Contact details
Dr Ian Goodfellow
Our research interests focus on the molecular mechanisms that positive stranded RNA viruses used to translate and replicate their genomes. We work on many members of the Caliciviridae family of small RNA viruses with one of our major interesting being noroviruses.
Often referred to as ‘winter-vomiting disease’, the human enteric caliciviruses (including Noroviruses) are a major cause of gastroenteritis worldwide and frequently cause the closure of hospital wards in the UK. Best estimates suggest that 23 million cases of calicivirus GE occur in the US and >1 million cases UK each year. Despite the significant impact of caliciviruses, in particular members of the Norovirus and Sapovirus genera on society, progress on understanding the molecular mechanisms of virus replication and progress towards methods of either preventing or controlling outbreaks has been limited.
Our lab uses a combination of molecular, cellular and biochemical approaches to gain a better understanding of the biology of caliciviruses and to identify methods of controlling or preventing outbreaks of these economically important pathogens.
More detailed information regarding previous and ongoing work within the lab can be found within our research group web page:
