Dr Julia Gorelik

Publications


Journals

  • Ibrahim M; Moshkov AV; Hall AR; Shattock MJ; Baines A; Bennett P; Yacoub MH; Gorelik J; et alTerracciano CM. (23 Nov 2010). Cytoskeletal Protein 4.1R is Required for Normal Cardiac Myocyte Membrane Structure and Stiffness. CIRCULATION. 122. Author weblink.
  • Shevchuk AI; Novak P; Taylor M; Diakonov IA; Ziyadeh-Isleem A; Bitoun M; Guicheney P; Lab MJ; et alGorelik J; Merrifield CJ; Klenerman D; Korchev YE. (7 May 2012). An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy. J Cell Biol. DOI.
  • Lyon AR; Nikolaev VO; Miragoli M; Paur H; Bernard L; Hulot J-S; Kohlbrenner E; Hajjar RJ; et alPeters NS; Korchev YE; Harding SE; Gorelik J. (22 Nov 2011). Plasticity of Surface Structures and Beta 2-adrenergic Receptor Localization in Failing Ventricular Cardiomyocytes During Recovery From Heart Failure. CIRCULATION. 124. Author weblink.
  • Potter CM; Schobesberger S; Lundberg MH; Weinberg PD; Mitchell JA; Gorelik J. (2012). Shape and compliance of endothelial cells after shear stress in vitro or from different aortic regions: scanning ion conductance microscopy study. PLoS One. 7:e31228. DOI.
  • Weber B; Schoenauer R; Papadopulos F; Modregger P; Peter S; Stampanoni M; Mauri A; Mazza E; et alGorelik J; Agarkova I; Frese L; Breymann C; Kretschmar O; Hoerstrup SP. (1 Dec 2011). Engineering of living autologous human umbilical cord cell-based septal occluder membranes using composite PGA-P4HB matrices. BIOMATERIALS. 32:9630-9641. Author weblink DOI.
  • Ibrahim M; Gorelik J; Yacoub MH; Terracciano CM. (22 Sep 2011). The structure and function of cardiac t-tubules in health and disease. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 278:2714-2723. DOI.
  • Miragoli M; Kadir SH; Sheppard MN; Salvarani N; Virta M; Wells S; Lab MJ; Nikolaev VO; et alMoshkov A; Hague WM; Rohr S; Williamson C; Gorelik J. (Oct 2011). A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart. Hepatology. 54:1282-1292. DOI.
  • Ibrahim M; Gorelik J; Yacoub MH; Terracciano CM. (22 Sep 2011). The structure and function of cardiac t-tubules in health and disease. Proc Biol Sci. 278:2714-2723. DOI.
  • Williamson C; Miragoli M; Sheikh Abdul Kadir S; Abu-Hayyeh S; Papacleovoulou G; Geenes V; Gorelik J. (2011). Bile acid signaling in fetal tissues: implications for intrahepatic cholestasis of pregnancy. Dig Dis. 29:58-61. DOI.
  • Shevchuk AI; Novak P; Takahashi Y; Clarke R; Miragoli M; Babakinejad B; Gorelik J; Korchev YE; et alKlenerman D. (Apr 2011). Realizing the biological and biomedical potential of nanoscale imaging using a pipette probe. Nanomedicine (Lond). 6:565-575. DOI.
  • Ruenraroengsak P; Novak P; Berhanu D; Thorley AJ; Valsami-Jones E; Gorelik J; Korchev YE; Tetley TD. (Feb 2012). Respiratory epithelial cytotoxicity and membrane damage (holes) caused by amine-modified nanoparticles. Nanotoxicology. 6:94-108. DOI.
  • Miragoli M; Moshkov A; Novak P; Shevchuk A; Nikolaev VO; El-Hamamsy I; Potter CM; Wright P; et alKadir SH; Lyon AR; Mitchell JA; Chester AH; Klenerman D; Lab MJ; Korchev YE; Harding SE; Gorelik J. (6 Jul 2011). Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells. J R Soc Interface. 8:913-925. DOI.
  • Potter CM; Lundberg MH; Harrington LS; Warboys CM; Warner TD; Berson RE; Moshkov AV; Gorelik J; et alWeinberg PD; Mitchell JA. (Feb 2011). Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms. Arterioscler Thromb Vasc Biol. 31:384-391. DOI.
  • Földes G; Mioulane M; Wright JS; Liu AQ; Novak P; Merkely B; Gorelik J; Schneider MD; et alAli NN; Harding SE. (Feb 2011). Modulation of human embryonic stem cell-derived cardiomyocyte growth: a testbed for studying human cardiac hypertrophy?. J Mol Cell Cardiol. 50:367-376. DOI.
  • Ibrahim M; Al Masri A; Navaratnarajah M; Siedlecka U; Soppa GK; Moshkov A; Al-Saud SA; Gorelik J; et alYacoub MH; Terracciano CM. (Sep 2010). Prolonged mechanical unloading affects cardiomyocyte excitation-contraction coupling, transverse-tubule structure, and the cell surface. FASEB J. 24:3321-3329. DOI.
  • Nikolaev VO; Moshkov A; Lyon AR; Miragoli M; Novak P; Paur H; Lohse MJ; Korchev YE; et alHarding SE; Gorelik J. (26 Mar 2010). Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science. 327:1653-1657. DOI.
  • Sheikh Abdul Kadir SH; Miragoli M; Abu-Hayyeh S; Moshkov AV; Xie Q; Keitel V; Nikolaev VO; Williamson C; et alGorelik J. (2010). Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes. PLoS One. 5:e9689. DOI.
  • Lyon AR; MacLeod KT; Zhang Y; Garcia E; Kanda GK; Lab MJ; Korchev YE; Harding SE; et alGorelik J. (21 Apr 2009). Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc Natl Acad Sci U S A. 106:6854-6859. DOI.
  • Novak P; Li C; Shevchuk AI; Stepanyan R; Caldwell M; Hughes S; Smart TG; Gorelik J; et alOstanin VP; Lab MJ; Moss GWJ; Frolenkov GI; Klenerman D; Korchev YE. (1 Apr 2009). Nanoscale live-cell imaging using hopping probe ion conductance microscopy. NATURE METHODS. 6:279-281. Author weblink DOI.
  • Abdul Kadir SH; Ali NN; Mioulane M; Brito-Martins M; Abu-Hayyeh S; Foldes G; Moshkov AV; Williamson C; et alHarding SE; Gorelik J. (Sep 2009). Embryonic stem cell-derived cardiomyocytes as a model to study fetal arrhythmia related to maternal disease. J Cell Mol Med. 13:3730-3741. DOI.
  • Gorelik J; Ali NN; Kadir SHSA; Lab M; Stojkovic P; Armstrong L; Sviderskaya EV; Negulyaev YA; et alKlenerman D; Bennett DC; Lako M; Harding SE; Stojkovic M; Korchev YE. (1 Dec 2008). Non-invasive Imaging of Stem Cells by Scanning Ion Conductance Microscopy: Future Perspective. TISSUE ENGINEERING PART C-METHODS. 14:311-318. Author weblink DOI.
  • Kemp SJ; Thorley AJ; Gorelik J; Seckl MJ; O'Hare MJ; Arcaro A; Korchev Y; Goldstraw P; et alTetley TD. (1 Nov 2008). Immortalization of Human Alveolar Epithelial Cells to Investigate Nanoparticle Uptake. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 39:591-597. DOI.
  • Sánchez D; Johnson N; Li C; Novak P; Rheinlaender J; Zhang Y; Anand U; Anand P; et alGorelik J; Frolenkov GI; Benham C; Lab M; Ostanin VP; Schäffer TE; Klenerman D; Korchev YE. (15 Sep 2008). Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette. Biophys J. 95:3017-3027. DOI.
  • Zhang Y; Sanchez D; Gorelik J; Klenerman D; Lab M; Edwards C; Korchev Y. (Jun 2007). Basolateral P2X4-like receptors regulate the extracellular ATP-stimulated epithelial Na+ channel activity in renal epithelia. Am J Physiol Renal Physiol. 292:F1734-F1740. DOI.
  • Harding SE; Ali NN; Brito-Martins M; Gorelik J. (Feb 2007). The human embryonic stem cell-derived cardiomyocyte as a pharmacological model. Pharmacol Ther. 113:341-353. DOI.
  • Sánchez D; Anand U; Gorelik J; Benham CD; Bountra C; Lab M; Klenerman D; Birch R; et alAnand P; Korchev Y. (15 Jan 2007). Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy. J Neurosci Methods. 159:26-34. DOI.
  • Gorelik J; Yang LQ; Zhang Y; Lab M; Korchev Y; Harding SE. (1 Dec 2006). A novel Z-groove index characterizing myocardial surface structure. Cardiovasc Res. 72:422-429. DOI.
  • Gorelik J; Patel P; Ng'andwe C; Vodyanoy I; Diakonov I; Lab M; Korchev Y; Williamson C. (May 2006). Genes encoding bile acid, phospholipid and anion transporters are expressed in a human fetal cardiomyocyte culture. BJOG. 113:552-558. DOI.
  • Gorelik J; Ali NN; Shevchuk AI; Lab M; Williamson C; Harding SE; Korchev YE. (Apr 2006). Functional characterization of embryonic stem cell-derived cardiomyocytes using scanning ion conductance microscopy. Tissue Eng. 12:657-664. DOI.
  • Gorelik J; Zhang Y; Sánchez D; Shevchuk A; Frolenkov G; Lab M; Klenerman D; Edwards C; et alKorchev Y. (18 Oct 2005). Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited. Proc Natl Acad Sci U S A. 102:15000-15005. DOI.
  • Zhang Y; Gorelik J; Sanchez D; Shevchuk A; Lab M; Vodyanoy I; Klenerman D; Edwards C; et alKorchev Y. (Sep 2005). Scanning ion conductance microscopy reveals how a functional renal epithelial monolayer maintains its integrity. Kidney Int. 68:1071-1077. DOI.
  • Ying LM; Bruckbauer A; Zhou DJ; Gorelik J; Shevehuk A; Lab M; Korchev Y; Klenerman D. (1 Jan 2005). The scanned nanopipette: A new tool for high resolution bioimaging and controlled deposition of biomolecules. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 7:2859-2866. Author weblink DOI.
  • Gorelik J; Shevchuk A; de Swiet M; Lab M; Korchev Y; Williamson C. (Aug 2004). Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an in vitro study of rat cardiomyocytes. BJOG. 111:867-870. DOI.
  • Gorelik J; Zhang Y; Shevchuk AI; Frolenkov GI; Sánchez D; Lab MJ; Vodyanoy I; Edwards CR; et alKlenerman D; Korchev YE. (31 Mar 2004). The use of scanning ion conductance microscopy to image A6 cells. Mol Cell Endocrinol. 217:101-108. DOI.
  • Darszon A; Wood CD; Beltran C; Sanchez D; Rodriguez E; Gorelik J; Korchev YE; Nishigaki T. (1 Jan 2004). Measuring lon fluxes in sperm. DEVELOPMENT OF SEA URCHINS, ASCIDIANS, AND OTHER INVERTEBRATE DEUTEROSTOMES: EXPERIMENTAL APPROACHES. 74:545-+. Author weblink.
  • Gorelik J; Vodyanoy I; Shevchuk AI; Diakonov IA; Lab MJ; Korchev YE. (31 Jul 2003). Esmolol is antiarrhythmic in doxorubicin-induced arrhythmia in cultured cardiomyocytes - determination by novel rapid cardiomyocyte assay. FEBS Lett. 548:74-78.
  • Gorelik J; Shevchuk AI; Frolenkov GI; Diakonov IA; Lab MJ; Kros CJ; Richardson GP; Vodyanoy I; et alEdwards CR; Klenerman D; Korchev YE. (13 May 2003). Dynamic assembly of surface structures in living cells. Proc Natl Acad Sci U S A. 100:5819-5822. DOI.
  • Gorelik J; Shevchuk AI; Diakonov I; de Swiet M; Lab M; Korchev Y; Williamson C. (May 2003). Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an in vitro study of rat cardiomyocytes. BJOG. 110:467-474.
  • Rothery AM; Gorelik J; Bruckbauer A; Yu W; Korchev YE; Klenerman D. (1 Feb 2003). A novel light source for SICM-SNOM of living cells. JOURNAL OF MICROSCOPY-OXFORD. 209:94-101. Author weblink DOI.
  • Gorelik J; Shevchuk A; Ramalho M; Elliott M; Lei C; Higgins CF; Lab MJ; Klenerman D; et alKrauzewicz N; Korchev Y. (10 Dec 2002). Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: application to single virus-like particle entry into a cell. Proc Natl Acad Sci U S A. 99:16018-16023. DOI.
  • Gorelik J; Gu Y; Spohr HA; Shevchuk AI; Lab MJ; Harding SE; Edwards CR; Whitaker M; et alMoss GW; Benton DC; Sánchez D; Darszon A; Vodyanoy I; Klenerman D; Korchev YE. (Dec 2002). Ion channels in small cells and subcellular structures can be studied with a smart patch-clamp system. Biophys J. 83:3296-3303. DOI.
  • Gorelik J; Harding SE; Shevchuk AI; Koralage D; Lab M; de Swiet M; Korchev Y; Williamson C. (Aug 2002). Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics. Clin Sci (Lond). 103:191-200.
  • Gu YC; Gorelik J; Spohr HA; Shevchuk A; Lab MJ; Harding SE; Vodyanoy I; Klenerman D; et alKorchev YE. (1 Mar 2002). High-resolution scanning patch-clamp: new insights into cell function. FASEB JOURNAL. 16:748-+. Author weblink DOI.
  • Rothery AM; Bruckbauer A; Ying LM; Gorelik J; Korchev YE; Klenerman D. (1 Jan 2002). A novel light source for SNOM of living cells. BIOPHYSICAL JOURNAL. 82:497A-497A. Author weblink.
  • Gorelik J; Gu YC; Spohr HA; Shevchuk A; Lab MJ; Harding SE; Vodyanoy I; Klenerman D; et alKorchev YE. (1 Jan 2002). High-resolution scanning patch-clamp technique. BIOPHYSICAL JOURNAL. 82:266A-266A. Author weblink.
  • Gu YC; Spohr HA; Gorelik J; Shevchuk A; Lab MJ; Harding SE; Vodyanoy I; Klenerman D; et alKorchev YE. (1 Jan 2002). High-resolution functional mapping of cardiac myocyte ion channels. BIOPHYSICAL JOURNAL. 82:596A-596A. Author weblink.
  • Shevchuk AI; Gorelik J; Harding SE; Lab MJ; Klenerman D; Korchev YE. (Sep 2001). Simultaneous measurement of Ca2+ and cellular dynamics: combined scanning ion conductance and optical microscopy to study contracting cardiac myocytes. Biophys J. 81:1759-1764. DOI.
  • Williamson C; Gorelik J; Eaton BM; Lab M; de Swiet M; Korchev Y. (Apr 2001). The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis. Clin Sci (Lond). 100:363-369.
  • Negulyaev Y; Gorelik J; Shevchuk A; Rothery A; Edwards C; Vodyanoy I; Lab M; Klenerman D; et alKorchev Y. (1 Jan 2001). Functional and optical imaging of living cells by local application via a micropipette. BIOPHYSICAL JOURNAL. 80:164A-164A. Author weblink.
  • Shevchuk A; Gorelik J; Gu Y; Spohr H; Edwards C; Vodyanoy I; Lab M; Klenerman D; et alKorchev Y. (1 Jan 2001). Simultaneous measurement of fluorescence and membrane dynamics in cardiac myocytes: Combined scanning ion conductance and laser confocal microscopy. BIOPHYSICAL JOURNAL. 80:163A-164A. Author weblink.
  • Korchev YE; Raval M; Lab MJ; Gorelik J; Edwards CR; Rayment T; Klenerman D. (May 2000). Hybrid scanning ion conductance and scanning near-field optical microscopy for the study of living cells. Biophys J. 78:2675-2679. DOI.
  • Korchev YE; Gorelik J; Lab MJ; Sviderskaya EV; Johnston CL; Coombes CR; Vodyanoy I; Edwards CR. (Jan 2000). Cell volume measurement using scanning ion conductance microscopy. Biophys J. 78:451-457. DOI.

Conferences

  • Ibrahim M; Navaratnarajah M; Siedlecka U; Abou A-SS; Rao C; Moshkov AV; Gorelik J; Yacoub MH; et alTerracciano C. Mechanical Unloading Of Failing Hearts Normalises Ca2+-induced Ca2+ Release By Reverse Remodelling Of The T-tubule System. Aswan Heart Science Centre: Science and Practice Series, 3 Jan 2011 - 6 Jan 2011.
  • Miragoli M; Lab MJ; Singh A; Sikkel M; Lyon A; Gorelik J. The progression towards heart failure exposes the heart to a mechano-arrhythmic response related to the cellular membrane compliance. 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, 30 Mar 2012 - 1 Apr 2012. 93:S46-S47. OXFORD UNIV PRESS (15 Mar 2012). Author weblink.
  • Wright PT; Diakonov I; Tokar S; Lyon AR; Sikkel M; Harding SE; Gorelik J. Beta-2 adrenergic receptor signaling in adult rat ventricular myocytes at 4, 8 and 16 weeks after myocardial infarction. 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, 30 Mar 2012 - 1 Apr 2012. 93:S24-S24. OXFORD UNIV PRESS (15 Mar 2012). Author weblink.
  • Wright PT; Pannell LMK; Lyon AR; Harding SE; Gorelik J. The negatively inotropic effect of adrenaline stress is not completely linked to the reduction of cAMP release mediated by the Gs/Gi switch. 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, 30 Mar 2012 - 1 Apr 2012. 93:S18-S18. OXFORD UNIV PRESS (15 Mar 2012). Author weblink.
  • Tokar S; Schobesberger S; Singh A; Wright PT; Miragoli M; Lyon AR; Sikkel M; Harding SE; et alGorelik J. Progressive changes in cardiomyocyte structure and beta-2 adrenergic receptors cAMP signaling localisation in a rat model of myocardial infarction. 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, 30 Mar 2012 - 1 Apr 2012. 93:S48-S48. OXFORD UNIV PRESS (15 Mar 2012). Author weblink.
  • Kadir SHSA; Ali NN; Abu-Hayyeh S; Harding SE; Williamson C; Gorelik J. The use of embryonic stem cell-derived cardiomyocytes as a model to study fetal arrhythmia related to maternal disease. 28th Annual Meeting of the European Section of the International-Society-for-Heart-Research, 28 May 2008 - 31 May 2008. 44:774-774. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD (1 Apr 2008). Author weblink DOI.
  • Kadir SHS; Abu-Hayyeh S; Williamson C; Gorelik J. Mechanisms of bile acid signalling in cardiomyocytes. 28th Annual Meeting of the European Section of the International-Society-for-Heart-Research. 44:774-775. (Apr 2008).
  • Lyon A; Gorelik J; Dubb S; Macleod K; Poole-Wilson P; Harding S. Surface morphology and calcium control in myocytes from a rat MI model of heart failure. 28th Annual Meeting of the European Section of the International-Society-for-Heart-Research. 44:750-750. (Apr 2008).
  • Gorelik J; Yang L; Zhang Y; Lab M; Korcbev YE; del Monte F; Harding SE. A novel Z-groove index characterizing myocardial surface structure and its modification in failing human heart. 19th World Congress of the ISHR, 22 Jun 2007 - 25 Jun 2007. 42:S153-S153. ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD (1 Jun 2007). Author weblink DOI.
  • Korchev Y; Sanchez D; Anand P; Gorelik J; Zhang Y; Shevchuk A; Vodyanoy I; Lab M; et alKlenerman D. "Non-contact" mechanical characterization and stimulation of cells using scanning ion conductance microscopy. 51st Annual Meeting of the Biophysical-Society, 3 Mar 2007 - 7 Mar 2007. 33A-33A. BIOPHYSICAL SOCIETY (1 Jan 2007). Author weblink.
  • Korchev Y; Zhang Y; Gorelik J; Edwards CRW. Paracrine role of ATP in aldosterone action on epithelial cells and cardiomyocytes. 11th Annual Meeting of the European-Council- for Cardiovascular Reseach, 29 Sep 2006 - 1 Oct 2006. 48:764-764. LIPPINCOTT WILLIAMS & WILKINS (1 Oct 2006). Author weblink.
  • Yang LQ; Gorelik J; Korchev Y; Harding SE. Increase in beta(1)AR-Gi coupling after detubulation in rat ventricular myocytes. 28th Annual International-Society-for-Heart-Research North American Section Meeting, 13 Jun 2006 - 16 Jun 2006. 40:923-924. ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD (1 Jun 2006). Author weblink DOI.
  • Duclohier HPM; Gorelik J; Yang LQ; Harding SE; Korchev YE. Distribution of sodium channels in ventricular heart cells. 49th Annual Meeting of the Biopysical-Society, 12 Feb 2005 - 16 Feb 2005. 88:378A-378A. BIOPHYSICAL SOCIETY (1 Jan 2005). Author weblink.
Share this on Delicious
Tweet this
Digg this
Stumble this
Share this on Facebook