari A; Purandare B; Mishra S; Goonetilleke N; Moore S; Mahmoud A; Gotch F; Styles T; Stout J; Dally L; Boaz MJ; Hayes P. Laboratory development and assay standardization for the evaluation of HIV vaccines in Africa and India. 6th Euroconference on Clinical Cell Analysis. 72B:120-120. (Mar 2007).
  • Kandil H; Yong P; Gotch FM; Ibrahim MAA. Regulation of interleukin-12 secretion by cell death in monocyte-derived dendritic cells of atopic subjects. Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology. 35:1416-1416. (Oct 2005).
  • Kandil H; Gotch FM; Ibrahim MAA. Dendritic cell response to necrosis is defective in atopy. 5th Annual Meeting of the Federation-of-Clinical-Immunology-Society, 12 May 2005 - 16 May 2005. 115:S26-S26. ACADEMIC PRESS INC ELSEVIER SCIENCE (1 Jan 2005). Author weblink.
  • Stebbing J; Bower M; Nelson M; Kebba A; Gotch F; Patterson S; Gazzard B. The role of HSPs and CD91 in the pathogenesis of HIV infection. 4th International Conference on Heat Shock Proteins in Immune Response, 10 Oct 2004 - 13 Oct 2004. 114:148-148. BLACKWELL PUBLISHING LTD (1 Jan 2005). Author weblink.
  • Gotch F; Hardy G; Imami N; Sullivan A; Nelson M; Burton C; Pido-Lopez J; Pires A; et alMoss R. The effects of immunotherapy with cytokines and/or vaccines in HAART treated patients. 14th International AIDS Conference, 7 Jul 2002 - 12 Jul 2002. 279-284. MEDIMOND S R L (1 Jan 2002). Author weblink.
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