Dr Jake Dunning

Dr Jake Dunning graduated with honours from Imperial College School of Medicine in 2001, having originally enrolled to read medicine at Charing Cross and Westminster Medical School. He obtained an intercalated BSc in pharmacology during his medical degree. 

He has been a Specialist Registrar in Infectious Diseases and General Internal Medicine and in October 2009 he was appointed as the CRI MOSAIC Clinical Research Fellow at Imperial College London. Dr Dunning receives funding from the Centre for Respiratory Infection and the Mechanisms of Severe Acute Influenza Consortium (MOSAIC), supported by a joint award from the Wellcome Trust and Medical Research Council. His PhD is being supervised by Professor Peter Openshaw and Professor Jonathan Weber. Dr Dunning is also a visiting researcher at the Division of Immunoregulation, MRC National Institute for Medical Research, where his transcriptomic analyses are supervised by Professor Anne O'Garra.

Clinical Interests

• Pandemic and severe influenza
• Dangerous pathogens, zoonoses and emerging infectious diseases
• Viral haemorrhagic fever
• HIV
• Tuberculosis and TB immune reconstitution inflammatory syndrome
• Improving TB and HIV healthcare provision in resource-limited settings

Research Interests

• The role of abberant immune responses in severe influenza A infection in humans, with a focus on cytokines and chemokines
• Whole blood transcriptomic profiling in severe influenza A infection in humans
• Comparison of soluble immune mediator responses in African HIV-infected and non-HIV-infected patients with influenza A infection (collaboration with Malawi-Liverpool-Wellcome Trust Centre, Malawi)
• The identification of immunomodulatory targets in infectious diseases

Awards

• Clinicopathological case presentation prize, British HIV Association Conference 2009
• International HIV Scholarship, St Stephen's AIDS Trust, 2009