School of Public Health

ALSPAC: the avon longitudinal study of parents and children

principal investigator
Pauline Emmett, Department of Child Health, University of Bristol, 24 Tyndall Avenue, Bristol BS8 1TQ

director of ALSPAC
Professor Jean Golding, Unit of Paediatric and Perinatal Epidemiology, University of Bristol

14,000 children born during 1991-92
This is a geographically defined population from the West of England, collected as part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC). The cohort has been followed since the 8th gestational week and at various ages between 0-7 years. Detailed data on pregnancy (clinical and biological markers including maternal blood samples), birth, child growth, socioeconomic circumstances and outcome (blood pressure, lipids, weight and height) are available. More detailed nutritional data are available for about 1,000 children. Over 8,500 children have been seen at age 7 years and 70% of these gave a blood sample.

During the EURO-BLCS study further nutritional data will be collected and data analysis will be carried out to assess the relationship between maternal, pregnancy, fetal, growth, nutrition and social factors and intermediate CVD risk factors.

ALSPAC web site: http://www.alspac.bristol.ac.uk/

Selected publications

Golding J, Pembrey M, Jones R. ALSPAC--the Avon Longitudinal Study of Parents and Children I. Study methodology. ALSPAC Study Team. Paediatr Perinat Epidemiol. 2001 Jan;15(1):74-87.

Jones RW, Ring S, Tyfield L, Hamvas R, Simmons H, Pembrey M, Golding J, Team AS. A new human genetic resource: a DNA bank established as part of the Avon longitudinal study of pregnancy and childhood (ALSPAC). Eur J Hum Genet 2000 Sep;8(9):653-60

Whincup PH, Bredow M, Payne F, Sadler S, Golding J. Size at birth and blood pressure at 3 years of age. The Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC). Am J Epidemiol 1999 Apr 15;149(8):730-

Rogers I, Emmett P, Baker D, Golding J. Financial difficulties, smoking habits, composition of the diet and birthweight in a population of pregnant women in the South West of England. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Eur J Clin Nutr 1998 Apr;52(4):251-60

Rogers I, Emmett P. Diet during pregnancy in a population of pregnant women in South West England. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Eur J Clin Nutr 1998 Apr;52(4):246-50

Golding J. Children of the nineties. A longitudinal study of pregnancy and childhood based on the population of Avon (ALSPAC). West Engl Med J 1990 Sep;105(3):80-2

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