Professor Stephen Franks

Publications


Journals

  • Torvinen A; Koivunen R; Pouta A; Franks S; Martikainen H; Bloigu A; Hartikainen AL; McCarthy MI; et alRuokonen A; Jarvelin MR; Morin-Papunen L. (Sep 2011). Metabolic and reproductive characteristics of first-degree relatives of women with self-reported oligo-amenorrhoea and hirsutism. GYNECOL ENDOCRINOL. 27:630-635. DOI.
  • Lajunen TK; Purhonen AK; Haapea M; Ruokonen A; Puukka K; Hartikainen AL; Savolainen MJ; Morin-Papunen L; et alTapanainen JS; Franks S; Järvelin MR; Herzig KH. (Mar 2012). Full-length visfatin levels are associated with inflammation in women with polycystic ovary syndrome. Eur J Clin Invest. 42:321-328. DOI.
  • Fenwick MA; Mansour YT; Franks S; Hardy K. (Sep 2011). Identification and regulation of bone morphogenetic protein antagonists associated with preantral follicle development in the ovary. Endocrinology. 152:3515-3526. DOI.
  • Hickey M; Doherty DA; Atkinson H; Sloboda DM; Franks S; Norman RJ; Hart R. (Jun 2011). Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis. HUM REPROD. 26:1469-1477. DOI.
  • Joharatnam J; Barber TM; Webber L; Conway GS; McCarthy MI; Franks S. (Jun 2011). Determinants of dyslipidaemia in probands with polycystic ovary syndrome and their sisters. Clin Endocrinol (Oxf). 74:714-719. DOI.
  • Hart R; Doherty DA; Mori T; Huang RC; Norman RJ; Franks S; Sloboda D; Beilin L; et alHickey M. (Jun 2011). Extent of metabolic risk in adolescent girls with features of polycystic ovary syndrome. FERTIL STERIL. 95:2347-U268. DOI.
  • Pasquali R; Stener-Victorin E; Yildiz BO; Duleba AJ; Hoeger K; Mason H; Homburg R; Hickey T; et alFranks S; Tapanainen JS; Balen A; Abbott DH; Diamanti-Kandarakis E; Legro RS. (Apr 2011). PCOS Forum: research in polycystic ovary syndrome today and tomorrow. CLIN ENDOCRINOL. 74:424-433. DOI.
  • Fowler PA; Anderson RA; Saunders PT; Kinnell H; Mason JI; Evans DB; Bhattacharya S; Flannigan S; et alFranks S; Monteiro A; O'Shaughnessy PJ. (Jun 2011). Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary. J Clin Endocrinol Metab. 96:1754-1762. DOI.
  • Franks S. (Feb 2011). When should an insulin sensitizing agent be used in the treatment of polycystic ovary syndrome?. CLIN ENDOCRINOL. 74:148-151. DOI.
  • Hart R; Doherty DA; Norman RJ; Franks S; Dickinson JE; Hickey M; Sloboda DM. (Aug 2010). Serum antimullerian hormone (AMH) levels are elevated in adolescent girls with polycystic ovaries and the polycystic ovarian syndrome (PCOS). FERTIL STERIL. 94:1118-1121. DOI.
  • Hickey M; Sloboda DM; Atkinson HC; Doherty DA; Franks S; Norman RJ; Newnham JP. (Oct 2009). The relationship between maternal and umbilical cord androgen levels and polycystic ovary syndrome in adolescence: a prospective cohort study. Journal of Clincal Endocrinology and Metabolism. 94:3714-3720.
  • Franks S. (Sep 2009). Do animal models of polycystic ovary syndrome help to understand its pathogenesis and management? Yes, but their limitations should be recognized. Endocrinology. 150:3983-3985. DOI.
  • Vassiliadi DA; Barber TM; Hughes BA; McCarthy MI; Wass JA; Franks S; Nightingale P; Tomlinson JW; et alArlt W; Stewart PM. (Sep 2009). Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism. 94:3358-3366.
  • Balen A; Homburg R; Franks S. (13 Feb 2009). Defining polycystic ovary syndrome. BRIT MED J. 338. DOI.
  • Da Silva-Buttkus P; Marcelli G; Franks S; Stark J; Hardy K. (Jan 2009). Inferring biological mechanisms from spatial analysis: prediction of a local inhibitor in the ovary. Proceedings of the National Academy of Sciences of USA. 106:456-461.
  • Da Silva-Buttkus P; Jayasooriya GS; Mora JM; Mobberley M; Ryder TA; Baithun M; Stark J; Franks S; et alHardy K. (1 Dec 2008). Effect of cell shape and packing density on granulosa cell proliferation and formation of multiple layers during early follicle development in the ovary. J CELL SCI. 121:3890-3900. DOI.
  • Morin-Papunen L; Martikainen H; McCarthy MI; Franks S; Sovio U; Hartikainen AL; Ruokonen A; Leinonen M; et alLaitinen J; Järvelin MR. (Nov 2008). Comparison of metabolic and inflammatory outcomes in women who used oral contraceptives and the levonorgestrel-releasing intrauterine device in a general population. American Journal of Obstetrics and Gynecology. 199:529.e1-529.e10.
  • Koivunen R; Pouta A; Franks S; Martikainen H; Sovio U; Hartikainen AL; McCarthy MI; Ruokonen A; et alBloigu A; Järvelin MR; Morin-Papunen L; Northern Finland Birth Cohort 1966 Study. (Sep 2008). Fecundability and spontaneous abortions in women with self-reported oligo-amenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. Hum Reprod. 23:2134-2139. DOI.
  • Franks S; Webber LJ; Goh M; Valentine A; White DM; Conway GS; Wiltshire S; McCarthy MI. (Sep 2008). Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries. Journal of Clinical Endocrinology and Metabolism. 93:3396-3402.
  • Barber TM; Bennett AJ; Groves CJ; Sovio U; Ruokonen A; Martikainen H; Pouta; Pouta A; et alHartikainen AL; Elliott P; Lindgren CM; Freathy RM; Koch K; Ouwehand WH; Karpe F; Conway GS; Wass JA; Järvelin MR; Franks S; McCarthy MI. (Jul 2008). Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. Diabetalogia. 51:1153-1158.
  • Franks S; Stark J; Hardy K. (Jul 2008). Follicle dynamics and anovulation in polycystic ovary syndrome. Hum Reprod Update. 14:367-378. DOI.
  • Collins J; Diedrich K; Franks S; Geraedts JPM; Jacobs PA; Karges B; Kennedy S; Marozzi A; et alRegan L; Baird DT; Crosignani PG; Devroey P; Diczfalusy E; Evers JLH; Fauser BCJM; Fraser L; Gianaroli L; Glasier A; Liebaers I; Ragni G; Sunde A; Tarlatzis B; Van Steirteghem A; ESHRE Capri Workshop Grp. (Jul 2008). Genetic aspects of female reproduction. HUM REPROD UPDATE. 14:293-307. DOI.
  • Collins J; Diedrich K; Franks S; Geraedts JP; Jacobs PA; Karges B; Kennedy S; Marozzi A; et alRegan L; Baird DT; Crosignani PG; Devroey P; Diczfalusy E; Evers JL; Fauser BC; Fraser L; Gianaroli L; Glasier A; Liebaers I; Ragni G; Sunde A; Tarlatzis B; Van Steirteghem A. (Jul 2008). Genetic aspects of female reproduction. Human Reproduction Update. 14:293-307.
  • Franks S. (Jul 2008). Polycystic ovary syndrome in adolescents. INT J OBESITY. 32:1035-1041. DOI.
  • Barber TM; Hazell M; Christodoulides C; Golding SJ; Alvey C; Burling K; Vidal-Puig A; Groome NP; et alWass JA; Franks S; McCarthy MI. (Jul 2008). Serum levels of retinol-binding protein 4 and adiponectin in women with polycystic ovary syndrome: associations with visceral fat but no evidence for fat mass-independent effects on pathogenesis in this condition. Journal of Clinical Endocrinology and Metabolism. 97:2859-2865.
  • Barber TM; Casanueva FF; Karpe F; Lage M; Franks S; McCarthy MI; Wass JAH. (Apr 2008). Ghrelin levels are suppressed and show a blunted response to oral glucose in women with polycystic ovary syndrome. EUR J ENDOCRINOL. 158:511-516. DOI.
  • Tarlatzis BC; Fauser BC; Legro RS; Norman RJ; Hoeger K; Pasquali R; Franks S; Messinis I; et alCasper R; Homburg R; Lobo R; Rebar R; Fleming R; Carr B; Bouchard P; Chang RJ; Hugues JN; Azziz R; Kolibianakis EM; Griesinger G; Diedrich K; Balen A; Farquhar C; Devroey P; Ho PC; Collins J; Goulis DG; Eijkemans R; Crosignani PG; DeCherney A; Van Steirteghem A. (Mar 2008). Consensus on infertility treatment related to polycystic ovary syndrome. Human Reproduction. 23:462-477.
  • Barber TM; Golding SJ; Alvey C; Wass JA; Karpe F; Franks S; McCarthy MI. (Mar 2008). Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism. 93:999-1004.
  • Franks S; Layton A; Glasier A. (Feb 2008). Cyproterone acetate/ethinyl estradiol for acne and hirsutism: time to revise prescribing policy. HUM REPROD. 23:231-232. DOI.
  • Franks S. (Dec 2007). How good are we at diagnosing polycystic ovary syndrome?. Clin Endocrinol (Oxf). 67:809-810. DOI.
  • Stubbs SA; Stark J; Dilworth SM; Franks S; Hardy K. (Nov 2007). Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division. J CLIN ENDOCR METAB. 92:4418-4426. DOI.
  • Barber TM; Bennett AJ; Groves CJ; Sovio U; Ruokonen A; Martikainen H; Pouta A; Hartikainen AL; et alElliott P; Wass JA; Järvelin MR; Zeggini E; Franks S; McCarthy MI. (Nov 2007). Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS. Diabetologia. 50:2318-2322. DOI.
  • Das S; Bennett AJ; Sovio U; Ruokonen A; Martikainen H; Pouta A; Hartikainen AL; Franks S; et alElliott P; Poulton J; Järvelin MR; McCarthy MI. (Aug 2007). Detailed analysis of variation at and around mitochondrial position 16189 in a large Finnish cohort reveals no significant associations with early growth or metabolic phenotypes at age 31 years. J Clin Endocrinol Metab. 92:3219-3223. DOI.
  • Barber TM; Bennett AJ; Gloyn AL; Groves CJ; Sovio U; Ruokonen A; Martikainen H; Pouta A; et alTaponen S; Weedon MN; Hartikainen AL; Wass JA; Järvelin MR; Zeggini E; Franks S; McCarthy MI. (Jun 2007). Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels. Eur J Hum Genet. 15:679-684. DOI.
  • Neganova I; Al-Qassab H; Heffron H; Selman C; Choudhury AI; Lingard SJ; Diakonov I; Patterson M; et alGhatei M; Bloom SR; Franks S; Huhtaniemi I; Hardy K; Withers DJ. (Jun 2007). Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse. Biol Reprod. 76:1045-1053. DOI.
  • Webber LJ; Stubbs SA; Stark J; Margara RA; Trew GH; Lavery SA; Hardy K; Franks S. (May 2007). Prolonged survival in culture of preantral follicles from polycystic ovaries. J Clin Endocrinol Metab. 92:1975-1978. DOI.
  • Barber TM; Wass JA; McCarthy MI; Franks S. (Apr 2007). Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndrome. Clin Endocrinol (Oxf). 66:513-517. DOI.
  • Forsdike RA; Hardy K; Bull L; Stark J; Webber LJ; Stubbs S; Robinson JE; Franks S. (Feb 2007). Disordered follicle development in ovaries of prenatally androgenized ewes. J Endocrinol. 192:421-428. DOI.
  • Sorensen MB; Franks S; Robertson C; Pennell DJ; Collins P. (Nov 2006). Severe endothelial dysfunction in young women with polycystic ovary syndrome is only partially explained by known cardiovascular risk factors. Clin Endocrinol (Oxf). 65:655-659. DOI.
  • Roy P; Franks S; Read M; Huhtaniemi IT. (Sep 2006). Determination of androgen bioactivity in human serum samples using a recombinant cell based in vitro bioassay. J Steroid Biochem Mol Biol. 101:68-77. DOI.
  • Gorry A; White DM; Franks S. (Aug 2006). Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment. Endocrine. 30:27-33. DOI.
  • Barber TM; McCarthy MI; Wass JA; Franks S. (Aug 2006). Obesity and polycystic ovary syndrome. Clin Endocrinol (Oxf). 65:137-145. DOI.
  • Franks S. (Jul 2006). Candidate genes in women with polycystic ovary syndrome. Fertil Steril. 86 Suppl 1:S15. DOI.
  • Draper N; Powell BL; Franks S; Conway GS; Stewart PM; McCarthy MI. (Jul 2006). Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome. Clin Endocrinol (Oxf). 65:64-70. DOI.
  • Franks S. (May 2006). Genetic and environmental origins of obesity relevant to reproduction. Reprod Biomed Online. 12:526-531.
  • Franks S. (Mar 2006). Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria. J Clin Endocrinol Metab. 91:786-789. DOI.
  • Franks S; McCarthy MI; Hardy K. (Feb 2006). Development of polycystic ovary syndrome: involvement of genetic and environmental factors. INTERNATIONAL JOURNAL OF ANDROLOGY. 29:278-284. DOI.
  • Smith D; Crotty TB; Murphy JF; Crofton ME; Franks S; McKenna TJ. (Jan 2006). A steroid cell tumor outside the ovary is a rare cause of virilization. Fertil Steril. 85:227. DOI.
  • Stubbs SA; Hardy K; Da Silva-Buttkus P; Stark J; Webber LJ; Flanagan AM; Themmen AP; Visser JA; et alGroome NP; Franks S. (Oct 2005). Anti-müllerian hormone protein expression is reduced during the initial stages of follicle development in human polycystic ovaries. J Clin Endocrinol Metab. 90:5536-5543. DOI.
  • Powell BL; Haddad L; Bennett A; Gharani N; Sovio U; Groves CJ; Rush K; Goh MJ; et alConway GS; Ruokonen A; Martikainen H; Pouta A; Taponen S; Hartikainen AL; Halford S; Zeggini E; Järvelin MR; Franks S; McCarthy MI. (May 2005). Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits. J Clin Endocrinol Metab. 90:2988-2993. DOI.
  • Bennett A; Sovio U; Ruokonen A; Martikainen H; Pouta A; Taponen S; Hartikainen AL; Franks S; et alPeltonen L; Elliott P; Järvelin MR; McCarthy MI. (May 2005). No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort. Diabetologia. 48:886-891. DOI.
  • Rice S; Christoforidis N; Gadd C; Nikolaou D; Seyani L; Donaldson A; Margara R; Hardy K; et alFranks S. (Feb 2005). Impaired insulin-dependent glucose metabolism in granulosa-lutein cells from anovulatory women with polycystic ovaries. Hum Reprod. 20:373-381. DOI.
  • Roberts R; Iatropoulou A; Ciantar D; Stark J; Becker DL; Franks S; Hardy K. (Jan 2005). Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro. Biol Reprod. 72:107-118. DOI.
  • Hart R; Hickey M; Franks S. (Oct 2004). Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 18:671-683. DOI.
  • Roberts R; Stark J; Iatropoulou A; Becker DL; Franks S; Hardy K. (Jul 2004). Energy substrate metabolism of mouse cumulus-oocyte complexes: response to follicle-stimulating hormone is mediated by the phosphatidylinositol 3-kinase pathway and is associated with oocyte maturation. Biol Reprod. 71:199-209. DOI.
  • Gaasenbeek M; Powell BL; Sovio U; Haddad L; Gharani N; Bennett A; Groves CJ; Rush K; et alGoh MJ; Conway GS; Ruokonen A; Martikainen H; Pouta A; Taponen S; Hartikainen AL; Halford S; Järvelin MR; Franks S; McCarthy MI. (May 2004). Large-scale analysis of the relationship between CYP11A promoter variation, polycystic ovarian syndrome, and serum testosterone. J Clin Endocrinol Metab. 89:2408-2413.
  • Taponen S; Martikainen H; Järvelin MR; Sovio U; Laitinen J; Pouta A; Hartikainen AL; McCarthy MI; et alFranks S; Paldanius M; Ruokonen A; Northern Finland Birth Cohort 1966 Study. (May 2004). Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. J Clin Endocrinol Metab. 89:2114-2118.
  • Taponen S; Ahonkallio S; Martikainen H; Koivunen R; Ruokonen A; Sovio U; Hartikainen AL; Pouta A; et alLaitinen J; King V; Franks S; McCarthy MI; Järvelin MR. (May 2004). Prevalence of polycystic ovaries in women with self-reported symptoms of oligomenorrhoea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. Hum Reprod. 19:1083-1088. DOI.
  • Franks S; McCarthy M. (Mar 2004). Genetics of ovarian disorders: polycystic ovary syndrome. Rev Endocr Metab Disord. 5:69-76. DOI.
  • Cela E; Robertson C; Rush K; Kousta E; White DM; Wilson H; Lyons G; Kingsley P; et alMcCarthy MI; Franks S. (Nov 2003). Prevalence of polycystic ovaries in women with androgenic alopecia. Eur J Endocrinol. 149:439-442.
  • Webber LJ; Stubbs S; Stark J; Trew GH; Margara R; Hardy K; Franks S. (27 Sep 2003). Formation and early development of follicles in the polycystic ovary. Lancet. 362:1017-1021.
  • Franks S. (Sep 2003). Assessment and management of anovulatory infertility in polycystic ovary syndrome. Endocrinol Metab Clin North Am. 32:639-651.
  • Laitinen J; Taponen S; Martikainen H; Pouta A; Millwood I; Hartikainen AL; Ruokonen A; Sovio U; et alMcCarthy MI; Franks S; Järvelin MR. (Jun 2003). Body size from birth to adulthood as a predictor of self-reported polycystic ovary syndrome symptoms. Int J Obes Relat Metab Disord. 27:710-715. DOI.
  • Franks S; Roberts R; Hardy K. (Mar 2003). Gonadotrophin regimens and oocyte quality in women with polycystic ovaries. Reprod Biomed Online. 6:181-184.
  • Taponen S; Martikainen H; Järvelin MR; Laitinen J; Pouta A; Hartikainen AL; Sovio U; McCarthy MI; et alFranks S; Ruokonen A. (Jan 2003). Hormonal profile of women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study. J Clin Endocrinol Metab. 88:141-147.
  • Roberts R; Franks S; Hardy K. (Nov 2002). Culture environment modulates maturation and metabolism of human oocytes. Hum Reprod. 17:2950-2956.
  • Sharpe RM; Franks S. (Oct 2002). Environment, lifestyle and infertility--an inter-generational issue. Nat Cell Biol. 4 Suppl:s33-s40. DOI.
  • Abbott DH; Dumesic DA; Franks S. (Jul 2002). Developmental origin of polycystic ovary syndrome - a hypothesis. J Endocrinol. 174:1-5.
  • Franks S. (Jun 2002). Adult polycystic ovary syndrome begins in childhood. Best Pract Res Clin Endocrinol Metab. 16:263-272. DOI.
  • Joseph-Horne R; Mason H; Batty S; White D; Hillier S; Urquhart M; Franks S. (Jun 2002). Luteal phase progesterone excretion in ovulatory women with polycystic ovaries. Hum Reprod. 17:1459-1463.
  • Haddad L; Evans JC; Gharani N; Robertson C; Rush K; Wiltshire S; Frayling TM; Wilkin TJ; et alDemaine A; Millward A; Hattersley AT; Conway G; Cox NJ; Bell GI; Franks S; McCarthy MI. (Jun 2002). Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome. J Clin Endocrinol Metab. 87:2606-2610.
  • Nardo LG; Buckett WM; White D; Digesu AG; Franks S; Khullar V. (Apr 2002). Three-dimensional assessment of ultrasound features in women with clomiphene citrate-resistant polycystic ovarian syndrome (PCOS): ovarian stromal volume does not correlate with biochemical indices. Hum Reprod. 17:1052-1055.
  • Franks S; Gharani N; McCarthy M. (Jul 2001). Candidate genes in polycystic ovary syndrome. Hum Reprod Update. 7:405-410.
  • Franks S; Gharani N; McCarthy M. (Jul 2001). Genetics and infertility II - Candidate genes in polycystic ovary syndrome. HUM REPROD UPDATE. 7:405-410.
  • Clément F; Monniaux D; Stark J; Hardy K; Thalabard JC; Franks S; Claude D. (Jul 2001). Mathematical model of FSH-induced cAMP production in ovarian follicles. Am J Physiol Endocrinol Metab. 281:E35-E53.
  • Russell SH; Small CJ; Stanley SA; Franks S; Ghatei MA; Bloom SR. (Mar 2001). The in vitro role of tumour necrosis factor-alpha and interleukin-6 in the hypothalamic-pituitary gonadal axis. J Neuroendocrinol. 13:296-301.
  • Franks S. (2001). Abnormalities of steroidogenesis in polycystic ovaries. BIOL REPROD. 64:86-86.
  • Bonser J; Walker J; Purohit A; Reed MJ; Potter BV; Willis DS; Franks S; Mason HD. (Dec 2000). Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production. J Endocrinol. 167:465-471.
  • Gilling-Smith C; Mason H; Willis D; Franks S; Beard RW. (Dec 2000). In-vitro ovarian steroidogenesis in women with pelvic congestion. Hum Reprod. 15:2570-2576.
  • Kousta E; Cela E; Lawrence N; Penny A; Millauer B; White D; Wilson H; Robinson S; et alJohnston D; McCarthy M; Franks S. (Oct 2000). The prevalence of polycystic ovaries in women with a history of gestational diabetes. Clin Endocrinol (Oxf). 53:501-507.
  • Franks S; Mason H; Willis D. (25 May 2000). Follicular dynamics in the polycystic ovary syndrome. Mol Cell Endocrinol. 163:49-52.
  • Hardy K; Wright CS; Franks S; Winston RM. (2000). In vitro maturation of oocytes. Br Med Bull. 56:588-602.
  • Franks S; Gilling-Smith C; Gharani N; McCarthy M. (2000). Pathogenesis of polycystic ovary syndrome: evidence for a genetically determined disorder of ovarian androgen production. Hum Fertil (Camb). 3:77-79.
  • Kousta E; White DM; Cela E; McCarthy MI; Franks S. (Nov 1999). The prevalence of polycystic ovaries in women with infertility. HUM REPROD. 14:2720-2723.
  • Wright CS; Hovatta O; Margara R; Trew G; Winston RM; Franks S; Hardy K. (Jun 1999). Effects of follicle-stimulating hormone and serum substitution on the in-vitro growth of human ovarian follicles. Hum Reprod. 14:1555-1562.
  • Watson H; Franks S; Bonney RC. (Sep 1998). Regulation of epidermal growth factor receptor by androgens in human endometrial cells in culture. HUM REPROD. 13:2585-2591.
  • Franks S; Gharani N; Waterworth D; Batty S; White D; Williamson R; McCarthy M. (Dec 1997). The genetic basis of polycystic ovary syndrome. Hum Reprod. 12:2641-2648.
  • Hughes SCC; Mason HD; Franks S; Holly JMP. (Dec 1997). The insulin-like growth factors (IGFs) in follicular fluid are predominantly bound in the ternary complex. J ENDOCRINOL. 155:R1-R4.
  • Abir R; Franks S; Mobberley MA; Moore PA; Margara RA; Winston RML. (Oct 1997). Mechanical isolation and in vitro growth of preantral and small antral human follicles. FERTIL STERIL. 68:682-688.
  • GillingSmith C; Willis DS; Franks S. (Aug 1997). Oestradiol feedback stimulation of androgen biosynthesis by human theca cells. HUM REPROD. 12:1621-1628.
  • GillingSmith C; Story H; Rogers V; Franks S. (Jul 1997). Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. CLIN ENDOCRINOL. 47:93-99.
  • Kousta E; White DM; Franks S. (Jul 1997). Modern use of clomiphene citrate in induction of ovulation. HUM REPROD UPDATE. 3:359-365.
  • Hughes SCC; Mason HD; Franks S; Holly JMP. (Jul 1997). Modulation of the insulin-like growth factor-binding proteins by follicle size in the human ovary. J ENDOCRINOL. 154:35-43.
  • GillingSmith C; Story H; Rogers V; Franks S. (Jun 1997). Exaggerated 17 alpha-hydroxyprogesterone response to HCG during endogenous LH suppression in women with polycystic ovaries. HUM REPROD. 12:P212-P212.
  • Franks S. (May 1997). Polycystic ovary syndrome: Approaching the millennium. HUM REPROD. 12:43-45.
  • Franks S. (Feb 1997). The 17 alpha-hydroxylase/17,20 lyase gene (CYP17) and polycystic ovary syndrome. CLIN ENDOCRINOL. 46:135-136.
  • Robinson S; Henderson AD; Gelding SV; Kiddy D; Niththyananthan R; Bush A; Richmond W; Johnston DG; et alFranks S. (Mar 1996). Dyslipidaemia is associated with insulin resistance in women with polycystic ovaries. Clin Endocrinol (Oxf). 44:277-284.
  • HAMILTONFAIRLEY D; WHITE D; GRIFFITHS M; ANYAOKU V; KOISTINEN R; SEPPALA M; FRANKS S. (Aug 1995). DIURNAL-VARIATION OF SEX-HORMONE BINDING GLOBULIN AND INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 IN WOMEN WITH POLYCYSTIC-OVARY-SYNDROME. CLIN ENDOCRINOL. 43:159-165.
  • Hardy K; Robinson FM; Paraschos T; Wicks R; Franks S; Winston RM. (Aug 1995). Normal development and metabolic activity of preimplantation embryos in vitro from patients with polycystic ovaries. Hum Reprod. 10:2125-2135.
  • WHITE D; LEIGH A; WILSON C; DONALDSON A; FRANKS S. (May 1995). GONADOTROPIN AND GONADAL-STEROID RESPONSE TO A SINGLE-DOSE OF A LONG-ACTING AGONIST OF GONADOTROPIN-RELEASING-HORMONE IN OVULATORY AND ANOVULATORY WOMEN WITH POLYCYSTIC-OVARY-SYNDROME. CLIN ENDOCRINOL. 42:475-481.
  • Carey AH; Waterworth D; Patel K; White D; Little J; Novelli P; Franks S; Williamson R. (Oct 1994). Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17. Hum Mol Genet. 3:1873-1876.
  • MASON HD; WILLIS DS; HOLLY JMP; FRANKS S. (May 1994). INSULIN PREINCUBATION ENHANCES INSULIN-LIKE GROWTH FACTOR-II (IGF-II) ACTION ON STEROIDOGENESIS IN HUMAN GRANULOSA-CELLS. J CLIN ENDOCR METAB. 78:1265-1267.
  • MASON HD; MANNAERTS B; DELEEUW R; WILLIS DS; FRANKS S. (Nov 1993). EFFECTS OF RECOMBINANT HUMAN FOLLICLE-STIMULATING-HORMONE ON CULTURED HUMAN GRANULOSA-CELLS - COMPARISON WITH URINARY GONADOTROPINS AND ACTIONS IN PREOVULATORY FOLLICLES. HUM REPROD. 8:1823-1827.
  • HAMILTONFAIRLEY D; KIDDY D; ANYAOKU V; KOISTINEN R; SEPPALA M; FRANKS S. (Sep 1993). RESPONSE OF SEX-HORMONE BINDING GLOBULIN AND INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 TO AN ORAL GLUCOSE-TOLERANCE TEST IN OBESE WOMEN WITH POLYCYSTIC-OVARY-SYNDROME BEFORE AND AFTER CALORIE RESTRICTION. CLIN ENDOCRINOL. 39:363-367.
  • Robinson S; Kiddy D; Gelding SV; Willis D; Niththyananthan R; Bush A; Johnston DG; Franks S. (Sep 1993). The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clin Endocrinol (Oxf). 39:351-355.
  • Carey AH; Chan KL; Short F; White D; Williamson R; Franks S. (Jun 1993). Evidence for a single gene effect causing polycystic ovaries and male pattern baldness. Clin Endocrinol (Oxf). 38:653-658.
  • Mason HD; Willis D; Holly JM; Cwyfan-Hughes SC; Seppala M; Franks S. (Nov 1992). Inhibitory effects of insulin-like growth factor-binding proteins on steroidogenesis by human granulosa cells in culture. Mol Cell Endocrinol. 89:R1-R4.
  • Robinson S; Chan SP; Spacey S; Anyaoku V; Johnston DG; Franks S. (Jun 1992). Postprandial thermogenesis is reduced in polycystic ovary syndrome and is associated with increased insulin resistance. Clin Endocrinol (Oxf). 36:537-543.
  • Kiddy DS; Hamilton-Fairley D; Bush A; Short F; Anyaoku V; Reed MJ; Franks S. (Jan 1992). Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 36:105-111.
  • SHARP PS; KIDDY DS; REED MJ; ANYAOKU V; JOHNSTON DG; FRANKS S. (Sep 1991). CORRELATION OF PLASMA-INSULIN AND INSULIN-LIKE GROWTH FACTOR-I WITH INDEXES OF ANDROGEN TRANSPORT AND METABOLISM IN WOMEN WITH POLYCYSTIC-OVARY-SYNDROME. CLIN ENDOCRINOL. 35:253-257.
  • Sagle MA; Hamilton-Fairley D; Kiddy DS; Franks S. (Jan 1991). A comparative, randomized study of low-dose human menopausal gonadotropin and follicle-stimulating hormone in women with polycystic ovarian syndrome. Fertil Steril. 55:56-60.
  • Mason HD; Margara R; Winston RM; Beard RW; Reed MJ; Franks S. (Oct 1990). Inhibition of oestradiol production by epidermal growth factor in human granulosa cells of normal and polycystic ovaries. Clin Endocrinol (Oxf). 33:511-517.
  • Kiddy DS; Sharp PS; White DM; Scanlon MF; Mason HD; Bray CS; Polson DW; Reed MJ; et alFranks S. (Feb 1990). Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: an analysis of 263 consecutive cases. Clin Endocrinol (Oxf). 32:213-220.
  • Singh A; Hamilton-Fairley D; Koistinen R; Seppälä M; James VH; Franks S; Reed MJ. (Feb 1990). Effect of insulin-like growth factor-type I (IGF-I) and insulin on the secretion of sex hormone binding globulin and IGF-I binding protein (IBP-I) by human hepatoma cells. J Endocrinol. 124:R1-R3.
  • KIDDY DS; HAMILTONFAIRLEY D; SEPPALA M; KOISTINEN R; JAMES VHT; REED MJ; FRANKS S. (Dec 1989). DIET-INDUCED CHANGES IN SEX-HORMONE BINDING GLOBULIN AND FREE TESTOSTERONE IN WOMEN WITH NORMAL OR POLYCYSTIC OVARIES - CORRELATION WITH SERUM-INSULIN AND INSULIN-LIKE GROWTH FACTOR-I. CLIN ENDOCRINOL. 31:757-763.
  • Franks S. (Jul 1989). Polycystic ovary syndrome: a changing perspective. Clin Endocrinol (Oxf). 31:87-120.
  • Polson DW; Kiddy DS; Mason HD; Franks S. (Jan 1989). Induction of ovulation with clomiphene citrate in women with polycystic ovary syndrome: the difference between responders and nonresponders. Fertil Steril. 51:30-34.
  • Scanlon MJ; Whorwood CB; Franks S; Reed MJ; James VH. (Nov 1988). Serum androstanediol glucuronide concentrations in normal and hirsute women and patients with thyroid dysfunction. Clin Endocrinol (Oxf). 29:529-538.
  • Mason HD; Sagle M; Polson DW; Kiddy D; Dobriansky D; Adams J; Franks S. (Jun 1988). Reduced frequency of luteinizing hormone pulses in women with weight loss-related amenorrhoea and multifollicular ovaries. Clin Endocrinol (Oxf). 28:611-618.
  • Polson DW; Franks S; Reed MJ; Cheng RW; Adams J; James VH. (May 1987). The distribution of oestradiol in plasma in relation to uterine cross-sectional area in women with polycystic or multifollicular ovaries. Clin Endocrinol (Oxf). 26:581-588.
  • FRANKS S; NEAGLE G; LEAKE R; MASON H; HARLOW C; WINSTON R; MARGARA R; REED M. (Mar 1987). EPIDERMAL GROWTH-FACTOR (EGF) CONCENTRATIONS IN FOLLICULAR-FLUID FROM NORMAL OR POLYCYSTIC OVARIES (PCO). J ENDOCRINOL. 112:120-120.
  • Polson DW; Mason HD; Franks S. (Feb 1987). Bromocriptine treatment of women with clomiphene-resistant polycystic ovary syndrome. Clin Endocrinol (Oxf). 26:197-203.
  • Polson DW; Mason HD; Saldahna MB; Franks S. (Feb 1987). Ovulation of a single dominant follicle during treatment with low-dose pulsatile follicle stimulating hormone in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 26:205-212.
  • Franks S; Sagle M; Mason HD; Kiddy D. (1987). Use of LHRH agonists in the treatment of anovulation in women with polycystic ovary syndrome. Horm Res. 28:164-168.

Chapters in books

  • Gilling-Smith C; Franks S. Hirsutism & Virilization. In In Gynaecology. 387-399. Shaw RW (ed); Soutter WP (ed); Stanton SL (ed). Churchill Livingstone, Edinburgh (2003).
  • Franks S. Female endocrinology. In Oxford textbook of endocrinology and diabetes. 1063-1226. (2002).
  • Gilling-Smith C; Franks S. Hirsutism. In Oxford Textbook of Endocrinology and Diabetes. 1148-1159. (2002).
  • Franks S; White DM. Low-dose gonadotrophin treatment in polycystic ovary syndrome:the 'step-up' protocol. In Ovulation Induction (Series-European practice in gynaecology and obstetrics,3). (2002).
  • Gilling-Smith C; Franks S. Ovary. In Comprehensive Clinical Endocrinology. 3rd:375-393. (2002).
  • Gilling-Smith C; Franks S. Ovary. In In Comprehensive Clinical Endocrinology. 375-393. Thorner MO (ed); Besser GM (ed). Mosby, London (2002).
  • Franks S; Cela E; Gharani N; Waterworth D; McCarthy M. Polycystic ovary syndrome:candidate genes for hyperandrogenism and hyperinsulinaemia. In Genetics in Endocrinology. 267-273. (2002).
  • Franks S; Gharani N; McCarthy M. Role of genes encoding steroidogenic enzymes in polycystic ovary syndrome. In Polycystic Ovary Syndrome. 247-259. (2002).
  • Webber LJ; Franks S. The breast. In Oxford Textbook of Endocrinology and Diabetes. 1202-1213. (2002).

Conferences

  • Morin-Papunen L; Martikainen H; McCarthy MI; Franks S; Sovio U; Hartikainen AL; Ruokonen A; Leinonen M; et alLaitinen J; Jarvelin MR; Pouta A. Comparison of metabolic and inflammatory outcomes in women who used oral contraceptives and the levonorgestrel-releasing intrauterine device in a general population. 199. (Nov 2008). DOI.
  • Franks S; Gharani N; Waterworth D; Batty S; White D; Williamson R; McCarthy M. Genetics of polycystic ovary syndrome. 145:123-128. (25 Oct 1998).
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